@incollection{Wilhelm1987, author = {Wilhelm, Gernot}, title = {EA 24}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-70436}, publisher = {Universit{\"a}t W{\"u}rzburg}, year = {1987}, abstract = {No abstract available.}, subject = {Amarna}, language = {fr} } @incollection{ShephardHegiLutz1987, author = {Shephard, S. E. and Hegi, M. E. and Lutz, Werner K.}, title = {In-vitro assays to detect alkylating and mutagenic activities of dietary components nitrosated in situ}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-86194}, publisher = {Universit{\"a}t W{\"u}rzburg}, year = {1987}, abstract = {Nitrosation of dietary components has been combined with the 4-(para-nitrobenzyl)pyridine (NBP) colorimetric test for screening alkylating agents and with the Ames test for the detection of mutagenic activity. This allowed the investigation of short-hved nitrosation products of dietary components which generate electrophilic degradation products requiring no metabolic activation (natural amino acids and some derivatives, ureas, guanidines, primary alkyl and aryl amines). In a first system, precursor, nitrous acid and NBP were present simultaneously. All amino acids tested, except glutamic acid and glutamine, gave positive results. The reactivities spanned more than three orders of magnitude, with the aromatic amino acids and methionine the most active; two primary amines, tryptamine and histamine, were also strongly reactive. All guanidines tested, except the amino acid arginine, gave negative results. A second system consisted of two phases: NBP was added only after destruction of residual nitrite and adjustment of the pH to neutrality. This system was useful for the study of ureas, which are stable in acid but not in neutral media. The range of responses covered more than two orders of magnitude. Most amino acids and primary amines also gave positive results, but could be assessed only after analysing the kinetics of the competing reactions and choosing appropriate reaction times. In a third system, Salmonella typhimurium strain TA1OO replaced NBP. Representatives of the class of amino acids, ureas, the primary amine tryptamine, and aniline became higbly mutagenic upon nitrosation. Methylguanidine was only weakly mutagenic under the present assay conditions. The results indicate that further studies with unstable nitrosation products of dietary components are required to understand more thoroughly the role of endogenous nitrosation in gastric cancer.}, subject = {Medizin}, language = {en} } @incollection{ShephardSchlatterLutz1987, author = {Shephard, S. E. and Schlatter, C. and Lutz, Werner K.}, title = {Model risk analysis of nitrosatable compounds in the diet as precursors of potential endogenous carcinogens}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-86188}, publisher = {Universit{\"a}t W{\"u}rzburg}, year = {1987}, abstract = {The potential health risk posed by the endogenous formation of N-nitroso compounds (NOC) from nitrosation of dietary ureas, guanidines, amides, amino acids and amanes (primary, secondary and aromatic) was estimated according to the model: Risk = ( daily intake of precursor] X (gastric concentration of nitrite ]n X [nitrosatability rate constant] X [cilrcinogenicity of derivative]. The daily intakes ofthese compound classes span five orders ofmagnitude (100 g/day amides, top; 1-10 mg/day secondary amines, ureas, bottom); the nitrosation rate constants span seven orders of magnitude (aryl amines, ureas, top; amides, secondary amines, bottom); and the carcinogenicity estimates span a 10 000-fold range from 'very strong' to 'virtually noncarcinogenic'. The resulting risk estimates likewise span an enormous range (nine orders of magnitude ): dietary ureas and aromatic amines combined with high nitrite concentration could pose as great a risk as the intake of preformed N-nitrosodimethylamine in the diet. In contrast, the risk posed by the in-vivo nitrosation of primary and secondary amines is probably negligible. The risk contributed by amides (including protein), guanidines and primary amino acids is intermediate between these two extremes.}, subject = {Risikoanalyse}, language = {en} } @incollection{ZimmermannStopper1987, author = {Zimmermann, U. and Stopper, Helga}, title = {Electrofusion and electropermeabilization of cells}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-73065}, publisher = {Universit{\"a}t W{\"u}rzburg}, year = {1987}, abstract = {No abstract available.