@article{TackeBentlageSheldricketal.1982,
  author    = {Tacke, R. and Bentlage, A. and Sheldrick, W. S. and Ernst, L. and Towart, R. and Stoepel, K.},
  title     = {Sila-Pharmaka, 24. Mitt. [1]. Sila-Analoga von Nifedipin-{\"a}hnlichen 4-Aryl-2.6-dimethyl-1.4-dihydropyridin- 3.5-dicarbons{\"a}ure-dialkylestern, II.},
  series = {Zeitschrift f{\"u}r Naturforschung B},
  volume    = {37},
  journal   = {Zeitschrift f{\"u}r Naturforschung B},
  number    = {4},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-128381},
  pages     = {443-450},
  year      = {1982},
  abstract  = {In the course of systematic studies on sila-substituted drugs the nifedipine-like 1.4-dihydropyridine derivatives 4a, 4b and 4c were prepared and investigated with respect to sila-substitution effects. By X-ray diffraction analyses 4a, 4b and 4c were found to be isostructural. The C/Si-analogues exhibit similar spasmolytic activities (in vitro, guinea pig ileum), comparable with that of nifedipine. However, the compounds differ substantially in their in vivo activity, as measured by the antihypertensive effect on the renal-hypertensive rat. The experimental results are discussed with respect to the carbon/silicon exchange.},
  language  = {de}
}
@article{TackeStreckerSheldricketal.1979,
  author    = {Tacke, R. and Strecker, M. and Sheldrick, W. S. and Heeg, E. and Berndt, B. and Knapstein, K. M.},
  title     = {Sila-Pharmaka, 14. Mitt. Darstellung und Eigenschaften sowie Kristall-und Molek{\"u}lstruktur von Sila-Difenidol},
  series = {Zeitschrift f{\"u}r Naturforschung B},
  volume    = {34},
  journal   = {Zeitschrift f{\"u}r Naturforschung B},
  number    = {9},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-128391},
  pages     = {1279-1285},
  year      = {1979},
  abstract  = {Sila-difenidol (6b), a sila-analogue of the drug difenidol (6a), was synthesized according to Scheme 1. 6b and its new precursors 3 and 5 were characterized by their physical and chemical properties, and their structures confirmed by elementary analyses, 1H NMR and mass spectroscopy. 6 b crystallizes orthorhombic \(P2_12_12_1\) with a = 11.523(1), b = 14.366(4), c = 11.450(1) {\AA}, Z = 4, \(D_{ber} = 1.14 gcm^{-3}\). The structure was refined to R = 0.050 for 1897 reflexions. A strong nearly linear intramolecular O-H···N hydrogen bond of 2.685 {\AA} is observed. The anticholinergic, histaminolytic and musculotropic spasmolytic activities of 6 a and 6 b are reported.},
  language  = {de}
}