@article{JockelSchneiderHarksHaubitzetal.2014, author = {Jockel-Schneider, Yvonne and Harks, Inga and Haubitz, Imme and Fickl, Stefan and Eigenthaler, Martin and Schlagenhauf, Ulrich and Baulmann, Johannes}, title = {Arterial Stiffness and Pulse Wave Reflection Are Increased in Patients Suffering from Severe Periodontitis}, series = {PLOS ONE}, volume = {9}, journal = {PLOS ONE}, number = {8}, issn = {1932-6203}, doi = {10.1371/journalone.0103449}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-119459}, pages = {e103449}, year = {2014}, abstract = {Aim: This single blind cross-sectional study compared the vascular health of subjects suffering from severe chronic periodontitis, severe aggressive periodontitis and periodontal healthy controls by evaluating pulse wave velocity (PWV), augmentation index (AIx) and pulse pressure amplification (PPA). Material and Methods: In a total of 158 subjects, 92 suffering from severe periodontitis and 66 matched periodontal healthy controls, PWV, AIx, central and peripheral blood pressure were recorded using an oscillometric device (Arteriograph). Results: Subjects suffering from severe chronic or aggressive periodontitis exhibited significantly higher PWV (p = 0.00004), higher AIx (p = 0.0049) and lower PPA (p = 0.028) than matched periodontal healthy controls. Conclusions: The results of this study confirm the association between periodontal inflammation and increased cardiovascular risk shown by impaired vascular health in case of severe periodontitis. As impaired vascular health is a common finding in patients suffering from severe periodontal disease a concomitant routine cardiovascular evaluation may be advised.}, language = {en} } @article{SchlagenhaufJakobEigenthaleretal.2016, author = {Schlagenhauf, Ulrich and Jakob, Lena and Eigenthaler, Martin and Segerer, Sabine and Jockel-Schneider, Yvonne and Rehn, Monika}, title = {Regular consumption of Lactobacillus reuteri-containing lozenges reduces pregnancy gingivitis: an RCT}, series = {Journal of Clinical Periodontology}, volume = {43}, journal = {Journal of Clinical Periodontology}, number = {11}, doi = {10.1111/jcpe.12606}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-186783}, pages = {948-954}, year = {2016}, abstract = {Aim: This randomized controlled trial assessed the impact of Lactobacillus reuteri on pregnancy gingivitis in healthy women. Materials and Methods: Forty-five healthy women (24 test/21 placebo) with pregnancy gingivitis in the third trimester of pregnancy were enrolled. At baseline Gingival Index (GI) and Plaque Index (PlI) were assessed at the Ramfjord teeth and venous blood taken for TNF-alpha analysis. Subsequently participants were randomly provided with lozenges to be consumed 2 9 daily until birth (approx. 7 weeks) containing >= 10(8) CFU L. reuteri ATCC PTA 5289 and >= 10(8) CFU L. reuteri DSM 17938 (test) or being devoid of L. reuteri (placebo). Within 2 days after birth recording of GI, PlI and blood sampling were repeated. Results: At baseline, mean GI and mean PlI did not differ significantly between both groups. In the test group mean TNF-alpha serum level was significantly (p < 0.02) lower than in the placebo group. At reevaluation, mean GI and mean PlI of the test group were both significantly (p < 0.0001) lower than in the placebo group. Mean TNF-alpha serum level did no longer differ significantly between the groups. Conclusions: The consumption of L. reuteri lozenges may be a useful adjunct in the control of pregnancy gingivitis.}, language = {en} } @phdthesis{BuechsenschuetzGoebeler2017, author = {B{\"u}chsensch{\"u}tz-G{\"o}beler, Annekathrin}, title = {Parodontitis und kardiovaskul{\"a}re Erkrankungen - Einfluss der Ver{\"a}nderung des subgingivalen Mikrobioms nach systematischer Parodontaltherapie auf Parameter der arteriellen Gef{\"a}ßsteifigkeit}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-154415}, school = {Universit{\"a}t W{\"u}rzburg}, year = {2017}, abstract = {Es l{\"a}sst sich feststellen, dass in der vorliegenden Untersuchung eine nichtchirurgische systemische Parodontaltherapie mit und ohne adjuvante Antibiose die beobachteten Keimzahlen der parodontitisassoziierten Keime Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis und Tannerella forsythia signifikant reduzieren konnte. Es konnte jedoch kein direkter Zusammenhang zwischen der beobachteten Keimreduktion des subgingivalen Mikrobioms und der Ver{\"a}nderung der erfassten Parameter der arteriellen Gef{\"a}ßsteifigkeit festgestellt werden. Weitere Interventionsstudien mit h{\"o}heren Patientenzahlen und einer hierdurch m{\"o}glichen differenzierteren Subanalyse des Patientenguts bez{\"u}glich Risikofaktoren wie Tabakkonsum, Medikation oder Lebensalter, sowie der Unterscheidung zwischen aggressiver und chronischer Parodontitis sind erforderlich, um die m{\"o}gliche Existenz eines kausalen Zusammenhangs beider Erkrankungen definitiv abkl{\"a}ren zu k{\"o}nnen.