@article{FujiKappEinsele2013,
  author    = {Fuji, Shigeo and Kapp, Markus and Einsele, Hermann},
  title     = {Monitoring of Pathogen-Specific T-Cell Immune Reconstitution after Allogeneic Hematopoietic Stem Cell Transplantation},
  series = {Frontiers in Immunology},
  volume    = {4},
  journal   = {Frontiers in Immunology},
  number    = {276},
  doi       = {10.3389/fimmu.2013.00276},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-129250},
  year      = {2013},
  abstract  = {The clinical outcome after allogeneic hematopoietic stem cell transplantation (HSCT) has been significantly improved during the last decades with regard to the reduction in organ failure, infection, and severe acute graft-versus-host disease. However, severe complications due to infectious diseases are still one of the major causes of morbidity and mortality after allogeneic HSCT, in particular in patients receiving haploidentical HSCT or cord blood transplant due to a slow and often incomplete immune reconstitution. In order to improve the immune control of pathogens without an increased risk of alloreactivity, adoptive immunotherapy using highly enriched pathogen-specificT cells offers a promising approach. In order to identify patients who are at high risk for infectious diseases, several monitoring assays have been developed with potential for the guidance of immunosuppressive drugs and adoptive immunotherapy in clinical practice. In this article, we aim to give a comprehensive overview regarding current developments of T-cell monitoring techniques focusing on T cells against viruses and fungi. In particular, we will focus on rather simple, fast, non-labor-intensive, cellular assays which could be integrated in routine clinical screening approaches.},
  language  = {en}
}
@article{GoettschBeerenwinkelDengetal.2021,
  author    = {Goettsch, Winfried and Beerenwinkel, Niko and Deng, Li and D{\"o}lken, Lars and Dutilh, Bas E. and Erhard, Florian and Kaderali, Lars and Kleist, Max von and Marquet, Roland and Matthijnssens, Jelle and McCallin, Shawna and McMahon, Dino and Rattei, Thomas and Van Rij, Ronald P. and Robertson, David L. and Schwemmle, Martin and Stern-Ginossar, Noam and Marz, Manja},
  title     = {ITN—VIROINF: Understanding (harmful) virus-host interactions by linking virology and bioinformatics},
  series = {Viruses},
  volume    = {13},
  journal   = {Viruses},
  number    = {5},
  issn      = {1999-4915},
  doi       = {10.3390/v13050766},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-236687},
  year      = {2021},
  abstract  = {Many recent studies highlight the fundamental importance of viruses. Besides their important role as human and animal pathogens, their beneficial, commensal or harmful functions are poorly understood. By developing and applying tailored bioinformatical tools in important virological models, the Marie Skłodowska-Curie Initiative International Training Network VIROINF will provide a better understanding of viruses and the interaction with their hosts. This will open the door to validate methods of improving viral growth, morphogenesis and development, as well as to control strategies against unwanted microorganisms. The key feature of VIROINF is its interdisciplinary nature, which brings together virologists and bioinformaticians to achieve common goals.},
  language  = {en}
}
@article{BumillerBiniHochKohlerAugustoetal.2022,
  author    = {Bumiller-Bini Hoch, Val{\´e}ria and Kohler, Ana Fl{\´a}via and Augusto, Danillo G. and Lobo-Alves, Sara Cristina and Malheiros, Danielle and Cipolla, Gabriel Adelman and Winter Boldt, Angelica Beate and Braun-Prado, Karin and Wittig, Michael and Franke, Andre and Pf{\"o}hler, Claudia and Worm, Margitta and van Beek, Nina and Goebeler, Matthias and S{\´a}rdy, Mikl{\´o}s and Ibrahim, Saleh and Busch, Hauke and Schmidt, Enno and Hundt, Jennifer Elisabeth and Araujo-Souza, Patr{\´i}cia Savio de and Petzl-Erler, Maria Luiza},
  title     = {Genetic associations and differential mRNA expression levels of host genes suggest a viral trigger for endemic pemphigus foliaceus},
  series = {Viruses},
  volume    = {14},
  journal   = {Viruses},
  number    = {5},
  issn      = {1999-4915},
  doi       = {10.3390/v14050879},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-270572},
  year      = {2022},
  abstract  = {The long search for the environmental trigger of the endemic pemphigus foliaceus (EPF, fogo selvagem) has not yet resulted in any tangible findings. Here, we searched for genetic associations and the differential expression of host genes involved in early viral infections and innate antiviral defense. Genetic variants could alter the structure, expression sites, or levels of the gene products, impacting their functions. By analyzing 3063 variants of 166 candidate genes in 227 EPF patients and 194 controls, we found 12 variants within 11 genes associated with differential susceptibility (p < 0.005) to EPF. The products of genes TRIM5, TPCN2, EIF4E, EIF4E3, NUP37, NUP50, NUP88, TPR, USP15, IRF8, and JAK1 are involved in different mechanisms of viral control, for example, the regulation of viral entry into the host cell or recognition of viral nucleic acids and proteins. Only two of nine variants were also associated in an independent German cohort of sporadic PF (75 patients, 150 controls), aligning with our hypothesis that antiviral host genes play a major role in EPF due to a specific virus-human interaction in the endemic region. Moreover, CCL5, P4HB, and APOBEC3G mRNA levels were increased (p < 0.001) in CD4+ T lymphocytes of EPF patients. Because there is limited or no evidence that these genes are involved in autoimmunity, their crucial role in antiviral responses and the associations that we observed support the hypothesis of a viral trigger for EPF, presumably a still unnoticed flavivirus. This work opens new frontiers in searching for the trigger of EPF, with the potential to advance translational research that aims for disease prevention and treatment.},
  language  = {en}
}