@techreport{OPUS4-35963,
  title     = {Platelets - Molecular, cellular and systemic functions in health and disease},
  editor    = {Nieswandt, Bernhard},
  organization    = {Collaborative Research Centre/Transregio 240},
  doi       = {10.25972/OPUS-35963},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-359636},
  pages     = {25},
  year      = {2024},
  abstract  = {Besides their central role in haemostasis and thrombosis, platelets are increasingly recognised as versatile effector cells in inflammation, the innate and adaptive immune response, extracellular matrix reorganisation and fibrosis, maintenance of barrier and organ integrity, and host response to pathogens. These platelet functions, referred to as thrombo-inflammation and immunothrombosis, have gained major attention in the COVID-19 pandemic, where patients develop an inflammatory disease state with severe and life-threatening thromboembolic complications. In the CRC/TR 240, a highly interdisciplinary team of basic, translational and clinical scientists explored these emerging roles of platelets with the aim to develop novel treatment concepts for cardiovascular disorders and beyond. We have i) unravelled mechanisms leading to life-threatening thromboembolic complica-tions following vaccination against SARS-CoV-2 with adenoviral vector-based vaccines, ii) identified unrecognised functions of platelet receptors and their regulation, offering new potential targets for pharmacological intervention and iii) developed new methodology to study the biology of megakar-yocytes (MKs), the precursor cells of platelets in the bone marrow, which lay the foundation for the modulation of platelet biogenesis and function. The projects of the CRC/TR 240 built on the unique expertise of our research network and focussed on the following complementary fields: (A) Cell bi-ology of megakaryocytes and platelets and (B) Platelets as regulators and effectors in disease. To achieve this aim, we followed a comprehensive approach starting out from in vitro systems and animal models to clinical research with large prospective patient cohorts and data-/biobanking. Despite the comparably short funding period the CRC/TR 240 discovered basic new mechanisms of platelet biogenesis, signal transduction and effector function and identified potential MK/platelet-specific molecular targets for diagnosis and therapy of thrombotic, haemorrhagic and thrombo-inflammatory disease states.},
  subject      = {Thrombozyt},
  language  = {en}
}
@techreport{NordPetzke2023,
  author    = {Nord, Ilona and Petzke, Judith},
  title     = {Religious Education in the digital change. Concepts and reflections from a German context},
  edition   = {revised version},
  doi       = {10.25972/OPUS-32858},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-328582},
  pages     = {30},
  year      = {2023},
  abstract  = {The article presents results from the project Religious Education Laboratory digital (RELab digital): At a time when exclusive access to religion in the classroom seems less and less plausible, the concept of digital religion education we propose leads back to the existential needs for religion. It can refer to the thematic fields of digital religions, which in turn are not new for religious education, but remix its traditions and themes in the mirror of transforming communication cultures: authority, community, truth, communication, autonomy, religion, identity, and ritual. Chapter 1 contains a description of the project structure. Chapter 2 is dedicated to the pedagogical challenge of teaching Religious Education (RE) in the digital change. Chapter 3 reflects from a pedagogical standpoint on empirical findings of the project, which were developed in the context of classroom observations and interviews. Chapter 4 focuses on topics related to the profession of teachers: What self-concepts are pursued by teachers of Religious Education and/or can be reconstructed through the way they act in the classroom? How can the often critical perceptions of teachers who use digital media in religious education be put to good use in the future? The conclusion bundles the most important insights and highlights examples of further research.},
  subject      = {Digitalisierung},
  language  = {en}
}
