@article{WahlenRoewerKranke2010,
  author    = {Wahlen, Bianca M. and Roewer, Norbert and Kranke, Peter},
  title     = {Use of local anaesthetics and adjuncts for spinal and epidural anaesthesia and analgesia at German and Austrian University Hospitals: an online survey to access current standard practice},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-67847},
  year      = {2010},
  abstract  = {Background: The present anonymous multicenter online survey was conducted to evaluate the application of regional anaesthesia techniques as well as the used local anaesthetics and adjuncts at German and Austrian university hospitals. Methods: 39 university hospitals were requested to fill in an online questionnaire, to determine the kind of regional anaesthesia and preferred drugs in urology, obstetrics and gynaecology. Results: 33 hospitals responded. No regional anaesthesia is conducted in 47\% of the minor gynaecological and 44\% of the urological operations; plain bupivacaine 0.5\% is used in 38\% and 47\% respectively. In transurethral resections of the prostate and bladder no regional anaesthesia is used in 3\% of the responding hospitals, whereas plain bupivacaine 0.5\% is used in more than 90\%. Regional anaesthesia is only used in selected major gynaecological and urological operations. On the contrary to the smaller operations, the survey revealed a large variety of used drugs and mixtures. Almost 80\% prefer plain bupivacaine or ropivacaine 0.5\% in spinal anaesthesia in caesarean section. Similarly to the use of drugs in major urological and gynaecological operations a wide range of drugs and adjuncts is used in epidural anaesthesia in caesarean section and spontaneous delivery. Conclusions: Our results indicate a certain agreement in short operations in spinal anaesthesia. By contrast, a large variety concerning the anaesthesiological approach in larger operations as well as in epidural analgesia in obstetrics could be revealed, the causes of which are assumed to be primarily rooted in particular departmental structures.},
  subject      = {An{\"a}sthesiologie},
  language  = {en}
}
@article{MarkensteinAppeltMenzelMetzgeretal.2014,
  author    = {Markenstein, Lisa and Appelt-Menzel, Antje and Metzger, Marco and Wenz, Gerhard},
  title     = {Conjugates of methylated cyclodextrin derivatives and hydroxyethyl starch (HES): Synthesis, cytotoxicity and inclusion of anaesthetic actives},
  series = {Beilstein Journal of Organic Chemistry},
  volume    = {10},
  journal   = {Beilstein Journal of Organic Chemistry},
  issn      = {1860-5397},
  doi       = {10.3762/bjoc.10.325},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-114280},
  pages     = {3087 - 3096},
  year      = {2014},
  abstract  = {The mono-6-deoxy-6-azides of 2,6-di-O-methyl-beta-cyclodextrin (DIMEB) and randomly methylated-beta-cyclodextrin (RAMEB) were conjugated to propargylated hydroxyethyl starch (HES) by Cu+-catalysed [2 + 3] cycloaddition. The resulting water soluble polymers showed lower critical solution temperatures (LCST) at 52.5 degrees C (DIMEB-HES) and 84.5 degrees C (RAMEB-HES), respectively. LCST phase separations could be completely avoided by the introduction of a small amount of carboxylate groups at the HES backbone. The methylated CDs conjugated to the HES backbone exhibited significantly lower cytotoxicities than the corresponding monomeric CD derivatives. Since the binding potentials of these CD conjugates were very high, they are promising candidates for new oral dosage forms of anaesthetic actives.},
  language  = {en}
}