@article{HerrmannGlotzbachMuehlbergeretal.2011, author = {Herrmann, Martin J. and Glotzbach, Evelyn and M{\"u}hlberger, Andreas and Gschwendtner, Kathrin and Fallgatter, Andreas J. and Pauli, Paul}, title = {Prefrontal Brain Activation During Emotional Processing: A Functional Near Infrared Spectroscopy Study (fNIRS)}, series = {The Open Neuroimaging Journal}, journal = {The Open Neuroimaging Journal}, doi = {10.2174/1874440001105010033}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-97437}, year = {2011}, abstract = {The limbic system and especially the amygdala have been identified as key structures in emotion induction and regulation. Recently research has additionally focused on the influence of prefrontal areas on emotion processing in the limbic system and the amygdala. Results from fMRI studies indicate that the prefrontal cortex (PFC) is involved not only in emotion induction but also in emotion regulation. However, studies using fNIRS only report prefrontal brain activation during emotion induction. So far it lacks the attempt to compare emotion induction and emotion regulation with regard to prefrontal activation measured with fNIRS, to exclude the possibility that the reported prefrontal brain activation in fNIRS studies are mainly caused by automatic emotion regulation processes. Therefore this work tried to distinguish emotion induction from regulation via fNIRS of the prefrontal cortex. 20 healthy women viewed neutral pictures as a baseline condition, fearful pictures as induction condition and reappraised fearful pictures as regulation condition in randomized order. As predicted, the view-fearful condition led to higher arousal ratings than the view-neutral condition with the reappraise-fearful condition in between. For the fNIRS results the induction condition showed an activation of the bilateral PFC compared to the baseline condition (viewing neutral). The regulation condition showed an activation only of the left PFC compared to the baseline condition, although the direct comparison between induction and regulation condition revealed no significant difference in brain activation. Therefore our study underscores the results of previous fNIRS studies showing prefrontal brain activation during emotion induction and rejects the hypothesis that this prefrontal brain activation might only be a result of automatic emotion regulation processes.}, language = {en} } @article{GlotzbachMuehlbergerGschwendtneretal.2011, author = {Glotzbach, Evelyn and M{\"u}hlberger, Andreas and Gschwendtner, Kathrin and Fallgatter, Andreas J and Pauli, Paul and Herrmann, Martin J}, title = {Prefrontal Brain Activation During Emotional Processing: A Functional Near Infrared Spectroscopy Study (fNIRS)}, series = {The Open Neuroimaging Journal}, volume = {5}, journal = {The Open Neuroimaging Journal}, doi = {10.2174/1874440001105010033}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-141714}, pages = {33-39}, year = {2011}, abstract = {The limbic system and especially the amygdala have been identified as key structures in emotion induction and regulation. Recently research has additionally focused on the influence of prefrontal areas on emotion processing in the limbic system and the amygdala. Results from fMRI studies indicate that the prefrontal cortex (PFC) is involved not only in emotion induction but also in emotion regulation. However, studies using fNIRS only report prefrontal brain activation during emotion induction. So far it lacks the attempt to compare emotion induction and emotion regulation with regard to prefrontal activation measured with fNIRS, to exclude the possibility that the reported prefrontal brain activation in fNIRS studies are mainly caused by automatic emotion regulation processes. Therefore this work tried to distinguish emotion induction from regulation via fNIRS of the prefrontal cortex. 20 healthy women viewed neutral pictures as a baseline condition, fearful pictures as induction condition and reappraised fearful pictures as regulation condition in randomized order. As predicted, the view-fearful condition led to higher arousal ratings than the view-neutral condition with the reappraise-fearful condition in between. For the fNIRS results the induction condition showed an activation of the bilateral PFC compared to the baseline condition (viewing neutral). The regulation condition showed an activation only of the left PFC compared to the baseline condition, although the direct comparison between induction and regulation condition revealed no significant difference in brain activation. Therefore our study underscores the results of previous fNIRS studies showing prefrontal brain activation during emotion induction and rejects the hypothesis that this prefrontal brain activation might only be a result of automatic emotion regulation processes.}, language = {en} } @article{EgetemeirStennekenKoehleretal.2011, author = {Egetemeir, Johanna and Stenneken, Prisca and Koehler, Saskia and Fallgatter, Andreas J. and Herrmann, Martin J.