@article{AbuHalimaHaeuslerBackesetal.2017,
  author    = {Abu-Halima, Masood and H{\"a}usler, Sebastian and Backes, Christina and Fehlmann, Tobias and Staib, Claudia and Nestel, Sigrun and Nazarenko, Irina and Meese, Eckart and Keller, Andreas},
  title     = {Micro-ribonucleic acids and extracellular vesicles repertoire in the spent culture media is altered in women undergoing \(In\) \(Vitro\) Fertilization},
  series = {Scientific Reports},
  volume    = {7},
  journal   = {Scientific Reports},
  doi       = {10.1038/s41598-017-13683-8},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-173632},
  year      = {2017},
  abstract  = {MicroRNAs (miRNAs) are class of small RNA molecules with major impact on gene regulation. We analyzed the potential of miRNAs secreted from pre-implantation embryos into the embryonic culture media as biomarkers to predict successful pregnancy. Using microarray analysis, we profiled the miRNome of the 56 spent culture media (SCM) after embryos transfer and found a total of 621 miRNAs in the SCM. On average, we detected 163 miRNAs in SCM of samples with failed pregnancies, but only 149 SCM miRNAs of embryos leading to pregnancies. MiR-634 predicted an embryo transfer leading to a positive pregnancy with an accuracy of 71\% and a sensitivity of 85\%. Among the 621 miRNAs, 102 (16.4\%) showed a differential expression between positive and negative outcome of pregnancy with miR-29c-3p as the most significantly differentially expressed miRNA. The number of extracellular vehicles was lower in SCM with positive outcomes (3.8 × 10\(^9\)/mL EVs), as compared to a negative outcome (7.35 × 10\(^9\)/mL EVs) possibly explaining the reduced number of miRNAs in the SCM associated with failed pregnancies. The analysis of the miRNome in the SCM of couples undergoing fertility treatment lays the ground towards development of biomarkers to predict successful pregnancy and towards understanding the role of embryonic miRNAs found in the SCM.},
  language  = {en}
}
@article{AdrianMartinezAlbertAndreetal.2017,
  author    = {Adri{\´a}n-Mart{\´i}nez, S. and Albert, A. and Andr{\´e}, M. and Anghinolfi, M. and Anton, G. and Ardid, M. and Aubert, J.-J. and Baret, B. and Barrios-Marti, J. and Basa, S. and Bertin, V. and Biagi, S. and Bormuth, R. and Bouwhuis, M.C. and Bruijn, R. and Brunner, J. and Buto, J. and Capone, A. and Caramete, L. and Carr, J. and Chiarusi, T. and Circella, M. and Coniglione, R. and Costantini, H. and Coyle, P. and Creusot, A. and Dekeyser, I. and Deschamps, A. and De Bonis, G. and Distefano, C.},
  title     = {Stacked search for time shifted high energy neutrinos from gamma ray bursts with the ANTARES neutrino telescope},
  series = {European Physical Journal C},
  volume    = {77},
  journal   = {European Physical Journal C},
  number    = {1},
  doi       = {10.1140/epjc/s10052-016-4496-8},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-181251},
  pages     = {10},
  year      = {2017},
  abstract  = {A search for high-energy neutrino emission correlated with gamma-ray bursts outside the electromagnetic prompt-emission time window is presented. Using a stacking approach of the time delays between reported gamma-ray burst alerts and spatially coincident muon-neutrino signatures, data from the Antares neutrino telescope recorded between 2007 and 2012 are analysed. One year of public data from the IceCube detector between 2008 and 2009 have been also investigated. The respective timing profiles are scanned for statistically significant accumulations within 40 days of the Gamma Ray Burst, as expected from Lorentz Invariance Violation effects and some astrophysical models. No significant excess over the expected accidental coincidence rate could be found in either of the two data sets. The average strength of the neutrino signal is found to be fainter than one detectable neutrino signal per hundred gamma-ray bursts in the Antares data at 90\% confidence level.},
  language  = {en}
}
@article{AeschlimannBrixnerCinchettietal.2017,
  author    = {Aeschlimann, Martin and Brixner, Tobias and Cinchetti, Mirko and Frisch, Benjamin and Hecht, Bert and Hensen, Matthias and Huber, Bernhard and Kramer, Christian and Krauss, Enno and Loeber, Thomas H. and Pfeiffer, Walter and Piecuch, Martin and Thielen, Philip},
  title     = {Cavity-assisted ultrafast long-range periodic energy transfer between plasmonic nanoantennas},
  series = {Light: Science \& Applications},
  volume    = {6},
  journal   = {Light: Science \& Applications},
  doi       = {10.1038/lsa.2017.111},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-173265},
  year      = {2017},
  abstract  = {Radiationless energy transfer is at the core of diverse phenomena, such as light harvesting in photosynthesis\(^1\), energy-transfer-based microspectroscopies\(^2\), nanoscale quantum entanglement\(^3\) and photonic-mode hybridization\(^4\). Typically, the transfer is efficient only for separations that are much shorter than the diffraction limit. This hampers its application in optical communication and quantum information processing, which require spatially selective addressing. Here, we demonstrate highly efficient radiationless coherent energy transfer over a distance of twice the excitation wavelength by combining localized and delocalized\(^5\) plasmonic modes. Analogous to the Tavis-Cummings model, two whispering-gallery-mode antennas\(^6\) placed in the foci of an elliptical plasmonic cavity\(^7\) fabricated from single-crystal gold plates act as a pair of oscillators coupled to a common cavity mode. Time-resolved two-photon photoemission electron microscopy (TR 2P-PEEM) reveals an ultrafast long-range periodic energy transfer in accordance with the simulations. Our observations open perspectives for the optimization and tailoring of mesoscopic energy transfer and long-range quantum emitter coupling.},
  language  = {en}
}
@article{AhmedOjhaHirschetal.2017,
  author    = {Ahmed, Bilal and Ojha, Animesh K. and Hirsch, Florian and Fischer, Ingo and Patrice, Donfack and Materny, Arnulf},
  title     = {Tailoring of enhanced interfacial polarization in WO\(_3\) nanorods grown over reduced graphene oxide synthesized by a one-step hydrothermal method},
  series = {RSC Advances},
  volume    = {7},
  journal   = {RSC Advances},
  number    = {23},
