@article{ReinersAsamFreyetal.2021, author = {Reiners, Philipp and Asam, Sarah and Frey, Corinne and Holzwarth, Stefanie and Bachmann, Martin and Sobrino, Jose and G{\"o}ttsche, Frank-M. and Bendix, J{\"o}rg and Kuenzer, Claudia}, title = {Validation of AVHRR Land Surface Temperature with MODIS and in situ LST — a TIMELINE thematic processor}, series = {Remote Sensing}, volume = {13}, journal = {Remote Sensing}, number = {17}, issn = {2072-4292}, doi = {10.3390/rs13173473}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-246051}, year = {2021}, abstract = {Land Surface Temperature (LST) is an important parameter for tracing the impact of changing climatic conditions on our environment. Describing the interface between long- and shortwave radiation fluxes, as well as between turbulent heat fluxes and the ground heat flux, LST plays a crucial role in the global heat balance. Satellite-derived LST is an indispensable tool for monitoring these changes consistently over large areas and for long time periods. Data from the AVHRR (Advanced Very High-Resolution Radiometer) sensors have been available since the early 1980s. In the TIMELINE project, LST is derived for the entire operating period of AVHRR sensors over Europe at a 1 km spatial resolution. In this study, we present the validation results for the TIMELINE AVHRR daytime LST. The validation approach consists of an assessment of the temporal consistency of the AVHRR LST time series, an inter-comparison between AVHRR LST and in situ LST, and a comparison of the AVHRR LST product with concurrent MODIS (Moderate Resolution Imaging Spectroradiometer) LST. The results indicate the successful derivation of stable LST time series from multi-decadal AVHRR data. The validation results were investigated regarding different LST, TCWV and VA, as well as land cover classes. The comparisons between the TIMELINE LST product and the reference datasets show seasonal and land cover-related patterns. The LST level was found to be the most determinative factor of the error. On average, an absolute deviation of the AVHRR LST by 1.83 K from in situ LST, as well as a difference of 2.34 K from the MODIS product, was observed.}, language = {en} } @phdthesis{Bleuel2021, author = {Bleuel, Gabriel}, title = {Entwicklung und Validierung eines quantitativen Verfahrens zur Beurteilung der Viabilit{\"a}t von entsprechend der GMP-Richtlinien hergestellter Knorpelimplantate f{\"u}r das Knie}, doi = {10.25972/OPUS-24248}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-242481}, school = {Universit{\"a}t W{\"u}rzburg}, year = {2021}, abstract = {Due to the reversing age pyramid in Germany, more and more people are already suffering from joint cartilage damage. But not only age, but also accidents and sports injuries and being overweight can lead to irreversible cartilage defects. Although there are various treatment options, the previous methods cannot be considered a permanent cure. As part of the international research project BIO-CHIP, a promising treatment method with novel drugs was to be investigated. The patient's own cartilage cells from the nose serve as the starting material for the drug, a manufactured cartilage implant. These are isolated, multiplied and ultimately cultivated on a matrix to form a cartilage implant. In addition to toxicological and biological safety tests, an essential prerequisite for the approval of the implant is the assessment of the viability. This was previously carried out on the basis of histology from the pathology department. The aim of the present work was the development and validation of a standardized and objective viability test for the chondrocytes within the cartilage matrix. For this, the LDH was used as a marker for irreversibly damaged cells. The LDH concentration could be measured with the CyQuant LDH assay by measuring the absorption. It could be proven that LDH has the required stability and detectability in the medium. With the help of the lysis, of cultivated mini-cartilage implants, the maximum achievable LDH concentrations could be determined. A calibration curve was generated using these concentrations. This serves to assess the viability of future measured absorptions of the supernatant medium. The developed method does not require any invasive interventions on the implant and is characterized by its simple implementation, since only the protrusion has to be measured. The validation of the method certified a high level of robustness, linearity, accuracy and precision.