@article{KittelSchneiderDavidovaKaloketal.2022,
  author    = {Kittel-Schneider, Sarah and Davidova, Petra and Kalok, Miriam and Essel, Corina and Ahmed, Fadia Ben and Kingeter, Yasmina and Matentzoglu, Maria and Leutritz, Anna and Kersken, Katharina and Koreny, Carolin and Weber, Heike and Kollert, Leoniee and McNeill, Rihannon V. and Reif, Andreas and Bahlmann, Franz and Trautmann-Villalba, Patricia},
  title     = {A pilot study of multilevel analysis of BDNF in paternal and maternal perinatal depression},
  series = {Archives of Women's Mental Health},
  volume    = {25},
  journal   = {Archives of Women's Mental Health},
  number    = {1},
  issn      = {1435-1102},
  doi       = {10.1007/s00737-021-01197-2},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-268849},
  pages     = {237-249},
  year      = {2022},
  abstract  = {Depression in the perinatal period is common in mothers worldwide. Emerging research indicates that fathers are also at risk of developing perinatal depression. However, knowledge regarding biological risk factors and pathophysiological mechanisms of perinatal depression is still scarce, particularly in fathers. It has been suggested that the neurotrophin BDNF may play a role in maternal perinatal depression; however, there is currently no data regarding paternal perinatal depression. For this pilot study, 81 expecting parents were recruited and assessed at several time points. We screened for depression using EPDS and MADRS, investigated several psychosocial variables, and took blood samples for BDNF val66met genotyping, epigenetic, and protein analysis. Between pregnancy and 12 months postpartum (pp), we found that 3.7 to 15.7\% of fathers screened positive for depression, and 9.6 to 24\% of mothers, with at least a twofold increased prevalence in both parents using MADRS compared with EPDS. We also identified several psychosocial factors associated with perinatal depression in both parents. The data revealed a trend that lower BDNF levels correlated with maternal depressive symptoms at 3 months pp. In the fathers, no significant correlations between BDNF and perinatal depression were found. Pregnant women demonstrated lower BDNF methylation and BDNF protein expression compared with men; however, these were found to increase postpartum. Lastly, we identified correlations between depressive symptoms and psychosocial/neurobiological factors. The data suggest that BDNF may play a role in maternal perinatal depression, but not paternal.},
  language  = {en}
}
@article{WeberMaihoferJaksicetal.2022,
  author    = {Weber, Heike and Maihofer, Adam X. and Jaksic, Nenad and Bojic, Elma Feric and Kucukalic, Sabina and Dzananovic, Emina Sabic and Uka, Aferdita Goci and Hoxha, Blerina and Haxhibeqiri, Valdete and Haxhibeqiri, Shpend and Kravic, Nermina and Umihanic, Mirnesa Muminovic and Franc, Ana Cima and Babic, Romana and Pavlovic, Marko and Mehmedbasic, Alma Bravo and Aukst-Margetic, Branka and Kucukalic, Abdulah and Marjanovic, Damir and Babic, Dragan and Jakovljevic, Miro and Sinanovic, Osman and Avidbegović, Esmina and Agani, Ferid and Warrings, Bodo and Domschke, Katharina and Nievergelt, Caroline M. and Dzubur-Kulenovic, Alma and Erhardt, Angelika},
  title     = {Association of polygenic risk scores, traumatic life events and coping strategies with war-related PTSD diagnosis and symptom severity in the South Eastern Europe (SEE)-PTSD cohort},
  series = {Journal of Neural Transmission},
  volume    = {129},
  journal   = {Journal of Neural Transmission},
  number    = {5-6},
  issn      = {1435-1463},
  doi       = {10.1007/s00702-021-02446-5},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-268541},
  pages     = {661-674},
  year      = {2022},
  abstract  = {Objectives Posttraumatic stress disorder (PTSD) is triggered by extremely stressful environmental events and characterized by high emotional distress, re-experiencing of trauma, avoidance and hypervigilance. The present study uses polygenic risk scores (PRS) derived from the UK Biobank (UKBB) mega-cohort analysis as part of the PGC PTSD GWAS effort to determine the heritable basis of PTSD in the South Eastern Europe (SEE)-PTSD cohort. We further analyzed the relation between PRS and additional disease-related variables, such as number and intensity of life events, coping, sex and age at war on PTSD and CAPS as outcome variables. Methods Association of PRS, number and intensity of life events, coping, sex and age on PTSD were calculated using logistic regression in a total of 321 subjects with current and remitted PTSD and 337 controls previously subjected to traumatic events but not having PTSD. In addition, PRS and other disease-related variables were tested for association with PTSD symptom severity, measured by the Clinician Administrated PTSD Scale (CAPS) by liner regression. To assess the relationship between the main outcomes PTSD diagnosis and symptom severity, each of the examined variables was adjusted for all other PTSD related variables. Results The categorical analysis showed significant polygenic risk in patients with remitted PTSD and the total sample, whereas no effects were found on symptom severity. Intensity of life events as well as the individual coping style were significantly associated with PTSD diagnosis in both current and remitted cases. The dimensional analyses showed as association of war-related frequency of trauma with symptom severity, whereas the intensity of trauma yielded significant results independently of trauma timing in current PTSD. Conclusions The present PRS application in the SEE-PTSD cohort confirms modest but significant polygenic risk for PTSD diagnosis. Environmental factors, mainly the intensity of traumatic life events and negative coping strategies, yielded associations with PTSD both categorically and dimensionally with more significant p-values. This suggests that, at least in the present cohort of war-related trauma, the association of environmental factors and current individual coping strategies with PTSD psychopathology was stronger than the polygenic risk.},
  language  = {en}
}