  doi       = {10.1039/c7ra00730b},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-181829},
  pages     = {13985-13996},
  year      = {2017},
  abstract  = {In the present report, well-defined WO3 nanorods (NRs) and a rGO-WO\(_3\) composite were successfully synthesized using a one-pot hydrothermal method. The crystal phase, structural morphology, shape, and size of the as-synthesized samples were studied using X-ray diffraction (XRD) and transmission electron microscopy (TEM) measurements. The optical properties of the synthesized samples were investigated by Raman, ultraviolet-visible (UV-Vis) and photoluminescence (PL) spectroscopy. Raman spectroscopy and TEM results validate the formation of WO\(_3\) (NRs) on the rGO sheet. The value of the dielectric constant (ε′) of WO3 NRs and rGO-WO\(_3\) composite is decreased with an increase in frequency. At low frequency (2.5 to 3.5 Hz), the value of ε′ for the rGO-WO3 composite is greater than that of pure WO\(_3\) NRs. This could be due to the fact that the induced charges follow the ac signal. However, at higher frequency (3.4 to 6.0), the value of ε′ for the rGO-WO\(_3\) composite is less compared to that of the pure WO3 NRs. The overall decrease in the value of ε′ could be due to the occurrence of a polarization process at the interface of the rGO sheet and WO3 NRs. Enhanced interfacial polarization in the rGO-WO\(_3\) composite is observed, which may be attributed to the presence of polar functional groups on the rGO sheet. These functional groups trap charge carriers at the interface, resulting in an enhancement of the interfacial polarization. The value of the dielectric modulus is also calculated to further confirm this enhancement. The values of the ac conductivity of the WO\(_3\) NRs and rGO-WO\(_3\) composite were calculated as a function of the frequency. The greater value of the ac conductivity in the rGO-WO\(_3\) composite compared to that of the WO\(_3\) NRs confirms the restoration of the sp:\(^{++}\) network during the in situ synthesis of the rGO-WO\(_3\) composite, which is well supported by the results obtained by Raman spectroscopy.},
  language  = {en}
}
@article{AichAkhundzadahKnuerretal.2017,
  author    = {Aich, Valentin and Akhundzadah, Noor Ahmad and Knuerr, Alec and Khoshbeen, Ahmad Jamshed and Hattermann, Fred and Paeth, Heiko and Scanlon, Andrew and Paton, Eva Nora},
  title     = {Climate change in Afghanistan deduced from reanalysis and coordinated regional climate downscaling experiment (CORDEX)—South Asia Simulations},
  series = {Climate},
  volume    = {5},
  journal   = {Climate},
  number    = {2},
  issn      = {2225-1154},
  doi       = {10.3390/cli5020038},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-198024},
  pages     = {38},
  year      = {2017},
  abstract  = {Past and the projected future climate change in Afghanistan has been analyzed systematically and differentiated with respect to its different climate regions to gain some first quantitative insights into Afghanistan's vulnerability to ongoing and future climate changes. For this purpose, temperature, precipitation and five additional climate indices for extremes and agriculture assessments (heavy precipitation; spring precipitation; growing season length (GSL), the Heat Wave Magnitude Index (HWMI); and the Standardized Precipitation Evapotranspiration Index (SPEI)) from the reanalysis data were examined for their consistency to identify changes in the past (data since 1950). For future changes (up to the year 2100), the same parameters were extracted from an ensemble of 12 downscaled regional climate models (RCM) of the Coordinated Regional Climate Downscaling Experiment (CORDEX)-South Asia simulations for low and high emission scenarios (Representative Concentration Pathways 4.5 and 8.5). In the past, the climatic changes were mainly characterized by a mean temperature increase above global level of 1.8 °C from 1950 to 2010; uncertainty with regard to reanalyzed rainfall data limited a thorough analysis of past changes. Climate models projected the temperature trend to accelerate in the future, depending strongly on the global carbon emissions (2006-2050 Representative Concentration Pathways 4.5/8.5: 1.7/2.3 °C; 2006-2099: 2.7/6.4 °C, respectively). Despite the high uncertainty with regard to precipitation projections, it became apparent that the increasing evapotranspiration is likely to exacerbate Afghanistan's already existing water stress, including a very strong increase of frequency and magnitude of heat waves. Overall, the results show that in addition to the already extensive deficiency in adaptation to current climate conditions, the situation will be aggravated in the future, particularly in regard to water management and agriculture. Thus, the results of this study underline the importance of adequate adaptation to climate change in Afghanistan. This is even truer taking into account that GSL is projected to increase substantially by around 20 days on average until 2050, which might open the opportunity for extended agricultural husbandry or even additional harvests when water resources are properly managed.},
  language  = {en}
}
@phdthesis{AlHazza2017,
  author    = {Al-Hazza, Aseel},
  title     = {Zu Grad, Konfiguration und Verlauf der Schallempfindungsschwerh{\"o}rigkeit bei Kindern mit einer Connexin-26-Mutation},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-150966},
  school      = {Universit{\"a}t W{\"u}rzburg},
  year      = {2017},
  abstract  = {Verschiedene Forschungsergebnisse der letzten zehn Jahre ergaben, dass die weitaus h{\"a}ufigeren, nicht-syndromalen Schwerh{\"o}rigkeiten durch Mutation eines Gens (GJB2-Gen) entstehen, welches im Cortischen Organ des Innenohrs exprimiert wird. Das GJB2-Gen (Connexin-26-Gen), dessen Ver{\"a}nderung etwa 50 \% der F{\"a}lle von autosomal rezessiver Schwerh{\"o}rigkeit ausmacht, liegt im Chromosomenbereich 13q11-12. Aktuell identifiziert sind mehr als 70 weitere Loki, die in Verbindung mit nicht-syndromalen Formen von Schwerh{\"o}rigkeit stehen. Die Pr{\"a}valenz von NSHL betr{\"a}gt nach neusten Studien ca. 1,33 pro 1000 Neugeborenen. In W{\"u}rzburg wurden bis zum Jahr 2011 auf der Neugeborenenstation der Frauenklinik der Universit{\"a}tsklinik in einem bew{\"a}hrten zweistufigen Neugeborenen-H{\"o}rscreening ca. 12853 Babys untersucht. Ziel des Neugeborenen-H{\"o}rscreenings ist eine fr{\"u}hestm{\"o}gliche Erkennung von Schwerh{\"o}rigkeit bei Neugeborenen, damit durch die Behandlung eine ungehinderte Sprachentwicklung gew{\"a}hrleistet werden kann. In dieser Arbeit wurde der Zusammenhang zwischen der Mutation im Connexin-26-Gen und dem Grad, dem Verlauf und der Konfiguration der H{\"o}rminderung untersucht. Hierf{\"u}r wurden 59 Patienten im Alter von 1 bis 15 Jahren mit beidseitigen, nicht-syndromalen H{\"o}rst{\"o}rungen der Schallempfindung verschiedenen Grades rekrutiert. Mithilfe der molekulargenetischen Befunde konnten Ver{\"a}nderungen im Connexin-26-Gen diagnostiziert werden. Anschließend wurde versucht, unter Zuhilfenahme aller vorhandenen Befunde der individuellen Audiogramm- und BERA- oder ASSR-Befunde eine Genotyp-Ph{\"a}notyp-Korrelation abzuleiten.},