@techreport{BoeschStielerLydonetal.2023,
  author    = {B{\"o}sch, Carolin and Stieler, Malena and Lydon, Salomon and Hesse, Martin and Ali, Hassan and Finzel, Matthias and Faraz Ali, Syed and Salian, Yash and Alnoor, Hiba and John, Jeena and Lakkad, Harsh and Bhosale, Devraj and Jafarian, Timon and Parvathi, Uma and Ezzatpoor, Narges and Datar, Tanuja},
  title     = {Venus Research Station},
  issn      = {2747-9374},
  doi       = {10.25972/OPUS-32869},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-328695},
  pages     = {232},
  year      = {2023},
  abstract  = {Because of the extreme conditions in the atmosphere, Venus has been less explored than for example Mars. Only a few probes have been able to survive on the surface for very short periods in the past and have sent data. The atmosphere is also far from being fully explored. It could even be that building blocks of life can be found in more moderate layers of the planet's atmosphere. It can therefore be assumed that the planet Venus will increasingly become a focus of exploration. One way to collect significantly more data in situ is to build and operate an atmospheric research station over an extended period of time. This could carry out measurements at different positions and at different times and thus significantly expand our knowledge of the planet. In this work, the design of a Venus Research Station floating within the Venusian atmosphere is presented, which is complemented by the design of deployable atmospheric Scouts. The design of these components is done on a conceptual basis.},
  subject      = {Venus},
  language  = {en}
}
@techreport{BofingerGeissendoerferHaasetal.2023,
  author    = {Bofinger, Peter and Geißend{\"o}rfer, Lisa and Haas, Thomas and Mayer, Fabian},
  title     = {Credit as an Instrument for Growth: A Monetary Explanation of the Chinese Growth Story},
  doi       = {10.25972/OPUS-32880},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-328804},
  pages     = {148},
  year      = {2023},
  abstract  = {This study describes the Chinese growth model over the past 40 years. We show that China's growth model, with its dominant role of the banking system and "the banker", is a perfect illustration of the necessity and power of Schumpeter's "monetary analysis". This approach has allowed us to elaborate theoretically and empirically the uniqueness of the Chinese model. In our empirical analysis, we use a new dataset of Chinese provincial data to analyze the impact of the financial system, especially banks, on Chinese economic development. We also empirically assess the role of the financial system in Chinese industrial policy and provide case studies of the effects of industrial policy in specific sectors. Finally, we also discuss macroeconomic dimensions of the Chinese growth process and lessons that can be drawn from the Chinese experience for other countries.},
  subject      = {Industriepolitik},
  language  = {en}
}
@techreport{NordPetzke2023,
  author    = {Nord, Ilona and Petzke, Judith},
  title     = {Religious Education in the digital change. Concepts and reflections from a German context},
  doi       = {10.25972/OPUS-32280},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-322802},
  pages     = {30},
  year      = {2023},
  abstract  = {The article presents results from the project Religious Education Laboratory digital (RELab digital): At a time when exclusive access to religion in the classroom seems less and less plausible, the concept of digital religion education we propose leads back to the existential needs for religion. It can refer to the thematic fields of digital religions, which in turn are not new for religious education, but remix its traditions and themes in the mirror of transforming communication cultures: authority, community, truth, communication, autonomy, religion, identity, and ritual. Chapter 1 contains a description of the project structure. Chapter 2 is dedicated to the pedagogical challenge of teaching Religious Education (RE) in the digital change. Chapter 3 reflects from a pedagogical standpoint on empirical findings of the project, which were developed in the context of classroom observations and interviews. Chapter 4 focuses on topics related to the profession of teachers: What self-concepts are pursued by teachers of Religious Education and/or can be reconstructed through the way they act in the classroom? How can the often critical perceptions of teachers who use digital media in religious education be put to good use in the future? The conclusion bundles the most important insights and highlights examples of further research.},
