@article{SchwabMeeuwsenEhlickeetal.2017,
  author    = {Schwab, Andrea and Meeuwsen, Annick and Ehlicke, Franziska and Hansmann, Jan and Mulder, Lars and Smits, Anthal and Walles, Heike and Kock, Linda},
  title     = {Ex vivo culture platform for assessment of cartilage repair treatment strategies},
  series = {ALTEX - Alternatives to animal experimentation},
  volume    = {34},
  journal   = {ALTEX - Alternatives to animal experimentation},
  number    = {2},
  doi       = {10.14573/altex.1607111},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-181665},
  pages     = {267-277},
  year      = {2017},
  abstract  = {There is a great need for valuable ex vivo models that allow for assessment of cartilage repair strategies to reduce the high number of animal experiments. In this paper we present three studies with our novel ex vivo osteochondral culture platform. It consists of two separated media compartments for cartilage and bone, which better represents the in vivo situation and enables supply of factors pecific to the different needs of bone and cartilage. We investigated whether separation of the cartilage and bone compartments and/or culture media results in the maintenance of viability, structural and functional properties of cartilage tissue. Next, we valuated for how long we can preserve cartilage matrix stability of osteochondral explants during long-term culture over 84 days. Finally, we determined the optimal defect size that does not show spontaneous self-healing in this culture system. It was demonstrated that separated compartments for cartilage and bone in combination with tissue-specific medium allow for long-term culture of osteochondral explants while maintaining cartilage viability, atrix tissue content, structure and mechanical properties for at least 56 days. Furthermore, we could create critical size cartilage defects of different sizes in the model. The osteochondral model represents a valuable preclinical ex vivo tool for studying clinically relevant cartilage therapies, such as cartilage biomaterials, for their regenerative potential, for evaluation of drug and cell therapies, or to study mechanisms of cartilage regeneration. It will undoubtedly reduce the number of animals needed for in vivotesting.},
  language  = {en}
}
@article{DongKuzmanoskiWehneretal.2017,
  author    = {Dong, Hailong and Kuzmanoski, Ana and Wehner, Tobias and Mueller-Buschbaum, Klaus and Feldmann, Claus},
  title     = {Microwave-assisted polyol synthesis of water dispersible red-emitting Eu\(^{3+}\)-modified carbon dots},
  series = {Materials},
  volume    = {10},
  journal   = {Materials},
  doi       = {10.3390/ma10010025},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-181674},
  year      = {2017},
  abstract  = {Eu\(^{3+}\)-modified carbon dots (C-dots), 3-5 nm in diameter, were prepared, functionalized, and stabilized via a one-pot polyol synthesis. The role of Eu\(^{2+}\)/Eu\(^{3+}\), the influence of O\(_2\) (oxidation) and H\(_2\)O (hydrolysis), as well as the impact of the heating procedure (conventional resistance heating and microwave (MW) heating) were explored. With the reducing conditions of the polyol at the elevated temperature of synthesis (200-230 °C), first of all, Eu\(^{2+}\) was obtained resulting in the blue emission of the C-dots. Subsequent to O\(_2\)-driven oxidation, Eu\(^{3+}\)-modified, red-emitting C-dots were realized. However, the Eu\(^{3+}\) emission is rapidly quenched by water for C-dots prepared via conventional resistance heating. In contrast to the hydroxyl functionalization of conventionally-heated C-dots, MW-heating results in a carboxylate functionalization of the C-dots. Carboxylate-coordinated Eu\(^{3+}\), however, turned out as highly stable even in water. Based on this fundamental understanding of synthesis and material, in sum, a one-pot polyol approach is established that results in H\(_2\)O-dispersable C-dots with intense red Eu\(^{3+}\)-line-type emission.},
  language  = {en}
}
@article{RudnoRudzińskiSyperekAndrezejewskietal.2017,
  author    = {Rudno-Rudziński, W. and Syperek, M. and Andrezejewski, J. and Maryński, A. and Misiewicz, J. and Somers, A. and H{\"o}fling, S. and Reithmaier, J. P. and Sęk, G.},
  title     = {Carrier delocalization in InAs/InGaAlAs/InP quantum-dash-based tunnel injection system for 1.55 μm emission},
  series = {AIP Advances},
  volume    = {7},
  journal   = {AIP Advances},
  number    = {1},
  doi       = {10.1063/1.4975634},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-181787},
  year      = {2017},