}, subject = {Parodontitis}, language = {de} } @phdthesis{Rehder2018, author = {Rehder, Juliane}, title = {Einfluss des t{\"a}glichen Konsums L. reuteri-haltiger Lutschtabletten auf die Mundgesundheit von Besatzungsmitgliedern eines Marineschiffes in See}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-164074}, school = {Universit{\"a}t W{\"u}rzburg}, year = {2018}, abstract = {Die Hemmwirkung des regelm{\"a}ßigen Konsums probiotischer Lactobacillus reuteri-St{\"a}mme auf die Auspr{\"a}gung oraler Entz{\"u}ndungen ist mittlerweile durch eine ganze Reihe klinischer Interventionsstudien gut belegt. Die allgemeinen Lebensumst{\"a}nde der untersuchten Probanden waren dabei jedoch in der Regel wenig standardisiert, so dass eine m{\"o}gliche Beeintr{\"a}chtigung der Validit{\"a}t der Studiendaten durch nicht kontrollierte externe Faktoren wie etwa Lebensstil oder Ern{\"a}hrung bislang nicht ausgeschlossen werden konnte. Daher war es das Ziel dieser prospektiven, randomisierten, doppelt verblindeten und placebokontrollierten Interventionsstudie {\"u}ber einen Beobachtungszeitraum von sechs Wochen die Auswirkungen des t{\"a}glichen Konsums probiotischer, L. reuteri-haltiger Lutschtabletten auf Parameter der oralen Gesundheit von 72 Besatzungsmitgliedern einer Fregatte der Deutschen Marine zu evaluieren, die w{\"a}hrend einer Einsatzvorbereitung in See unter weitgehend vergleichbaren Lebens- und Ern{\"a}hrungsbedingungen ihren Dienst versahen. Zu Studienbeginn, sowie nach zwei und sechs Wochen wurden an den Ramfjordz{\"a}hnen (Z{\"a}hne 16, 21, 24, 36, 41, 44) der Probanden die Anzahl der auf Sondierung blutenden Zahnfleischtaschen (BoP) als prim{\"a}rem Studien-endpunkt erfasst. Dar{\"u}ber hinaus wurden als sekund{\"a}re Endpunkte die Taschensondierungstiefe (PPD), das klinische Attachmentniveau (CAL), der Gingival-Index (GI) und der Plaque Control Record (PCR) aufgezeichnet. Mit Hilfe einer doppelt verblindeten Zuteilungsstrategie wurden die Probanden zuf{\"a}llig der L. reuteri-Gruppe (n=36) oder der Placebogruppe (n=36) zuge-ordnet. Sie erhielten nachfolgend einen f{\"u}r die Studiendauer ausreichenden Vorrat an L. reuteri- oder Placebo-Lutschtabletten mit der Anweisung, diese in den n{\"a}chsten sechs Wochen zweimal t{\"a}glich zu konsumieren. 30 Probanden der L. reuteri-Gruppe sowie 32 Probanden der Placebogruppe beendeten die Studie mit vollst{\"a}ndig erfassten Datens{\"a}tzen. Ihre Analyse enth{\"u}llte f{\"u}r die L. reuteri-Gruppe einen signifikanten (p<0,001) R{\"u}ckgang der beobachteten BoP-Mittelwerte von initial 41\% (±22 SD) aller erfassten Messstellen auf 10 \% (±13 SD) nach sechs Wochen. In der Placebogruppe hingegen kam es w{\"a}hrend des Beobachtungszeitraums zu einer signifikanten (p=0.05) Zunahme der BoP-Mittelwerte gegen{\"u}ber der Ausgangssituation von initial 37 \% (±20 SD) auf 43 \% (±17 SD) am Studienende. Auch bez{\"u}glich aller sekund{\"a}ren Endpunkte (PPD, CAL, GI, PCR) konnte in der L. reuteri-Gruppe eine signifikante Verbesserung der oralen Gesundheit zwischen Studienbeginn und Studienende beobachtet werden, w{\"a}hrend sich wiederum in der Placebo-Gruppe im Beobachtungszeitraum eine statistisch verifizierbare Verschlech¬terung aller erfassten sekund{\"a}ren Endpunkte ergab. Die Ergebnisse dieser unter weitgehend kontrollierten Lebens- und Ern{\"a}hrungsbedingungen durchgef{\"u}hrten Untersuchung belegen, dass der regelm{\"a}ßigem Konsum probiotischer, L. reuteri-haltiger Lutschtabletten unter den Einsatzbedingungen in See nicht nur eine in der Placebogruppe beobachtete Verschlechterung der oralen Gesundheit verhinderte, sondern diese vielmehr im Vergleich zum Ausgangsbefund signifikant verbesserte. Der adjunktive Konsum L. reuteri-haltiger Lutschtabletten k{\"o}nnte daher eine kosteng{\"u}nstige und einfach zu implementierende Maßnahme darstellen, um einer unter milit{\"a}rischen Einsatzbedingungen h{\"a}ufiger zu beobachtenden Verschlechterung der oralen Gesundheit wirksam vorzubeugen.}, subject = {Probiotikum}, language = {de} } @phdthesis{Rothermel2018, author = {Rothermel, Michael}, title = {Die Freilegung von Implantaten mittels eines apikal repositionierten Verschiebelappens zur Gewinnung von keratinisierter Gingiva}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-151933}, school = {Universit{\"a}t W{\"u}rzburg}, year = {2018}, abstract = {EINLEITUNG: Der apikal repositionierte Verschiebelappen (ARF) ist eine chirurgische Technik zur Augmentation der periimplant{\"a}ren keratinisierten Gingiva (KG). Ziel der Studie war die Quantifizierung des Gewinnes an KG sowie die Abh{\"a}ngigkeit des Behandlungsergebnisses von verschiedenen patientenbezogenen Faktoren. MATERIAL UND METHODEN: Die Studienpopulation bestand aus 13 Patienten mit insgesamt 31 Implantaten, bei allen wurde eine Augmentation der KG mittels des ARFs durchgef{\"u}hrt. Es wurden vier verschiedene Messungen der Breite der KG durchgef{\"u}hrt: pr{\"a}operativ, postoperativ, zum Zeitpunkt der endg{\"u}ltigen prothetischen Versorgung und die durch die orale Inzision mobilisierte Breite der KG. Neben den absoluten Werten wurde die Abh{\"a}ngigkeit des Ergebnisses von verschiedenen patientenbezogenen Faktoren (Alter, Geschlecht, Einheildauer; Position des Implantates) ausgewertet. ERGEBNISSE: Die Breite der KG postoperativ (+3,94 mm, p < 0,0001) und zum Zeitpunkt der prothetischen Restauration (+3,55 mm, p < 0,0001) haben sich signifikant im Vergleich zu den Werten pr{\"a}operativ erh{\"o}ht. In der Einheilungsphase kam es zu einer signifikanten Schrumpfung der KG (-0,39 mm, p < 0,0421). Beim Vergleich der verschiedenen Gruppen konnten keine statistisch signifikanten Zusammenh{\"a}nge festgestellt werden. ZUSAMMENFASSUNG: Der apikal repositionierte Verschiebelappen ist eine zuverl{\"a}ssige Methode zur Augmentation der KG.