  subject      = {Connexin-26-Mutation},
  language  = {de}
}
@phdthesis{Ali2017,
  author    = {Ali, Qasim},
  title     = {Distributed Control of Cooperating Mini UAVs},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-140686},
  school      = {Universit{\"a}t W{\"u}rzburg},
  year      = {2017},
  abstract  = {Mini Unmanned Aerial Vehicles (MUAVs) werden immer beliebtere Forschungsplattformen. Vor allem in den letzten Jahren ziehen sie aufgrund ihrer Erschwinglichkeit und ihrer Flexibilit{\"a}t, die es erlaubt sie in fast allen Lebensbereichen einzusetzen, betr{\"a}chtliche Aufmerksamkeit auf sich. MUAVs haben offensichtliche Vorteile gegen{\"u}ber bemannten Plattformen einschließlich ihrer viel geringeren Herstellungs- und Betriebskosten, Risikovermeidung f{\"u}r den menschlichen Piloten, der M{\"o}glichkeit sicher niedrig und langsam fliegen zu k{\"o}nnen, und Realisierung von Operationen, die {\"u}ber die inh{\"a}renten Grenzen des menschlichen K{\"o}rpers hinausgehen. Der Fortschritt in der Micro Electro-Mechanical System (MEMS) Technologie, Avionik und Miniaturisierung von Sensoren spielte auch eine bedeutende Rolle bei der Entwicklung der MUAVs. Diese Flugger{\"a}te reichen von einfachem Spielzeug aus dem Elektrofachhandel bis zu hoch entwickelten, kommerziellen Plattformen, die die Durchf{\"u}hrung neuer Aufgaben wie Offshore-Windkraftwerk Inspektionen, 3D-Modellierung von Geb{\"a}uden usw. erlauben. MUAVs sind auch umweltfreundlich, da sie weniger Luftverschmutzung und L{\"a}rm verursachen. Unbemannt ist daher un{\"u}bertroffen. Aktuelle Forschung konzentriert sich auf die M{\"o}glichkeit mehrere kosteng{\"u}nstige Flugger{\"a}te zusammen fliegen zu lassen, w{\"a}hrend die erforderliche relative r{\"a}umliche Trennungen beibehalten wird. Dies erm{\"o}glicht es effizient Aufgaben zu erf{\"u}llen im Vergleich zu einem einzigen sehr teuren Flugger{\"a}t. Durch die Redundanz entf{\"a}llt auch das Risiko des Scheiterns der Mission durch den Verlust eines einzigen Flugger{\"a}ts. Wertvolle Aufgaben, die kooperative Flugger{\"a}te ausf{\"u}hren k{\"o}nnen, sind beispielsweise gemeinsame Lasttransporte, Such- und Rettungsmissionen, mobile Kommunikationsrelais, Spr{\"u}hen von Pestiziden und Wetterbeobachtung. Obwohl die Realisierung von Fl{\"u}gen mit mehreren, gekoppelten UAVs komplex ist, rechtfertigen dennoch offensichtliche Vorteile diese m{\"u}hsame und aufw{\"a}ndige Entwicklungsarbeit. Verteilte Steuerung von kooperierenden Einheiten ist ein multidisziplin{\"a}res Thema, das es erfordert in diversifizierten Bereichen zu arbeiten. Dazu geh{\"o}ren MUAV Hardware und Software, Kommunikationstechniken f{\"u}r den notwendigen Informationsaustausch, Flugdynamik, Regelungstechnik, insbesondere f{\"u}r verteilte / kooperative Steuerungstechniken, Graphentheorie f{\"u}r Kommunikationstopologie Modellierung und Sensoren-Technologie wie Differential GPS (DGPS). F{\"u}r eine Flotte von Agenten, die in unmittelbarer N{\"a}he fliegen, ist eine genaue Positionsbestimmung zwingend n{\"o}tig um Kollisionen zu vermeiden und die Anforderungen f{\"u}r die meisten Missionen wie Georeferenzierung zu erf{\"u}llen. F{\"u}r solche Szenarien ist DGPS ein potenzieller Kandidat. Ein Teil der Forschung konzentriert sich daher auf die Entwicklung von DGPS Code. Eines der Module dieser Forschung war Hardware-Implementierung. Ein einfacher Test-Aufbau zur Realisierung von Basisfunktionalit{\"a}ten f{\"u}r Formationsflug von Quadrocoptern wurde am Lehrstuhl f{\"u}r Informationstechnik in der Luft- und Raumfahrt der Universit{\"a}t W{\"u}rzburg entwickelt. Diese Testumgebung kann nicht nur zur Pr{\"u}fung und Validierung von Algorithmen f{\"u}r Formationsflug in realer Umgebung genutzt werden, sondern dient auch zur Ausbildung von Studenten. Ein bereits vorhandener Pr{\"u}fstand f{\"u}r einzelne Quadrocopter wurde mit den notwendigen Kommunikation und verteilten Steuerung erweitert, um Algorithmen f{\"u}r Formationsfl{\"u}ge in drei Freiheitsgraden (Roll / Nick / Gier) zu testen. Diese Studie umfasst die Bereiche der Kommunikation, Steuerungstechnik und Embedded-System-Programmierung. Das Bluetooth-Protokoll wurde f{\"u}r die gegenseitige Kommunikation zwischen zwei Quadrocoptern verwendet. Eine einfache Technik der Proportional-Integral-Differential (PID) Steuerung in Kombination mit Kalman-Filter wurde genutzt. Die MATLAB Instrument Control Toolbox wurde f{\"u}r die Datenanzeige, die Analyse und das Plotten verwendet. Plots k{\"o}nnen in Echtzeit gezeichnet werden und empfangene Daten k{\"o}nnen auch in Form von Dateien zur sp{\"a}teren Verwendung und Analyse gespeichert werden. Das System wurde preisg{\"u}nstig, unter Ber{\"u}cksichtigung eines einfachen Aufbaus, entwickelt. Der vorgeschlagene Aufbau ist sehr flexibel und kann einfach an ver{\"a}nderte Anforderungen angepasst werden. Als verteiltes Steuerungsschema wurde ein zentralisierter, heterogener Formationsflug Positionsregler formuliert, der einen „explicit model following Linear Quadratic Regulator Proportional Integral (LQR PI)" Regler verwendet. Der Anf{\"u}hrer Quadrocopter ist ein stabiles Referenzmodell mit der gew{\"u}nschten Dynamik, deren Ausgang vollkommen von den beiden Wingmen Quadrocopter verfolgt wird. Der Anf{\"u}hrer selbst wird durch Pole Placement Steuerverfahren mit den gew{\"u}nschten Stabilit{\"a}tseigenschaften gesteuert, w{\"a}hrend die beiden Anh{\"a}nger durch robuste und adaptive LQR PI Steuerverfahren geregelt werden. F{\"u}r diese Studie wird ein Vollzustandsvektor der Quadrocopter betrachtet w{\"a}hrend nur die resultierende Leistung