@article{MaglioccaMoneDiIorioetal.2022,
  author    = {Magliocca, Giorgia and Mone, Pasquale and Di Iorio, Biagio Raffaele and Heidland, August and Marzocco, Stefania},
  title     = {Short-chain fatty acids in Chronic Kidney Disease: focus on inflammation and oxidative stress regulation},
  series = {International Journal of Molecular Sciences},
  volume    = {23},
  journal   = {International Journal of Molecular Sciences},
  number    = {10},
  issn      = {1422-0067},
  doi       = {10.3390/ijms23105354},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-284587},
  year      = {2022},
  abstract  = {Chronic Kidney Disease (CKD) is a debilitating disease associated with several secondary complications that increase comorbidity and mortality. In patients with CKD, there is a significant qualitative and quantitative alteration in the gut microbiota, which, consequently, also leads to reduced production of beneficial bacterial metabolites, such as short-chain fatty acids. Evidence supports the beneficial effects of short-chain fatty acids in modulating inflammation and oxidative stress, which are implicated in CKD pathogenesis and progression. Therefore, this review will provide an overview of the current knowledge, based on pre-clinical and clinical evidence, on the effect of SCFAs on CKD-associated inflammation and oxidative stress.},
  language  = {en}
}
@article{RapaDiIorioCampigliaetal.2019,
  author    = {Rapa, Shara Francesca and Di Iorio, Biagio Raffaele and Campiglia, Pietro and Heidland, August and Marzocco, Stefania},
  title     = {Inflammation and oxidative stress in chronic kidney disease — Potential therapeutic role of minerals, vitamins and plant-derived metabolites},
  series = {International Journal of Molecular Sciences},
  volume    = {21},
  journal   = {International Journal of Molecular Sciences},
  number    = {1},
  issn      = {1422-0067},
  doi       = {10.3390/ijms21010263},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-284998},
  year      = {2019},
  abstract  = {Chronic kidney disease (CKD) is a debilitating pathology with various causal factors, culminating in end stage renal disease (ESRD) requiring dialysis or kidney transplantation. The progression of CKD is closely associated with systemic inflammation and oxidative stress, which are responsible for the manifestation of numerous complications such as malnutrition, atherosclerosis, coronary artery calcification, heart failure, anemia and mineral and bone disorders, as well as enhanced cardiovascular mortality. In addition to conventional therapy with anti-inflammatory and antioxidative agents, growing evidence has indicated that certain minerals, vitamins and plant-derived metabolites exhibit beneficial effects in these disturbances. In the current work, we review the anti-inflammatory and antioxidant properties of various agents which could be of potential benefit in CKD/ESRD. However, the related studies were limited due to small sample sizes and short-term follow-up in many trials. Therefore, studies of several anti-inflammatory and antioxidant agents with long-term follow-ups are necessary.},
  language  = {en}
}
@phdthesis{Fischer2011,
  author    = {Fischer, Regina Maria},
  title     = {Einfluß verschiedener extrakorporaler Dialyseverfahren auf endotheliale Vorl{\"a}uferzellen},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-71353},
  school      = {Universit{\"a}t W{\"u}rzburg},
  year      = {2011},
  abstract  = {Zirkulierende endotheliale Vorl{\"a}uferzellen, kurz EPCs, werden als Biomarker f{\"u}r kardiovaskul{\"a}re Erkrankungen genutzt. In einer prospektiven, randomisierten Cross-over-Studie wurden 18 chronische Dialysepatienten w{\"a}hrend jeweils vier Wochen mit Low-Flux-HD, High-Flux-HD sowie H{\"a}modiafilatration behandelt. EPCs wurden zu Beginn sowie am Ende jedes Intervalls bestimmt. Trotz deutlicher Unterschiede bez{\"u}glich der Toxinentfernung im mittelmolekularen Bereich zeigte sich kein Einfluss auf Qualit{\"a}t und Quantit{\"a}t der EPCs},
  subject      = {endotheliale Vorl{\"a}uferzellen},
  language  = {de}
}
@article{SchuppHeidlandStopper2010,
  author    = {Schupp, Nicole and Heidland, August and Stopper, Helga},
  title     = {Genomic Damage in Endstage Renal Disease - Contribution of Uremic Toxins},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-68653},
  year      = {2010},
  abstract  = {Patients with end-stage renal disease (ESRD), whether on conservative, peritoneal or hemodialysis therapy, have elevated genomic damage in peripheral blood lymphocytes and an increased cancer incidence, especially of the kidney. The damage is possibly due to accumulation of uremic toxins like advanced glycation endproducts or homocysteine. However, other endogenous substances with genotoxic properties, which are increased in ESRD, could be involved, such as the blood pressure regulating hormones angiotensin II and aldosterone or the inflammatory cytokine TNF-. This review provides an overview of genomic damage observed in ESRD patients, focuses on possible underlying causes and shows modulations of the damage by modern dialysis strategies and vitamin upplementation.},
  subject      = {Toxin},
  language  = {en}
}
@phdthesis{Fink2008,
  author    = {Fink, Kristin},
  title     = {Toxins in Renal Disease and Dialysis Therapy : Genotoxic Potential and Mechanisms},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-31082},
  school      = {Universit{\"a}t W{\"u}rzburg},
  year      = {2008},
  abstract  = {In patients suffering from end-stage renal disease who are treated by hemodialysis genomic damage as well as cancer incidence is elevated. One possible cause for the increased genomic damage could be the accumulation of genotoxic substances in the blood of patients. Two possible sources for those toxins have to be considered. The first possibility is that substances from dialysers, the blood tubing system or even contaminated dialysis solutions may leach into the blood of the patients during dialysis. Secondly, the loss of renal filtration leads to an accumulation of substances which are normally excreted by the kidney. If those substances possess toxic potential, they are called uremic toxins. Several of these uremic toxins are potentially genotoxic. Within this thesis several exemplary uremic toxins have been tested for genotoxic effects (homocysteine, homocysteine-thiolactone,leptine, advanced glycated end-products). Additionally, it was analysed whether substances are leaching from dialysers or blood tubing and whether they cause effects in in vitrotoxicity testing. The focus of chemical analytisis was on bisphenol A (BPA), the main component of plastics used in dialysers and dialyser membranes.},
  subject      = {Bisphenol A},
  language  = {en}
}