}, title = {Exploring the neural basis of real-life joint action: measuring brain activation during joint table setting with functional near-infrared spectroscopy}, series = {FRONTIERS IN HUMAN NEUROSCIENCE}, volume = {5}, journal = {FRONTIERS IN HUMAN NEUROSCIENCE}, number = {9, Artikel 95}, doi = {10.3389/fnhum.2011.00095}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-137054}, pages = {1-9}, year = {2011}, abstract = {Many every-day life situations require two or more individuals to execute actions together. Assessing brain activation during naturalistic tasks to uncover relevant processes underlying such real-life joint action situations has remained a methodological challenge. In the present study, we introduce a novel joint action paradigm that enables the assessment of brain activation during real-life joint action tasks using functional near-infrared spectroscopy (fNIRS). We monitored brain activation of participants who coordinated complex actions with a partner sitting opposite them. Participants performed table setting tasks, either alone (solo action) or in cooperation with a partner (joint action), or they observed the partner performing the task (action observation). Comparing joint action and solo action revealed stronger activation (higher [oxy-Hb]-concentration) during joint action in a number of areas. Among these were areas in the inferior parietal lobule (IPL) that additionally showed an overlap of activation during action observation and solo action. Areas with such a close link between action observation and action execution have been associated with action simulation processes. The magnitude of activation in these IPL areas also varied according to joint action type and its respective demand on action simulation. The results validate fNIRS as an imaging technique for exploring the functional correlates of interindividual action coordination in real-life settings and suggest that coordinating actions in real-life situations requires simulating the actions of the partner.}, language = {en} } @phdthesis{Bretscher2011, author = {Bretscher, Franziska}, title = {Pr{\"a}frontale Aktivierung w{\"a}hrend einer Aufgabe zum Arbeitsged{\"a}chtnis bei Kindern mit ADHS}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-66037}, school = {Universit{\"a}t W{\"u}rzburg}, year = {2011}, abstract = {Bei Kindern mit Aufmerksamkeitsdefizit-/Hyperaktivit{\"a}tsst{\"o}rung (ADHS) konnten Defizite in der Leistung des Arbeitsged{\"a}chtnisses nachgewiesen werden. In zahlreichen funktionell bildgebenden Studien zeigte sich außerdem ein mit dem Arbeitsged{\"a}chtnis assoziierter Unterschied in der pr{\"a}frontalen Aktivierung im Vergleich zu Gesunden. Bisher wurde jedoch noch nicht n{\"a}her analysiert, ob diese Defizite von der Komponente (visuell-r{\"a}umliches (SWM) oder visuell-bildliches Arbeitsged{\"a}chtnis (OWM)) oder dem Prozess des Arbeitsged{\"a}chtnisses (untergeordnete Speichersysteme oder zentrale Exekutive) abh{\"a}ngig sind. Diese Arbeit ist die erste, die mit der funktionellen Nah-Infrarot Spektroskopie (fNIRS) das Arbeitsged{\"a}chtnis bei Kindern mit ADHS untersucht. Dabei war das Hauptziel zum einen die Replikation von Gruppenunterschieden in Verhalten und pr{\"a}frontaler Aktivierung und zum anderen die Gewinnung n{\"a}herer Informationen {\"u}ber die differentielle Auspr{\"a}gung der pr{\"a}frontalen Defizite bei ADHS. Die Stichprobe bestand aus 19 Kindern mit ADHS vom kombinierten Typ (DSM-IV) und 19 Kontrollkindern, die vergleichbar waren nach Alter (8-15 Jahre), Geschlecht, H{\"a}ndigkeit und Intelligenz. Das von uns gew{\"a}hlte Paradigma differenzierte zwischen Aufgaben zum OWM und SWM, innerhalb derer wiederum zwei prozessabh{\"a}ngige Phasen (Speicherung und Abgleich) unterschieden wurden, und enthielt zus{\"a}tzlich eine Kontrollaufgabe (CON). Die pr{\"a}frontale Aktivierung wurde mittels fNIRS {\"u}ber die Konzentrations{\"a}nderungen der Chromophoren oxygeniertes H{\"a}moglobin (O2Hb) und deoxygeniertes H{\"a}moglobin (HHb) bestimmt. Es zeigte sich ein signifikant unterschiedliches Verhalten abh{\"a}ngig von der Bedingung (CON > SWM > OWM). Eine typische pr{\"a}frontale Aktivierung des Arbeitsged{\"a}chtnisses mit der h{\"o}chsten Aktivierung im dorsolateralen pr{\"a}frontalen Kortex (DLPFC) beschr{\"a}nkte sich auf die Abgleichphase. Weder in Hinblick auf das Verhalten noch auf die pr{\"a}frontale Aktivierung konnten signifikante Gruppenunterschiede nachgewiesen werden. F{\"u}r das Nichtauftreten von Gruppenunterschieden k{\"o}nnen verschiedene m{\"o}gliche Gr{\"u}nde angef{\"u}hrt werden. Unter anderem legten explorative Analysen nahe, dass Kinder mit ADHS und gesunde Kinder unterschiedlichen Reifungsprozessen unterliegen. Auch scheint die chronische Einnahme der ADHS-Standardmedikation einen Einfluss auf die Hirnaktivit{\"a}t zu nehmen. Die Diskussion unserer Ergebnisse stellt zusammen mit der Offenlegung von Kritikpunkten an unserer sowie an vorhergehenden Studien einen wichtigen Ansatzpunkt zur Versuchsoptimierung in zuk{\"u}nftigen Arbeiten dar. Dar{\"u}ber hinaus ist weitere Forschung n{\"o}tig, um detailliertere Kenntnisse {\"u}ber den Einfluss von Alter, Reifungsprozessen, chronischer MPH-Medikation, ADHS-Subtypen und dem Aufgabendesign zu erlangen.}, subject = {Aufmerksamkeits-Defizit-Syndrom}, language = {de} }