@article{KerkauSchmittLandgrafSchimpletal.1989,
  author    = {Kerkau, Thomas and Schmitt-Landgraf, Renate and Schimpl, Anneliese and Wecker, Eberhard},
  title     = {Downregulation of HLA Class I Antigensin HIV-1-Infected Cells},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-47172},
  year      = {1989},
  abstract  = {By means of indirect immunofluorescence analysis we investigated the effect of HIV -1 infection on HLA class I surface antigens. We report here that in CD4\(^+\) HeLa cells, in H9 cells, and in peripheral T Iymphocytes HLA class I antigens are down regulated following infection with HIV -1. The downregulation is effected at a posttranscriptional level since the amounts of HLA class I specific mRNA are similar in infected and uninfected cells. This phenomenon is not only correlated with the state of infection, that is, the presence of P24 of HIV-l in the cells, but also depends on the time of infection. Upon HLA class I downregulation by HIV infection, the specific lysis of peripheral blood cells by allogeneic CTL is reduced.},
  language  = {en}
}
@article{KneitzKerkauMuelleretal.1993,
  author    = {Kneitz, Christian and Kerkau, Thomas and M{\"u}ller, Justus and Coulibaly, Cheick and Stahl-Henning, Christiane and Hunsmann, Gerhard and H{\"u}nig, Thomas and Schimpl, Anneliese},
  title     = {Early phenotypic and functional alterations in lymphocytes from simian immunodeficiency virus infected macaques},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-32593},
  year      = {1993},
  abstract  = {Phenotypic and functional changes in lymphocytes from rhesus monkeys (Macaca mulatta) were investigated during the first 6 months after infection with SIVmac 32H. Animals preimmunized with keyhole limpet hemocyanin (KLH) were sacrificed l, 3, 6, 12, and 24 weeks post infection. Subset composition and function of lymphocytes from blood, spleen, lymph node and thymus were analysed. In addition to a rapid decline in CD4/CD8 ratios, a massive reduction in CD29+CD4+ cells was seen in the periphery. Although depletion of this subset was observed throughout the course of this experiment, the loss of proliferative T cell responses was most pronounced very early after infection and partially recovered after Month 3. Polyclonal cytotoxic responses were only slightly affected. In the thymus, a gradual, but moderate loss of CD4 + CD8 + immature thymocytes, and a relative increase in both CD4 + and CD8 + mature subsets was observed. Infectious virus was readily recovered from homogenates of lymph node and spleen, but not of thymus tissue. Interestingly, however, virus was detected in thymocytes from all infected animals by cocultivation with a simian immunodeficiency virus (SIV) susceptible cell line.},
  language  = {en}
}