}, subject = {Hyaliner Knorpel}, language = {de} } @article{SzymskiAschenbachKrutschetal.2021, author = {Szymski, Dominik and Aschenbach, Leonard and Krutsch, Volker and Alt, Volker and Meffert, Rainer and Krutsch, Werner and Fehske, Kai}, title = {Injury epidemiology in men's professional team sports: is media analysis helpful?}, series = {Archives of Orthopaedic and Trauma Surgery}, volume = {141}, journal = {Archives of Orthopaedic and Trauma Surgery}, number = {4}, issn = {1434-3916}, doi = {10.1007/s00402-020-03743-6}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-266690}, pages = {655-661}, year = {2021}, abstract = {Introduction Epidemiological injury surveillance in professional sports is often based on online media analysis in order to collect necessary data. However, the validation of this study protocol is lacking. Therefore, this study aimed to identify the validity of injury surveillance in men's professional team sports based on media reports. Methods In a retrospective cohort study, the validity of media-data-relating injuries was investigated in participating teams of the highest two German divisions in men's professional basketball (BB) and handball (HB) in the season 2018/2019. Injury protocols completed by the team physicians were compared to those of sports media injury reports. Results The study population was composed of 133 athletes (54 BB and 79 HB). Of 343 injuries reported by the team physicians, 151 (44\%) could be identified by means of sports media reports. Severe injuries (n = 75, 72\%) were reported more likely in sports media compared to less severe injuries (n = 76, 32\%, p < 0.00001). Odds ratio (OR) was 5.33 (95\% CI 3.22-8.82). No differences regarding injury reporting could be seen between the two team sports. Conclusion For severe injuries, media analysis may be a sufficient method for data collection in popular men's professional ball sports. An underestimation of true injury prevalence lies within the range of previous reported investigations concerning the validation of injury surveillance methods. Non-severe injuries could not be verified via media analysis in professional handball and basketball.}, language = {en} } @article{MayrKleinRutzingeretal.2021, author = {Mayr, Stefan and Klein, Igor and Rutzinger, Martin and Kuenzer, Claudia}, title = {Determining temporal uncertainty of a global inland surface water time series}, series = {Remote Sensing}, volume = {13}, journal = {Remote Sensing}, number = {17}, issn = {2072-4292}, doi = {10.3390/rs13173454}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-245234}, year = {2021}, abstract = {Earth observation time series are well suited to monitor global surface dynamics. However, data products that are aimed at assessing large-area dynamics with a high temporal resolution often face various error sources (e.g., retrieval errors, sampling errors) in their acquisition chain. Addressing uncertainties in a spatiotemporal consistent manner is challenging, as extensive high-quality validation data is typically scarce. Here we propose a new method that utilizes time series inherent information to assess the temporal interpolation uncertainty of time series datasets. For this, we utilized data from the DLR-DFD Global WaterPack (GWP), which provides daily information on global inland surface water. As the time series is primarily based on optical MODIS (Moderate Resolution Imaging Spectroradiometer) images, the requirement of data gap interpolation due to clouds constitutes the main uncertainty source of the product. With a focus on different temporal and spatial characteristics of surface water dynamics, seven auxiliary layers were derived. Each layer provides probability and reliability estimates regarding water observations at pixel-level. This enables the quantification of uncertainty corresponding to the full spatiotemporal range of the product. Furthermore, the ability of temporal layers to approximate unknown pixel states was evaluated for stratified artificial gaps, which were introduced into the original time series of four climatologic diverse test regions. Results show that uncertainty is quantified accurately (>90\%), consequently enhancing the product's quality with respect to its use for modeling and the geoscientific community.