@phdthesis{TshitengeTshitenge2019,
  author    = {Tshitenge Tshitenge, Dieudonn{\´e}},
  title     = {Isolation and Structural Elucidation of Novel Anti-Infective Naphthylisoquinoline Alkaloids from Ancistrocladus ealaensis, and Phytochemical Analysis of Two Congolese Medicinal Plants},
  doi       = {10.25972/OPUS-15417},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-154175},
  school      = {Universit{\"a}t W{\"u}rzburg},
  year      = {2019},
  abstract  = {Herein described are the isolation, structural elucidation, and biological evaluation of highly thrilling monomeric and dimeric new naphthylisoquinoline alkaloids from A. ealaensis. The separation, chiral resolution, and characterization of a series of stereoisomeric 2,3-dihydrobenzofuran neolignans are also reported. The analytical and phytochemical analysis on two Congolese antimalarial herbal drugs is part of the last chapter of the results. In this last case, major concerns on widely used Congolese herbal drugs are discussed.},
  subject      = {Naphthylisochinolinalkaloide},
  language  = {en}
}
@article{TshitengeTshitengeBruhnFeineisetal.2019,
  author    = {Tshitenge Tshitenge, Dieudonn{\´e} and Bruhn, Torsten and Feineis, Doris and Mudogo, Virima and Kaiser, Marcel and Brun, Reto and Bringmann, Gerhard},
  title     = {An unusually broad series of seven cyclombandakamines, bridged dimeric naphthylisoquinoline alkaloids from the Congolese liana Ancistrocladus ealaensis},
  series = {Scientific Reports},
  volume    = {9},
  journal   = {Scientific Reports},
  doi       = {10.1038/s41598-019-46336-z.},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-200759},
  pages     = {9812},
  year      = {2019},
  abstract  = {A series of seven unusual dimeric naphthylisoquinoline alkaloids was isolated from the leaves of the tropical liana Ancistrocladus ealaensis J. L{\´e}onard, named cyclombandakamine A (1), 1-epi-cyclombandakamine A (2), and cyclombandakamines A3-7 (3-7). These alkaloids have a chemically thrilling structural array consisting of a twisted dihydrofuran-cyclohexenone-isochromene system. The 1′″-epimer of 4, cyclombandakamine A1 (8), had previously been discovered in an unidentified Ancistrocladus species related to A. ealaensis. Both lianas produce the potential parent precursor, mbandakamine A (9), but only A. ealaensis synthesizes the corresponding cyclized form, along with a broad series of slightly modified analogs. The challenging isolation required, besides multi-dimensional chromatography, the use of a pentafluorophenyl stationary phase. Featuring up to six stereocenters and two types of chiral axes, their structures were elucidated by means of 1D and 2D NMR, HRESIMS, in combination with oxidative chemical degradation experiments as well as chiroptical (electronic circular dichroism spectroscopy) and quantum chemical calculations. Compared to the 'open-chain' parent compound 9, these dimers displayed rather moderate antiplasmodial activities.},
  language  = {en}
}