@article{FerianecFueloepJežovičovaetal.2020,
  author    = {Ferianec, Vladim{\´i}r and F{\"u}l{\"o}p, Matej and Ježovičov{\´a}, Miriam and Radošinsk{\´a}, Jana and Husseinov{\´a}, Marta and Feriancov{\´a}, Michaela and Radošinsk{\´a}, Dominika and Baranč{\´i}k, Miroslav and Muchov{\´a}, Jana and Hȍgger, Petra and Ďuračkov{\´a}, Zdeňka},
  title     = {The oak-wood extract Robuvit\(^®\) improves recovery and oxidative stress after hysterectomy: a randomized, double-blind, placebo-controlled pilot study},
  series = {Nutrients},
  volume    = {12},
  journal   = {Nutrients},
  number    = {4},
  issn      = {2072-6643},
  doi       = {10.3390/nu12040913},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-203265},
  year      = {2020},
  abstract  = {Hysterectomy has a variety of medical indications and improves pre-operative symptoms but might compromise the quality of life during recovery due to symptoms such as fatigue, headache, nausea, depression, or pain. The aim of the present study was to determine the effect of a standardized extract from French oak wood (Quercus robur) containing at least 40\% polyphenols of the ellagitannins class, Robuvit\(^®\), on convalescence and oxidative stress of women after hysterectomy. Recovery status was monitored with the SF-36 questionnaire. The supplementation with Robuvit\(^®\) (300 mg/day) during 4 weeks significantly improved general and mental health, while under placebo some items significantly deteriorated. Oxidative stress and enhancement of MMP-9 activity was significantly reduced by Robuvit\(^®\) versus placebo. After 8 weeks of intervention, the patients' condition improved independently of the intervention. Our results suggest that the use of Robuvit\(^®\) as a natural supplement relieves post-operative symptoms of patients after hysterectomy and reduces oxidative stress. The study was registered with ID ISRCTN 11457040 (13/09/2019).},
  language  = {en}
}
@article{VolppFerianecJežovičovaetal.2020,
  author    = {Volpp, Linda and Ferianec, Vladim{\´i}r and Ježovičov{\´a}, Miriam and Ďuračkov{\´a}, Zdeňka and Scherf-Clavel, Oliver and H{\"o}gger, Petra},
  title     = {Constituents and Metabolites of a French Oak Wood Extract (Robuvit®) in Serum and Blood Cell Samples of Women Undergoing Hysterectomy},
  series = {Frontiers in Pharmacology},
  volume    = {11},
  journal   = {Frontiers in Pharmacology},
  number    = {74},
  issn      = {1663-9812},
  doi       = {10.3389/fphar.2020.00074},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-200105},
  year      = {2020},
  abstract  = {Ellagitannins are signature constituents of oak wood and their consumption has been associated with various health benefits. In vivo, they undergo metabolic degradation including gut microbial metabolism yielding urolithins. Only limited data is available about compounds being present in blood after intake of an extract from French oak wood, Robuvit®. In the course of a randomized, double-blind, controlled clinical investigation, 66 patients undergoing hysterectomy received placebo or 300 mg Robuvit® per day before and over 8 weeks after surgery. Serum and blood cell samples were analyzed by liquid chromatography electrospray ionization tandem mass spectrometry (LC-ESI-MS/MS). The number of urolithin producers and the urolithin levels increased after intake of Robuvit®. In serum samples, the median concentration of urolithin A was 14.0 ng/ml [interquartile range (IQR) 57.4] after 8 weeks. Urolithin B was determined at 22.3 ng/ml (IQR 12.6), urolithin C at 2.66 ng/ml (IQR 2.08). In blood cells, lower concentrations and only urolithins A and B were detected. A statistically significant association of lower post-surgical pain scores with metabotype A was detected (p < 0.05). To conclude, supplementation with French oak wood extract raised urolithin generation in patients and suggested health advantages for urolithin-producers.},
  language  = {en}
}