@phdthesis{LauerSchmaltz2022,
  author    = {Lauer-Schmaltz, Sandra},
  title     = {Durchflusszytometrische Analyse CEACAM1-exprimierender Immunzellen bei Patienten mit Multipler Sklerose},
  doi       = {10.25972/OPUS-28913},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-289138},
  school      = {Universit{\"a}t W{\"u}rzburg},
  year      = {2022},
  abstract  = {Da die Pathogenese der Multiplen Sklerose (MS) bis heute nicht vollst{\"a}ndig gekl{\"a}rt ist, befassten wir uns mit der Rolle CEACAM1-exprimierender Immunzellen bei Patienten mit MS und untersuchten diese mittels durchflusszytometrischer Untersuchung. Bei CEACAM1 (Carcinoembryonic-antigen-related cell adhesion molecule) handelt es sich um ein Zelladh{\"a}sionsmolek{\"u}l, das sowohl an inter- als auch intrazellul{\"a}ren Signalmechanismen modulatorisch beteiligt ist. Anhand unserer Ergebnisse scheint CEACAM1 keine zentrale Rolle in der Pathogenese der MS zu spielen. Es ließ sich jedoch eine signifikante Erh{\"o}hung CD56+dim NK-Zellen (nat{\"u}rliche Killerzellen) im peripheren Blut von Patienten mit schubf{\"o}rmig remittierender MS feststellen. Dies st{\"u}tzt die These, dass die „dim"-Subpopulation der NK-Zellen eine proinflammatorische Rolle in der Pathogenese der MS einnehmen k{\"o}nnte. Demnach sollte in Zukunft hinsichtlich der Entwicklung neuer Biomarker in der MS der Fokus auf NK-Zellen und Monozyten sowie deren Subpopulationen gerichtet werden.},
  subject      = {Durchflusscytometrie},
  language  = {de}
}
@article{DrenckhahnBaumgartnerZonneveld2017,
  author    = {Drenckhahn, Detlev and Baumgartner, Werner and Zonneveld, Ben},
  title     = {Different genome sizes of Western and Eastern Ficaria verna lineages shed light on steps of Ficaria evolution},
  series = {Forum Geobotanicum},
  volume    = {7},
  journal   = {Forum Geobotanicum},
  issn      = {1867-9315},
  doi       = {10.3264/FG.2017.1122},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-155061},
  pages     = {27-33},
  year      = {2017},
  abstract  = {The genus Ficaria is now considered to comprize eight Eurasian species. The most widespread European species is the tetraploid F. verna Huds. The present study provides evidence for the existence of two main lineages of F. verna that differ considerably in their genomic size by about 3 pg. A Western F. verna lineage west of river Rhine displays a mean genome size (2C-value) of 34.2 pg and is almost precisely codistributed with the diploid F. ambigua Boreau (20 pg) north of the Mediterranean. The remaining part of Europe appears to be occupied by the Eastern F. verna lineage solely (mean genome size of 31.3 pg) which codistributes in South-Eastern Europe with the diploid F. calthifolia Rchb. (15 pg). There is little overlap at the boundary of Western and Eastern F. verna lineages with the occurrence of a separate intermediate group in the Netherlands (mean genomic size of 33.2 pg) that appears to result from hybridization of both lineages. On the basis of these observations and further considerations we propose development of F. ambigua and F. calthifolia south of the Alps with subsequent divergence to populate their current Western and Eastern European ranges, respectively. The Western F. verna lineage is proposed to originate from autotetraploidization of F. ambigua (precursor) with moderate genomic downsizing and the Eastern F. verna lineage from auto¬tetraploidization of F. calthifolia (precursor).},
  subject      = {Durchflusscytometrie},
  language  = {en}
}