}, language = {en} } @article{UrlaubKaiserScherf‐Claveletal.2021, author = {Urlaub, Jonas and Kaiser, Reinhard P. and Scherf-Clavel, Oliver and Bolm, Carsten and Holzgrabe, Ulrike}, title = {Investigation of isomerization of dexibuprofen in a ball mill using chiral capillary electrophoresis}, series = {Electrophoresis}, volume = {42}, journal = {Electrophoresis}, number = {17-18}, doi = {10.1002/elps.202000307}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-225852}, pages = {1790 -- 1799}, year = {2021}, abstract = {Besides the racemate, the S-enantiomer of ibuprofen (Ibu) is used for the treatment of inflammation and pain. Since the configurational stability of S-Ibu in solid state is of interest, it was studied by means of ball milling experiments. For the evaluation of the enantiomeric composition, a chiral CE method was developed and validated according to the ICH guideline Q2(R1). The addition of Mg\(^{2+}\), Ca\(^{2+}\), or Zn\(^{2+}\) ions to the background electrolyte (BGE) was found to improve Ibu enantioresolution. Chiral separation of Ibu enantiomers was achieved on a 60.2 cm (50.0 cm effective length) x 75 μm fused-silica capillary using a background electrolyte (BGE) composed of 50 mM sodium acetate, 10 mM magnesium acetate tetrahydrate, and 35 mM heptakis-(2,3,6-tri-O-methyl)-β-cyclodextrin (TM-β-CD) as chiral selector. The quantification of R-Ibu in the mixture was performed using the normalization procedure. Linearity was evaluated in the range of 0.68-5.49\% R-Ibu (R\(^{2}\) = 0.999), recovery was found to range between 97 and 103\%, the RSD of intra- and interday precision below 2.5\%, and the limit of quantification for R- in S-Ibu was calculated to be 0.21\% (extrapolated) and 0.15\% (dilution of racemic ibuprofen), respectively. Isomerization of S-Ibu was observed under basic conditions by applying long milling times and high milling frequencies.}, language = {en} } @article{WertgenRichter2020, author = {Wertgen, Andreas G. and Richter, Tobias}, title = {Source credibility modulates the validation of implausible information}, series = {Memory \& Cognition}, volume = {48}, journal = {Memory \& Cognition}, issn = {0090-502X}, doi = {10.3758/s13421-020-01067-9}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-234825}, pages = {1359-1375}, year = {2020}, abstract = {Validation of text information as a general mechanism for detecting inconsistent or false information is an integral part of text comprehension. This study examined how the credibility of the information source affects validation processes. Two experiments investigated combined effects of source credibility and plausibility of information during validation with explicit (ratings) and implicit (reading times) measurements. Participants read short stories with a high-credible versus low-credible person that stated a consistent or inconsistent assertion with general world knowledge. Ratings of plausibility and ratings of source credibility were lower when a credible source stated a world-knowledge inconsistent assertion compared with a low-credible source. Reading times on target sentences and on spillover sentences were slower when a credible source stated an assertion inconsistent with world knowledge compared with a low-credible source, suggesting that source information modulated the validation of implausible information. These results show that source credibility modulates validation and suggest a bidirectional relationship of perceived plausibility and source credibility in the reading process.}, language = {en} } @article{AppelSchulerVogeletal.2017, author = {Appel, Patricia and Schuler, Michael and Vogel, Heiner and Oezelsel, Amina and Faller, Hermann}, title = {Short Questionnaire for Workplace Analysis (KFZA): factorial validation in physicians and nurses working in hospital settings}, series = {Journal of Occupational Medicine and Toxicology}, volume = {12}, journal = {Journal of Occupational Medicine and Toxicology}, number = {11}, doi = {10.1186/s12995-017-0157-6}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-157510}, year = {2017}, abstract = {Background: In recent years, there has been an increasing interest in psychosocial workplace risk assessments in Germany. One of the questionnaires commonly employed for this purpose is the Short Questionnaire for Workplace Analysis (KFZA). Originally, the KFZA was developed and validated for office workers. The aim of the present study was to examine the factorial validity of