verfolgt wird. Die ausgew{\"a}hlte 3D Formationsgeometrie und die statische Stabilit{\"a}t bleibt unter einer Vielzahl von m{\"o}glichen St{\"o}rungen erhalten. Bei Kommunikationsverlust zwischen Anf{\"u}hrer und einem der Anh{\"a}nger, leitet der andere Anh{\"a}nger die Daten, die er vom Anf{\"u}hrer erhalten hat, an den betroffenen Anh{\"a}nger weiter. Die Stabilit{\"a}t des Regelsystems wurde unter Verwendung von Singul{\"a}rwerten analysiert. Der vorgeschlagene Ansatz f{\"u}r eng gekoppelten Formationsflug von MUAVs wurde mit Hilfe von umfangreichen Simulationen unter MATLAB® / Simulink® validiert und ergab viel versprechende Ergebnisse. Auch die Tracking-Leistung wurde f{\"u}r zeitlich ver{\"a}nderliche Befehle gezeigt. Die vorgeschlagene Architektur ist skalierbar und kann problemlos erweitert werden. Dieser Ansatz ist f{\"u}r die Szenarien geeignet, die eng gekoppelte Formationsflug ben{\"o}tigen, wie kooperatives Greifen oder gemeinsame Lasttransporte. Ein innovatives Framework f{\"u}r die Teamarbeit von zwei Quadrocopter Flotten wurde entwickelt. Als Beispielmission wurde ein Szenario gew{\"a}hlt, bei dem ein Feuer auf einer gr{\"o}ßeren Fl{\"a}che gel{\"o}scht werden muss. Jede Formation hat ihre angegebene Formationsgeometrie und eine zugewiesene Aufgabe. Die Lageregelung f{\"u}r die Quadrocopter in einer der Formationen wurde durch ein LQR PI-Regelschema, das auf „explicit model following" basiert, umgesetzt. Die Quadrocopter in anderen Formation werden durch ein LQR PI Servomechanismus Regelsystem gesteuert. Die beiden Steuersysteme werden in Bezug auf ihre Leistung und ihren Steuerungsaufwand verglichen. Beide Formationen werden durch entsprechende Bodenstationen durch virtuelle Anf{\"u}hrer kommandiert. Die Bodenstationen tauschen die befohlene H{\"o}heninformation aus, um gegenseitig eine sichere Trennung zwischen den Formationen zu gew{\"a}hrleisten. Die Quadrocopter k{\"o}nnen kommandierte Solltrajektorien folgen und {\"u}ber erw{\"u}nschten Punkten f{\"u}r eine vorgegebene Zeit schweben. Bei Kommunikationsverlust zwischen Bodenstation und einem der Quadcopter leitet der benachbarte Quadrocopter die Befehlsdaten, die er von der Bodenstation erhalten hat, an die betroffene Einheit weiter. Das vorgeschlagene Framework wurde durch umfangreiche Simulationen mit Hilfe von MATLAB® / Simulink® validiert und liefert sehr brauchbare Ergebnisse. Cluster-Rekonfiguration von Agenten wird in unserer Arbeit ebenfalls gezeigt. Dies erlaubt es die Formationsgeometrie w{\"a}hrend des Fluges auf eine beliebige neue Form umzuschalten. F{\"u}r die genannten Anwendungen sind Konsens Algorithmen nicht erw{\"u}nscht, da wir von den Quadrocopter Flotten fordern, dass sie dem von uns gew{\"a}hlten Weg folgen, und nicht ihren Weg selbst w{\"a}hlen. Eine Reihe der praktischen Probleme von Kommunikationsnetzen kann in geeigneter Weise durch Graphen dargestellt werden. Dies erleichtert die Problemformulierung und den Analyseprozess. Kommunikationstopologien f{\"u}r Netzwerke mit einer großen Anzahl von Einheiten, wie zum Beispiel Schw{\"a}rme von Luftfahrzeugen, k{\"o}nnen durch einen graphentheoretischen Ansatz untersucht werden. Um die Bildung solcher Probleme zu erleichtern, wird der Graph mit Hilfe der Laplace-Matrix dargestellt. Eigenwerte der Laplace-Matrix wurden in unserer Studie angemessene Ber{\"u}cksichtigung gegeben einen Einblick in die Graphen / Subgraphen Eigenschaften zu verleihen. Der gleiche wurden genutzt um die bekannte Euler Formel zu verallgemeinern und somit auf Graphen und Subgraphen anwendbar zu machen. Eine modifizierte Euler-Formel wird ebenfalls vorgestellt. Die Verwendung der Graphentheorie in verteilten / kooperativen Regelsystemen wird auch durch Simulationen gezeigt. Kooperative Kontrolschemas, die auf auf Konsens-Algorithmen beruhenden, wurden f{\"u}r die Lageregelung von Quadrocopter-Flotten, in denen kein expliziter Anf{\"u}hrer existiert, verwendet. Konsens-Algorithmen wurden in Kombination mit verschiedenen Steuersystemen verwendet, was zur Autonomie von Quadrocoptern beitr{\"a}gt. Die Steuersysteme, die f{\"u}r diesen Zweck verwendet werden, umfassen LQR PI-Regelung basierend auf „model following" und LQR PI Servo-Mechanismus. Die Regelungen wurden unter verschiedenen Kommunikationstopologien untersucht, darunter voll verbundene ungerichtete Graphen, gerichteten Graphen und Zyklus-Topologie. Der Informationsfluss unter den Agenten in einem Cluster wurde durch Laplace-Matrix modelliert. Die Auswirkungen von Eingangs Verzerrungen auf Konsens Werte wurden ebenfalls untersucht. Quadrocopter k{\"o}nnen durch gegenseitigen Konsens Flugbahnen verfolgen und die Zielpunkte erreichen. Die vorgeschlagenen Regelungssysteme wurden unter verschiedenen Kommunikationstopologien in Matlab / Simulink-Umgebung durch umfangreiche Simulationen validiert. Die Ergebnisse bescheinigen die Wirksamkeit der pr{\"a}sentierten Schemata mit dem zus{\"a}tzlichen Vorteil der Einfachheit der Umsetzung. Das vorgeschlagene Regelungssystem ist skalierbar f{\"u}r große Gruppen von MUAVs. F{\"u}r Formationsflug sind die Anforderungen an die Positionsgenauigkeit sehr hoch. GPS-Signale allein bieten keine ausreichend hohe Positionsgenauigkeit um die Anforderung zu erf{\"u}llen; eine Technik f{\"u}r die genauere Positionsbestimmung ist daher erforderlich, beispielsweise DGPS. Es existiert eine Anzahl von {\"o}ffentlichen Codes f{\"u}r die GPS-Positionsbestimmung und Baseline-Bestimmung im Offline-Modus. Es existiert jedoch keine Software f{\"u}r DGPS, die Korrekturfaktoren der Basisstationen nutzt, ohne auf Doppel Differenz Informationen zu vertrauen. Um dies zu erreichen, wurde eine Methodik in MATLAB-Umgebung f{\"u}r DGPS mit C/A Pseudoranges nur auf einzelne Frequenz L1 eingef{\"u}hrt es machbar f{\"u}r Empf{\"a}nger kosteng{\"u}nstig GPS zu nutzen. Unsere Basisstation wird an einem genau vermessen Referenzpunkt aufgestellt. Pseudoranges und geometrische Abst{\"a}nde werden an der Basisstation verglichen, um die Korrekturfaktoren zu berechnen. Diese Korrekturfaktoren, f{\"u}r aller g{\"u}ltigen Satelliten w{\"a}hrend einer Epoche, werden dann an einen Rover {\"u}bergeben. Das Rover ber{\"u}cksichtigt innerhalb der entsprechenden Epoche diese f{\"u}r seine eigene wahre Positionsbestimmung. Zur Validierung der vorgeschlagenen Algorithmen wird unsere Rover ebenfalls an einer vorbestimmten Stelle platziert. Der vorgeschlagene Code ist ein geeignetes und einfaches Werkzeug f{\"u}r die Nachbearbeitung von GPS-Rohdaten f{\"u}r eine genaue Positionsbestimmung eines Rover, z.B. eines UAV w{\"a}hrend der Post-Missionsanalyse.},
