@article{BajdaWieckowskaHebdaetal.2013,
  author    = {Bajda, Marek and Wieckowska, Anna and Hebda, Michalina and Guzior, Natalia and Sotriffer, Christoph A. and Malawska, Barbara},
  title     = {Structure-Based Search for New Inhibitors of Cholinesterases},
  series = {International Journal of Molecular Sciences},
  volume    = {14},
  journal   = {International Journal of Molecular Sciences},
  number    = {3},
  doi       = {10.3390/ijms14035608},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-129423},
  pages     = {5608-5632},
  year      = {2013},
  abstract  = {Cholinesterases are important biological targets responsible for regulation of cholinergic transmission, and their inhibitors are used for the treatment of Alzheimer's disease. To design new cholinesterase inhibitors, of different structure-based design strategies was followed, including the modification of compounds from a previously developed library and a fragment-based design approach. This led to the selection of heterodimeric structures as potential inhibitors. Synthesis and biological evaluation of selected candidates confirmed that the designed compounds were acetylcholinesterase inhibitors with \(IC_{50}\) values in the mid-nanomolar to low micromolar range, and some of them were also butyrylcholinesterase inhibitors.},
  language  = {en}
}