the KFZA when applied to hospital settings. Therefore, we examined the factorial structure of a questionnaire that contained all the original items plus an extension adding 11 questions specific to hospital workplaces and analyzed both, the original version and the extended version. Methods: We analyzed questionnaire data of a total of 1731 physicians and nurses obtained over a 10-year period. Listwise exclusion of data sets was applied to account for variations in questionnaire versions and yielded 1163 questionnaires (1095 for the extended version) remaining for factor analysis. To examine the factor structure, we conducted a principal component factor analysis. The number of factors was determined using the Kaiser criterion and scree-plot methods. Factor interpretation was based on orthogonal Varimax rotation as well as oblique rotation. Results: The Kaiser criterion revealed a 7-factor solution for the 26 items of the KFZA, accounting for 62.0\% of variance. The seven factors were named: "Social Relationships", "Job Control", "Opportunities for Participation and Professional Development", "Quantitative Work Demands", "Workplace Environment", "Variability" and "Qualitative Work Demands". The factor analysis of the 37 items of the extended version yielded a 9-factor solution. The two additional factors were named "Consequences of Strain" and "Emotional Demands". Cronbach's α ranged from 0.63 to 0.87 for these scales. Conclusions: Overall, the KFZA turned out to be applicable to hospital workers, and its content-related structure was replicated well with some limitations. However, instead of the 11 factors originally proposed for office workers, a 7-factor solution appeared to be more suitable when employed in hospitals. In particular, the items of the KFZA factor "Completeness of Task" might need adaptation for the use in hospitals. Our study contributes to the assessment of the validity of this popular instrument and should stimulate further psychometric testing.}, language = {en} } @article{RodriguesUlrichMusseletal.2017, author = {Rodrigues, Johannes and Ulrich, Natalie and Mussel, Patrick and Carlo, Gustavo and Hewig, Johannes}, title = {Measuring prosocial tendencies in Germany: sources of validity and reliablity of the revised prosocial tendency measure}, series = {Frontiers in Psychology}, volume = {8}, journal = {Frontiers in Psychology}, doi = {10.3389/fpsyg.2017.02119}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-159351}, pages = {2119}, year = {2017}, abstract = {The prosocial tendencies measure (PTM; Carlo and Randall, 2002) is a widely used measurement for prosocial tendencies in English speaking participants. This instrument distinguishes between six different types of prosocial tendencies that partly share some common basis, but also can be opposed to each other. To examine these constructs in Germany, a study with 1067 participants was conducted. The study investigated the structure of this German version of the PTM-R via exploratory factor analysis, confirmatory factor analysis, correlations with similar constructs in subsamples as well as via measurement invariance test concerning the original English version. The German translation showed a similar factor structure to the English version in exploratory factor analysis and in confirmatory factor analysis. Measurement invariance was found between the English and German language versions of the PTM and support for the proposed six-factor structure (altruistic, anonymous, compliant, dire, emotional and public prosocial behavior) was also found in confirmatory factor analysis. Furthermore, the expected interrelations of these factors of prosocial behavior tendencies were obtained. Finally, correlations of the prosocial behavior tendencies with validating constructs and behaviors were found. Thus, the findings stress the importance of seeing prosocial behavior not as a single dimension construct, but as a factored construct which now can also be assessed in German speaking participants.