  abstract  = {We have investigated optical properties of hybrid two-dimensional-zero-dimensional (2D-0D) tunnel structures containing strongly elongated InAs/InP(001) quantum dots (called quantum dashes), emitting at 1.55 μm. These quantum dashes (QDashes) are separated by a 2.3 nm-width barrier from an InGaAs quantum well (QW), lattice matched to InP. We have tailored quantum-mechanical coupling between the states confined in QDashes and a QW by changing the QW thickness. By combining modulation spectroscopy and photoluminescence excitation, we have determined the energies of all relevant optical transitions in the system and proven the carrier transfer from the QW to the QDashes, which is the fundamental requirement for the tunnel injection scheme. A transformation between 0D and mixed-type 2D-0D character of an electron and a hole confinement in the ground state of the hybrid system have been probed by time-resolved photoluminescence that revealed considerable changes in PL decay time with the QW width changes. The experimental discoveries have been explained by band structure calculations in the framework of the eight-band k·p model showing that they are driven by delocalization of the lowest energy hole state. The hole delocalization process from the 0D QDash confinement is unfavorable for optical devices based on such tunnel injection structures.},
  language  = {en}
}
@article{RyczkoMisiewiczHoflingetal.2017,
  author    = {Ryczko, K. and Misiewicz, J. and Hofling, S. and Kamp, M. and Sęk, G.},
  title     = {Optimizing the active region of interband cascade lasers for passive mode-locking},
  series = {AIP Advances},
  volume    = {7},
  journal   = {AIP Advances},
  number    = {1},
  doi       = {10.1063/1.4973937},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-181790},
  year      = {2017},
  abstract  = {The work proposes possible designs of active regions for a mode-locked interband cascade laser emitting in the mid infrared. For that purpose we investigated the electronic structure properties of respectively modified GaSb-based type II W-shaped quantum wells, including the effect of external bias in order to simultaneously fulfil the requirements for both the absorber as well as the gain sections of a device. The results show that introducing multiple InAs layers in type II InAs/GaInSb quantum wells or introducing a tensely-strained GaAsSb layer into "W-shaped" type II QWs offers significant difference in optical transitions' oscillator strengths (characteristic lifetimes) of the two oppositely polarized parts of such a laser, being promising for utilization in mode-locked devices.},
  language  = {en}
}
@article{LavyshSokolovaSlashchevaetal.2017,
  author    = {Lavysh, Daria and Sokolova, Maria and Slashcheva, Marina and F{\"o}rstner, Konrad U. and Severinov, Konstantin},
  title     = {Transcription profiling of "bacillus subtilis" cells infected with AR9, a giant phage encoding two multisubunit RNA polymerases},
  series = {mBio},
  volume    = {8},
  journal   = {mBio},
  number    = {1},
  doi       = {10.1128/mBio.02041-16},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-181810},
  year      = {2017},
  abstract  = {Bacteriophage AR9 is a recently sequenced jumbo phage that encodes two multisubunit RNA polymerases. Here we investigated the AR9 transcription strategy and the effect of AR9 infection on the transcription of its host, Bacillus subtilis. Analysis of whole-genome transcription revealed early, late, and continuously expressed AR9 genes. Alignment of sequences upstream of the 5′ ends of AR9 transcripts revealed consensus sequences that define early and late phage promoters. Continuously expressed AR9 genes have both early and late promoters in front of them. Early AR9 transcription is independent of protein synthesis and must be determined by virion RNA polymerase injected together with viral DNA. During infection, the overall amount of host mRNAs is significantly decreased. Analysis of relative amounts of host transcripts revealed notable differences in the levels of some mRNAs. The physiological significance of up- or downregulation of host genes for AR9 phage infection remains to be established. AR9 infection is significantly affected by rifampin, an inhibitor of host RNA polymerase transcription. The effect is likely caused by the antibiotic-induced killing of host cells, while phage genome transcription is solely performed by viral RNA polymerases.},
  language  = {en}
}
@article{AhmedOjhaHirschetal.2017,
  author    = {Ahmed, Bilal and Ojha, Animesh K. and Hirsch, Florian and Fischer, Ingo and Patrice, Donfack and Materny, Arnulf},
  title     = {Tailoring of enhanced interfacial polarization in WO\(_3\) nanorods grown over reduced graphene oxide synthesized by a one-step hydrothermal method},
  series = {RSC Advances},
  volume    = {7},