  subject      = {Digitalisierung},
  language  = {en}
}
@techreport{MuellerSchererLorenzenAmmeretal.2022,
  author    = {M{\"u}ller, J{\"o}rg and Scherer-Lorenzen, Michael and Ammer, Christian and Eisenhauer, Nico and Seidel, Dominik and Schuldt, Bernhard and Biedermann, Peter and Schmitt, Thomas and K{\"u}nzer, Claudia and Wegmann, Martin and Cesarz, Simone and Peters, Marcell and Feldhaar, Heike and Steffan-Dewenter, Ingolf and Claßen, Alice and B{\"a}ssler, Claus and von Oheimb, Goddert and Fichtner, Andreas and Thorn, Simon and Weisser, Wolfgang},
  title     = {BETA-FOR: Erh{\"o}hung der strukturellen Diversit{\"a}t zwischen Waldbest{\"a}nden zur Erh{\"o}hung der Multidiversit{\"a}t und Multifunktionalit{\"a}t in Produktionsw{\"a}ldern. Antragstext f{\"u}r die DFG Forschungsgruppe FOR 5375},
  doi       = {10.25972/OPUS-29084},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-290849},
  pages     = {210},
  year      = {2022},
  abstract  = {Der in j{\"u}ngster Zeit beobachtete kontinuierliche Verlust der β-Diversit{\"a}t in {\"O}kosystemen deutet auf homogene Gemeinschaften auf Landschaftsebene hin, was haupts{\"a}chlich auf die steigende Landnutzungsintensit{\"a}t zur{\"u}ckgef{\"u}hrt wird. Biologische Vielfalt ist mit zahlreichen Funktionen und der Stabilit{\"a}t von {\"O}kosystemen verkn{\"u}pft. Es ist daher zu erwarten, dass eine abnehmende β-Diversit{\"a}t auch die Multifunktionalit{\"a}t verringert. Wir kombinieren hier Fachwissen aus der Forstwissenschaft, der {\"O}kologie, der Fernerkundung, der chemischen {\"O}kologie und der Statistik in einem gemeinschaftlichen und experimentellen β-Diversit{\"a}tsdesign, um einerseits die Auswirkungen der Homogenisierung zu bewerten und andererseits Konzepte zu entwickeln, um negative Auswirkungen durch Homogenisierung in W{\"a}ldern r{\"u}ckg{\"a}ngig zu machen. Konkret werden wir uns mit der Frage besch{\"a}ftigen, ob die Verbesserung der strukturellen β-Komplexit{\"a}t (ESBC) in W{\"a}ldern durch Waldbau oder nat{\"u}rliche St{\"o}rungen die Biodiversit{\"a}t und Multifunktionalit{\"a}t in ehemals homogenen Produktionsw{\"a}ldern erh{\"o}hen kann. Unser Ansatz wird m{\"o}gliche Mechanismen hinter den beobachteten Homogenisierungs-Diversit{\"a}ts-Beziehungen identifizieren und zeigen, wie sich diese auf die Multifunktionalit{\"a}t auswirken. An elf Standorten in ganz Deutschland haben wir dazu zwei Waldbest{\"a}nde als zwei kleine "Waldlandschaften" ausgew{\"a}hlt. In einem dieser beiden Best{\"a}nde haben wir ESBC (Enhancement of Structural Beta Complexity)-Behandlungen durchgef{\"u}hrt. Im zweiten, dem Kontrollbestand, werden wir die gleich Anzahl 50x50m Parzellen ohne ESBC einrichten. Auf allen Parzellen werden wir 18 taxonomische Artengruppen aller trophischer Ebenen und 21 {\"O}kosystemfunktionen, einschließlich der wichtigsten Funktionen in W{\"a}ldern der gem{\"a}ßigten Zonen, messen. Der statistische Rahmen wird eine umfassende Analyse der Biodiversit{\"a}t erm{\"o}glichen, indem verschiedenen Aspekte (taxonomische, funktionelle und phylogenetische Vielfalt) auf verschiedenen Skalenebenen (α-, β-, γ-Diversit{\"a}t) quantifiziert werden. Um die Gesamtdiversit{\"a}t zu kombinieren, werden wir das Konzept der Multidiversit{\"a}t auf die 18 Taxa anwenden. Wir werden neue Ans{\"a}tze zur Quantifizierung und Aufteilung der Multifunktionalit{\"a}t auf α- und β-Skalen verwenden und entwickeln. Durch die experimentelle Beschreibung des Zusammenhangs zwischen β-Diversit{\"a}t und Multifunktionalit{\"a}t in einer Reallandschaft wird unsere Forschung einen neuen Weg einschlagen. Dar{\"u}ber hinaus werden wir dazu beitragen, verbesserte Leitlinien f{\"u}r waldbauliche Konzepte und f{\"u}r das Management nat{\"u}rlicher St{\"o}rungen zu entwickeln, um Homogenisierungseffekte der Vergangenheit umzukehren.},
  subject      = {Wald{\"o}kosystem},
  language  = {en}
}
@techreport{Gross2022,
  author    = {Groß, Lennart},