}, language = {en} } @article{ScharbatkeBehrensSchmalzingetal.2016, author = {Scharbatke, Eva C. and Behrens, Frank and Schmalzing, Marc and Koehm, Michaela and Greger, Gerd and Gnann, Holger and Burkhardt, Harald and Tony, Hans-Peter}, title = {Association of improvement in pain with therapeutic response as determined by individual improvement criteria in patients with rheumatoid arthritis}, series = {Arthritis Care \& Research}, volume = {68}, journal = {Arthritis Care \& Research}, number = {11}, doi = {10.1002/acr.22884}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-186817}, pages = {1607-1615}, year = {2016}, abstract = {Objective To use statistical methods to establish a threshold for individual response in patient-reported outcomes (PROs) in patients with rheumatoid arthritis. Methods We used an analysis of variance model in patients on stable therapy (discovery cohort) to establish critical differences (d(crit)) for the minimum change associated with a significant individual patient response (beyond normal variation) in the PRO measures of pain (0-10), fatigue (0-10), and function (Funktionsfragebogen Hannover questionnaire; 0-100). We then evaluated PRO responses in patients initiating adalimumab in a noninterventional study (treatment cohort). Results In the discovery cohort (n=700), PROs showed excellent long-term retest reliability. The minimum change that exceeded random fluctuation was conservatively determined to be 3 points for pain, 4 points for fatigue, and 16 points for function. In the treatment cohort (n=2,788), 1,483 patients (53.2\%) achieved a significant individual therapeutic response as assessed by Disease Activity Score in 28 joints (DAS28)-d(crit) (1.8 points) after 12 months of adalimumab treatment; 68.5\% of patients with a DAS28-d(crit) response achieved a significant improvement in pain, whereas approximately 40\% achieved significant improvements in fatigue or function. Significant improvements in all 3 PROs occurred in 22.7\% of patients; 22.8\% did not have any significant PRO responses. In contrast, significant improvements in all 3 PROs occurred in only 4.4\% of 1,305 patients who did not achieve a DAS28-d(crit) response at month 12, and 59.1\% did not achieve any significant PRO responses. Conclusion The establishment of critical differences in PROs distinguishes true responses from random variation and provides insights into appropriate patient management.}, language = {en} } @article{TimmermansvanderTolTimmermansetal.2015, author = {Timmermans, Wim J. and van der Tol, Christiaan and Timmermans, Joris and Ucer, Murat and Chen, Xuelong and Alonso, Luis and Moreno, Jose and Carrara, Arnaud and Lopez, Ramon and Fernando de la Cruz, Tercero and Corcoles, Horacio L. and de Miguel, Eduardo and Sanchez, Jose A. G. and Perez, Irene and Belen, Perez and Munoz, Juan-Carlos J. and Skokovic, Drazen and Sobrino, Jose and Soria, Guillem and MacArthur, Alasdair and Vescovo, Loris and Reusen, Ils and Andreu, Ana and Burkart, Andreas and Cilia, Chiara and Contreras, Sergio and Corbari, Chiara and Calleja, Javier F. and Guzinski, Radoslaw and Hellmann, Christine and Herrmann, Ittai and Kerr, Gregoire and Lazar, Adina-Laura and Leutner, Benjamin and Mendiguren, Gorka and Nasilowska, Sylwia and Nieto, Hector and Pachego-Labrador, Javier and Pulanekar, Survana and Raj, Rahul and Schikling, Anke and Siegmann, Bastian and von Bueren, Stefanie and Su, Zhongbo (Bob)}, title = {An Overview of the Regional Experiments for Land-atmosphere Exchanges 2012 (REFLEX 2012) Campaign}, series = {Acta Geophysica}, volume = {63}, journal = {Acta Geophysica}, number = {6}, doi = {10.2478/s11600-014-0254-1}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-136491}, pages = {1465-1484}, year = {2015}, abstract = {The REFLEX 2012 campaign was initiated as part of a training course on the organization of an airborne campaign to support advancement of the understanding of land-atmosphere interaction processes. This article describes the campaign, its objectives and observations, remote as well as in situ. The observations took place at the experimental Las Tiesas farm in an agricultural area in the south of Spain. During the period of ten days, measurements were made to capture the main processes controlling the local and regional land-atmosphere exchanges. Apart from multi-temporal, multi-directional and multi-spatial space-borne and airborne observations, measurements of the local meteorology, energy fluxes, soil temperature profiles, soil moisture profiles, surface temperature, canopy structure as well as leaf-level measurements were carried out. Additional thermo-dynamical monitoring took place at selected sites. After presenting the different types of measurements, some examples are given to illustrate the potential of the observations made.}, language = {en} }