  journal   = {RSC Advances},
  number    = {23},
  doi       = {10.1039/c7ra00730b},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-181829},
  pages     = {13985-13996},
  year      = {2017},
  abstract  = {In the present report, well-defined WO3 nanorods (NRs) and a rGO-WO\(_3\) composite were successfully synthesized using a one-pot hydrothermal method. The crystal phase, structural morphology, shape, and size of the as-synthesized samples were studied using X-ray diffraction (XRD) and transmission electron microscopy (TEM) measurements. The optical properties of the synthesized samples were investigated by Raman, ultraviolet-visible (UV-Vis) and photoluminescence (PL) spectroscopy. Raman spectroscopy and TEM results validate the formation of WO\(_3\) (NRs) on the rGO sheet. The value of the dielectric constant (ε′) of WO3 NRs and rGO-WO\(_3\) composite is decreased with an increase in frequency. At low frequency (2.5 to 3.5 Hz), the value of ε′ for the rGO-WO3 composite is greater than that of pure WO\(_3\) NRs. This could be due to the fact that the induced charges follow the ac signal. However, at higher frequency (3.4 to 6.0), the value of ε′ for the rGO-WO\(_3\) composite is less compared to that of the pure WO3 NRs. The overall decrease in the value of ε′ could be due to the occurrence of a polarization process at the interface of the rGO sheet and WO3 NRs. Enhanced interfacial polarization in the rGO-WO\(_3\) composite is observed, which may be attributed to the presence of polar functional groups on the rGO sheet. These functional groups trap charge carriers at the interface, resulting in an enhancement of the interfacial polarization. The value of the dielectric modulus is also calculated to further confirm this enhancement. The values of the ac conductivity of the WO\(_3\) NRs and rGO-WO\(_3\) composite were calculated as a function of the frequency. The greater value of the ac conductivity in the rGO-WO\(_3\) composite compared to that of the WO\(_3\) NRs confirms the restoration of the sp:\(^{++}\) network during the in situ synthesis of the rGO-WO\(_3\) composite, which is well supported by the results obtained by Raman spectroscopy.},
  language  = {en}
}
@article{BenderRothJob2017,
  author    = {Bender, Oliver and Roth, Charlotte E. and Job, Hubert},
  title     = {Protected areas and population development in the alps},
  series = {eco.mont : Journal on Protected Mountain Areas Research and Management},
  volume    = {9},
  journal   = {eco.mont : Journal on Protected Mountain Areas Research and Management},
  number    = {Special issue},
  doi       = {10.1553/eco.mont-9-sis5},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-181901},
  year      = {2017},
  abstract  = {Nearly a quarter of the Alpine area is covered by a dense network of large protected areas (LPAs) of the four categories national park(NP), biosphere reserve (BR), nature park and world natural heritage site (WNHS). From the time of early industrialization, the Alpine area has undergone a mixed and increasingly polarized demographic development between the poles of immigration and emigration. This article investigates the possible mutual impact of population development and the existence of LPAs. The research design includes a quantitative survey of all Alpine LPAs in terms of their population development and the structure of immigration in the first decade of the 21st century. This will be linked with qualitative expert interviews in four selected NPs. The overall results allow an interpretation of the statistical correlations between type of LPA and migration.},
  language  = {en}
}
@article{HankirPattPattetal.2017,
  author    = {Hankir, Mohammed K. and Patt, Marianne and Patt, J{\"o}rg T. W. and Becker, Georg A. and Rullmann, Michael and Kranz, Mathias and Deuther-Conrad, Winnie and Schischke, Kristin and Seyfried, Florian and Brust, Peter and Hesse, Swen and Sabri, Osama and Kr{\"u}gel, Ute and Fenske, Wiebke},
  title     = {Suppressed fat appetite after Roux-en-Y gastric bypass surgery associates with reduced brain mu-opioid receptor availability in diet-induced obese male rats},
  series = {Frontiers in Neuroscience},
  volume    = {10},
  journal   = {Frontiers in Neuroscience},
  doi       = {10.3389/fnins.2016.00620},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-181130},
  year      = {2017},
