@article{SabelFleischhackTippeltetal.2016,
  author    = {Sabel, Magnus and Fleischhack, Gudrun and Tippelt, Stephan and Gustafsson, G{\"o}ran and Doz, Fran{\c{c}}ois and Kortmann, Rolf and Massimino, Maura and Navajas, Aurora and von Hoff, Katja and Rutkowski, Stefan and Warmuth-Metz, Monika and Clifford, Steven C. and Pietsch, Torsten and Pizer, Barry and Linnering, Birgitta},
  title     = {Relapse patterns and outcome after relapse in standard risk medulloblastoma: a report from the HIT-SIOP-PNET4 study},
  series = {Journal of Neurooncology},
  volume    = {129},
  journal   = {Journal of Neurooncology},
  number    = {3},
  organization    = {SIOP-E Brain Tumour Group},
  doi       = {10.1007/s11060-016-2202-1},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-187498},
  pages     = {515-524},
  year      = {2016},
  abstract  = {The HIT-SIOP-PNET4 randomised trial for standard risk medulloblastoma (MB) (2001-2006) included 338 patients and compared hyperfractionated and conventional radiotherapy. We here report the long-term outcome after a median follow up of 7.8 years, including detailed information on relapse and the treatment of relapse. Data were extracted from the HIT Group Relapsed MB database and by way of a specific case report form. The event-free and overall (OS) survival at 10 years were 76 +/- 2 \% and 78 +/- 2 \% respectively with no significant difference between the treatment arms. Seventy-two relapses and three second malignant neoplasms were reported. Thirteen relapses (18 \%) were isolated local relapses in the posterior fossa (PF) and 59 (82 \%) were craniospinal, metastatic relapses (isolated or multiple) with or without concurrent PF disease. Isolated PF relapse vs all other relapses occurred at mean/median of 38/35 and 28/26 months respectively (p = 0.24). Late relapse, i.e. > 5 years from diagnosis, occurred in six patients (8 \%). Relapse treatment consisted of combinations of surgery (25 \%), focal radiotherapy (RT 22 \%), high dose chemotherapy with stem cell rescue (HDSCR 21 \%) and conventional chemotherapy (90 \%). OS at 5 years after relapse was 6.0 +/- 4 \%. In multivariate analysis; isolated relapse in PF, and surgery were significantly associated with prolonged survival whereas RT and HDSCR were not. Survival after relapse was not related to biological factors and was very poor despite several patients receiving intensive treatments. Exploration of new drugs is warranted, preferably based on tumour biology from biopsy of the relapsed tumour.},
  language  = {en}
}
@article{KupperStigloherFeldhaaretal.2016,
  author    = {Kupper, Maria and Stigloher, Christian and Feldhaar, Heike and Gross, Roy},
  title     = {Distribution of the obligate endosymbiont Blochmannia floridanus and expression analysis of putative immune genes in ovaries of the carpenter ant Camponotus floridanus},
  series = {Arthropod Structure \& Development},
  volume    = {45},
  journal   = {Arthropod Structure \& Development},
  number    = {5},
  doi       = {10.1016/j.asd.2016.09.004},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-187482},
  pages     = {475-487},
  year      = {2016},
  abstract  = {The bacterial endosymbiont Blochmannia floridanus of the carpenter ant Camponotus floridanus contributes to its hosts' ontogeny via nutritional upgrading during metamorphosis. This primary endosymbiosis is essential for both partners and vertical transmission of the endosymbionts is guaranteed by bacterial infestation of oocytes. Here we present a detailed analysis of the presence and localisation of B. floridanus in the ants' ovaries obtained by FISH and TEM analyses. The most apical part of the germarium harbouring germ-line stem cells (GSCs) is not infected by the bacteria. The bacteria are detectable for the first time in lower parts of the germarium when cystocytes undergo the 4th and 5th division and B. floridanus infects somatic cells lying under the basal lamina surrounding the ovarioles. With the beginning of cystocyte differentiation, the endosymbionts are exclusively transported from follicle cells into the growing oocytes. This infestation of the oocytes by bacteria very likely involves exocytosis endocytosis processes between follicle cells and the oocytes. Nurse cells were never found to harbour the endosymbionts. Furthermore we present first gene expression data in C floridanus ovaries. These data indicate a modulation of immune gene expression which may facilitate tolerance towards the endosymbionts and thus may contribute to their transovarial transmission.},
