@article{WinterKampfHelluyetal.2013,
  author    = {Winter, Patrick and Kampf, Thomas and Helluy, Xavier and Gutjahr, Fabian T. and Meyer, Cord B. and Rommel, Eberhard and Bauer, Wolfgang R. and Jakob, Peter M. and Herold, Volker},
  title     = {Fast retrospectively triggered local pulse-wave velocity measurements in mice with CMR-microscopy using a radial trajectory},
  series = {Journal of Cardiovascular Magnetic Resonance},
  journal   = {Journal of Cardiovascular Magnetic Resonance},
  doi       = {10.1186/1532-429X-15-88},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-96602},
  year      = {2013},
  abstract  = {Background The aortic pulse-wave velocity (PWV) is an important indicator of cardiovascular risk. In recent studies MRI methods have been developed to measure this parameter noninvasively in mice. Present techniques require additional hardware for cardiac and respiratory gating. In this work a robust self-gated measurement of the local PWV in mice without the need of triggering probes is proposed. Methods The local PWV of 6-months-old wild-type C57BL/6J mice (n=6) was measured in the abdominal aorta with a retrospectively triggered radial Phase Contrast (PC) MR sequence using the flow-area (QA) method. A navigator signal was extracted from the CMR data of highly asymmetric radial projections with short repetition time (TR=3 ms) and post-processed with high-pass and low-pass filters for retrospective cardiac and respiratory gating. The self-gating signal was used for a reconstruction of high-resolution Cine frames of the aortic motion. To assess the local PWV the volume flow Q and the cross-sectional area A of the aorta were determined. The results were compared with the values measured with a triggered Cartesian and an undersampled triggered radial PC-Cine sequence. Results In all examined animals a self-gating signal could be extracted and used for retrospective breath-gating and PC-Cine reconstruction. With the non-triggered measurement PWV values of 2.3±0.2 m/s were determined. These values are in agreement with those measured with the triggered Cartesian (2.4±0.2 m/s) and the triggered radial (2.3±0.2 m/s) measurement. Due to the strong robustness of the radial trajectory against undersampling an acceleration of more than two relative to the prospectively triggered Cartesian sampling could be achieved with the retrospective method. Conclusion With the radial flow-encoding sequence the extraction of a self-gating signal is feasible. The retrospective method enables a robust and fast measurement of the local PWV without the need of additional trigger hardware.},
  language  = {en}
}
@article{GehrkeScherzadHagenetal.2019,
  author    = {Gehrke, Thomas and Scherzad, Agmal and Hagen, Rudolf and Hackenberg, Stephan},
  title     = {Risk factors for children requiring adenotonsillectomy and their impact on postoperative complications: a retrospective analysis of 2000 patients},
  series = {Anaesthesia},
  volume    = {74},
  journal   = {Anaesthesia},
  number    = {12},
  doi       = {10.1111/anae.14844},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-204787},
  pages     = {1572-1579},
  year      = {2019},
  abstract  = {Adenotonsillectomies are commonly performed procedures and sleep-disordered breathing is becoming increasingly important as an indication for surgery. Because of the higher risks in patients with obstructive sleep apnoea, the required level of postoperative care for these patients is currently under discussion, and better identification of patients at risk may reduce unnecessary postoperative monitoring. To evaluate the influence of obstructive sleep apnoea, and other risk factors, on peri-operative complications in children requiring adenotonsillectomy, we performed a retrospective case-control study that included 1995 patients treated between January 2009 and June 2017. In our analysis, young age (OR 3.8, 95\%CI 2.1-7.1), low body weight (OR 2.6, 95\%CI 1.5-4.4), obstructive sleep apnoea (OR 2.4, 95\%CI 1.5-3.8), pre-existing craniofacial or syndromal disorders (OR 2.3, 95\%CI 1.4-3.8) and adenotonsillectomy, compared with adenoidectomy alone, (OR 7.9, 95\%CI 4.7-13.1) were identified as risk factors for complications during or after surgery, p < 0.001. All 13 patients suffering from complications more than 3 h postoperatively had obstructive sleep apnoea plus at least one more of these risk factors. Patients at risk of postoperative complications can therefore be identified by several criteria pre-operatively, and should be monitored postoperatively using pulse oximetry overnight. For all other patients, postoperative observation on a surgical ward without extra monitoring is sufficient. Admission to paediatric intensive care should be reserved for patients suffering serious intra-operative complications.},
  language  = {en}
}