  abstract  = {Brain μ-opioid receptors (MORs) stimulate high-fat (HF) feeding and have been implicated in the distinct long term outcomes on body weight of bariatric surgery and dieting. Whether alterations in fat appetite specifically following these disparate weight loss interventions relate to changes in brain MOR signaling is unknown. To address this issue, diet-induced obese male rats underwent either Roux-en-Y gastric bypass (RYGB) or sham surgeries. Postoperatively, animals were placed on a two-choice diet consisting of low-fat (LF) and HF food and sham-operated rats were further split into ad libitum fed (Sham-LF/HF) and body weight-matched (Sham-BWM) to RYGB groups. An additional set of sham-operated rats always only on a LF diet (Sham-LF) served as lean controls, making four experimental groups in total. Corresponding to a stage of weight loss maintenance for RYGB rats, two-bottle fat preference tests in conjunction with small-animal positron emission tomography (PET) imaging studies with the selective MOR radioligand [\(^{11}\)C]carfentanil were performed. Brains were subsequently collected and MOR protein levels in the hypothalamus, striatum, prefrontal cortex and orbitofrontal cortex were analyzed by Western Blot. We found that only the RYGB group presented with intervention-specific changes: having markedly suppressed intake and preference for high concentration fat emulsions, a widespread reduction in [\(^{11}\)C]carfentanil binding potential (reflecting MOR availability) in various brain regions, and a downregulation of striatal and prefrontal MOR protein levels compared to the remaining groups. These findings suggest that the suppressed fat appetite caused by RYGB surgery is due to reduced brain MOR signaling, which may contribute to sustained weight loss unlike the case for dieting.},
  language  = {en}
}
@article{HalderAbdelfatahJoetal.2017,
  author    = {Halder, Luke D. and Abdelfatah, Mahmoud A. and Jo, Emeraldo A. H. and Jacobsen, Ilse D. and Westermann, Martin and Beyersdorf, Niklas and Lorkowski, Stefan and Zipfel, Peter F. and Skerka, Christine},
  title     = {Factor H binds to extracellular DNA traps released from human blood monocytes in response to Candida albicans},
  series = {Frontiers in Immunology},
  volume    = {7},
  journal   = {Frontiers in Immunology},
  doi       = {10.3389/fimmu.2016.00671},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-181127},
  year      = {2017},
  abstract  = {Upon systemic infection with human pathogenic yeast Candida albicans (C. albicans), human monocytes and polymorph nuclear neutrophilic granulocytes are the first immune cells to respond and come into contact with C. albicans. Monocytes exert immediate candidacidal activity and inhibit germination, mediate phagocytosis, and kill fungal cells. Here, we show that human monocytes spontaneously respond to C. albicans cells via phagocytosis, decondensation of nuclear DNA, and release of this decondensed DNA in the form of extracellular traps (called monocytic extracellular traps: MoETs). Both subtypes of monocytes (CD14\(^{++}\)CD16\(^-\)/CD14\(^+\)CD16\(^+\)) formed MoETs within the first hours upon contact with C. albicans. MoETs were characterized by the presence of citrullinated histone, myeloperoxidase, lactoferrin, and elastase. MoETs were also formed in response to Staphylococcus aureus and Escherichia coli, indicating a general reaction of monocytes to infectious microbes. MoET induction differs from extracellular trap formation in macrophages as MoETs are not triggered by simvastatin, an inhibitor of cholesterol synthesis and inducer of extracellular traps in macrophages. Extracellular traps from both monocytes and neutrophils activate complement and C3b is deposited. However, factor H (FH) binds via C3b to the extracellular DNA, mediates cofactor activity, and inhibits the induction of the inflammatory cytokine interleukin-1 beta in monocytes. Altogether, the results show that human monocytes release extracellular DNA traps in response to C. albicans and that these traps finally bind FH via C3b to presumably support clearance without further inflammation.},
  language  = {en}
}
@article{PetruskiIvlevaKucharskaNewtonPaltaetal.2017,
  author    = {Petruski-Ivleva, Natalia and Kucharska-Newton, Anna and Palta, Priya and Couper, David and Meyer, Katie and Graff, Misa and Haring, Bernhard and Sharrett, Richey and Heiss, Gerardo},
  title     = {Milk intake at midlife and cognitive decline over 20 years. The Atherosclerosis risk in communities (ARIC) study},
  series = {Nutrients},
  volume    = {9},
  journal   = {Nutrients},
  number    = {10},
  doi       = {10.3390/nu9101134},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-173909},
  year      = {2017},