  subject      = {Micro Air Vehicle},
  language  = {en}
}
@article{AltieriSbieraDellaCasaetal.2017,
  author    = {Altieri, Barbara and Sbiera, Silviu and Della Casa, Silvia and Weigand, Isabel and Wild, Vanessa and Steinhauer, Sonja and Fadda, Guido and Kocot, Arkadius and Bekteshi, Michaela and Mambretti, Egle M. and Rosenwald, Andreas and Pontecorvi, Alfredo and Fassnacht, Martin and Ronchi, Cristina L.},
  title     = {Livin/BIRC7 expression as malignancy marker in adrenocortical tumors},
  series = {Oncotarget},
  volume    = {8},
  journal   = {Oncotarget},
  number    = {6},
  doi       = {10.18632/oncotarget.14067},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-171887},
  pages     = {9323-9338},
  year      = {2017},
  abstract  = {Livin/BIRC7 is a member of the inhibitors of apoptosis proteins family, which are involved in tumor development through the inhibition of caspases. Aim was to investigate the expression of livin and other members of its pathway in adrenocortical tumors and in the adrenocortical carcinoma (ACC) cell line NCI-H295R. The mRNA expression of livin, its isoforms α and β, XIAP, CASP3 and DIABLO was evaluated by qRT-PCR in 82 fresh-frozen adrenal tissues (34 ACC, 25 adenomas = ACA, 23 normal adrenal glands = NAG). Livin protein expression was assessed by immunohistochemistry in 270 paraffin-embedded tissues (192 ACC, 58 ACA, 20 NAG). Livin, CASP3 and cleaved caspase-3 were evaluated in NCI-H295R after induction of livin overexpression. Relative livin mRNA expression was significantly higher in ACC than in ACA and NAG (0.060 ± 0.116 vs 0.004 ± 0.014 and 0.002 ± 0.009, respectively, p < 0.01), being consistently higher in tumors than in adjacent NAG and isoform β more expressed than α. No significant differences in CASP3, XIAP and DIABLO levels were found among these groups. In immunohistochemistry, livin was localized in both cytoplasm and nuclei. The ratio between cytoplasmic and nuclear staining was significantly higher in ACC (1.51 ± 0.66) than in ACA (0.80 ± 0.35) and NAG (0.88 ± 0.27; p < 0.0001). No significant correlations were observed between livin expression and histopathological parameters or clinical outcome. In NCI-H295R cells, the livin overexpression slightly reduced the activation of CASP3, but did not correlate with cell viability. In conclusion, livin is specifically over-expressed in ACC, suggesting that it might be involved in adrenocortical tumorigenesis and represent a new molecular marker of malignancy.},
  language  = {en}
}
@article{AmorettiAreanArgurioetal.2017,
  author    = {Amoretti, Andrea and Are{\´a}n, Daniel and Argurio, Riccardo and Musso, Daniele and Zayas, Leopoldo A. Pando},
  title     = {A holographic perspective on phonons and pseudo-phonons},
  series = {Journal of High Energy Physics},
  volume    = {5},
  journal   = {Journal of High Energy Physics},
  number    = {51},
  doi       = {10.1007/JHEP05(2017)051},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-170882},
  year      = {2017},
  abstract  = {We analyze the concomitant spontaneous breaking of translation and conformal symmetries by introducing in a CFT a complex scalar operator that acquires a spatially dependent expectation value. The model, inspired by the holographic Q-lattice, provides a privileged setup to study the emergence of phonons from a spontaneous translational symmetry breaking in a conformal field theory and offers valuable hints for the treatment of phonons in QFT at large. We first analyze the Ward identity structure by means of standard QFT techniques, considering both spontaneous and explicit symmetry breaking. Next, by implementing holographic renormalization, we show that the same set of Ward identities holds in the holographic Q-lattice. Eventually, relying on the holographic and QFT results, we study the correlators realizing the symmetry breaking pattern and how they encode information about the low-energy spectrum.},
  language  = {en}
}
@article{AmpattuHagmannLiangetal.2017,
  author    = {Ampattu, Biju Joseph and Hagmann, Laura and Liang, Chunguang and Dittrich, Marcus and Schl{\"u}ter, Andreas and Blom, Jochen and Krol, Elizaveta and Goesmann, Alexander and Becker, Anke and Dandekar, Thomas and M{\"u}ller, Tobias and Schoen, Christoph},
  title     = {Transcriptomic buffering of cryptic genetic variation contributes to meningococcal virulence},
  series = {BMC Genomics},
  volume    = {18},
  journal   = {BMC Genomics},
  number    = {282},
  doi       = {10.1186/s12864-017-3616-7},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-157534},
  year      = {2017},
  abstract  = {Background: Commensal bacteria like Neisseria meningitidis sometimes cause serious disease. However, genomic comparison of hyperinvasive and apathogenic lineages did not reveal unambiguous hints towards indispensable virulence factors. Here, in a systems biological approach we compared gene expression of the invasive strain MC58 and the carriage strain α522 under different ex vivo conditions mimicking commensal and virulence compartments to assess the strain-specific impact of gene regulation on meningococcal virulence. Results: Despite indistinguishable ex vivo phenotypes, both strains differed in the expression of over 500 genes under infection mimicking conditions. These differences comprised in particular metabolic and information processing genes as well as genes known to be involved in host-damage such as the nitrite reductase and numerous LOS biosynthesis genes. A model based analysis of the transcriptomic differences in human blood suggested ensuing metabolic flux differences in energy, glutamine and cysteine metabolic pathways along with differences in the activation of the stringent response in both strains. In support of the computational findings, experimental analyses revealed differences in cysteine and glutamine auxotrophy in both strains as well as a strain and condition dependent essentiality of the (p)ppGpp synthetase gene relA and of a short non-coding AT-rich repeat element in its promoter region. Conclusions: Our data suggest that meningococcal virulence is linked to transcriptional buffering of cryptic genetic variation in metabolic genes including global stress responses. They further highlight the role of regulatory elements for bacterial virulence and the limitations of model strain approaches when studying such genetically diverse species as N. meningitidis.},
