@article{SchneiderSchauliesHuenigSchimpletal.1986, author = {Schneider-Schaulies, J{\"u}rgen and H{\"u}nig, T. and Schimpl, A. and Wecker, E.}, title = {Kinetics of cellular oncogene expression in mouse lymphocytes ; I. Expression of c-myc and c-ras Ha in T lymphocytes induced by various mitogens}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-54803}, year = {1986}, abstract = {Murine spienie T lymphocytes display maximal cellular myc gene (c-myc) expression already 3 h after concanavalin A timulation and sub equent down-regulation before the onset of DNA syntbesis. Stimulation by leucoagglulinin in the prcsence or absence of interleukin 2 Ieads to only low initiaJ Ievels of c-myc-specific RNA which, however, increase later on. A similar pattero of c-myc expression is shown by the Lyt- 2+ T cell subpopulation stimuiated with eilher concanavalin A or leucoagglutinin in the prescncc of interleukin 2. Although eH]thyn1idine incorporation was identical, the leucoagglutinin-stimulated Lyt-2+ T cells werc void of any demon. trable c-mycspeci. fic RNA at 3 h post-stimulation. Thus, the kinetics of c-myc expression in mause T lymphocytes arenot at all uniform, but depend on the mitogen and the subpopulation. [n contrast, lcvel8 of c-rasH•-spccific R A wcre always low at early times, always increased towards tbe onset ofDNA synthesis and down-regulationwas not observed.}, subject = {Immunologie}, language = {en} } @article{SchneiderSchauliesKnauerHuenigetal.1984, author = {Schneider-Schaulies, J{\"u}rgen and Knauer, R. and H{\"u}nig, T. and Schimpl, A. and Wecker, E.}, title = {Induction of c-onc expression in polyclonally activated mouse lymphocytes}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-54784}, year = {1984}, abstract = {No abstract available}, subject = {Lymphozyt}, language = {en} }