  title     = {Advices derived from troubleshooting a sensor-based adaptive optics direct stochastic optical reconstruction microscope},
  doi       = {10.25972/OPUS-28995},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-289951},
  pages     = {20},
  year      = {2022},
  abstract  = {One rarely finds practical guidelines for the implementation of complex optical setups. Here, we aim to provide technical details on the decision making of building and revising a custom sensor-based adaptive optics (AO) direct stochastic optical reconstruction microscope (dSTORM) to provide practical assistance in setting up or troubleshooting similar devices. The foundation of this report is an instrument constructed as part of a master's thesis in 2021, which was built for deep tissue imaging. The setup is presented in the following way: (1) An optical and mechanical overview of the system at the beginning of this internship is given. (2) The optical components are described in detail in the order at which the light passes through, highlighting their working principle and implementation in the system. The optical component include (2A) a focus on even sample illumination, (2B) restoring telecentricity when working with commercial microscope bodies, (2C) the AO elements, namely the deformable mirror (DM) and the wavefront sensor, and their integration, and (2D) the separation of wavefront and image capture using fluorescent beads and a dichroic mirror. After addressing the limitations of the existing setup, modification options are derived. The modifications include the implementation of adjustment only light paths to improve system stability and revise the degrees of freedom of the components and changes in lens choices to meet the specifications of the AO components. Last, the capabilities of the modified setup are presented and discussed: (1) First, we enable epifluorescence imaging of bead samples through 180 µm unstained murine hippocampal tissue with wavefront error correction of ~ 90 \%. Point spread function, wavefront shape and Zernike decomposition of bead samples are presented. (2) Second, we move from epifluorescent to dSTORM imaging of tubulin stained primary mouse hippocampal cells, which are imaged through up to 180 µm of unstained murine hippocampal tissue. We show that full width at half maximum (FWHM) of prominent features can be reduced in size by nearly a magnitude from uncorrected epiflourescence images to dSTORM images corrected by the adaptive optics. We present dSTORM localization count and FWHM of prominent features as as a function of imaging depth.},
  subject      = {Einzelmolek{\"u}lmikroskopie},
  language  = {en}
}
@techreport{MeyerJobLaneretal.2022,
  author    = {Meyer, Constantin and Job, Hubert and Laner, Peter and Omizzolo, Andrea and Kollmann, Nadia and Clare, Jasmin and Vesely, Philipp and Riedler, Walter and Plassmann, Guido and Coronado, Oriana and Praper Gulič, Sergeja and Gulič, Andrej and Koblar, Simon and Teofili, Corrado and Rohringer, Verena and Schoßleitner, Richard and Ainz, Gerhard},
  title     = {OpenSpaceAlps Planning Handbook: Perspectives for consistent safeguarding of open spaces in the Alpine region},
  doi       = {10.25972/OPUS-27040},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-270401},
  pages     = {110},
  year      = {2022},
  abstract  = {In the Alpine region, the continuous consumption of open spaces for settlement areas and technical infrastructure and the associated soil sealing can be observed. This leads primarily to the loss of agricultural land. Depending on the extent of development, there is also increased landscape fragmentation, which is associated with the isolation of natural habitats and the restriction of ecological connectivity, as well as other negative consequences. The OpenSpaceAlps project has addressed this issue and, based on cooperative procedures in several pilot regions, has developed approaches and solution strategies for the sustainable safeguarding of open spaces. This handbook supports the activities and decision-making of various stakeholders, first and foremost planners in public planning authorities. Based on an analysis of the challenges and framework conditions in the Alpine region, the handbook presents and compares central "principles" of open space planning. Furthermore, integrated planning strategies for different spatial categories are discussed.},
