@article{EiseleBlozikStoerketal.2013,
  author    = {Eisele, Marion and Blozik, Eva and St{\"o}rk, Stefan and Tr{\"a}der, Jens-Martin and Herrmann-Lingen, Christoph and Scherer, Martin},
  title     = {Recognition of depression and anxiety and their association with quality of life, hospitalization and mortality in primary care patients with heart failure - study protocol of a longitudinal observation study},
  series = {BMC Family Practice},
  volume    = {14},
  journal   = {BMC Family Practice},
  number    = {180},
  issn      = {1471-2296},
  doi       = {10.1186/1471-2296-14-180},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-121881},
  year      = {2013},
  abstract  = {Background: International disease management guidelines recommend the regular assessment of depression and anxiety in heart failure patients. Currently there is little data on the effect of screening for depression and anxiety on the quality of life and the prognosis of heart failure (HF). We will investigate the association between the recognition of current depression/anxiety by the general practitioner (GP) and the quality of life and the patients' prognosis. Methods/Design: In this multicenter, prospective, observational study 3,950 patients with HF are recruited by general practices in Germany. The patients fill out questionnaires at baseline and 12-month follow-up. At baseline the GPs are interviewed regarding the somatic and psychological comorbidities of their patients. During the follow-up assessment, data on hospitalization and mortality are provided by the general practice. Based on baseline data, the patients are allocated into three observation groups: HF patients with depression and/or anxiety recognized by their GP (P+/+), those with depression and/or anxiety not recognized (P+/-) and patients without depression and/or anxiety (P-/-). We will perform multivariate regression models to investigate the influence of the recognition of depression and/or anxiety on quality of life at 12 month follow-up, as well as its influences on the prognosis (hospital admission, mortality). Discussion: We will display the frequency of GP-acknowledged depression and anxiety and the frequency of installed therapeutic strategies. We will also describe the frequency of depression and anxiety missed by the GP and the resulting treatment gap. Effects of correctly acknowledged and missed depression/anxiety on outcome, also in comparison to the outcome of subjects without depression/anxiety will be addressed. In case results suggest a treatment gap of depression/anxiety in patients with HF, the results of this study will provide methodological advice for the efficient planning of further interventional research.},
  language  = {en}
}
@phdthesis{Wagner2023,
  author    = {Wagner, Camilla Olga Luise},
  title     = {Prognostischer Wert eines Echokardiographie-basierten Risikoscores bei Patient*innen mit isch{\"a}mischer Herzinsuffizienz und reduzierter Ejektionsfraktion},
  doi       = {10.25972/OPUS-32178},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-321786},
  school      = {Universit{\"a}t W{\"u}rzburg},
  year      = {2023},
  abstract  = {Zielsetzung Entwicklung einer umfassenden echokardiographiebasierten Score-Methode zur Risikobewertung von Patienten mit isch{\"a}mischer Herzinsuffizienz (IHF) und reduzierter linksventrikul{\"a}rer Ejektionsfraktion (<50\%). Methoden In diese Studie wurden 1355 IHF-Patienten mit einer Ejektionsfraktion <50\% aufgenommen, die mittlere klinische Nachbeobachtungszeit betrug 25 Monate. Mit Hilfe multivariabler Cox-Hazard-Modelle wurden die Zusammenh{\"a}nge zwischen echokardiographischen Variablen [einschließlich 13 Standardparameter und globaler longitudinaler Dehnung (GLS)] und den wichtigsten unerw{\"u}nschten Ergebnissen [einschließlich Gesamtmortalit{\"a}t, kardiovaskul{\"a}rem Tod und kardiovaskul{\"a}r bedingten Krankenhausaufenthalten] bewertet. Ergebnisse Die Gesamtmortalit{\"a}t, die kardiovaskul{\"a}re Mortalit{\"a}t und das kombinierte Risiko f{\"u}r kardiovaskul{\"a}re Ereignisse, einschließlich Tod und Krankenhausaufenthalt, betrugen 29,2 \%, 18,2 \% bzw. 41,1 \%. Rechtsventrikul{\"a}rer mittlerer Hohlraumdurchmesser (RVD) >38 mm, systolische Exkursion der mitralen Anularebene (MAPSE) <8 mm, systolische Exkursion der Trikuspidalebene (TAPSE) <12 mm, Verh{\"a}ltnis zwischen transmissaler Fr{\"u}hflussgeschwindigkeit und mitraler Anularebene (E/E') >14. 