  language  = {en}
}
@article{ChagtaiZillDaineseetal.2016,
  author    = {Chagtai, Tasnim and Zill, Christina and Dainese, Linda and Wegert, Jenny and Savola, Suvi and Popov, Sergey and Mifsud, William and Vujanic, Gordan and Sebire, Neil and Le Bouc, Yves and Ambros, Peter F. and Kager, Leo and O`Sullivan, Maureen J. and Blaise, Annick and Bergeron, Christophe and Holmquist Mengelbier, Linda and Gisselsson, David and Kool, Marcel and Tytgat, Godelieve A.M. and van den Heuvel-Eibrink, Marry M. and Graf, Norbert and van Tinteren, Harm and Coulomb, Aurore and Gessler, Manfred and Williams, Richard Dafydd and Pritchard-Jones, Kathy},
  title     = {Gain of 1q As a Prognostic Biomarker in Wilms Tumors (WTs) Treated With Preoperative Chemotherapy in the International Society of Paediatric Oncology (SIOP) WT 2001 Trial: a SIOP Renal Tumours Biology Consortium Study},
  series = {Journal of Clinical Oncology},
  volume    = {34},
  journal   = {Journal of Clinical Oncology},
  number    = {26},
  doi       = {10.1200/JCO.2015.66.0001},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-187478},
  pages     = {3195-3205},
  year      = {2016},
  abstract  = {Purpose Wilms tumor (WT) is the most common pediatric renal tumor. Treatment planning under International Society of Paediatric Oncology (SIOP) protocols is based on staging and histologic assessment of response to preoperative chemotherapy. Despite high overall survival (OS), many relapses occur in patients without specific risk factors, and many successfully treated patients are exposed to treatments with significant risks of late effects. To investigate whether molecular biomarkers could improve risk stratification, we assessed 1q status and other potential copy number biomarkers in a large WT series. Materials and Methods WT nephrectomy samples from 586 SIOP WT 2001 patients were analyzed using a multiplex ligation-dependent probe amplification (MLPA) assay that measured the copy number of 1q and other regions of interest. Results One hundred sixty-seven (28\%) of 586 WTs had 1q gain. Five-year event-free survival (EFS) was 75.0\% in patients with 1q gain (95\% CI, 68.5\% to 82.0\%) and 88.2\% in patients without gain (95\% CI, 85.0\% to 91.4\%). OS was 88.4\% with gain (95\% CI, 83.5\% to 93.6\%) and 94.4\% without gain (95\% CI, 92.1\% to 96.7\%). In univariable analysis, 1q gain was associated with poorer EFS (P<.001; hazard ratio, 2.33) and OS (P=.01; hazard ratio, 2.16). The association of 1q gain with poorer EFS retained significance in multivariable analysis adjusted for 1p and 16q loss, sex, stage, age, and histologic risk group. Gain of 1q remained associated with poorer EFS in tumor subsets limited to either intermediate-risk localized disease or nonanaplastic localized disease. Other notable aberrations associated with poorer EFS included MYCN gain and TP53 loss. Conclusion Gain of 1q is a potentially valuable prognostic biomarker in WT, in addition to histologic response to preoperative chemotherapy and tumor stage.},
  language  = {en}
}
@article{DreinerKraussO'Learyetal.2016,
  author    = {Dreiner, Herbi K. and Krauss, Manuel E. and O'Leary, Ben and Opferkuch, Toby and Staub, Florian},
  title     = {Validity of the CMSSM interpretation of the diphoton excess},
  series = {Physical Review D},
  volume    = {94},
  journal   = {Physical Review D},
  number    = {5},
  doi       = {10.1103/PhysRevD.94.055013},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-187429},
  pages     = {055013},
  year      = {2016},