  abstract  = {Background: Faster rates of cognitive decline are likely to result in earlier onset of cognitive impairment and dementia. d-galactose, a derivative of lactose, is used in animal studies to induce neurodegeneration. Milk is the primary source of lactose in the human diet, and its effects on cognitive decline have not been fully evaluated. Objective: Assess the association of milk intake with change in cognitive function over 20 years. Methods: A total of 13,751 participants of the Atherosclerosis Risk in Communities (ARIC) cohort completed a food frequency questionnaire and three neurocognitive evaluations from 1990 through 2013. Two single nucleotide polymorphisms (SNPs) were used to determine lactase persistence (LCT-13910 C/T for Whites and LCT-14010 G/C for Blacks). Mixed-effects models were used to study the association of milk intake with cognitive change. Multiple imputations by chained equations were used to account for attrition. Results: Milk intake greater than 1 glass/day was associated with greater decline in the global z-score over a 20-year period. The difference in decline was 0.10 (95\% CI: 0.16, 0.03) z-scores, or an additional 10\% decline, relative to the group reporting "almost never" consuming milk. Conclusions: Replication of these results is warranted in diverse populations with greater milk intake and higher variability of lactase persistence genotype.},
  language  = {en}
}
@article{SbirkovKwokBhamraetal.2017,
  author    = {Sbirkov, Yordan and Kwok, Colin and Bhamra, Amandeep and Thompson, Andrew J. and Gil, Veronica and Zelent, Arthur and Petrie, Kevin},
  title     = {Semi-quantitative mass spectrometry in AML cells identifies new non-genomic targets of the EZH2 methyltransferase},
  series = {International Journal of Molecular Sciences},
  volume    = {18},
  journal   = {International Journal of Molecular Sciences},
  number    = {7},
  issn      = {1422-0067},
  doi       = {10.3390/ijms18071440},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-285541},
  year      = {2017},
  abstract  = {Alterations to the gene encoding the EZH2 (KMT6A) methyltransferase, including both gain-of-function and loss-of-function, have been linked to a variety of haematological malignancies and solid tumours, suggesting a complex, context-dependent role of this methyltransferase. The successful implementation of molecularly targeted therapies against EZH2 requires a greater understanding of the potential mechanisms by which EZH2 contributes to cancer. One aspect of this effort is the mapping of EZH2 partner proteins and cellular targets. To this end we performed affinity-purification mass spectrometry in the FAB-M2 HL-60 acute myeloid leukaemia (AML) cell line before and after all-trans retinoic acid-induced differentiation. These studies identified new EZH2 interaction partners and potential non-histone substrates for EZH2-mediated methylation. Our results suggest that EZH2 is involved in the regulation of translation through interactions with a number of RNA binding proteins and by methylating key components of protein synthesis such as eEF1A1. Given that deregulated mRNA translation is a frequent feature of cancer and that eEF1A1 is highly expressed in many human tumours, these findings present new possibilities for the therapeutic targeting of EZH2 in AML.},
  language  = {en}
}
@article{KoenigerKuerten2017,
  author    = {Koeniger, Tobias and Kuerten, Stefanie},
  title     = {Splitting the "unsplittable": Dissecting resident and infiltrating macrophages in experimental autoimmune encephalomyelitis},
  series = {International Journal of Molecular Sciences},
  volume    = {18},
  journal   = {International Journal of Molecular Sciences},
  number    = {10},
  issn      = {1422-0067},
  doi       = {10.3390/ijms18102072},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-285067},
  year      = {2017},
  abstract  = {Macrophages predominate the inflammatory landscape within multiple sclerosis (MS) lesions, not only regarding cellularity but also with respect to the diverse functions this cell fraction provides during disease progression and remission. Researchers have been well aware of the fact that the macrophage pool during central nervous system (CNS) autoimmunity consists of a mixture of myeloid cells. Yet, separating these populations to define their unique contribution to disease pathology has long been challenging due to their similar marker expression. Sophisticated lineage tracing approaches as well as comprehensive transcriptome analysis have elevated our insight into macrophage biology to a new level enabling scientists to dissect the roles of resident (microglia and non-parenchymal macrophages) and infiltrating macrophages with unprecedented precision. To do so in an accurate way, researchers have to know their toolbox, which has been filled with diverse, discriminating approaches from decades of studying neuroinflammation in animal models. Every method has its own strengths and weaknesses, which will be addressed in this review. The focus will be on tools to manipulate and/or identify different macrophage subgroups within the injured murine CNS.},