5, systolischer Pulmonalarteriendruck (sPAP) >38mmHg und absolute GLS<8\% wurden in den multivariablen Cox-Modellen als unabh{\"a}ngige echokardiographische Marker f{\"u}r ein schlechteres klinisches Ergebnis identifiziert.Auf der Grundlage dieser Marker wurde ein echokardiographischer Risikoscore (Echo Risk Score, von 0 bis 6 Punkten) erstellt, und die Patienten wurden in drei Risikogruppen eingeteilt: ein Score von 0 bis 1 als geringes Risiko, ein Score von 2 bis 3 als mittleres Risiko und ein Score von 4-6 als hohes Risiko. Nach Adjustierung f{\"u}r alle klinischen Kovariaten hatten Hochrisikopatienten im Vergleich zu Patienten mit niedrigem Risiko ein zwei- bis dreifach erh{\"o}htes Gesamtmortalit{\"a}tsrisiko (HR 2,42, 95\% CI 1,81-3,24), ein erh{\"o}htes Risiko f{\"u}r kardiovaskul{\"a}re Ereignisse (HR 2,75, 95\% CI 1,88-4,02) und ein erh{\"o}htes kombiniertes Risiko f{\"u}r kardiovaskul{\"a}re Ereignisse (HR 1,84, 95\% CI 1,43-2,36). Eine erh{\"o}hte Vorhersagekraft wurde nach Hinzuf{\"u}gung des Echo-Risiko-Scores entweder zu dem Modell mit klinischen Risikofaktoren oder zu dem Modell mit klinischen Risikofaktoren und N-terminalem Prohormon des natriuretischen Peptids des Gehirns festgestellt (alle P<0,001). Fazit Der neuartige echokardiografiebasierte Risikoscore ist signifikant und unabh{\"a}ngig mit der Gesamtmortalit{\"a}t und der kardiovaskul{\"a}ren Mortalit{\"a}t oder Hospitalisierung bei Patienten mit isch{\"a}mischer Herzinsuffizienz und reduzierter Ejektionsfraktion assoziiert. Weitere Studien sind erforderlich, um die Vorhersagekraft dieses echokardiographiebasierten Risikoscores bei Patienten mit isch{\"a}mischer Herzinsuffizienz und reduzierter Ejektionsfraktion zu validieren.},
  subject      = {Ultraschallkardiografie},
  language  = {de}
}
@article{ZacherWollankaSaueretal.2023,
  author    = {Zacher, Magdalena and Wollanka, Nele and Sauer, Christina and Haßtenteufel, Kathrin and Wallwiener, Stephanie and Wallwiener, Markus and Maatouk, Imad},
  title     = {Prenatal paternal depression, anxiety, and somatic symptom burden in different risk samples: an explorative study},
  series = {Archives of Gynecology and Obstetrics},
  volume    = {307},
  journal   = {Archives of Gynecology and Obstetrics},
  number    = {4},
  doi       = {10.1007/s00404-022-06612-2},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-324465},
  pages     = {1255-1263},
  year      = {2023},
  abstract  = {Purpose Growing evidence implies that transition to parenthood triggers symptoms of mental burden not only in women but likewise in men, especially in high-risk pregnancies. This is the first study that examined and compared the prevalence rates of depression, anxiety, and somatic symptom burden of expectant fathers who face different risk situations during pregnancy. Methods Prevalence rates of paternal depression (Edinburgh postnatal depression scale), anxiety (generalized anxiety disorder seven), and somatic symptom burden (somatic symptom scale eight) were examined in two risk samples and one control group in the third trimester of their partners' pregnancy: risk sample I (n = 41) consist of expectant fathers whose partners were prenatally hospitalized due to medical complications; risk sample II (n = 52) are fathers whose partners were prenatally mentally distressed; and control group (n = 70) are those non-risk pregnancies. Results On a purely descriptive level, the data display a trend of higher symptom burden of depression, anxiety, and somatic symptoms in the two risk samples, indicating that expectant fathers, whose pregnant partners were hospitalized or suffered prenatal depression, were more prenatally distressed. Exploratory testing of group differences revealed an almost three times higher prevalence rate of anxiety in fathers whose partner was hospitalized (12.2\%) compared to those non-risks (4.3\%). Conclusion Results underline the need for screening implementations for paternal prenatal psychological distress, as well as specific prevention and treatment programs, especially for fathers in risk situations, such as their pregnant partners' prenatal hospitalization. The study was registered with the German clinical trials register (DRKS00020131) on 2019/12/09.},
  language  = {en}
}
@article{SteppuhnLangenScheidtNaveetal.2013,
  author    = {Steppuhn, Henriette and Langen, Ute and Scheidt-Nave, Christa and Keil, Thomas},
  title     = {Major comorbid conditions in asthma and association with asthma-related hospitalizations and emergency department admissions in adults: results from the German national health telephone interview survey (GEDA) 2010},
  series = {BMC Pulmonary Medicine},
  volume    = {13},
  journal   = {BMC Pulmonary Medicine},
  number    = {46},
  doi       = {10.1186/1471-2466-13-46},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-122121},
  year      = {2013},