  abstract  = {It has been proposed that the observed diphoton excess at 750 GeV could be explained within the constrained minimal supersymmetric standard model via resonantly produced stop bound states. We reanalyze this scenario critically and extend previous work to include the constraints from the stability of the electroweak vacuum and from the decays of the stoponium into a pair of Higgs bosons. It is shown that the interesting regions of parameter space with a light stop and Higgs of the desired mass are ruled out by these constraints. This conclusion is not affected by the presence of the bound states because the binding energy is usually very small in the regions of parameter space which can explain the Higgs mass. Thus, this also leads to strong constraints on the diphoton production cross section which is in general too small.},
  language  = {en}
}
@article{BurnsGoldsteinNewgreenetal.2016,
  author    = {Burns, Alan J. and Goldstein, Allan M. and Newgreen, Donald F. and Stamp, Lincon and Sch{\"a}fer, Karl-Herbert and Metzger, Marco and Hotta, Ryo and Young, Heather M. and Andrews, Peter W. and Thapar, Nikhil and Belkind-Gerson, Jaime and Bondurand, Nadege and Bornstein, Joel C. and Chan, Wood Yee and Cheah, Kathryn and Gershon, Michael D. and Heuckeroth, Robert O. and Hofstra, Robert M.W. and Just, Lothar and Kapur, Raj P. and King, Sebastian K. and McCann, Conor J. and Nagy, Nandor and Ngan, Elly and Obermayr, Florian and Pachnis, Vassilis and Pasricha, Pankaj J. and Sham, Mai Har and Tam, Paul and Vanden Berghe, Pieter},
  title     = {White paper on guidelines concerning enteric nervous system stem cell therapy for enteric neuropathies},
  series = {Developmental Biology},
  volume    = {417},
  journal   = {Developmental Biology},
  number    = {2},
  doi       = {10.1016/j.ydbio.2016.04.001},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-187415},
  pages     = {229-251},
  year      = {2016},
  abstract  = {Over the last 20 years, there has been increasing focus on the development of novel stem cell based therapies for the treatment of disorders and diseases affecting the enteric nervous system (ENS) of the gastrointestinal tract (so-called enteric neuropathies). Here, the idea is that ENS progenitor/stem cells could be transplanted into the gut wall to replace the damaged or absent neurons and glia of the ENS. This White Paper sets out experts' views on the commonly used methods and approaches to identify, isolate, purify, expand and optimize ENS stem cells, transplant them into the bowel, and assess transplant success, including restoration of gut function. We also highlight obstacles that must be overcome in order to progress from successful preclinical studies in animal models to ENS stem cell therapies in the clinic.},
  language  = {en}
}
@article{SzczerbaZukrowskiPrzybylskietal.2016,
  author    = {Szczerba, Wojciech and Zukrowski, Jan and Przybylski, Marek and Sikora, Marcin and Safonova, Olga and Shmeliov, Aleksey and Nicolosi, Valeria and Schneider, Michael and Granath, Tim and Oppmann, Maximilian and Straßer, Marion and Mandel, Karl},
  title     = {Pushing up the magnetisation values for iron oxide nanoparticles via zinc doping: X-ray studies on the particle's sub-nano structure of different synthesis routes},
  series = {Physical Chemistry Chemical Physics},
  volume    = {18},
  journal   = {Physical Chemistry Chemical Physics},
  number    = {36},
  doi       = {10.1039/c6cp04221j},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-187390},
  pages     = {25221-25229},
  year      = {2016},
  abstract  = {The maximum magnetisation (saturation magnetisation) obtainable for iron oxide nanoparticles can be increased by doping the nanocrystals with non-magnetic elements such as zinc. Herein, we closely study how only slightly different synthesis approaches towards such doped nanoparticles strongly influence the resulting sub-nano/atomic structure. We compare two co-precipitation approaches, where we only vary the base (NaOH versus NH\(_3\)), and a thermal decomposition route. These methods are the most commonly applied ones for synthesising doped iron oxide nanoparticles. The measurable magnetisation change upon zinc doping is about the same for all systems. However, the sub-nano structure, which we studied with Mossbauer and X-ray absorption near edge spectroscopy, differs tremendously. We found evidence that a much more complex picture has to be drawn regarding what happens upon Zn doping compared to what textbooks tell us about the mechanism. Our work demonstrates that it is crucial to study the obtained structures very precisely when "playing'' with the atomic order in iron oxide nanocrystals.},