}, subject = {keratinisierte Gingiva}, language = {de} } @phdthesis{Richter2019, author = {Richter, Timo}, title = {Parodontale Parameter in Abh{\"a}ngigkeit vom gingivalen Biotyp - eine klinische Studie}, doi = {10.25972/OPUS-18494}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-184944}, school = {Universit{\"a}t W{\"u}rzburg}, year = {2019}, abstract = {Die Einsch{\"a}tzung des gingivalen Biotypes stellt f{\"u}r den praktizierenden Zahnarzt ein wichtiges Hilfsmittel zur Auswahl der Therapie pathogener Befunde und zur Prognose des Therapieerfolges dar. Ziel der vorliegenden Arbeit war es daher zu untersuchen, ob die Bestimmung des gingivalen Biotypes {\"u}ber die Transluzens einer Parodontalsonde durch die bukkale Gingiva, als eine einfach durchzuf{\"u}hrende klinische Untersuchung, von der tats{\"a}chlichen Dicke des Weichgewebes abh{\"a}ngt. Dar{\"u}ber hinaus wurde er{\"o}rtert, ob verschiedene parodontale Parameter eher mit einem dicken oder einem d{\"u}nnen gingivalem Biotyp vergesellschaftet sind. Zuletzt wurden die Studienteilnehmer auf eine bestehende Relation zwischen dem Biotyp des Zahnfleisches und der Form der Frontzahnkronen des Oberkiefers hin untersucht. Zu diesem Zweck wurden an 36 Probanden der gingivale Biotyp {\"u}ber die Transluzens einer Parodontalsonde durch die bukkale marginale Gingiva bestimmt. Anschließend wurde die tats{\"a}chliche Dicke der Gingiva auf H{\"o}he des gingivalen Sulkus mit einer individualisierten Messlehre ermittelt. Des weiteren wurden gingivale Parameter (Taschentiefe, Breite der keratinisierten Mukosa, Papillenh{\"o}he) erhoben, sowie die Form der Zahnkronen der Schneidez{\"a}hne im Oberkiefer anhand von Gipsmodellen bestimmt. Die erhobenen Messwerte wurden anschließend auf Unterschiede zwischen den beiden Gruppen untersucht. Um eine Abh{\"a}ngigkeit von der tats{\"a}chlich gemessenen Gewebedicke zu er{\"o}rtern, wurden zwei Extremgruppen aus den Probanden mit den jeweils sechs h{\"o}chsten, beziehungsweise niedrigsten Messwerten gebildet. Die statistische Auswertung stellt die Transluzens einer Parodontalsonde durch die bukkale marginale Gingiva als verl{\"a}ssliches Mittel zur Einsch{\"a}tzung des gingivalen Biotyps heraus, wobei anzumerken ist, dass die Sichtbarkeit der Sonde durch die Gingiva nicht ausschließlich von der Gewebedicke beeinflusst wird. Dar{\"u}ber hinaus konnte eine gr{\"o}ßere Kronenl{\"a}nge und, {\"a}quivalent dazu, eine h{\"o}here mesiale Papille f{\"u}r den dicken gingivalen Biotyp dargestellt werden. Bei dem Vergleich der Extremgruppen konnte ausserdem eine signifikant h{\"o}here Taschensondierungstiefe und eine breitere befestigte Gingiva f{\"u}r die Gruppe mit einem sehr dicken Gewebe aufgezeigt werden.}, subject = {Biotype}, language = {de} } @phdthesis{Conrath2020, author = {Conrath, Moritz Valentin}, title = {Verbund zwischen Reparatur- und F{\"u}llungskomposit nach unterschiedlichen Konditionierungsmaßnahmen (in vitro)}, doi = {10.25972/OPUS-20838}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-208386}, school = {Universit{\"a}t W{\"u}rzburg}, year = {2020}, abstract = {In-vitro Untersuchung der Verbundfestigkeit von Kompositreparaturen runder Pr{\"u}fk{\"o}rper im Zugversuch. Filtek Surpreme und Tetric EvoCeram wurden gestrahlt und/oder mit 37\% Orthophosphors{\"a}ure ge{\"a}tzt und mit Scotchbond Universal oder Optibond FL gebonded. Strahlverfahren erh{\"o}hten die Verbundfestigkeit, die zus{\"a}tzliche {\"A}tzung von abgestrahlten Oberfl{\"a}chen beeinflusste die Verbundfestigkeit nicht.}, subject = {Komposit}, language = {de} } @article{DannewitzSommererStoelzeletal.2020, author = {Dannewitz, Bettina and Sommerer, Claudia and St{\"o}lzel, Peggy and Baid-Agrawal, Seema and Nadal, Jennifer and B{\"a}rthlein, Barbara and Wanner, Christoph and Eckardt, Kai-Uwe and Zeier, Martin and Schlagenhauf, Ulrich and Krane, Vera and Jockel-Schneider, Yvonne}, title = {Status of periodontal health in German patients suffering from chronic kidney disease—Data from the GCKD study}, series = {Journal of Clinical Periodontology}, volume = {47}, journal = {Journal of Clinical Periodontology}, number = {1}, doi = {10.1111/jcpe.13208}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-217821}, pages = {19 -- 29}, year = {2020}, abstract = {Aim To assess the prevalence and severity of periodontitis in patients with moderate chronic kidney disease (CKD) and comparing the results with the self-reported periodontitis awareness of the study subjects. Material and methods The periodontal status of 270 patients with moderate CKD randomly selected from a cohort of 5,217 subjects participating in the prospective observational German Chronic Kidney Disease (GCKD) project was analysed by recording bleeding on probing (BOP), probing pocket depth (PPD) and clinical attachment level (CAL). Furthermore, the awareness of the study subjects of their periodontal conditions was evaluated by a self-reported questionnaire. Results 24.4\% of the CKD study patients showed no or only mild signs of periodontal disease, 47.6\% displayed moderate and 27\% severe periodontitis. Questionnaire data revealed that 62.3\% of the study subjects with severe periodontitis were not aware of the presence of the disease, 44.4\% denied having received any systematic periodontal therapy so far, although 50\% of them indicated to visit their dentist regularly for professional tooth cleanings. Conclusion While the clinical study data confirm an increased prevalence of periodontitis in CKD patients, their self-reported awareness of periodontitis was low.