  subject      = {Raumordnung},
  language  = {en}
}
@techreport{RossiMaurelliUnnithanetal.2021,
  author    = {Rossi, Angelo Pio and Maurelli, Francesco and Unnithan, Vikram and Dreger, Hendrik and Mathewos, Kedus and Pradhan, Nayan and Corbeanu, Dan-Andrei and Pozzobon, Riccardo and Massironi, Matteo and Ferrari, Sabrina and Pernechele, Claudia and Paoletti, Lorenzo and Simioni, Emanuele and Maurizio, Pajola and Santagata, Tommaso and Borrmann, Dorit and N{\"u}chter, Andreas and Bredenbeck, Anton and Zevering, Jasper and Arzberger, Fabian and Reyes Mantilla, Camilo Andr{\´e}s},
  title     = {DAEDALUS - Descent And Exploration in Deep Autonomy of Lava Underground Structures},
  isbn      = {978-3-945459-33-1},
  issn      = {1868-7466},
  doi       = {10.25972/OPUS-22791},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-227911},
  pages     = {188},
  year      = {2021},
  abstract  = {The DAEDALUS mission concept aims at exploring and characterising the entrance and initial part of Lunar lava tubes within a compact, tightly integrated spherical robotic device, with a complementary payload set and autonomous capabilities. The mission concept addresses specifically the identification and characterisation of potential resources for future ESA exploration, the local environment of the subsurface and its geologic and compositional structure. A sphere is ideally suited to protect sensors and scientific equipment in rough, uneven environments. It will house laser scanners, cameras and ancillary payloads. The sphere will be lowered into the skylight and will explore the entrance shaft, associated caverns and conduits. Lidar (light detection and ranging) systems produce 3D models with high spatial accuracy independent of lighting conditions and visible features. Hence this will be the primary exploration toolset within the sphere. The additional payload that can be accommodated in the robotic sphere consists of camera systems with panoramic lenses and scanners such as multi-wavelength or single-photon scanners. A moving mass will trigger movements. The tether for lowering the sphere will be used for data communication and powering the equipment during the descending phase. Furthermore, the connector tether-sphere will host a WIFI access point, such that data of the conduit can be transferred to the surface relay station. During the exploration phase, the robot will be disconnected from the cable, and will use wireless communication. Emergency autonomy software will ensure that in case of loss of communication, the robot will continue the nominal mission.},
  subject      = {Mond},
  language  = {en}
}
@techreport{GrigorjewMetzgerHossfeldetal.2020,
  author    = {Grigorjew, Alexej and Metzger, Florian and Hoßfeld, Tobias and Specht, Johannes and G{\"o}tz, Franz-Josef and Schmitt, J{\"u}rgen and Chen, Feng},
  title     = {Technical Report on Bridge-Local Guaranteed Latency with Strict Priority Scheduling},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-198310},
  year      = {2020},
  abstract  = {Bridge-local latency computation is often regarded with caution, as historic efforts with the Credit-Based Shaper (CBS) showed that CBS requires network wide information for tight bounds. Recently, new shaping mechanisms and timed gates were applied to achieve such guarantees nonetheless, but they require support for these new mechanisms in the forwarding devices. This document presents a per-hop latency bound for individual streams in a class-based network that applies the IEEE 802.1Q strict priority transmission selection algorithm. It is based on self-pacing talkers and uses the accumulated latency fields during the reservation process to provide upper bounds with bridge-local information. The presented delay bound is proven mathematically and then evaluated with respect to its accuracy. It indicates the required information that must be provided for admission control, e.g., implemented by a resource reservation protocol such as IEEE 802.1Qdd. Further, it hints at potential improvements regarding new mechanisms and higher accuracy given more information.},
  subject      = {Echtzeit},
  language  = {en}
}