@incollection{HammannHeunischSchuessler1989,
  author    = {Hammann, W. and Heunisch, C. and Sch{\"u}ssler, Ulrich},
  title     = {Organische Mikrofossilien (Chlorophyta, Acritarcha, Sporae diversae, Scolecodonten) aus den Schichten des Streichengrundes, Unterdevon, im Raum Guttenberg-Kupferberg des Frankenwaldes.},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-39152},
  publisher      = {Universit{\"a}t W{\"u}rzburg},
  year      = {1989},
  abstract  = {Aus einer SE von Guttenberg im Frankenwald auftretenden Abfolge von bisher zur ordovizischen Randschieferserie gez{\"a}hlten grauen Schiefern und Tuffiten, den "Streichengrund-Schichten", wird eine reiche Assoziation organischer Mikrofossilien mit einem unterdevonisehen (Unter-Ems) Ablagerungsalter und mit aufgearbeitetem Unterordovizium (Ober-Arenig) beschrieben. Diese umfaßt 11 Arten der Chlorophyten, 44 Arten der Acritarchen - davon neu Uncillisphaera spinifurcillata 11. sp., sowie 42 Taxa der Sporae dispersae und Scolecodonten. Die somit als tektonische Schuppe innerhalb der ordovizischen Randschieferserie liegenden Streichengrund-Schichten stellen eine im Frankenwald bisher unbekannte Fazieseinheit des Unterdevon dar, die mit ihren vulkanischen Anteilen bayerische, mit ihren klastischen Anteilen th{\"u}ringische Z{\"u}ge besitzt. Lithologische Vergleiche mit den in streichender Verl{\"a}ngerung nach S hin auftretenden dunklen Schiefern der stratiformen Lagerst{\"a}tte von Kupferberg legen ein Unterdevon-Alter auch f{\"u}r diese Einheit nahe.},
  subject      = {Frankenwald},
  language  = {de}
}
@article{DembekBarquistBoinettetal.2015,
  author    = {Dembek, Marcin and Barquist, Lars and Boinett, Christine J. and Cain, Amy K. and Mayho, Matthew and Lawley, Trevor D. and Fairweather, Neil F. and Fagan, Robert P.},
  title     = {High-throughput analysis of gene essentiality and sporulation in Clostridium difficile},
  series = {mBio},
  volume    = {6},
  journal   = {mBio},
  number    = {2},
  doi       = {10.1128/mBio.02383-14},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-143745},
  pages     = {e02383-14},
  year      = {2015},
  abstract  = {Clostridium difficile is the most common cause of antibiotic-associated intestinal infections and a significant cause of morbidity and mortality. Infection with C. difficile requires disruption of the intestinal microbiota, most commonly by antibiotic usage. Therapeutic intervention largely relies on a small number of broad-spectrum antibiotics, which further exacerbate intestinal dysbiosis and leave the patient acutely sensitive to reinfection. Development of novel targeted therapeutic interventions will require a detailed knowledge of essential cellular processes, which represent attractive targets, and species-specific processes, such as bacterial sporulation. Our knowledge of the genetic basis of C. difficile infection has been hampered by a lack of genetic tools, although recent developments have made some headway in addressing this limitation. Here we describe the development of a method for rapidly generating large numbers of transposon mutants in clinically important strains of C. difficile. We validated our transposon mutagenesis approach in a model strain of C. difficile and then generated a comprehensive transposon library in the highly virulent epidemic strain R20291 (027/BI/NAP1) containing more than 70,000 unique mutants. Using transposon-directed insertion site sequencing (TraDIS), we have identified a core set of 404 essential genes, required for growth in vitro. We then applied this technique to the process of sporulation, an absolute requirement for C. difficile transmission and pathogenesis, identifying 798 genes that are likely to impact spore production. The data generated in this study will form a valuable resource for the community and inform future research on this important human pathogen.},
  language  = {en}
}