@article{LiWongNongetal.2014,
  author    = {Li, Lei and Wong, Hin-chung and Nong, Wenyan and Cheung, Man Kit and Law, Patrick Tik Wan and Kam, Kai Man and Kwan, Hoi Shan},
  title     = {Comparative genomic analysis of clinical and environmental strains provides insight into the pathogenicity and evolution of Vibrio parahaemolyticus},
  series = {BMC Genomics},
  volume    = {15},
  journal   = {BMC Genomics},
  number    = {1135},
  issn      = {1471-2164},
  doi       = {10.1186/1471-2164-15-1135},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-118080},
  year      = {2014},
  abstract  = {Background: Vibrio parahaemolyticus is a Gram-negative halophilic bacterium. Infections with the bacterium could become systemic and can be life-threatening to immunocompromised individuals. Genome sequences of a few clinical isolates of V. parahaemolyticus are currently available, but the genome dynamics across the species and virulence potential of environmental strains on a genome-scale have not been described before. Results: Here we present genome sequences of four V. parahaemolyticus clinical strains from stool samples of patients and five environmental strains in Hong Kong. Phylogenomics analysis based on single nucleotide polymorphisms revealed a clear distinction between the clinical and environmental isolates. A new gene cluster belonging to the biofilm associated proteins of V. parahaemolyticus was found in clincial strains. In addition, a novel small genomic island frequently found among clinical isolates was reported. A few environmental strains were found harboring virulence genes and prophage elements, indicating their virulence potential. A unique biphenyl degradation pathway was also reported. A database for V. parahaemolyticus (http://kwanlab.bio.cuhk.edu.hk/vp webcite) was constructed here as a platform to access and analyze genome sequences and annotations of the bacterium. Conclusions: We have performed a comparative genomics analysis of clinical and environmental strains of V. parahaemolyticus. Our analyses could facilitate understanding of the phylogenetic diversity and niche adaptation of this bacterium. "},
  language  = {en}
}
@article{VandeKerkhofFeenstravanderHeijdenetal.2012,
  author    = {Van de Kerkhof, Noortje W. A. and Feenstra, Ilse and van der Heijden, Frank M. M. A. and de Leeuw, Nicole and Pfundt, Rolph and St{\"o}ber, Gerald and Egger, Jos I. M. and Verhoeven, Willem M. A.},
  title     = {Copy number variants in a sample of patients with psychotic disorders: is standard screening relevant for actual clinical practice?},
  series = {Neuropsychiatric Disease and Treatment},
  volume    = {8},
  journal   = {Neuropsychiatric Disease and Treatment},
  doi       = {10.2147/NDT.S32903},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-134769},
  pages     = {295-300},
  year      = {2012},
  abstract  = {With the introduction of new genetic techniques such as genome-wide array comparative genomic hybridization, studies on the putative genetic etiology of schizophrenia have focused on the detection of copy number variants (CNVs), ie, microdeletions and/or microduplications, that are estimated to be present in up to 3\% of patients with schizophrenia. In this study, out of a sample of 100 patients with psychotic disorders, 80 were investigated by array for the presence of CNVs. The assessment of the severity of psychiatric symptoms was performed using standardized instruments and ICD-10 was applied for diagnostic classification. In three patients, a submicroscopic CNV was demonstrated, one with a loss in 1q21.1 and two with a gain in 1p13.3 and 7q11.2, respectively. The association between these or other CNVs and schizophrenia or schizophrenia-like psychoses and their clinical implications still remain equivocal. While the CNV affected genes may enhance the vulnerability for psychiatric disorders via effects on neuronal architecture, these insights have not resulted in major changes in clinical practice as yet. Therefore, genome-wide array analysis should presently be restricted to those patients in whom psychotic symptoms are paired with other signs, particularly dysmorphisms and intellectual impairment.},
  language  = {en}
}
@article{HarringtonScelsiHarteletal.2012,
  author    = {Harrington, John M. and Scelsi, Chris and Hartel, Andreas and Jones, Nicola G. and Engstler, Markus and Capewell, Paul and MacLeod, Annette and Hajduk, Stephen},
  title     = {Novel African Trypanocidal Agents: Membrane Rigidifying Peptides},
  series = {PLoS One},
  volume    = {7},
  journal   = {PLoS One},
  number    = {9},
  doi       = {10.1371/journal.pone.0044384},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-135179},
  pages     = {e44384},
  year      = {2012},
  abstract  = {The bloodstream developmental forms of pathogenic African trypanosomes are uniquely susceptible to killing by small hydrophobic peptides. Trypanocidal activity is conferred by peptide hydrophobicity and charge distribution and results from increased rigidity of the plasma membrane. Structural analysis of lipid-associated peptide suggests a mechanism of phospholipid clamping in which an internal hydrophobic bulge anchors the peptide in the membrane and positively charged moieties at the termini coordinate phosphates of the polar lipid headgroups. This mechanism reveals a necessary phenotype in bloodstream form African trypanosomes, high membrane fluidity, and we suggest that targeting the plasma membrane lipid bilayer as a whole may be a novel strategy for the development of new pharmaceutical agents. Additionally, the peptides we have described may be valuable tools for probing the biosynthetic machinery responsible for the unique composition and characteristics of African trypanosome plasma membranes.},
