@phdthesis{Gentzsch2021,
  author    = {Gentzsch, Christian},
  title     = {Molecular Imaging of Opioid Receptors and Butyrylcholinesterase with Selective, Tailored Probes Using Positron Emission Tomography and Fluorescence Microscopy},
  doi       = {10.25972/OPUS-24752},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-247529},
  school      = {Universit{\"a}t W{\"u}rzburg},
  year      = {2021},
  abstract  = {The present thesis concerns the molecular imaging of opioid receptors and human butyrylcholinesterase with the aid of tailored probes, which are suitable for the respective applied imaging techniques. The first part focusses on imaging of opioid receptors with selective probes using total internal reflection- and single molecule fluorescence microscopy. Design and synthesis of the ligands are presented and their pharmacological characterization and application in microscopy experiments are shown. The second part of this thesis focused on the development of 18F-labeled, selective radiotracers for imaging of butyrylcholinesterase via positron emission tomography. The design and synthesis of each a reversible and pseudoirreversible 18F-labeled tracer are presented. After evaluation of the binding properties of each tracer, their initial application in ex vivo autoradiography- and preliminary in vivo microPET studies is described and analyzed.},
  subject      = {Fluoreszenzmikroskopie},
  language  = {en}
}