@article{ToussaintRichterManteletal.2016,
  author    = {Toussaint, Andr{\´e} and Richter, Anne and Mantel, Frederick and Flickinger, John C. and Grills, Inga Siiner and Tyagi, Neelam and Sahgal, Arjun and Letourneau, Daniel and Sheehan, Jason P. and Schlesinger, David J. and Gerszten, Peter Carlos and Guckenberger, Matthias},
  title     = {Variability in spine radiosurgery treatment planning - results of an international multi-institutional study},
  series = {Radiation Oncology},
  volume    = {11},
  journal   = {Radiation Oncology},
  number    = {57},
  doi       = {10.1186/s13014-016-0631-9},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-146687},
  year      = {2016},
  abstract  = {Background The aim of this study was to quantify the variability in spinal radiosurgery (SRS) planning practices between five international institutions, all member of the Elekta Spine Radiosurgery Research Consortium. Methods Four institutions provided one representative patient case each consisting of the medical history, CT and MR imaging. A step-wise planning approach was used where, after each planning step a consensus was generated that formed the basis for the next planning step. This allowed independent analysis of all planning steps of CT-MR image registration, GTV definition, CTV definition, PTV definition and SRS treatment planning. In addition, each institution generated one additional SRS plan for each case based on intra-institutional image registration and contouring, independent of consensus results. Results Averaged over the four cases, image registration variability ranged between translational 1.1 mm and 2.4 mm and rotational 1.1° and 2.0° in all three directions. GTV delineation variability was 1.5 mm in axial and 1.6 mm in longitudinal direction averaged for the four cases. CTV delineation variability was 0.8 mm in axial and 1.2 mm in longitudinal direction. CTV-to-PTV margins ranged between 0 mm and 2 mm according to institutional protocol. Delineation variability was 1 mm in axial directions for the spinal cord. Average PTV coverage for a single fraction18 Gy prescription was 87 ± 5 \%; Dmin to the PTV was 7.5 ± 1.8 Gy averaged over all cases and institutions. Average Dmax to the PRV_SC (spinal cord + 1 mm) was 10.5 ± 1.6 Gy and the average Paddick conformity index was 0.69 ± 0.06. Conclusions Results of this study reflect the variability in current practice of spine radiosurgery in large and highly experienced academic centers. Despite close methodical agreement in the daily workflow, clinically significant variability in all steps of the treatment planning process was demonstrated. This may translate into differences in patient clinical outcome and highlights the need for consensus and established delineation and planning criteria.},
  language  = {en}
}
@article{KlaesnerBuchmannGemptetal.2015,
  author    = {Kl{\"a}sner, Benjamin and Buchmann, Niels and Gempt, Jens and Ringel, Florian and Lapa, Constantin and Krause, Bernd Joachim},
  title     = {Early [\(^{18}\)F]FET-PET in Gliomas after Surgical Resection: Comparison with MRI and Histopathology},
  series = {PLoS One},
  volume    = {10},
  journal   = {PLoS One},
  number    = {10},
  doi       = {10.1371/journal.pone.0141153},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-139549},
  pages     = {e0141153},
  year      = {2015},
  abstract  = {Background The precise definition of the post-operative resection status in high-grade gliomas (HGG) is crucial for further management. We aimed to assess the feasibility of assessment of the resection status with early post-operative positron emission tomography (PET) using [\(^{18}\)F]O-(2-[\(^{18}\)F]-fluoroethyl)-L-tyrosine ([\(^{18}\)F]FET). Methods 25 patients with the suspicion of primary HGG were enrolled. All patients underwent preoperative [\(^{18}\)F]FET-PET and magnetic resonance imaging (MRI). Intra-operatively, resection status was assessed using 5-aminolevulinic acid (5-ALA). Imaging was repeated within 72h after neurosurgery. Post-operative [\(^{18}\)F]FET-PET was compared with MRI, intra-operative assessment and clinical follow-up. Results [\(^{18}\)F]FET-PET, MRI and intra-operative assessment consistently revealed complete resection in 12/25 (48\%) patients and incomplete resection in 6/25 cases (24\%). In 7 patients, PET revealed discordant findings. One patient was re-resected. 3/7 experienced tumor recurrence, 3/7 died shortly after brain surgery. Conclusion Early assessment of the resection status in HGG with [\(^{18}\)F]FET-PET seems to be feasible.},
  language  = {en}
}