  language  = {en}
}
@article{HibarAdamsJahanshadetal.2017,
  author    = {Hibar, Derrek P. and Adams, Hieab H.H. and Jahanshad, Neda and Chauhan, Ganesh and Stein, Jason L and Hofer, Edith and Renteria, Miguel E. and Bis, Joshua C. and Arias-Vasquez, Alejandro and Ikram, M. Kamran and Desrivi{\`e}res, Sylvane and Vernooij, Meike W. and Abramovic, Lucija and Alhusaini, Saud and Amin, Najaf and Andersson, Micael and Arfanakis, Konstantinos and Aribisala, Benjamin S. and Armstrong, Nicola J. and Athanasiu, Lavinia and Axelsson, Tomas and Beecham, Ashley H. and Beiser, Alexa and Bernard, Manon and Blanton, Susan H. and Bohlken, Marc M. and Boks, Marco P. and Bralten, Janita and Brickman, Adam M. and Carmichael, Owen},
  title     = {Novel genetic loci associated with hippocampal volume},
  series = {Nature Communications},
  volume    = {8},
  journal   = {Nature Communications},
  doi       = {10.1038/ncomms13624},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-182115},
  pages     = {12},
  year      = {2017},
  abstract  = {The hippocampal formation is a brain structure integrally involved in episodic memory, spatial navigation, cognition and stress responsiveness. Structural abnormalities in hippocampal volume and shape are found in several common neuropsychiatric disorders. To identify the genetic underpinnings of hippocampal structure here we perform a genome-wide association study (GWAS) of 33,536 individuals and discover six independent loci significantly associated with hippocampal volume, four of them novel. Of the novel loci, three lie within genes (ASTN2, DPP4 and MAST4) and one is found 200 kb upstream of SHH. A hippocampal subfield analysis shows that a locus within the MSRB3 gene shows evidence of a localized effect along the dentate gyrus, subiculum, CA1 and fissure. Further, we show that genetic variants associated with decreased hippocampal volume are also associated with increased risk for Alzheimer's disease (r\(_g\)=-0.155). Our findings suggest novel biological pathways through which human genetic variation influences hippocampal volume and risk for neuropsychiatric illness.},
  language  = {en}
}
@article{VargasCasanovaRodriguezGuerraUmanaPerezetal.2017,
  author    = {Vargas Casanova, Yerly and Rodr{\´i}guez Guerra, Jorge Antonio and Uma{\~n}a P{\´e}rez, Yadi Adriana and Leal Castro, Aura Luc{\´i}a and Almanzar Reina, Giovanni and Garc{\´i}a Casta{\~n}eda, Javier Eduardo and Rivera Monroy, Zuly Jenny},
  title     = {Antibacterial synthetic peptides derived from bovine lactoferricin exhibit cytotoxic effect against MDA-MB-468 and MDA-MB-231 breast cancer cell lines},
  series = {Molecules},
  volume    = {22},
  journal   = {Molecules},
  number    = {10},
  doi       = {10.3390/molecules22101641},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-173887},
  year      = {2017},
  abstract  = {Linear, dimeric, tetrameric, and cyclic peptides derived from lactoferricin B, containing the RRWQWR motif, were designed, synthesized, purified, and characterized using RP-HPLC chromatography and MALDI-TOF mass spectrometry. The antibacterial activity of the designed peptides against E. coli (ATCC 11775 and 25922) and their cytotoxic effect against MDA-MB-468 and MDA-MB-231 breast cancer cell lines were evaluated. Dimeric and tetrameric peptides showed higher antibacterial activity in both bacteria strains than linear peptides. The dimeric peptide (RRWQWR)\(_2\)K-Ahx exhibited the highest antibacterial activity against the tested bacterial strains. Furthermore, the peptides with high antibacterial activity exhibited significant cytotoxic effect against the tested breast cancer cell lines. This cytotoxic effect was fast and dependent on the peptide concentration. The tetrameric molecule containing RRWQWR motif has an optimal cytotoxic effect at a concentration of 22 µM. The evaluated dimeric and tetrameric peptides could be considered as candidates for developing new therapeutic agents against breast cancer. Polyvalence of linear sequences could be considered as a novel and versatile strategy for obtaining molecules with high anticancer activity.},
  language  = {en}
}
@article{VangeelPishvaHompesetal.2017,
  author    = {Vangeel, Elise Beau and Pishva, Ehsan and Hompes, Titia and van den Hove, Daniel and Lambrechts, Diether and Allegaert, Karel and Freson, Kathleen and Izzi, Benedetta and Claes, Stephan},
  title     = {Newborn genome-wide DNA methylation in association with pregnancy anxiety reveals a potential role for \(GABBR1\)},
  series = {Clinical Epigenetics},
  volume    = {9},