  language  = {en}
}
@phdthesis{Wang2010,
  author    = {Wang, Chenxing},
  title     = {Praktisches Bewertungsmodell von Umwelt- und Klimaschutzaspekten f{\"u}r die Nutzung von Biogas im deutsch-chinesischen Vergleich},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-49428},
  school      = {Universit{\"a}t W{\"u}rzburg},
  year      = {2010},
  abstract  = {In den Themenbereichen Klimawandel, Klimaschutz und Erneuerbare Energien wurden in den letzten Jahren zunehmend neue Bewertungsmethoden in der geowissenschaftlichen und umweltwissenschaftlichen Forschung eingesetzt. Mit Blick auf die Biogasnutzung kann festgestellt werden, dass diese aus Umwelt- und Klimaschutzgr{\"u}nden sehr wichtig ist, da die Verg{\"a}rung von Biomasse mit der nachfolgenden indirekten Erzeugung von Strom und W{\"a}rme {\"u}ber Blockheizkraftwerke, bzw. der direkten Nutzung des Biogases als Feuerungsgas bzw. als Treibstoff , einen besonderen Beitrag zum Klimaschutz leistet. In Deutschland ist die Biogasnutzung heute einer der wichtigsten Erneuerbaren Energietr{\"a}ger geworden. In China hat die Biogasnutzung zudem ein riesiges Entwicklungspotenzial. Der Autor versucht, im interdisziplin{\"a}ren Themenkreis „Umwelt- und Klimaschutz" ein Bewertungsmodell f{\"u}r die Biogasnutzung zu entwickeln, um die tats{\"a}chlichen und potentiellen umwelt- und klimaschutzrelevanten Auswirkungen der Biogasnutzung zu bewerten. Um das Bewertungsmodell f{\"u}r die Biogasnutzung nach Umwelt- und Klimaschutzaspekten m{\"o}glichst umfassend zu entwickeln, ist die Verzahnung der interdisziplin{\"a}ren umweltwissenschaftlichen, geowissenschaftlichen, rechtlichen, sowie lokal-, national- und internationalen politischen sowie technischen Faktoren mit ihren umweltbezogenen und klimabezogenen Auswirkungen von h{\"o}chster Bedeutung. Das in der vorliegenden Arbeit entwickelte Bewertungsmodell erhebt den Anspruch, f{\"u}r den praktischen Einsatz vor Ort tauglich zu sein. Hierzu wurden umwelt- und klimaschutzrechtliche, sowie nationale und internationale politische Anforderungen zur Kategorisierung und Bewertung herangezogen und damit die Durchf{\"u}hrbarkeit gew{\"a}hrleistet. Der L{\"o}sungsweg zur Bewertung nach Umwelt- und Klimaschutzaspekten f{\"u}hrt zum Einen {\"u}ber die Umwelt- und Klimaschutzbilanzierung und zum Anderen {\"u}ber eine Umweltrisikobewertung sowie eine umweltbezogene Standortbewertung. Anhand der praktischen Arbeit und der Analyse von insgesamt 23 Biogasprojekten aus Deutschland und China, konnten bestimmte Charakteristika der Biogasnutzung ermittelt werden. F{\"u}r die Ermittlung der Bewertungskriterien des Bewertungsmodells wurden insgesamt 3 Themenbereiche (Teil I: Substratversorgung; Teil II: Biogasanlagenbau; Teil III: Biogasverwertung) der Biogasnutzung unterschieden. Jene wurden hinsichtlich der technischen, rechtlichen und politischen Kriterien nach negativen Umwelt- und Klimaschutzauswirkungen {\"u}ber die verschiedenen Belastungspfade der Umweltmedien (Boden, Wasser und Luft) untersucht. Ziel dieser Studie war es auch, durch die Anwendung des Bewertungsmodells auf je drei deutsche und chinesische Fallbeispiele, die ausgereiften deutschen Erfahrungen, die deutsche Technologie und das Know-How der Biogasnutzung auf deren {\"U}bertragbarkeit auf die chinesischen Verh{\"a}ltnisse zu pr{\"u}fen.},
  subject      = {Klimaschutz},
  language  = {de}
}
@phdthesis{AlFarajat2001,
  author    = {Al-Farajat, Mohammad},
  title     = {Hydrogeo-Eco-Systems in Aquaba/Jordan - Coasts and Region},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-1182066},
  school      = {Universit{\"a}t W{\"u}rzburg},
  year      = {2001},
  abstract  = {The coast of Aqaba and the Aqaba region (Jordan) were investigated on their hydrogeo-ecosystem. The results of the research were translated into digits to build a geo-spatial data base. The fillings of the graben aquifer receive indirect type of recharge through the side wadis which drain the highlands. Surface water balance was modeled for a period of 20 years of daily climate records using MODBIL program which attributes direct recharge to wet years only. The hydrodynamic fresh water/seawater interface in the coastal zones was investigated by applying vertical geoelectric surveys and models of several methods to confirm its coincidence with the aquifer's flow amounts, where human impacts in terms of over-pumping allowed more encroachment of seawater into land, and unintended recharge which led to seaward interface migration. A groundwater balance and solute transport were approached by developing a flow model from the hydrogeological and hydrochemical data. The nature of soil cover and aquifer whose physical properties enhance human impacts indicated the vulnerability of groundwater to pollution. This certainly threatens the marine ecology which forms the sink where the in-excess flow ends. The constructed digital background was exported into GIS to sub-zone the study area in terms of the aquifer's vulnerability to pollution risks using DRASTIC index. However, it was unable to meet all geo-spatial factors that proved to have significant impacts on the vulnerability. Consequently, a comprehensive index -SALUFT- was developed. This suggests the suitable land use units for each zone in the light of vulnerability grades aiming at protecting the available groundwater resources.},
  subject      = {Golf von Akaba},
  language  = {en}
}