  abstract  = {Background: It remains unclear to what extent asthma in adults is linked to allergic rhinitis (AR), gastroesophageal reflux disease (GERD), and acetylsalicylic acid exacerbated respiratory disease (AERD), and how these comorbidities may affect asthma outcomes in the general population. We therefore aimed to assess the prevalence of these major comorbidities among adults with asthma and examine their impact on asthma exacerbations requiring hospital care. Methods: A total of 22,050 adults 18 years and older were surveyed in the German National Health Telephone Interview Survey (GEDA) 2010 using a highly standardized computer-assisted interview technique. The study population comprised participants with self-reported physician-diagnosed asthma, among which the current (last 12 months) prevalence of AR and GERD-like symptoms (GERS), and life-time prevalence of AERD was estimated. Weighted bivariate analyses and logistic regression models were applied to assess the association of each comorbid condition with the asthma outcome (any self-reported asthma-related hospitalization and/or emergency department (ED) admission in the past year). Results: Out of 1,136 adults with asthma, 49.6\% had GERS and 42.3\% had AR within the past 12 months; 14.0\% met the criteria of AERD, and 75.7\% had at least one out of the three conditions. Overall, the prevalence of at least one exacerbation requiring emergency room or hospital admission within the past year was 9.0\%. Exacerbation prevalence was higher among participants with comorbidities than among those without (9.8\% vs. 8.2\% for GERS; 11.2\% vs. 7.6\% for AR, and 22.2\% vs. 7.0\% for AERD), but only differences in association with AERD were statistically significant. A strong association between asthma exacerbation and AERD persisted in multivariable logistic regression analyses adjusting for sex, age group, level of body mass index, smoking status, educational attainment, and duration of asthma: odds ratio (OR) = 4.5, 95\% confidence interval (CI) = 2.5-8.2. Conclusions: Data from this large nation-wide study provide evidence that GERS, AR and AERD are all common comorbidities among adults with asthma. Our data underline the public health and clinical impact of asthma with complicating AERD, contributing considerably to disease-specific hospitalization and/or ED admission in a defined asthma population, and emphasize the importance of its recognition in asthma care.},
  language  = {en}
}
@article{GoettlerNieklerLieseetal.2022,
  author    = {Goettler, David and Niekler, Patricia and Liese, Johannes G. and Streng, Andrea},
  title     = {Epidemiology and direct healthcare costs of Influenza-associated hospitalizations - nationwide inpatient data (Germany 2010-2019)},
  series = {BMC Public Health},
  volume    = {22},
  journal   = {BMC Public Health},
  doi       = {10.1186/s12889-022-12505-5},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-265888},
  year      = {2022},
  abstract  = {Introduction Detailed and up-to-date data on the epidemiology and healthcare costs of Influenza are fundamental for public health decision-making. We analyzed inpatient data on Influenza-associated hospitalizations (IAH), selected complications and risk factors, and their related direct costs for Germany during ten consecutive years. Methods We conducted a retrospective cost-of-illness study on patients with laboratory-confirmed IAH (ICD-10-GM code J09/J10 as primary diagnosis) by ICD-10-GM-based remote data query using the Hospital Statistics database of the German Federal Statistical Office. Clinical data and associated direct costs of hospital treatment are presented stratified by demographic and clinical variables. Results Between January 2010 to December 2019, 156,097 persons were hospitalized due to laboratory-confirmed Influenza (J09/J10 primary diagnosis). The annual cumulative incidence was low in 2010, 2012 and 2014 (1.3 to 3.1 hospitalizations per 100,000 persons) and high in 2013 and 2015-2019 (12.6 to 60.3). Overall direct per patient hospitalization costs were mean (SD) 3521 EUR (± 8896) and median (IQR) 1805 EUR (1502; 2694), with the highest mean costs in 2010 (mean 8965 EUR ± 26,538) and the lowest costs in 2012 (mean 2588 EUR ± 6153). Mean costs were highest in 60-69 year olds, and in 50-59, 70-79 and 40-49 year olds; they were lowest in 10-19 year olds. Increased costs were associated with conditions such as diabetes (frequency 15.0\%; 3.45-fold increase compared to those without diabetes), adiposity (3.3\%; 2.09-fold increase) or immune disorders (5.6\%; 1.88-fold increase) and with Influenza-associated complications such as Influenza pneumonia (24.3\%; 1.95-fold), bacterial pneumonia (6.3\%; 3.86-fold), ARDS (1.2\%; 10.90-fold increase) or sepsis (2.3\%; 8.30-fold). Estimated overall costs reported for the 10-year period were 549.6 Million euros (95\% CI 542.7-556.4 million euros). Conclusion We found that the economic burden of IAH in Germany is substantial, even when considering solely laboratory-confirmed IAH reported as primary diagnosis. The highest costs were found in the elderly, patients with certain underlying risk factors and patients who required advanced life support treatment, and median and mean costs showed considerable variations between single years. Furthermore, there was a relevant burden of disease in middle-aged adults, who are not covered by the current vaccination recommendations in Germany.},
  language  = {en}
}