@article{PoppeAndersKneitzetal.2012, author = {Poppe, Lidia Marilia and Anders, Diana and Kneitz, Hermann and Br{\"o}cker, Eva-Bettina and Benoit, Sandrine}, title = {Flagellate dermatitis caused by shiitake mushrooms}, series = {Anais Brasileiros de Dermatologia}, volume = {87}, journal = {Anais Brasileiros de Dermatologia}, number = {3}, doi = {10.1590/S0365-05962012000300017 }, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-134362}, pages = {463-465}, year = {2012}, abstract = {Shiitake (Lentinus edodes) is the second most consumed mushroom in the world. It has long been known in Asian medicine for its anticarcinogenic, antihypertensive and serum cholesterol level reduction properties. Nevertheless, the consumption of raw or not well-cooked mushrooms may cause skin eruptions which usually occur 24 to 48 hours after ingestion and are characterized by linearly arranged pruritic erythematous papules and plaques. We present a 36-year-old patient that developed typical symptoms 24 hours after consumption of shiitake mushrooms and summarize therapeutic options and particularities of this disease.}, language = {en} } @article{AndersTrautmann2013, author = {Anders, Diana and Trautmann, Axel}, title = {Allergic anaphylaxis due to subcutaneously injected heparin}, series = {Allergy, Asthma \& Clinical Immunology}, journal = {Allergy, Asthma \& Clinical Immunology}, doi = {10.1186/1710-1492-9-1}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-96214}, year = {2013}, abstract = {Heparins are one of the most used class of anticoagulants in daily clinical practice. Despite their widespread application immune-mediated hypersensitivity reactions to heparins are rare. Among these, the delayed-type reactions to s.c. injected heparins are well-known usually presenting as circumscribed eczematous plaques at the injection sites. In contrast, potentially life-threatening systemic immediate-type anaphylactic reactions to heparins are extremely rare. Recently, some cases of non-allergic anaphylaxis could be attributed to undesirable heparin contaminants. A 43-year-old patient developed severe anaphylaxis symptoms within 5-10 minutes after s.c. injection of enoxaparin. Titrated skin prick testing with wheal and flare responses up to an enoxaparin dilution of 1:10.000 indicated a probable allergic mechanism of the enoxaparin-induced anaphylaxis. The basophil activation test as an additional in-vitro test method was negative. Furthermore, skin prick testing showed rather broad cross-reactivity among different heparin preparations tested. In the presented case, history, symptoms, and results of skin testing strongly suggested an IgE-mediated allergic hypersensitivity against different heparins. Therefore, as safe alternative anticoagulants the patient could receive beneath coumarins the hirudins or direct thrombin inhibitors. Because these compounds have a completely different molecular structure compared with the heparin-polysaccharides.}, language = {en} }