  language  = {en}
}
@article{PloetzPolyutovIvanovetal.2016,
  author    = {Pl{\"o}tz, P.-A. and Polyutov, S. P. and Ivanov, S. D. and Fennel, F. and Wolter, S. and Niehaus, T. and Xie, Z. and Lochbrunner, S. and W{\"u}rthner, Frank and K{\"u}hn, O.},
  title     = {Biphasic aggregation of a perylene bisimide dye identified by exciton-vibrational spectra},
  series = {Physical Chemistry Chemical Physics},
  volume    = {18},
  journal   = {Physical Chemistry Chemical Physics},
  number    = {36},
  doi       = {10.1039/c6cp04898f},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-187387},
  pages     = {25110-25119},
  year      = {2016},
  abstract  = {The quantum efficiency of light emission is a crucial parameter of supramolecular aggregates that can be tuned by the molecular design of the monomeric species. Here, we report on a strong variation of the fluorescence quantum yield due to different phases of aggregation for the case of a perylene bisimide dye. In particular, a change of the dominant aggregation character from H- to J-type within the first aggregation steps is found, explaining the observed dramatic change in quantum yield. This behaviour is rationalised by means of a systematic study of the intermolecular potential energy surfaces using the time-dependent density functional based tight-binding (TD-DFTB) method. This provides a correlation between structural changes and a coupling strength and supports the notion of H- type stacked dimers and J-type stack-slipped dimers. The exciton-vibrational level structure is modelled by means of an excitonic dimer model including two effective vibrational modes per monomer. Calculated absorption and fluorescence spectra are found to be in reasonable agreement with experimental ones, thus supporting the conclusion on the aggregation behaviour.},
  language  = {en}
}
@article{WieserReichertsJuravleetal.2016,
  author    = {Wieser, Matthias J. and Reicherts, Philipp and Juravle, Georgiana and von Leupoldt, Andreas},
  title     = {Attention mechanisms during predictable and unpredictable threat - a steady-state visual evoked potential approach},
  series = {NeuroImage},
  volume    = {139},
  journal   = {NeuroImage},
  doi       = {10.1016/j.neuroimage.2016.06.026},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-187365},
  pages     = {167-175},
  year      = {2016},
  abstract  = {Fear is elicited by imminent threat and leads to phasic fear responses with selective attention, whereas anxiety is characterized by a sustained state of heightened vigilance due to uncertain danger. In the present study, we investigated attention mechanisms in fear and anxiety by adapting the NPU-threat test to measure steady-state visual evoked potentials (ssVEPs). We investigated ssVEPs across no aversive events (N), predictable aversive events (P), and unpredictable aversive events (U), signaled by four-object arrays (30 s). In addition, central cues were presented during all conditions but predictably signaled imminent threat only during the P condition. Importantly, cues and context events were flickered at different frequencies (15 Hz vs. 20 Hz) in order to disentangle respective electrocortical responses. The onset of the context elicited larger electrocortical responses for U compared to P context. Conversely, P cues elicited larger electrocortical responses compared to N cues. Interestingly, during the presence of the P cue, visuocortical processing of the concurrent context was also enhanced. The results support the notion of enhanced initial hypervigilance to unpredictable compared to predictable threat contexts, while predictable cues show electrocortical enhancement of the cues themselves but additionally a boost of context processing.},
  language  = {en}
}