}, language = {en} } @article{SchlagenhaufRehderGelbrichetal.2020, author = {Schlagenhauf, Ulrich and Rehder, Juliane and Gelbrich, G{\"o}tz and Jockel-Schneider, Yvonne}, title = {Consumption of Lactobacillus reuteri-containing lozenges improves periodontal health in navy sailors at sea: A randomized controlled trial}, series = {Journal of Periodontology}, volume = {91}, journal = {Journal of Periodontology}, number = {10}, doi = {10.1002/JPER.19-0393}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-215577}, pages = {1328 -- 1338}, year = {2020}, abstract = {Background The objective of this trial was to evaluate whether the regular consumption of probiotics may improve the known deterioration of periodontal health in navy sailors during deployments at sea. Methods 72 healthy sailors of a naval ship on a practicing mission at sea were recruited and randomly provided with a blinded supply of lozenges to be consumed twice daily for the following 42 days containing either the probiotic strains Lactobacillus reuteri (DSM 17938 and L. reuteri (ATTC PTA 5289) (test n = 36) or no probiotics (placebo n = 36). At baseline, at day 14 and day 42 bleeding on probing (primary outcome), gingival index, plaque control record, probing attachment level, and probing pocket depth were assessed at the Ramfjord teeth. Results At baseline there were no significant differences between the groups. At day 14 and day 42 test group scores of all assessed parameters were significantly improved (P < 0.001) compared to baseline and to the placebo group which by contrast showed a significant (P < 0.001) deterioration of all parameters at the end of the study. Conclusions The consumption of probiotic L. reuteri-lozenges is an efficacious measure to improve and maintain periodontal health in situations with waning efficacy of personal oral hygiene.}, language = {en} } @article{MaternKochPetersmannetal.2020, author = {Matern, Johannes and Koch, Raphael and Petersmann, Astrid and Kocher, Thomas and Eickholz, Peter and Lorenz, Katrin and Kim, Ti-Sun and Meyle, J{\"o}rg and Kaner, Doğan and Schlagenhauf, Ulrich and Gravemeier, Martina and Harks, Inga and Ehmke, Benjamin}, title = {Effect of periodontal therapy on adipokine biomarkers in overweight}, series = {Journal of Clinical Periodontology}, volume = {47}, journal = {Journal of Clinical Periodontology}, number = {7}, doi = {10.1111/jcpe.13288}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-215546}, pages = {842 -- 850}, year = {2020}, abstract = {Aim The aim of this study was to evaluate the effect of non-surgical periodontal therapy on circulating levels of the systemic inflammation-associated biomarkers orosomucoid (ORM), high-sensitivity C-reactive protein (hsCRP), chemerin, and retinol-binding protein 4 (RBP4) in overweight or normal-weight patients with periodontitis at 27.5 months after therapy. Materials and methods This exploratory subanalysis includes patients from the ABPARO-trial (ClinicalTrials.gov NCT00707369). The per-protocol collective provided untreated periodontitis patients with high (≥28 kg/m\(^{2}\)) or moderate (21-24 kg/m\(^{2}\)) BMI. Out of the per-protocol collective, 80 patients were randomly selected and stratified for BMI group, sex, and treatment group (antibiotics/placebo), resulting in 40 overweight and normal-weight patients. Patients received non-surgical periodontal therapy and maintenance at 3-month intervals. Plasma samples from baseline and 27.5 months following initial treatment were used to measure the concentrations of ORM, hsCRP, chemerin, and RBP4. Results At the 27.5-month examination, ORM and hsCRP decreased noticeably in the overweight group (ORM: p = .001, hsCRP: p = .004) and normal-weight patients (ORM: p = .007, hsCRP: p < .001). Chemerin decreased in the overweight group (p = .048), and RBP4 concentrations remained stable. Conclusion Non-surgical periodontal therapy reduced systemically elevated inflammation-associated biomarkers in periodontitis patients. These improvements were more pronounced in overweight patients than in normal-weight patients.}, language = {en} } @phdthesis{Herter2021, author = {Herter, Daniel}, title = {Transmissionsgrad Lithium-Disilikat-verst{\"a}rkter Keramik f{\"u}r sichtbares blaues Licht in Abh{\"a}ngigkeit von Schichtst{\"a}rke und Farbe}, doi = {10.25972/OPUS-24897}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-248977}, school = {Universit{\"a}t W{\"u}rzburg}, year = {2021}, abstract = {Diese Studie untersucht den Transmissionsgrad von sichtbarem blauem Licht durch Lithium-Disilikat-verst{\"a}rkte Keramik in Abh{\"a}ngigkeit von der Schichtst{\"a}rke, Farbe und Transluzenz. Weiterhin wurde der Einfluss der Oberfl{\"a}chenbehandlung sowie des Zwischenmediums zwischen Lichtleiter und Keramikoberfl{\"a}che untersucht. Dazu wurden plane Proben mit einer Schichtst{\"a}rke von 1,25 mm, 2,5 mm, 5 mm, 7,5 mm der Keramik IPS e.max CAD und mit einem S{\"a}gemikrotom ges{\"a}gt und anschließend