  language  = {en}
}
@article{ApostolidisGkarpousisKoch2017,
  author    = {Apostolidis -Gkarpousis, Alexandros and Koch, Christian},
  title     = {Convergences et divergences dans les articles «Langage» de Louis de Jaucourt et «Langue» de Nicolas Beauz{\´e}e. Une comparaison de deux articles de l'Encyclop{\´e}die de Diderot et D'Alembert},
  series = {promptus - W{\"u}rzburger Beitr{\"a}ge zur Romanistik},
  volume    = {3},
  journal   = {promptus - W{\"u}rzburger Beitr{\"a}ge zur Romanistik},
  issn      = {2510-2613},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-172843},
  pages     = {19-36},
  year      = {2017},
  abstract  = {The two articles of «Langage» and «Langue», published in 1765 in the 9th volume of the great French Encyclop{\´e}die by Diderot and D'Alembert, treat some essential philosophical questions on the human ability of communication with linguistic signs. Nevertheless, as the two authors Jaucourt and Beauz{\´e}e did not share completely identic points of view, the comparative lecture of both articles reveals a complementary perspective, particularly relating to the origin of language as a divine gift or humans' creation for communicative needs. A further aspect of divergence concerns the textual composition of the article « Langage » as a structured informative text, and the article « Langue » as a long and freely composed writing including personal remarks by the author. The following article deals with the potential of approaches to the Encyclop{\´e}die in modern linguistics, concretely demonstrated in the comparative analysis of these two articles.},
  language  = {fr}
}
@article{AppelSchulerVogeletal.2017,
  author    = {Appel, Patricia and Schuler, Michael and Vogel, Heiner and Oezelsel, Amina and Faller, Hermann},
  title     = {Short Questionnaire for Workplace Analysis (KFZA): factorial validation in physicians and nurses working in hospital settings},
  series = {Journal of Occupational Medicine and Toxicology},
  volume    = {12},
  journal   = {Journal of Occupational Medicine and Toxicology},
  number    = {11},
  doi       = {10.1186/s12995-017-0157-6},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-157510},
  year      = {2017},
  abstract  = {Background: In recent years, there has been an increasing interest in psychosocial workplace risk assessments in Germany. One of the questionnaires commonly employed for this purpose is the Short Questionnaire for Workplace Analysis (KFZA). Originally, the KFZA was developed and validated for office workers. The aim of the present study was to examine the factorial validity of the KFZA when applied to hospital settings. Therefore, we examined the factorial structure of a questionnaire that contained all the original items plus an extension adding 11 questions specific to hospital workplaces and analyzed both, the original version and the extended version. Methods: We analyzed questionnaire data of a total of 1731 physicians and nurses obtained over a 10-year period. Listwise exclusion of data sets was applied to account for variations in questionnaire versions and yielded 1163 questionnaires (1095 for the extended version) remaining for factor analysis. To examine the factor structure, we conducted a principal component factor analysis. The number of factors was determined using the Kaiser criterion and scree-plot methods. Factor interpretation was based on orthogonal Varimax rotation as well as oblique rotation. Results: The Kaiser criterion revealed a 7-factor solution for the 26 items of the KFZA, accounting for 62.0\% of variance. The seven factors were named: "Social Relationships", "Job Control", "Opportunities for Participation and Professional Development", "Quantitative Work Demands", "Workplace Environment", "Variability" and "Qualitative Work Demands". The factor analysis of the 37 items of the extended version yielded a 9-factor solution. The two additional factors were named "Consequences of Strain" and "Emotional Demands". Cronbach's α ranged from 0.63 to 0.87 for these scales. Conclusions: Overall, the KFZA turned out to be applicable to hospital workers, and its content-related structure was replicated well with some limitations. However, instead of the 11 factors originally proposed for office workers, a 7-factor solution appeared to be more suitable when employed in hospitals. In particular, the items of the KFZA factor "Completeness of Task" might need adaptation for the use in hospitals. Our study contributes to the assessment of the validity of this popular instrument and should stimulate further psychometric testing.},
  language  = {en}
}
@article{AppeltMenzelCubukovaGuentheretal.2017,
  author    = {Appelt-Menzel, Antje and Cubukova, Alevtina and G{\"u}nther, Katharina and Edenhofer, Frank and Piontek, J{\"o}rg and Krause, Gerd and St{\"u}ber, Tanja and Walles, Heike and Neuhaus, Winfried and Metzger, Marco},
  title     = {Establishment of a Human Blood-Brain Barrier Co-culture Model Mimicking the Neurovascular Unit Using Induced Pluri- and Multipotent Stem Cells},
  series = {Stem Cell Reports},
  volume    = {8},
  journal   = {Stem Cell Reports},
  number    = {4},
  doi       = {10.1016/j.stemcr.2017.02.021},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-170982},
  pages     = {894-906},
  year      = {2017},
  abstract  = {In vitro models of the human blood-brain barrier (BBB) are highly desirable for drug development. This study aims to analyze a set of ten different BBB culture models based on primary cells, human induced pluripotent stem cells (hiPSCs), and multipotent fetal neural stem cells (fNSCs). We systematically investigated the impact of astrocytes, pericytes, and NSCs on hiPSC-derived BBB endothelial cell function and gene expression. The quadruple culture models, based on these four cell types, achieved BBB characteristics including transendothelial electrical resistance (TEER) up to 2,500 Ω cm\(^{2}\) and distinct upregulation of typical BBB genes. A complex in vivo-like tight junction (TJ) network was detected by freeze-fracture and transmission electron microscopy. Treatment with claudin-specific TJ modulators caused TEER decrease, confirming the relevant role of claudin subtypes for paracellular tightness. Drug permeability tests with reference substances were performed and confirmed the suitability of the models for drug transport studies.},
