@article{VermaSteinbacherSchmiedeletal.2016,
  author    = {Verma, Pramod Kumar and Steinbacher, Andreas and Schmiedel, Alexander and Nuernberger, Patrick and Brixner, Tobias},
  title     = {Excited-state intramolecular proton transfer of 2-acetylindan-1,3-dione studied by ultrafast absorption and fluorescence spectroscopy},
  series = {Structural Dynamics},
  volume    = {3},
  journal   = {Structural Dynamics},
  doi       = {10.1063/1.4937363},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-181301},
  year      = {2016},
  abstract  = {We employ transient absorption from the deep-UV to the visible region and fluorescence upconversion to investigate the photoinduced excited-state intramolecular proton-transfer dynamics in a biologically relevant drug molecule, 2-acetylindan-1,3-dione. The molecule is a ß-diketone which in the electronic ground state exists as exocyclic enol with an intramolecular H-bond. Upon electronic excitation at 300 nm, the first excited state of the exocyclic enol is initially populated, followed by ultrafast proton transfer (≈160 fs) to form the vibrationally hot endocyclic enol. Subsequently, solvent-induced vibrational relaxation takes place (≈10 ps) followed by decay (≈390 ps) to the corresponding ground state.},
  language  = {en}
}
@article{BossertdeBruinGoetzetal.2016,
  author    = {Bossert, Nelli and de Bruin, Donny and G{\"o}tz, Maria and Bouwmeester, Dirk and Heinrich, Doris},
  title     = {Fluorescence-tunable Ag-DNA biosensor with tailored cytotoxicity for live-cell applications},
  series = {Scientific Reports},
  volume    = {6},
  journal   = {Scientific Reports},
  number    = {37897},
  doi       = {10.1038/srep37897},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-167482},
  year      = {2016},
  abstract  = {DNA-stabilized silver clusters (Ag-DNA) show excellent promise as a multi-functional nanoagent for molecular investigations in living cells. The unique properties of these fluorescent nanomaterials allow for intracellular optical sensors with tunable cytotoxicity based on simple modifications of the DNA sequences. Three Ag-DNA nanoagent designs are investigated, exhibiting optical responses to the intracellular environments and sensing-capability of ions, functional inside living cells. Their sequence-dependent fluorescence responses inside living cells include (1) a strong splitting of the fluorescence peak for a DNA hairpin construct, (2) an excitation and emission shift of up to 120 nm for a single-stranded DNA construct, and (3) a sequence robust in fluorescence properties. Additionally, the cytotoxicity of these Ag-DNA constructs is tunable, ranging from highly cytotoxic to biocompatible Ag-DNA, independent of their optical sensing capability. Thus, Ag-DNA represents a versatile live-cell nanoagent addressable towards anti-cancer, patient-specific and anti-bacterial applications.},
  language  = {en}
}