kristallisiert. Die Messung des Transmissionsgrades des Lichtes eines LED-Lichtger{\"a}tes erfolgte mit einem faseroptischen Spektralfotometer. Je dicker, opaker und dunkler eine Keramikprobe ist, desto geringer ist ihr Transmissionsgrad. Die Abnahme des Transmissionsgrades konnte durch das Lambert-Beer'sche-Gesetz beschrieben werden. Der Einfluss der Reflexion und / oder Streuung an der Oberfl{\"a}che muss als Absorptionsgrad α miteinbezogen werden. Der Absorptionsgrad α ist von der Oberfl{\"a}chenbehandlung und dem Medium zwischen Lichtleiter und Keramikoberfl{\"a}che abh{\"a}ngig. Die Durchf{\"u}hrung einer multiplen linearen Regressionsanalyse zeigt, dass die Schichtst{\"a}rke, Transluzenz, Helligkeitsstufen und die Farben einen signifikanten Einfluss auf den Transmissionsgrad haben. Den st{\"a}rksten Einfluss hat die Keramikschichtst{\"a}rke. Der Transmissionsgrad der Farben B und D unterscheidet sich nicht signifikant vom Transmissionsgrad der Farbe A. Dagegen weist die Keramik der Farbe Bleach einen signifikant h{\"o}heren und die Keramik der Farbe C einen signifikant niedrigeren Transmissionsgrad auf. Der Absorptionsgrad der glasierten Oberfl{\"a}che und der Absorptionsgrad bei Belichtung durch die Zwischenmedien ist im Vergleich zum Absorptionsgrad einer ges{\"a}gten Oberfl{\"a}che, bzw. bei Belichtung ohne Zwischenmedium signifikant niedriger. Dagegen ist der Unterschied des Absorptionsgrades der polierten Oberfl{\"a}che zum Absorptionsgrad der ges{\"a}gten Oberfl{\"a}che bei Mittelung der Versuche ohne bzw. mit Zwischenmedien knapp nicht signifikant.}, subject = {Transmissionsgrad}, language = {de} } @article{FicklThereseKroegerDietrichetal.2021, author = {Fickl, Stefan and Therese Kr{\"o}ger, Annika and Dietrich, Thomas and Kebschull, Moritz}, title = {Influence of soft tissue augmentation procedures around dental implants on marginal bone level changes-A systematic review}, series = {Clinical Oral Implants Research}, volume = {32}, journal = {Clinical Oral Implants Research}, number = {S21}, doi = {10.1111/clr.13829}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-258394}, pages = {108-137}, year = {2021}, abstract = {Objectives This systematic review assessed the influence of soft tissue augmentation procedures on marginal bone level changes in partial or fully edentulous patients. Material and Methods We identified three relevant PICO questions related to soft tissue augmentation procedures and conducted a systematic search of four major electronic databases for clinical studies in systemically healthy patients receiving at least one dental implant and a minimum follow-up of one year after implant placement. The primary outcome was mean difference in marginal bone levels, and secondary outcomes were clinical and patient-related outcomes such as thickness of peri-implant mucosa, bleeding indices, and Pink Esthetic Score. Results We identified 20 publications reporting on 16 relevant comparisons. Studies varied considerably and thus only two meta-analyses could be performed. This systematic review showed that: Soft tissue augmentation either for augmentation of keratinized mucosa or soft tissue volume inconsistently had an effect on marginal bone level changes when compared to no soft tissue augmentation, but consistently improved secondary outcomes. The combination soft and hard tissue augmentation showed no statistically significant difference in terms of marginal bone level changes when compared to hard tissue augmentation alone, but resulted in less marginal soft tissue recession as shown by a meta-analysis. Soft or hard tissue augmentation performed as contour augmentations resulted in comparable marginal bone level changes. Conclusions Peri-implant soft and hard tissues seem to have a bidirectional relationship: "Bone stands hard, but soft tissue is the guard".}, language = {en} } @article{FriedmannFicklFischeretal.2021, author = {Friedmann, Anton and Fickl, Stefan and Fischer, Kai R. and Dalloul, Milad and Goetz, Werner and Kauffmann, Frederic}, title = {Horizontal augmentation of chronic mandibular defects by the Guided Bone Regeneration approach: a randomized study in dogs}, series = {Materials}, volume = {15}, journal = {Materials}, number = {1}, issn = {1996-1944}, doi = {10.3390/ma15010238}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-252351}, year = {2021}, abstract = {Various biomaterial combinations have been studied focusing on their ability to stabilize blood clots and maintain space under soft tissue to support new bone formation. A popular combination is Deproteinized Bovine Bone Mineral (DBBM) placed with a native collagen membrane (NCM) tacked to native bone. In this study, we compared the outcome of this treatment option to those achieved with three different graft/membrane combinations with respect to total newly occupied area and the mineralized compound inside. After bi-lateral extraction of two mandibular premolars in five adult beagles L-shaped alveolar defects were created. A total of 20 defects healed for 6 weeks resulting in chronic type bone defects. At baseline, four options were randomly allocated to five defects each: a. DBBM + NCM with a four-pin fixation across the ridge; b. DBBM + RCLC (ribose cross-linked collagen membrane); c. DBBM + NPPM (native porcine pericardium membrane); and