  journal   = {Clinical Epigenetics},
  doi       = {10.1186/s13148-017-0408-5},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-173825},
  year      = {2017},
  abstract  = {Background: There is increasing evidence for the role of prenatal stress in shaping offspring DNA methylation and disease susceptibility. In the current study, we aimed to identify genes and pathways associated with pregnancy anxiety using a genome-wide DNA methylation approach. Methods: We selected 22 versus 23 newborns from our Prenatal Early Life Stress (PELS) cohort, exposed to the lowest or highest degree of maternal pregnancy anxiety, respectively. Cord blood genome-wide DNA methylation was assayed using the HumanMethylation450 BeadChip (HM450, n = 45) and candidate gene methylation using EpiTYPER (n = 80). Cortisol levels were measured at 2, 4, and 12 months of age to test infant stress system (re)activity. Results: Data showed ten differentially methylated regions (DMR) when comparing newborns exposed to low versus high pregnancy anxiety scores. We validated a top DMR in the GABA-B receptor subunit 1 gene (GABBR1) revealing the association with pregnancy anxiety particularly in male newborns (most significant CpG Pearson R = 0.517, p = 0.002; average methylation Pearson R = 0.332, p = 0.039). Cord blood GABBR1 methylation was associated with infant cortisol levels in response to a routine vaccination at 4 months old. Conclusions: In conclusion, our results show that pregnancy anxiety is associated with differential DNA methylation patterns in newborns and that our candidate gene GABBR1 is associated with infant hypothalamic-pituitary-adrenal axis response to a stressor. Our findings reveal a potential role for GABBR1 methylation in association with stress and provide grounds for further research.},
  language  = {en}
}
@article{SalkerSinghZengetal.2017,
  author    = {Salker, Madhuri S. and Singh, Yogesh and Zeng, Ni and Chen, Hong and Zhang, Shaqiu and Umbach, Anja T. and Fakhri, Hajar and Kohlhofer, Ursula and Quintanilla-Martinez, Leticia and Durairaj, Ruban R. Peter and Barros, Flavio S. V. and Vrljicak, Pavle and Ott, Sascha and Brucker, Sara Y. and Wallwiener, Diethelm and Madunić, Ivana Vrhovac and Breljak, Davorka and Sabolić, Ivan and Koepsell, Hermann and Brosens, Jan J. and Lang, Florian},
  title     = {Loss of endometrial sodium glucose cotransporter SGLT1 is detrimental to embryo survival and fetal growth in pregnancy},
  series = {Scientific Reports},
  volume    = {7},
  journal   = {Scientific Reports},
  doi       = {10.1038/s41598-017-11674-3},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-173814},
  year      = {2017},
  abstract  = {Embryo implantation requires a hospitable uterine environment. A key metabolic change that occurs during the peri-implantation period, and throughout early pregnancy, is the rise in endometrial glycogen content. Glycogen accumulation requires prior cellular uptake of glucose. Here we show that both human and murine endometrial epithelial cells express the high affinity Na\(^+\)-coupled glucose carrier SGLT1. Ussing chamber experiments revealed electrogenic glucose transport across the endometrium in wild type (\(Slc5a1^{+/+}\)) but not in SGLT1 defcient (\(Slc5a1^{-/-}\)) mice. Endometrial glycogen content, litter size and weight of offspring at birth were signifcantly lower in \(Slc5a1^{-/-}\) mice. In humans, \(SLC5A1\) expression was upregulated upon decidualization of primary endometrial stromal cells. Endometrial \(SLC5A1\) expression during the implantation window was attenuated in patients with recurrent pregnancy loss when compared with control subjects. Our fndings reveal a novel mechanism establishing adequate endometrial glycogen stores for pregnancy. Disruption of this histiotrophic pathway leads to adverse pregnancy outcome.},
  language  = {en}
}
@article{CernaVelazcoFaberJonesPerezetal.2017,
  author    = {Cerna-Velazco, Nhell and Faber, Thomas and Jones-P{\´e}rez, Joel and Porod, Werner},
  title     = {Constraining sleptons at the LHC in a supersymmetric low-scale seesaw scenario},
  series = {European Physical Journal C},
  volume    = {77},
  journal   = {European Physical Journal C},
  doi       = {10.1140/epjc/s10052-017-5231-9},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-173809},
  year      = {2017},
  abstract  = {We consider a scenario inspired by natural supersymmetry, where neutrino data is explained within a low-scale seesaw scenario. We extend the Minimal Supersymmetric Standard Model by adding light right-handed neutrinos and their superpartners, the R-sneutrinos, and consider the lightest neutralinos to be higgsino-like. We consider the possibilities of having either an R-sneutrino or a higgsino as lightest supersymmetric particle. Assuming that squarks and gauginos are heavy, we systematically evaluate the bounds on slepton masses due to existing LHC data.},
