@phdthesis{VermaFuehring2022, author = {Verma-F{\"u}hring, Raoul}, title = {Die Trabekulopunktion als Pr{\"a}diktiver Test f{\"u}r den Erfolg der Ab Interno Trabekulektomie im Schweineaugenmodell}, doi = {10.25972/OPUS-28263}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-282633}, school = {Universit{\"a}t W{\"u}rzburg}, year = {2022}, abstract = {To investigate trabeculopuncture (TP) for predicting the outcome of ab interno trabeculectomy (AIT). Ex vivo porcine anterior segments were perfused and sequentially underwent two procedures, TP and AIT. We concluded that a 10\% reduction in IOP after TP can be used to predict the success (>20\% IOP decrease) of AIT in porcine eyes. As porcine eyes share many similarities with human eyes, our findings may have implications on the validity of this test as a predictor for surgical outcomes of AITs in humans.}, subject = {Glaukom}, language = {en} } @article{YousefStrzalkowskaHillenkampetal.2020, author = {Yousef, Yousef Al and Strzalkowska, Alicja and Hillenkamp, Jost and Rosentreter, Andr{\´e} and Loewen, Nils A.}, title = {Comparison of a second-generation trabecular bypass (iStent inject) to ab interno trabeculectomy (Trabectome) by exact matching}, series = {Graefe's Archive for Clinical and Experimental Ophthalmology}, volume = {258}, journal = {Graefe's Archive for Clinical and Experimental Ophthalmology}, issn = {0721-832X}, doi = {10.1007/s00417-020-04933-z}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-232613}, pages = {2775-2780}, year = {2020}, abstract = {Purpose To achieve a highly balanced comparison of trabecular bypass stenting (IS2, iStent inject) with ab interno trabeculectomy (T, Trabectome) by exact matching. Methods Fifty-three IS2 eyes were matched to 3446 T eyes. Patients were matched using exact matching by baseline intraocular pressure (IOP), the number of glaucoma medications, and glaucoma type, and using nearest neighbor matching by age. Individuals without a close match were excluded. All surgeries were combined with phacoemulsification. Results A total of 78 eyes (39 in each group) could be matched as exact pairs with a baseline IOP of 18.3 ± 5.1 mmHg and glaucoma medications of 2.7 ± 1.2 in each. IOP in IS2 was reduced to 14.6 ± 4.2 mmHg at 3 months and in T to a minimum of 13.1 ± 3.2 mmHg at 1 month. In IS2, IOP began to rise again at 6 months, eventually exceeding baseline. At 24 months, IOP in IS2 was 18.8 ± 9.0 mmHg and in T 14.2 ± 3.5 mmHg. IS2 had a higher average IOP than T at all postoperative visits (p < 0.05 at 1, 12, 18 months). Glaucoma medications decreased to 2.0 ± 1.5 in IS2 and to 1.5 ± 1.4 in T. Conclusion T resulted in a larger and sustained IOP reduction compared with IS2 where a rebound occurred after 6 months to slightly above preoperative values.}, language = {en} }