  language  = {en}
}
@article{ArenasRoces2017,
  author    = {Arenas, Andr{\´e}s and Roces, Flavio},
  title     = {Avoidance of plants unsuitable for the symbiotic fungus in leaf-cutting ants: Learning can take place entirely at the colony dump},
  series = {PLoS ONE},
  volume    = {12},
  journal   = {PLoS ONE},
  number    = {3},
  doi       = {10.1371/journal.pone.0171388},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-157559},
  pages     = {e0171388},
  year      = {2017},
  abstract  = {Plants initially accepted by foraging leaf-cutting ants are later avoided if they prove unsuitable for their symbiotic fungus. Plant avoidance is mediated by the waste produced in the fungus garden soon after the incorporation of the unsuitable leaves, as foragers can learn plant odors and cues from the damaged fungus that are both present in the recently produced waste particles. We asked whether avoidance learning of plants unsuitable for the symbiotic fungus can take place entirely at the colony dump. In order to investigate whether cues available in the waste chamber induce plant avoidance in na{\"i}ve subcolonies, we exchanged the waste produced by subcolonies fed either fungicide-treated privet leaves or untreated leaves and measured the acceptance of untreated privet leaves before and after the exchange of waste. Second, we evaluated whether foragers could perceive the avoidance cues directly at the dump by quantifying the visits of labeled foragers to the waste chamber. Finally, we asked whether foragers learn to specifically avoid untreated leaves of a plant after a confinement over 3 hours in the dump of subcolonies that were previously fed fungicide-treated leaves of that species. After the exchange of the waste chambers, workers from subcolonies that had access to waste from fungicide-treated privet leaves learned to avoid that plant. One-third of the labeled foragers visited the dump. Furthermore, na{\"i}ve foragers learned to avoid a specific, previously unsuitable plant if exposed solely to cues of the dump during confinement. We suggest that cues at the dump enable foragers to predict the unsuitable effects of plants even if they had never been experienced in the fungus garden.},
  language  = {en}
}
@article{ArmbrusterKriegWeissenbergeretal.2017,
  author    = {Armbruster, Nicole and Krieg, Jennifer and Weißenberger, Manuel and Scheller, Carsten and Steinert, Andre F.},
  title     = {Rescued Chondrogenesis of Mesenchymal Stem Cells under Interleukin 1 Challenge by Foamyviral Interleukin 1 Receptor Antagonist Gene Transfer},
  series = {Frontiers in Pharmacology},
  volume    = {8},
  journal   = {Frontiers in Pharmacology},
  number    = {255},
  doi       = {10.3389/fphar.2017.00255},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-170919},
  year      = {2017},
  abstract  = {Background: Mesenchymal stem cells (MSCs) and their chondrogenic differentiation have been extensively investigated in vitro as MSCs provide an attractive source besides chondrocytes for cartilage repair therapies. Here we established prototype foamyviral vectors (FVV) that are derived from apathogenic parent viruses and are characterized by a broad host range and a favorable integration pattern into the cellular genome. As the inflammatory cytokine interleukin 1 beta (IL1β) is frequently present in diseased joints, the protective effects of FVV expressing the human interleukin 1 receptor antagonist protein (IL1RA) were studied in an established in vitro model (aggregate culture system) of chondrogenesis in the presence of IL1β. Materials and Methods: We generated different recombinant FVVs encoding enhanced green fluorescent protein (EGFP) or IL1RA and examined their transduction efficiencies and transgene expression profiles using different cell lines and human primary MSCs derived from bone marrow-aspirates. Transgene expression was evaluated by fluorescence microscopy (EGFP), flow cytometry (EGFP), and ELISA (IL1RA). For evaluation of the functionality of the IL1RA transgene to block the inhibitory effects of IL1β on chondrogenesis of primary MSCs and an immortalized MSC cell line (TERT4 cells), the cells were maintained following transduction as aggregate cultures in standard chondrogenic media in the presence or absence of IL1β. After 3 weeks of culture, pellets were harvested and analyzed by histology and immunohistochemistry for chondrogenic phenotypes. Results: The different FVV efficiently transduced cell lines as well as primary MSCs, thereby reaching high transgene expression levels in 6-well plates with levels of around 100 ng/ml IL1RA. MSC aggregate cultures which were maintained in chondrogenic media without IL1β supplementation revealed a chondrogenic phenotype by means of strong positive staining for collagen type II and matrix proteoglycan (Alcian blue). Addition of IL1β was inhibitory to chondrogenesis in untreated control pellets. In contrast, foamyviral mediated IL1RA expression rescued the chondrogenesis in pellets cultured in the presence of IL1β. Transduced MSC pellets reached thereby very high IL1RA transgene expression levels with a peak of 1087 ng/ml after day 7, followed by a decrease to 194 ng/ml after day 21, while IL1RA concentrations of controls were permanently below 200 pg/ml. Conclusion: Our results indicate that FVV are capable of efficient gene transfer to MSCs, while reaching IL1RA transgene expression levels, that were able to efficiently block the impacts of IL1β in vitro. FVV merit further investigation as a means to study the potential as a gene transfer tool for MSC based therapies for cartilage repair.},
  language  = {en}
}
@phdthesis{Arnaudov2017,
  author    = {Arnaudov, Theresa Irina},
  title     = {Anthocyane - Modulation oxidativen Stresses in vivo und in vitro},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-152593},
  school      = {Universit{\"a}t W{\"u}rzburg},
  year      = {2017},