d. Ca-sulfate (CS) + RCLC membrane. Membranes in b/c/d were not fixed; complete tensionless wound closure was achieved by CAF. Termination after 3 months and sampling followed, and non-decalcified processing and toluidine blue staining were applied. Microscopic images obtained at standardized magnification were histomorphometrically assessed by ImageJ software (NIH). An ANOVA post hoc test was applied; histomorphometric data are presented in this paper as medians and interquartile ranges (IRs). All sites healed uneventfully, all sites were sampled and block separation followed before Technovit embedding. Two central sections per block for each group were included. Two of five specimen were lost due to processing error and were excluded from group b. New bone area was significantly greater for option b. compared to a. (p = 0.001), c. (p = 0.002), and d. (p = 0.046). Residual non-bone graft area was significantly less for option d. compared to a. (p = 0.026) or c. (p = 0.021). We conclude that collagen membranes with a prolonged resorption/barrier profile combined with bone substitutes featuring different degradation profiles sufficiently support new bone formation. Tacking strategy/membrane fixation appears redundant when using these biomaterials.}, language = {en} } @article{JockelSchneiderSchlagenhaufPetsosetal.2021, author = {Jockel-Schneider, Yvonne and Schlagenhauf, Ulrich and Petsos, Hari and R{\"u}ttermann, Stefan and Schmidt, Jana and Ziebolz, Dirk and Wehner, Christian and Laky, Markus and Rott, Thea and Noack, Michael and Noack, Barbara and Lorenz, Katrin}, title = {Impact of 0.1\% octenidine mouthwash on plaque re-growth in healthy adults: a multi-center phase 3 randomized clinical trial}, series = {Clinical Oral Investigations}, volume = {25}, journal = {Clinical Oral Investigations}, number = {7}, issn = {1432-6981}, doi = {10.1007/s00784-021-03781-3}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-307629}, pages = {4681-4689}, year = {2021}, abstract = {Objectives To investigate plaque inhibition of 0.1\% octenidine mouthwash (OCT) vs. placebo over 5 days in the absence of mechanical plaque control. Materials and methods For this randomized, placebo-controlled, double-blind, parallel group, multi-center phase 3 study, 201 healthy adults were recruited. After baseline recording of plaque index (PI) and gingival index (GI), collection of salivary samples, and dental prophylaxis, subjects were randomly assigned to OCT or placebo mouthwash in a 3:1 ratio. Rinsing was performed twice daily for 30 s. Colony forming units in saliva were determined before and after the first rinse. At day 5, PI, GI, and tooth discoloration index (DI) were assessed. Non-parametric van Elteren tests were applied with a significance level of p < 0.05. Results Treatment with OCT inhibited plaque formation more than treatment with placebo (PI: 0.36 vs. 1.29; p < 0.0001). OCT reduced GI (0.04 vs. placebo 0.00; p = 0.003) and salivary bacterial counts (2.73 vs. placebo 0.24 lgCFU/ml; p < 0.0001). Tooth discoloration was slightly higher under OCT (DI: 0.25 vs. placebo 0.00; p = 0.0011). Mild tongue staining and dysgeusia occurred. Conclusions OCT 0.1\% mouthwash inhibits plaque formation over 5 days. It therefore can be recommended when regular oral hygiene is temporarily compromised. Clinical relevance When individual plaque control is compromised, rinsing with octenidine mouthwash is recommended to maintain healthy oral conditions while side effects are limited.}, language = {en} } @article{WeiderSchlagenhaufSeefried2022, author = {Weider, Margareta and Schlagenhauf, Ulrich and Seefried, Lothar}, title = {Oral health status of adult hypophosphatasia patients: A cross-sectional study}, series = {Journal of Clinical Periodontology}, volume = {49}, journal = {Journal of Clinical Periodontology}, number = {12}, doi = {10.1111/jcpe.13718}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-293777}, pages = {1253 -- 1261}, year = {2022}, abstract = {Aim This study evaluated the oral health status of adult patients with hypophosphatasia (HPP). Materials and Methods Parameters of oral health assessment comprised decayed/missing/filled teeth (DMFT) index, probing pocket depth and clinical attachment level (CAL) as well as documentation of tooth loss and periodontal health status according to CCD/AAP criteria. Findings were compared with national reference data (DMS V survey) reporting oral health status in age-related controls. Within-group comparisons were made between the HPP patients harbouring one versus two alkaline phosphatase liver/bone/kidney type (ALPL) gene variants. Results Of 80 HPP patients (64 female) with a mean age of 46.4 years (range 24-78) and one (n = 55) or two (n = 18) variants (n = 7 lacking testing) within the ALPL gene, those with two variants displayed substantially higher tooth loss rate (14.0 ± 9.3) than those affected by only one ALPL variant (4.1 ± 5.4), who did not differ substantially from healthy DMS V controls. While DMFT score and severe periodontal diseases (PDs) of HPP patients with one variant only increased with progressing age, the two-variant sub-cohort age independently exhibited increased DMFT scores and a higher rate of severe PDs. Conclusions HPP patients affected by two variants of the ALPL gene exhibited a higher risk of periodontitis and tooth loss than the general population, while patients with one variant developed clinically relevant oral disease symptoms with progressing ageing.