@article{EngemannUlrichsThiedeetal.1990, author = {Engemann, R. and Ulrichs, Karin and Thiede, A. and M{\"u}ller-Ruchholtz, W. and Hamelmann, H.}, title = {Value of a physiological liver transplant model in rats. Induction of specific graft tolerance in a fully allogeneic strain combination}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-45622}, year = {1990}, abstract = {No abstract available}, language = {en} } @article{UlrichsYuDunckeretal.1984, author = {Ulrichs, Karin and Yu, MY and Duncker, D. and M{\"u}ller-Ruchholtz, W.}, title = {Immunosuppression by cytostatic drugs?}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-45574}, year = {1984}, abstract = {In the present study, an attempt was made to characterize the immunomodulating abilities of the cytostatic drugs cydophosphamide, ifosfamide, vinblastine, vincristine, procarbazine, dacarbazine, 6-mercaptopurine, methotrexate, 5-f/uor-uracil and adriamycine in a defined experimental model. Varying combinations of drug plus transplantation alloantigen, (C3H-lymphocytes) were injected into Balb/c mice at different time intervals in vivo. The resulting T-effector cell reactivity was determined in vitro with the microcytotoxicity assay on day + 5 for primary (r) and day + 7 for secondary (2°) sensitized mice. According to the type of drug (alkylating agent vs. vinca alkaloid vs. antimetabolite vs. cytostatic antibiotic), the dosage (20\% LD50 vs. 60\% LD50), the state of sensitization (r vs. 2° sensitized recipients), and the time of drug application in relation to the antigen treatment on day 0 (in varying steps from day -6 to day +4), so-called "pharmaconantigen- variation-effects" (PA VE) were established for each of the investigated drugs in form of reaction profiles. The results were as folIows: (1) For almost alt substances, characteristic reaction profiles involving immunostimulation and/or immunosuppression could be established. Similarities in the profiles of different substances made it possible to classify the drugs according to different reaction types. The reaction type however is not definitely correlated to the biochemical mechanism of drug action. (2) The PA VE are decisively inf/uenced by so me of the biological parameters, such as the time of drug application in relation to the antigen treatment and the state of sensitization but relatively !ittle by the dosage of the drug. (3) Considering the different processes occurring du ring primary and secondary immune responses, the PAVE may give hints for a distinct manipulation of the immunoregulation and thus information on the immunobiological mechanism of drug action.}, subject = {Immunologie}, language = {en} } @inproceedings{WinotoMorbachUlrichsMuellerRuchholtz1991, author = {Winoto-Morbach, S. and Ulrichs, Karin and M{\"u}ller-Ruchholtz, W.}, title = {New Developments in Biodegradable Microspheres For Magnetic Separation Techniques}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-45712}, year = {1991}, abstract = {No abstract available}, subject = {Immunbiologie}, language = {en} } @inproceedings{EcksteinUlrichsMeinckeetal.1991, author = {Eckstein, V. and Ulrichs, Karin and Meincke, G. and M{\"u}lller-Ruchholtz, W.}, title = {Transplantation of Diabetic Patients With Xenogeneic Pancreatic Islets Has to Consider Natural Xenophile Antibodies (NXA) In Patients Sera As a Major Obstacle to Success}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-45707}, year = {1991}, abstract = {No abstract available}, subject = {Immunbiologie}, language = {en} } @misc{UlrichsMuellerRuchholtz1989, author = {Ulrichs, Karin and M{\"u}ller-Ruchholtz, W.}, title = {Identification and Manipulation of Human Islet Alloimmunogenicity: Morphologic and Functional in Vitro Studies with Various Islet Preparations}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-45584}, year = {1989}, abstract = {No abstract available}, subject = {Immunbiologie}, language = {en} } @inproceedings{HeiserUlrichsMuellerRuchholtz1994, author = {Heiser, A. and Ulrichs, Karin and M{\"u}ller-Ruchholtz, W.}, title = {Enzyme Activities in Commercial Collagenase Preparations and Their Kinetics During Islet Isolation Procedure}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-45633}, year = {1994}, abstract = {No abstract available}, subject = {Transplantation}, language = {en} } @inproceedings{WangUlrichsMuellerRuchholtz1993, author = {Wang, HY and Ulrichs, Karin and M{\"u}ller-Ruchholtz, W.}, title = {Down-Regulation of Xenophile Antibodies by Specific Immunosuppressive Protocols to Facilitate Xenogeneic Organ Transplantation}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-45669}, year = {1993}, abstract = {No abstract available}, subject = {Immunbiologie}, language = {en} } @inproceedings{UlrichsEcksteinKorsgrenetal.1993, author = {Ulrichs, Karin and Eckstein, V. and Korsgren, O. and M{\"u}ller-Ruchholtz, W.}, title = {Expression of Porcine Pancreatic Islet Antigens Varies and Determines Binding of Human Natural Xenophile Antibodies (NXA)}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-45655}, year = {1993}, abstract = {No abstract available}, subject = {Immunbiologie}, language = {en} } @inproceedings{HedkeEcksteinMayetal.1993, author = {Hedke, K. and Eckstein, V. and May, G. and Kaden, J. and M{\"u}ller-Ruchholtz, W. and Ulrichs, Karin}, title = {Production of Xenophile Antibodies (XA) in Type I Diabetic Patients is Strongly Influenced by Diabetes and/or Dialysis}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-45642}, year = {1993}, abstract = {No abstract available}, language = {en} } @inproceedings{HeiserUlrichsEcksteinetal.1992, author = {Heiser, A. and Ulrichs, Karin and Eckstein, V. and M{\"u}ller-Ruchholtz, W.}, title = {The Human Cell Mediated Response to Xenogeneic (Porcine) Transplantation Antigen Depends on the Stimulator Cell Compartment}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-45670}, year = {1992}, abstract = {No abstract available}, language = {en} }