@article{HolzschuhDaineseGonzalezVaroetal.2016,
  author    = {Holzschuh, Andrea and Dainese, Matteo and Gonzalez-Varo, Juan P. and Mudri-Stojnic, Sonja and Riedinger, Verena and Rundl{\"o}f, Maj and Scheper, Jeroen and Wickens, Jennifer B. and Wickens, Victoria J. and Bommarco, Riccardo and Kleijn, David and Potts, Simon G. and Roberts, Stuart P. M. and Smith, Henrik G. and Vil{\`a}, Montserrat and Vujic, Ante and Steffan-Dewenter, Ingolf},
  title     = {Mass-flowering crops dilute pollinator abundance in agricultural landscapes across Europe},
  series = {Ecology Letters},
  volume    = {19},
  journal   = {Ecology Letters},
  number    = {10},
  doi       = {10.1111/ele.12657},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-187356},
  pages     = {1228-1236},
  year      = {2016},
  abstract  = {Mass-flowering crops (MFCs) are increasingly cultivated and might influence pollinator communities in MFC fields and nearby semi-natural habitats (SNHs). Across six European regions and 2 years, we assessed how landscape-scale cover of MFCs affected pollinator densities in 408 MFC fields and adjacent SNHs. In MFC fields, densities of bumblebees, solitary bees, managed honeybees and hoverflies were negatively related to the cover of MFCs in the landscape. In SNHs, densities of bumblebees declined with increasing cover of MFCs but densities of honeybees increased. The densities of all pollinators were generally unrelated to the cover of SNHs in the landscape. Although MFC fields apparently attracted pollinators from SNHs, in landscapes with large areas of MFCs they became diluted. The resulting lower densities might negatively affect yields of pollinator- dependent crops and the reproductive success of wild plants. An expansion of MFCs needs to be accompanied by pollinator-supporting practices in agricultural landscapes.},
  language  = {en}
}
@article{SchmittFunkBlumetal.2016,
  author    = {Schmitt, Dominique and Funk, Natalia and Blum, Robert and Asan, Esther and Andersen, Lill and R{\"u}licke, Thomas and Sendtner, Michael and Buchner, Erich},
  title     = {Initial characterization of a Syap1 knock-out mouse and distribution of Syap1 in mouse brain and cultured motoneurons},
  series = {Histochemistry and Cell Biology},
  volume    = {146},
  journal   = {Histochemistry and Cell Biology},
  number    = {4},
  doi       = {10.1007/s00418-016-1457-0},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-187258},
  pages     = {489-512},
  year      = {2016},
  abstract  = {Synapse-associated protein 1 (Syap1/BSTA) is the mammalian homologue of Sap47 (synapse-associated protein of 47 kDa) in Drosophila. Sap47 null mutant larvae show reduced short-term synaptic plasticity and a defect in associative behavioral plasticity. In cultured adipocytes, Syap1 functions as part of a complex that phosphorylates protein kinase B alpha/Akt1 (Akt1) at Ser\(^{473}\) and promotes differentiation. The role of Syap1 in the vertebrate nervous system is unknown. Here, we generated a Syap1 knock-out mouse and show that lack of Syap1 is compatible with viability and fertility. Adult knock-out mice show no overt defects in brain morphology. In wild-type brain, Syap1 is found widely distributed in synaptic neuropil, notably in regions rich in glutamatergic synapses, but also in perinuclear structures associated with the Golgi apparatus of specific groups of neuronal cell bodies. In cultured motoneurons, Syap1 is located in axons and growth cones and is enriched in a perinuclear region partially overlapping with Golgi markers. We studied in detail the influence of Syap1 knockdown and knockout on structure and development of these cells. Importantly, Syap1 knockout does not affect motoneuron survival or axon growth. Unexpectedly, neither knockdown nor knockout of Syap1 in cultured motoneurons is associated with reduced Ser\(^{473}\) or Thr\(^{308}\) phosphorylation of Akt. Our findings demonstrate a widespread expression of Syap1 in the mouse central nervous system with regionally specific distribution patterns as illustrated in particular for olfactory bulb, hippocampus, and cerebellum.},
  language  = {en}
}