@article{TappeStichLangeheineckeetal.2014, author = {Tappe, D. and Stich, A. and Langeheinecke, A. and von Sonnenburg, F. and Muntau, B. and Schaefer, J. and Slesak, G.}, title = {Suspected new wave of muscular sarcocystosis in travellers returning from Tioman Island, Malaysia, May 2014}, series = {Eurosurveillance}, volume = {19}, journal = {Eurosurveillance}, number = {21}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-116195}, pages = {8-10}, year = {2014}, abstract = {In May 2014, six patients presented in Germany with a Sarcocystis-associated febrile myositis syndrome after returning from Tioman Island, Malaysia. During two earlier waves of infections, in 2011 and 2012, about 100 travellers returning to various European countries from the island were affected. While the first two waves were associated with travel to Tioman Island mostly during the summer months, this current series of infections is associated with travel in early spring, possibly indicating an upcoming new epidemic.}, language = {en} } @article{BielaszewskaSchillerLammersetal.2014, author = {Bielaszewska, Martina and Schiller, Roswitha and Lammers, Lydia and Bauwens, Andreas and Fruth, Angelika and Middendorf, Barbara and Schmidt, M. Alexander and Tarr, Phillip I. and Dobrindt, Ulrich and Karch, Helge and Mellmann, Alexander}, title = {Heteropathogenic virulence and phylogeny reveal phased pathogenic metamorphosis in Escherichia coli O2:H6}, series = {EMBO Molecular Medicine}, volume = {6}, journal = {EMBO Molecular Medicine}, number = {3}, issn = {1757-4684}, doi = {10.1002/emmm.201303133}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-117254}, pages = {347-357}, year = {2014}, abstract = {Extraintestinal pathogenic and intestinal pathogenic (diarrheagenic) Escherichia coli differ phylogenetically and by virulence profiles. Classic theory teaches simple linear descent in this species, where non-pathogens acquire virulence traits and emerge as pathogens. However, diarrheagenic Shiga toxin-producing E.coli (STEC) O2:H6 not only possess and express virulence factors associated with diarrheagenic and uropathogenic E.coli but also cause diarrhea and urinary tract infections. These organisms are phylogenetically positioned between members of an intestinal pathogenic group (STEC) and extraintestinal pathogenic E.coli. STEC O2:H6 is, therefore, a 'heteropathogen,' and the first such hybrid virulent E.coli identified. The phylogeny of these E.coli and the repertoire of virulence traits they possess compel consideration of an alternate view of pathogen emergence, whereby one pathogroup of E.coli undergoes phased metamorphosis into another. By understanding the evolutionary mechanisms of bacterial pathogens, rational strategies for counteracting their detrimental effects on humans can be developed.}, language = {en} }