}, subject = {Elektrofusion}, language = {en} } @incollection{LohseKlotzSchwabe1987, author = {Lohse, Martin J. and Klotz, Karl-Norbert and Schwabe, Ulrich}, title = {Functional characterization of A1 adenoosine receptors by photoaffinity labelling}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-86097}, publisher = {Universit{\"a}t W{\"u}rzburg}, year = {1987}, abstract = {The ligand-binding subunit ofthe A1 adenosine receptor has been identified in membranes with the photoaffinity Iabel R-2-azido-N6-p-hydroxyphenylisopropyladenosine (R-AHPIA). Covalent labelling ofthe A1 receptor can also be achieved in intact cells. The dissociation of the radioiodinated label (1251-AHPIA) from isolated rat fat cells was incomplete after UV irradiation, leaving about 20°/o of irreversible specific binding. Such covalent labelling of the receptor led to a concentration-dependent reduction of cellular cyclic AMP levels. This persistent effect of covalent labeHing occurred with an IC50 value of 9 nM, as compared to an IC50 value of 0.9 nM for the direct reduction of cyclic AMP Ievels by the ligand. The difference in the IC5o values can be explained by assuming spare receptors. This hypothesis was verified in binding studies using [ 3HJPIA as a radioligand. R-AHPIA inhibited binding of [3H)PIA to intact fat cells with a K1 value of about 20 nM, which is about 20 tim es high er than the corresponding IC50 value of cyclic AMP reduction. These data show that the A1 receptor is activated according to the occupancy theory. The high sensitivity of the activation in intact ceJis is due to a large number of spare receptors.}, subject = {Adenosinrezeptor}, language = {en} } @incollection{FalesTusaWilhelmetal.1987, author = {Fales, Frederick Marion and Tusa, Sebastiano and Wilhelm, Gernot and Zaccagnini, Carlo}, title = {German-Italian expedition to Iraq: preliminary report on the first campaign of excavations within the Saddam Dam Reservoir Archaeological Rescue Project (1984)}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-78053}, publisher = {Universit{\"a}t W{\"u}rzburg}, year = {1987}, abstract = {No abstract available}, subject = {Orientalistik}, language = {en} } @incollection{Ellgring1987, author = {Ellgring, Johann Heinrich}, title = {Zur Entwicklung der Mimik als Verst{\"a}ndigungsmittel}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-56811}, publisher = {Universit{\"a}t W{\"u}rzburg}, year = {1987}, abstract = {No abstract available}, subject = {Mimik}, language = {de} } @incollection{Ellgring1987, author = {Ellgring, Johann Heinrich}, title = {FACS [Facial Action Coding System]}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-50370}, publisher = {Universit{\"a}t W{\"u}rzburg}, year = {1987}, abstract = {FACS, Abk. f. Facial Action Coding System, ein von EKMAN u. FRIESEN 1978, entwickeltes, auf den schwedischen Anatomen HJORTSJ{\"O} 1970 zur{\"u}ckgehendes System zur Beschreibung der Mimik. [W{\"o}rterbucheintrag]}, subject = {Psychologie}, language = {de} } @incollection{PressleyBorkowskiSchneider1987, author = {Pressley, Michael and Borkowski, John G. and Schneider, Wolfgang}, title = {Cognitive strategies: Good strategy users coordinate metacognition and knowledge}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-50469}, publisher = {Universit{\"a}t W{\"u}rzburg}, year = {1987}, abstract = {No abstract available}, subject = {Psychologie}, language = {en} } @incollection{Ellgring1987, author = {Ellgring, Johann Heinrich}, title = {Nichtverbale Kommunikation}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-50383}, publisher = {Universit{\"a}t W{\"u}rzburg}, year = {1987}, abstract = {No abstract available}, subject = {Psychologie}, language = {de} } @incollection{Ellgring1987, author = {Ellgring, Johann Heinrich}, title = {Ausdruck}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-50363}, publisher = {Universit{\"a}t W{\"u}rzburg}, year = {1987}, abstract = {No abstract available}, subject = {Psychologie}, language = {de} } @incollection{Ellgring1987, author = {Ellgring, Johann Heinrich}, title = {Ausdrucksforschung}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-50350}, publisher = {Universit{\"a}t W{\"u}rzburg}, year = {1987}, abstract = {No abstract available}, subject = {Psychologie}, language = {de} } @incollection{Hommers1987, author = {Hommers, Wilfried}, title = {Implizite Willenstheorien des rechtlichen Denkens aus empirisch psychologischer Perspektive}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-44128}, publisher = {Universit{\"a}t W{\"u}rzburg}, year = {1987}, abstract = {No abstract available}, subject = {Wille / Aufsatzsammlung / Rottach-Egern <1987> / Kongress / Ringberg