  language  = {en}
}
@article{OPUS4-17371,
  title     = {Search for triboson \({W^\pm}{W^\pm}{W^\mp}\) production in \(pp\) collisions at \(\sqrt{s}\) = 8 TeV with the ATLAS detector},
  series = {European Physical Journal C},
  volume    = {77},
  journal   = {European Physical Journal C},
  number    = {141},
  organization    = {The ATLAS Collaboration},
  doi       = {10.1140/epjc/s10052-017-4692-1},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-173710},
  year      = {2017},
  abstract  = {This paper reports a search for triboson \({W^\pm}{W^\pm}{W^\mp}\) production in two decay channels (\({W^\pm}{W^\pm}{W^\mp}\) → \({ℓ^\pm}{νℓ^\pm}{νℓ^\mp}{ν}\) and \({W^\pm}{W^\pm}{W^\mp}\) → \({ℓ^\pm}{νℓ^\pm}{νjj}\) with \(ℓ=e,μ\)) in proton-proton collision data corresponding to an integrated luminosity of 20.3 fb\(^{-1}\) at a centre-of-mass energy of 8 TeV with the ATLAS detector at the Large Hadron Collider. Events with exactly three charged leptons, or two leptons with the same electric charge in association with two jets, are selected. The total number of events observed in data is consistent with the Standard Model (SM) predictions. The observed 95\% confidence level upper limit on the SM \({W^\pm}{W^\pm}{W^\mp}\) production cross section is found to be 730 fb with an expected limit of 560 fb in the absence of SM \({W^\pm}{W^\pm}{W^\mp}\) production. Limits are also set on \(WWWW\) anomalous quartic gauge couplings.},
  language  = {en}
}
@article{OPUS4-17369,
  title     = {A measurement of the calorimeter response to single hadrons and determination of the jet energy scale uncertainty using LHC Run-1 \(pp\)-collision data with the ATLAS detector},
  series = {European Physical Journal C},
  volume    = {77},
  journal   = {European Physical Journal C},
  number    = {26},
  organization    = {The ATLAS Collaboration},
  doi       = {10.1140/epjc/s10052-016-4580-0},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-173690},
  year      = {2017},
  abstract  = {A measurement of the calorimeter response to isolated charged hadrons in the ATLAS detector at the LHC is presented. This measurement is performed with 3.2 nb\(^{-1}\) of proton-proton collision data at \(\sqrt{s}\) = 7 TeV from 2010 and 0.1 nb\(^{-1}\) of data at \(\sqrt{s}\) = 8 TeV from 2012. A number of aspects of the calorimeter response to isolated hadrons are explored. After accounting for energy deposited by neutral particles, there is a 5\% discrepancy in the modelling, using various sets of GEANT4 hadronic physics models, of the calorimeter response to isolated charged hadrons in the central calorimeter region. The description of the response to anti-protons at low momenta is found to be improved with respect to previous analyses. The electromagnetic and hadronic calorimeters are also examined separately, and the detector simulation is found to describe the response in the hadronic calorimeter well. The jet energy scale uncertainty and correlations in scale between jets of different momenta and pseudorapidity are derived based on these studies. The uncertainty is 2-5\% for jets with transverse momenta above 2 TeV, where this method provides the jet energy scale uncertainty for ATLAS.},
  language  = {en}
}
@article{ChiesaGreinerSchoenherretal.2017,
  author    = {Chiesa, Mauro and Greiner, Nicolas and Sch{\"o}nherr, Marek and Tramontano, Francesco},
  title     = {Electroweak corrections to diphoton plus jets},
  series = {Journal of High Energy Physics},
  journal   = {Journal of High Energy Physics},
  number    = {10},
  doi       = {10.1007/JHEP10(2017)181},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-173512},
  year      = {2017},
  abstract  = {We calculate the next-to-leading order electroweak corrections to the production of a photon pair in association with zero, one and two jets at the LHC. We use GoSam and Sherpa to obtain the results in a fully automated way. For a typical set of fiducial cuts the electroweak corrections lead to a modification of the total cross section of up to 3\%, depending on the jet multiplicity. We find substantial contributions in differential distributions, leading to tens of per cent corrections for phase space regions within the reach of the LHC. Furthermore we investigate the importance of photon induced processes as well as subleading contributions. Photon induced processes are found to be negligible, subleading contributions can have a sizeable impact however they can be removed by appropriate phase space cuts.},
  language  = {en}
}