}, language = {en} } @article{KrugOrtmannReichetal.2022, author = {Krug, Ralf and Ortmann, C. and Reich, S. and Hahn, B. and Krastl, G. and Soliman, S.}, title = {Tooth discoloration induced by apical plugs with hydraulic calcium silicate-based cements in teeth with open apices-a 2-year in vitro study}, series = {Clinical Oral Investigations}, volume = {26}, journal = {Clinical Oral Investigations}, number = {1}, issn = {1436-3771}, doi = {10.1007/s00784-021-04009-0}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-268856}, pages = {375-383}, year = {2022}, abstract = {Objectives To assess tooth discoloration induced by different hydraulic calcium silicate-based cements (HCSCs), including effects of blood and placement method. Materials and methods Eighty bovine teeth cut to a length of 18 mm (crown 8 mm, root 10 mm) were randomly assigned to 10 groups (n = 8), receiving orthograde apical plug treatment (APT). Apical plugs were 4 mm in length and made of ProRoot MTA (Dentsply), Medcem MTA (Medcem), TotalFill BC RRM Fast Set Putty (Brasseler), or Medcem Medical Portland Cement (Medcem) plus bismuth oxide (Bi2O3) with and without bovine blood. Further, orthograde (with or without preoperative adhesive coronal dentin sealing) and retrograde APT were compared. Teeth were obturated with gutta-percha and sealer, sealed with composite and stored in distilled water. Tooth color was measured on apical plug, gutta-percha/sealer, and crown surface before treatment versus 24 h, 1, 3, 6, 12, and 24 months after treatment by spectrophotometry. Color difference (ΔE) values were calculated and analyzed by Shapiro-Wilk test, ANOVA with post hoc tests, Friedman test, t test, and post hoc tests with Bonferroni correction (α = .05). Results Tooth discoloration occurred in all groups with no significant differences between HCSCs (p > .05). After 24 months, color changes were prominent on roots but insignificant on crowns. Blood contamination induced a significantly decreased luminescence (p < .05). Blood had a stronger impact on tooth color than Bi2O3. No relevant effects of retrograde placement (p > .05) or preoperative dentin sealing (p > .05) were detected. Conclusions Apical plugs of the tested HCSCs cause discoloration of bovine roots, but not discoloration of bovine tooth crowns within a 24-month period. Clinical relevance APT should be performed carefully while avoiding direct contact with the coronal dentin, and in that case no aesthetic impairments occur.}, language = {en} } @article{WaltherGonzalesGroegeretal.2022, author = {Walther, Kay-Arne and Gonzales, Jos{\´e} Roberto and Gr{\"o}ger, Sabine and Ehmke, Benjamin and Kaner, Dogan and Lorenz, Katrin and Eickholz, Peter and Kocher, Thomas and Kim, Ti-Sun and Schlagenhauf, Ulrich and Koch, Raphael and Meyle, J{\"o}rg}, title = {The role of polymorphisms at the Interleukin-1, Interleukin-4, GATA-3 and Cyclooxygenase-2 genes in non-surgical periodontal therapy}, series = {International Journal of Molecular Sciences}, volume = {23}, journal = {International Journal of Molecular Sciences}, number = {13}, issn = {1422-0067}, doi = {10.3390/ijms23137266}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-284386}, year = {2022}, abstract = {Periodontitis is a multifactorial disease. The aim of this explorative study was to investigate the role of Interleukin-(IL)-1, IL-4, GATA-3 and Cyclooxygenase-(COX)-2 polymorphisms after non-surgical periodontal therapy with adjunctive systemic antibiotics (amoxicillin/metronidazole) and subsequent maintenance in a Caucasian population. Analyses were performed using blood samples from periodontitis patients of a multi-center trial (ClinicalTrials.gov NCT00707369=ABPARO-study). Polymorphisms were analyzed using quantitative real-time PCR. Clinical attachment levels (CAL), percentage of sites showing further attachment loss (PSAL) ≥1.3 mm, bleeding on probing (BOP) and plaque score were assessed. Exploratory statistical analysis was performed. A total of 209 samples were genotyped. Patients carrying heterozygous genotypes and single-nucleotide-polymorphisms (SNP) on the GATA-3-IVS4 +1468 gene locus showed less CAL loss than patients carrying wild type. Heterozygous genotypes and SNPs on the IL-1A-889, IL-1B +3954, IL-4-34, IL-4-590, GATA-3-IVS4 +1468 and COX-2-1195 gene loci did not influence CAL. In multivariate analysis, CAL was lower in patients carrying GATA-3 heterozygous genotypes and SNPs than those carrying wild-types. For the first time, effects of different genotypes were analyzed in periodontitis progression after periodontal therapy and during supportive treatment using systemic antibiotics demonstrating a slight association of GATA-3 gene locus with CAL. This result suggests that GATA-3 genotypes are a contributory but non-essential risk factor for periodontal disease progression.