@phdthesis{KimbadiLombe2021,
  author    = {Kimbadi Lombe, Blaise},
  title     = {Novel-Type Dimeric Naphthylisoquinoline Alkaloids from Congolese Ancistrocladus Lianas: Isolation, Structural Elucidation, and Antiprotozoal and Anti-Tumoral Activities},
  doi       = {10.25972/OPUS-19178},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-191789},
  school      = {Universit{\"a}t W{\"u}rzburg},
  year      = {2021},
  abstract  = {Herein described is the discovery of three novel types of dimeric naphthylisoquinoline alkaloids, named mbandakamines, cyclombandakamines, and spirombandakamines. They were found in the leaves of a botanically as yet unidentified, potentially new Ancistrocladus species, collected in the rainforest of the Democratic Republic of the Congo (DRC). Mbandakamines showed an exceptional 6′,1′′-coupling, in the peri-position neighboring one of the outer axes, leading to an extremely high steric hindrance at the central axis, and to U-turn-like molecular shape, which - different from all other dimeric NIQs, whose basic structures are all quite linear - brings three of the four bicyclic ring systems in close proximity to each other. This created an unprecedented follow-up chemistry, involving ring closure reactions, leading to two further, structurally even more intriguing subclasses, the cyclo- and the spirombandakamines, displaying eight stereogenic elements (the highest total number ever found in naphthylisoquinoline alkaloids). The metabolites exhibited pronounced antiplasmodial and antitrypanosomal activities. Likewise reported in this doctoral thesis are the isolation and structural elucidation of naphthylisoquinoline alkaloids from two further potentially new Ancistrocladus species from DRC. Some of these metabolites have shown pronounced antiausterity activities against human pancreatic cancer PANC-1 cells.},
  subject      = {Naphthylisochinolinalkaloide},
  language  = {en}
}
@phdthesis{Shamburger2021,
  author    = {Shamburger, William},
  title     = {Total Synthesis of Mono- and Dimeric Naphthylisoquinoline Alkaloids and Related Analogs},
  doi       = {10.25972/OPUS-25061},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-250612},
  school      = {Universit{\"a}t W{\"u}rzburg},
  year      = {2021},
  abstract  = {Our research group focusses on the isolation, structural elucidation, and synthesis of bioactive natural products, among others, the naphthylisoquinoline alkaloids from tropical lianas. This intriguing class of compounds comprises representatives with activities against, e.g. P. falciparum, the cause of Malaria tropica, against the neglected disease leishmaniasis, and, as discovered more recently, against different types of cancer cells. Based on the high potency of theses extraordinary secondary metabolites, this thesis was devoted to the total synthesis of bioactive natural products and closely related analogs.},
  subject      = {Naphthylisochinolinalkaloide},
  language  = {en}
}