@article{LuxBanckSassmannshausenetal.2022, author = {Lux, Thomas J. and Banck, Michael and Saßmannshausen, Zita and Troya, Joel and Krenzer, Adrian and Fitting, Daniel and Sudarevic, Boban and Zoller, Wolfram G. and Puppe, Frank and Meining, Alexander and Hann, Alexander}, title = {Pilot study of a new freely available computer-aided polyp detection system in clinical practice}, series = {International Journal of Colorectal Disease}, volume = {37}, journal = {International Journal of Colorectal Disease}, number = {6}, doi = {10.1007/s00384-022-04178-8}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-324459}, pages = {1349-1354}, year = {2022}, abstract = {Purpose Computer-aided polyp detection (CADe) systems for colonoscopy are already presented to increase adenoma detection rate (ADR) in randomized clinical trials. Those commercially available closed systems often do not allow for data collection and algorithm optimization, for example regarding the usage of different endoscopy processors. Here, we present the first clinical experiences of a, for research purposes publicly available, CADe system. Methods We developed an end-to-end data acquisition and polyp detection system named EndoMind. Examiners of four centers utilizing four different endoscopy processors used EndoMind during their clinical routine. Detected polyps, ADR, time to first detection of a polyp (TFD), and system usability were evaluated (NCT05006092). Results During 41 colonoscopies, EndoMind detected 29 of 29 adenomas in 66 of 66 polyps resulting in an ADR of 41.5\%. Median TFD was 130 ms (95\%-CI, 80-200 ms) while maintaining a median false positive rate of 2.2\% (95\%-CI, 1.7-2.8\%). The four participating centers rated the system using the System Usability Scale with a median of 96.3 (95\%-CI, 70-100). Conclusion EndoMind's ability to acquire data, detect polyps in real-time, and high usability score indicate substantial practical value for research and clinical practice. Still, clinical benefit, measured by ADR, has to be determined in a prospective randomized controlled trial.}, language = {en} } @article{SudarevicTroyaFuchsetal.2023, author = {Sudarevic, Boban and Troya, Joel and Fuchs, Karl-Hermann and Hann, Alexander and Vereczkei, Andras and Meining, Alexander}, title = {Design and development of a flexible 3D-printed endoscopic grasping instrument}, series = {Applied Sciences}, volume = {13}, journal = {Applied Sciences}, number = {9}, issn = {2076-3417}, doi = {10.3390/app13095656}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-319186}, year = {2023}, abstract = {(1) Background: Interventional endoscopic procedures are growing more popular, requiring innovative instruments and novel techniques. Three-dimensional printing has demonstrated great potential for the rapid development of prototypes that can be used for the early assessment of various concepts. In this work, we present the development of a flexible endoscopic instrument and explore its potential benefits. (2) Methods: The properties of the instrument, such as its maneuverability, flexibility, and bending force, were evaluated in a series of bench tests. Additionally, the effectiveness of the instrument was evaluated in an ex vivo porcine model by medical experts, who graded its properties and performance. Furthermore, the time necessary to complete various interventional endoscopic tasks was recorded. (3) Results: The instrument achieved bending angles of ±216° while achieving a bending force of 7.85 (±0.53) Newtons. The time needed to reach the operating region was 120 s median, while it took 70 s median to insert an object in a cavity. Furthermore, it took 220 s median to insert the instrument and remove an object from the cavity. (4) Conclusions: This study presents the development of a flexible endoscopic instrument using three-dimensional printing technology and its evaluation. The instrument demonstrated high bending angles and forces, and superior properties compared to the current state of the art. Furthermore, it was able to complete various interventional endoscopic tasks in minimal time, thus potentially leading to the improved safety and effectiveness of interventional endoscopic procedures in the future.}, language = {en} } @article{KrenzerBanckMakowskietal.2023, author = {Krenzer, Adrian and Banck, Michael and Makowski, Kevin and Hekalo, Amar and Fitting, Daniel and Troya, Joel and Sudarevic, Boban and Zoller, Wolfgang G. and Hann, Alexander and Puppe, Frank}, title = {A real-time polyp-detection system with clinical application in colonoscopy using deep convolutional neural networks}, series = {Journal of Imaging}, volume = {9}, journal = {Journal of Imaging}, number = {2}, issn = {2313-433X}, doi = {10.3390/jimaging9020026}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-304454}, year = {2023}, abstract = {Colorectal cancer (CRC) is a leading cause of cancer-related deaths worldwide. The best method to prevent CRC is with a colonoscopy. During this procedure, the gastroenterologist searches for polyps. However, there is a potential risk of polyps being missed by the gastroenterologist. Automated detection of polyps helps to assist the gastroenterologist during a colonoscopy. There are already publications examining the problem of polyp detection in the literature. Nevertheless, most of these systems are only used in the research context and are not implemented for clinical application. Therefore, we introduce the first fully open-source automated polyp-detection system scoring best on current benchmark data and implementing it ready for clinical application. To create the polyp-detection system (ENDOMIND-Advanced), we combined our own collected data from different hospitals and practices in Germany with open-source datasets to create a dataset with over 500,000 annotated images. ENDOMIND-Advanced leverages a post-processing technique based on video detection to work in real-time with a stream of images. It is integrated into a prototype ready for application in clinical interventions. We achieve better performance compared to the best system in the literature and score a F1-score of 90.24\% on the open-source CVC-VideoClinicDB benchmark.}, language = {en} }