}, language = {en} } @article{Schlagenhauf2022, author = {Schlagenhauf, Ulrich}, title = {On the role of dietary nitrate in the maintenance of systemic and oral health}, series = {Dentistry Journal}, volume = {10}, journal = {Dentistry Journal}, number = {5}, issn = {2304-6767}, doi = {10.3390/dj10050084}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-275168}, year = {2022}, abstract = {The assessment of the significance of nitrates ingested with food has undergone a fundamental change in recent years after many controversial discussions. While for a long time, a diet as low in nitrates as possible was advocated on the basis of epidemiological data suggesting a cancer-promoting effect of nitrate-rich diets, more recent findings show that dietary nitrate, after its conversion to nitrite by nitrate-reducing bacteria of the oral microbiota, is an indispensable alternative source for the formation of nitric oxide (NO), which comprises a key element in the physiology of a variety of central body functions such as blood pressure control, defense against invading bacteria and maintenance of a eubiotic microbiota in the gut and oral cavity. This compact narrative review aims to present the evidence supported by clinical and in vitro studies on the ambivalent nature of dietary nitrates for general and oral health and to explain how the targeted adjuvant use of nitrate-rich diets could open new opportunities for a more cause-related control of caries and periodontal disease.}, language = {en} } @article{JockelSchneiderStoelzelHessetal.2022, author = {Jockel-Schneider, Yvonne and Stoelzel, Peggy and Hess, Jeanine and Haubitz, Imme and Fickl, Stefan and Schlagenhauf, Ulrich}, title = {Impact of a specific collagen peptide food supplement on periodontal inflammation in aftercare patients — a randomised controlled trial}, series = {Nutrients}, volume = {14}, journal = {Nutrients}, number = {21}, issn = {2072-6643}, doi = {10.3390/nu14214473}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-290471}, year = {2022}, abstract = {Background: This controlled clinical trial evaluated the impact of a specific collagen peptide food supplement on parameters of periodontal inflammation in aftercare patients. Methods: A total of 39 study patients were enrolled. At baseline, bleeding on probing (BoP; primary outcome), gingival index (GI), plaque control record (PCR), recession (REC) and probing pocket depth (PPD) for the calculation of the periodontal inflamed surface area (PISA) were documented. After subsequent professional mechanical plaque removal (PMPR), participants were randomly provided with a supply of sachets containing either a specific collagen peptide preparation (test group; n = 20) or a placebo (placebo group; n = 19) to be consumed dissolved in liquid once daily until reevaluation at day 90. Results: PMPR supplemented with the consumption of the specific collagen peptides resulted in a significantly lower mean percentage of persisting BoP-positive sites than PMPR plus placebo (test: 10.4\% baseline vs. 3.0\% reevaluation; placebo: 14.2\% baseline vs. 9.4\% reevaluation; effect size: 0.86). Mean PISA and GI values were also reduced compared to baseline, with a significant difference in favor of the test group (PISA test: 170.6 mm\(^2\) baseline vs. 53.7 mm\(^2\) reevaluation; PISA placebo: 229.4 mm\(^2\) baseline vs. 184.3 mm\(^2\) reevaluation; GI test: 0.5 baseline vs. 0.1 reevaluation; GI placebo: 0.4 baseline vs. 0.3 reevaluation). PCR was also significantly decreased in both experimental groups at revaluation, but the difference between the groups did not reach the level of significance. Conclusions: The supplementary intake of specific collagen peptides may further enhance the anti-inflammatory effect of PMPR in periodontal recall patients.}, language = {en} } @phdthesis{WeidergebOswald2023, author = {Weider [geb. Oswald], Margareta}, title = {Mundgesundheit von Hypophosphatasie-Patienten und Gendefekttr{\"a}gern - eine patientenorientierte Querschnittsstudie}, doi = {10.25972/OPUS-30278}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-302781}, school = {Universit{\"a}t W{\"u}rzburg}, year = {2023}, abstract = {Diese Studie evaluiert die Mundgesundheit von Hypophosphatasie (HPP)-Patienten und beinhaltet die Untersuchungen folgender Kenngr{\"o}ßen: erster Milchzahnverlust, Anzahl fehlender Z{\"a}hne, DMF/T-Index (Kari{\"o}s/Fehlend/Gef{\"u}llt), Blutung auf Sondierung (BOP), Sondierungstiefen (PPD), klinisches Attachmentniveau (CAL), Zahnlockerungen und kombinierter CDC/AAP Parodontal-Index. Die Daten wurden zwischen HHP-Patienten mit einer und zwei Mutationen auf dem f{\"u}r die alkalische Phosphatase kodierenden Genabschnitt (ALPL-Gen), sowie mit den Ergebnissen der DMS V verglichen, welche die Mundgesundheit der deutschen Allgemeinbev{\"o}lkerung repr{\"a}sentiert. 80 Patienten wurden untersucht; 64 von ihnen waren weiblich, 18 m{\"a}nnlich. Das Mittlere Alter lag bei 46,4 Jahren. 55 Studienteilnehmer wiesen eine Mutation und 18 zwei Mutationen des ALPL-Gens auf (n=7 keine Testung). Patienten, die von zwei Mutationen des f{\"u}r die alkalische Phosphatase kodierenden Genabschnitts betroffen waren, zeigten ein h{\"o}heres Risiko f{\"u}r Parodontitis und Zahnverlust als HPP-Patienten mit nur einer Mutation, sowie im Vergleich mit der deutschen Allgemeinbev{\"o}lkerung. Allerdings stiegen auch bei Patienten mit nur einer Mutation mit zunehmendem Lebensalter die Auspr{\"a}gungen parodontaler Erkrankungen, sowie die Zahnverlustrate im Vergleich zur Durchschnittsbev{\"o}lkerung in Deutschland.}, subject = {Hypophosphatasie}, language = {de} }