@article{WeiseBasseLuesebrinkKleinschnitzetal.2011,
  author    = {Weise, Gesa and Basse-L{\"u}sebrink, Thomas C. and Kleinschnitz, Christoph and Kampf, Thomas and Jakob, Peter M. and Stoll, Guido},
  title     = {In Vivo Imaging of Stepwise Vessel Occlusion in Cerebral Photothrombosis of Mice by \(^{19}\)F MRI},
  series = {PLoS One},
  volume    = {6},
  journal   = {PLoS One},
  number    = {12},
  doi       = {10.1371/journal.pone.0028143},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-137792},
  pages     = {e28143},
  year      = {2011},
  abstract  = {Background \(^{19}\)F magnetic resonance imaging (MRI) was recently introduced as a promising technique for in vivo cell tracking. In the present study we compared \(^{19}\)F MRI with iron-enhanced MRI in mice with photothrombosis (PT) at 7 Tesla. PT represents a model of focal cerebral ischemia exhibiting acute vessel occlusion and delayed neuroinflammation. Methods/Principal Findings Perfluorocarbons (PFC) or superparamagnetic iron oxide particles (SPIO) were injected intravenously at different time points after photothrombotic infarction. While administration of PFC directly after PT induction led to a strong \(^{19}\)F signal throughout the entire lesion, two hours delayed application resulted in a rim-like \(^{19}\)F signal at the outer edge of the lesion. These findings closely resembled the distribution of signal loss on T2-weighted MRI seen after SPIO injection reflecting intravascular accumulation of iron particles trapped in vessel thrombi as confirmed histologically. By sequential administration of two chemically shifted PFC compounds 0 and 2 hours after illumination the different spatial distribution of the \(^{19}\)F markers (infarct core/rim) could be visualized in the same animal. When PFC were applied at day 6 the fluorine marker was only detected after long acquisition times ex vivo. SPIO-enhanced MRI showed slight signal loss in vivo which was much more prominent ex vivo indicative for neuroinflammation at this late lesion stage. Conclusion Our study shows that vessel occlusion can be followed in vivo by \(^{19}\)F and SPIO-enhanced high-field MRI while in vivo imaging of neuroinflammation remains challenging. The timing of contrast agent application was the major determinant of the underlying processes depicted by both imaging techniques. Importantly, sequential application of different PFC compounds allowed depiction of ongoing vessel occlusion from the core to the margin of the ischemic lesions in a single MRI measurement.},
  language  = {en}
}
@article{LiuBudimanTianetal.2020,
  author    = {Liu, Zhiqiang and Budiman, Yudha P. and Tian, Ya-Ming and Friedrich, Alexandra and Huang, Mingming and Westcott, Stephen A. and Radius, Udo and Marder, Todd B.},
  title     = {Copper-Catalyzed Oxidative Cross-Coupling of Electron-Deficient Polyfluorophenylboronate Esters with Terminal Alkynes},
  series = {Chemistry - A European Journal},
  volume    = {26},
  journal   = {Chemistry - A European Journal},
  number    = {71},
  doi       = {10.1002/chem.202002888},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-224362},
  pages     = {17267 -- 17274},
  year      = {2020},
  abstract  = {We report herein a mild procedure for the copper-catalyzed oxidative cross-coupling of electron-deficient polyfluorophenylboronate esters with terminal alkynes. This method displays good functional group tolerance and broad substrate scope, generating cross-coupled alkynyl(fluoro)arene products in moderate to excellent yields. Thus, it represents a simple alternative to the conventional Sonogashira reaction.},
  language  = {en}
}
@article{BudimanWestcottRadiusetal.2021,
  author    = {Budiman, Yudha P. and Westcott, Stephen A. and Radius, Udo and Marder, Todd B.},
  title     = {Fluorinated Aryl Boronates as Building Blocks in Organic Synthesis},
  series = {Advanced Synthesis \& Catalysis},
  volume    = {363},
  journal   = {Advanced Synthesis \& Catalysis},
  number    = {9},
  doi       = {10.1002/adsc.202001291},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-225908},
  pages     = {2224 -- 2255},
  year      = {2021},
  abstract  = {Organoboron compounds are well known building blocks for many organic reactions. However, under basic conditions, polyfluorinated aryl boronic acid derivatives suffer from instability issues that are accelerated in compounds containing an ortho-fluorine group, which result in the formation of the corresponding protodeboronation products. Therefore, a considerable amount of research has focused on novel methodologies to synthesize these valuable compounds while avoiding the protodeboronation issue. This review summarizes the latest developments in the synthesis of fluorinated aryl boronic acid derivatives and their applications in cross-coupling reactions and other transformations. image},
  language  = {en}
}
@article{BudimanFriedrichRadiusetal.2019,
  author    = {Budiman, Yudha P. and Friedrich, Alexandra and Radius, Udo and Marder, Todd B.},
  title     = {Copper-catalysed Suzuki-Miyaura cross-coupling of highly fluorinated aryl boronate esters with aryl iodides and bromides and fluoroarene-arene π-stacking interactions in the products},
  series = {ChemCatChem},
  volume    = {11},
  journal   = {ChemCatChem},
  number    = {21},
  doi       = {10.1002/cctc.201901220},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-204839},
  pages     = {5387-5396},
  year      = {2019},
  abstract  = {A combination of copper iodide and phenanthroline as the ligand is an efficient catalyst for Suzuki-Miyaura cross-coupling of highly fluorinated boronate esters (aryl-Bpin) with aryl iodides and bromides to generate fluorinated biaryls in good to excellent yields. This method represents a nice alternative to traditional cross-coupling methods which require palladium catalysts and stoichiometric amounts of silver oxide. We note that π⋅⋅⋅π stacking interactions dominate the molecular packing in the partly fluorinated biaryl crystals investigated herein. They are present either between the arene and perfluoroarene, or solely between arenes or perfluoroarenes, respectively.},
  language  = {en}
}
@article{BischoffRieferWirthensohnetal.2020,
  author    = {Bischoff, Lisa A. and Riefer, Jarno and Wirthensohn, Raphael and Bischof, Tobias and Bertermann, R{\"u}diger and Ignat'ev, Nikolai V. and Finze, Maik},
  title     = {Pentafluoroethylaluminates: A Combined Synthetic, Spectroscopic, and Structural Study},
  series = {Chemistry - A European Journal},
  volume    = {26},
  journal   = {Chemistry - A European Journal},
  number    = {60},
  doi       = {10.1002/chem.202000667},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-214666},
  pages     = {13615 -- 13620},
  year      = {2020},
  abstract  = {Salts of the tetrakis(pentafluoroethyl)aluminate anion [Al(C\(_{2}\)F\(_{5}\))\(_{2}\)]\(^{-}\) were obtained from AlCl\(_{3}\) and LiC\(_{2}\)F\(_{5}\). They were isolated with different counter-cations and characterized by NMR and vibrational spectroscopy and mass spectrometry. Degradation of the [Al(C\(_{2}\)F\(_{5}\))\(_{4}\)]\(^{-}\) ion was found to proceed via 1,2-fluorine shifts and stepwise loss of CF(CF\(_{3}\)) under formation of [(C\(_{2}\)F\(_{5}\))\(_{4-n}\)AlF\(_{n}\)]- (n=1-4) as assessed by NMR spectroscopy and mass spectrometry and supported by results of DFT calculations. In addition, the [(C\(_{2}\)F\(_{5}\))AlF\(_{3}\)]\(^{-}\) ion was structurally characterized.},
  language  = {en}
}