@unpublished{Bartfeld2016,
  author    = {Bartfeld, Sina},
  title     = {Modeling infectious diseases and host-microbe interactions in gastrointestinal organoids},
  series = {Developmental Biology},
  journal   = {Developmental Biology},
  issn      = {0012-1606},
  doi       = {http://dx.doi.org/10.1016/j.ydbio.2016.09.014},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-138788},
  year      = {2016},
  abstract  = {Advances in stem cell research have allowed the development of 3-dimensional (3D) primary cell cultures termed organoid cultures, as they closely mimic the in vivo organization of different cell lineages. Bridging the gap between 2-dimensional (2D) monotypic cancer cell lines and whole organisms, organoids are now widely applied to model development and disease. Organoids hold immense promise for addressing novel questions in host-microbe interactions, infectious diseases and the resulting inflammatory conditions. Researchers have started to use organoids for modeling infection with pathogens, such as Helicobacter pylori or Salmonella enteritica, gut- microbiota interactions and inflammatory bowel disease. Future studies will broaden the spectrum of microbes used and continue to establish organoids as a standard model for human host-microbial interactions. Moreover, they will increasingly exploit the unique advantages of organoids, for example to address patient-specific responses to microbes.},
  language  = {en}
}