  abstract  = {Die menschliche Nahrung enth{\"a}lt antioxidative Stoffe, die den Menschen m{\"o}glicherweise vor oxidativem Stress und seinen Konsequenzen sch{\"u}tzen k{\"o}nnen. Im Fokus der vorliegenden Arbeit standen Anthocyane, die als vielversprechende antioxidative Pflanzenstoffe in unterschiedlichen Obst- und Gem{\"u}sesorten zu finden sind. Im ersten Teil der Arbeit wurden in einem HT-29-Zellkulturmodell die zwei wichtigsten Vertreter der Anthocyanidine, Delphinidin und Cyanidin, untersucht. Es galt zu pr{\"u}fen, ob beide Pflanzenstoffe in geringen Konzentrationen in humanen Zellen antioxidativ wirken und oxidativen Genomschaden verhindern k{\"o}nnen. Im Comet-Assay reduzierten sowohl Delphinidin (ab 3,2 µM) als auch Cyanidin (ab 1 µM) signifikant die durch 100 µM Wasserstoffperoxid induzierten DNA-Sch{\"a}den in den HT-29-Zellen. Im Comet-Assays mit FPG-Enzym wurde deutlich, dass eine Pr{\"a}inkubation mit Cyanidin wirksam die Oxidation der DNA-Basen verringert. Die Auswirkungen auf den Glutathionspiegel wurden mit Hilfe des Glutathion-Recycling-Assays nach Tietze untersucht. Die Pr{\"a}inkubation mit Cyanidin f{\"u}hrte hierbei zu keinen signifikanten Ver{\"a}nderungen. Um die Auswirkungen der Anthocyanidine auf die intrazellul{\"a}re ROS-Produktion zu beobachten, wurde der fluoreszierenden Farbstoffs DHE verwendet. Sowohl Delphinidin (10 und 15 µM) als auch Cyanidin (10 und 20 µM) senkten signifikant die durch 25 µM Antimycin A angeregte ROS-Produktion. Im zweiten Teil der Arbeit wurde ein anthocyanreicher roter Fruchtsaft in einer 10-w{\"o}chigen Interventionsstudie am Menschen getestet. Hieran nahmen sowohl 19 Fibromyalgiepatienten als auch 10 gesunde Probanden teil. Es sollte die Hypothese gepr{\"u}ft werden, dass die konzentrierte und andauernde Einnahme des Saftes messbar oxidative Stressparameter im Blut ver{\"a}ndert. Außerdem sollten m{\"o}gliche Unterschiede im oxidativen Stresslevel zwischen Patienten und gesunden Probanden aufgedeckt werden. Nach jeder Studienphase erfolgte eine Befragung nach klinischen Symptomen und die Abgabe einer Urin- und Blutprobe in der Schmerzambulanz der Uniklinik W{\"u}rzburg (2 Wochen Einwaschphase, 4 Wochen Fruchtsaftphase mit je 750 ml Saft t{\"a}glich, 4 Wochen Auswaschphase). Das ROS-Level wurde mit 2 Methoden in den mononukle{\"a}ren Blutzellen untersucht: In der photometrischen NBT-Messung konnten keine signifikanten Unterschiede zwischen den Gruppen oder Zeitpunkten beobachtet werden. Bei der durchflusszytometrischen Messung mit Hilfe des fluoreszierenden DCF-Farbstoffes lag das ROS-Level der Patientengruppe vor Fruchtsafteinnahme signifikant h{\"o}her als das der Kontrollgruppe. Zur Messung der antioxidativen Kapazit{\"a}t wurde die Eisen-Reduktionsf{\"a}higkeit (FRAP) im Plasma untersucht. In der Patientengruppe zeigte sich eine Steigerung der antioxidativen Kapazit{\"a}t nach Einnahme des Fruchtsaftes. Die Unterschiede zwischen den beiden Gruppen waren gering. Sowohl das Gesamtglutathion als auch die oxidierte und reduzierte Form wurden in den Erythrozyten der Probanden mit dem Glutathion-Recycling-Assay gemessen. Nach der Fruchtsafteinnahme stieg die Konzentration des Gesamtglutathions in der Patientengruppe an. Zusammenfassend konnte in dieser Arbeit gezeigt werden, dass Delphinidin und Cyanidin auch in geringen Konzentrationen (1µM - 20µM) einen antioxidativer Effekt in HT-29-Zellen haben und vor oxidativem DNA-Schaden sch{\"u}tzen k{\"o}nnen. Die Ergebnisse der Interventionsstudie unterschieden sich teilweise in den einzelnen Endpunkten. Es war nicht m{\"o}glich, den Fibromyalgiepatienten ein h{\"o}heres oxidatives Stresslevel nachzuweisen. Ein Grund f{\"u}r die geringeren Effekte des Fruchtsaftes k{\"o}nnte in der eher geringen Bioverf{\"u}gbarkeit der Anthocyane liegen. Außerdem k{\"o}nnte die Heterogenit{\"a}t der Fibromyalgieerkrankung genauso wie andere endogene oder exogene Faktoren wie etwa Alter oder Medikamenteneinnahme die teilweise großen interindividuellen Schwankungen der Messergebnisse hinsichtlich der oxidativen Stressparameter bedingen. Klinisch profitierten einige der Fibromyalgiepatienten von der Fruchtsafteinnahme insbesondere hinsichtlich der Reizdarmsymptomatik. Dieses Volksleiden k{\"o}nnte ein interessanter Ansatzpunkt f{\"u}r Folgeuntersuchungen mit einem anthocyanreichen Produkt sein.},
  subject      = {Oxidativer Stress},
  language  = {de}
}
@article{ArnholdtGilbertBlanketal.2017,
  author    = {Arnholdt, J{\"o}rg and Gilbert, Fabian and Blank, Marc and Papazoglou, Jannis and Rudert, Maximilian and N{\"o}th, Ulrich and Steinert, Andre F.},
  title     = {The Mayo conservative hip: complication analysis and management of the first 41 cases performed at a University level 1 department},
  series = {BMC Muskoskeletal Disorders},
  volume    = {18},
  journal   = {BMC Muskoskeletal Disorders},
  number    = {250},
  doi       = {10.1186/s12891-017-1613-2},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-157812},
  year      = {2017},
  abstract  = {Background: To prevent bone loss in hip arthroplasty, several short stem systems have been developed, including the Mayo conservative hip system. While there is a plethora of data confirming inherent advantages of these systems, only little is known about potential complications, especially when surgeons start to use these systems. Methods: In this study, we present a retrospective analysis of the patients' outcome, complications and the complication management of the first 41 Mayo conservative hips performed in 37 patients. For this reason, functional scores, radiographic analyses, peri- and postoperative complications were assessed at an average follow-up of 35 months. Results: The overall HHS improved from 61.2 pre-operatively to 85.6 post-operatively. The German Extra Short Musculoskeletal Function Assessment Questionnaire (XSFMA-D) improved from 30.3 pre-operatively to 12.2 post-operatively. The most common complication was an intraoperative non-displaced fracture of the proximal femur observed in 5 cases (12.1\%). Diabetes, higher BMI and older ages were shown to be risk factors for these intra-operative periprosthetic fractures (p < 0.01). Radiographic analysis revealed a good offset reconstruction in all cases. Conclusion: In our series, a high complication rate with 12.1\% of non-displaced proximal femoral fractures was observed using the Mayo conservative hip. This may be attributed to the flat learning curve of the system or the inherent patient characteristics of the presented cohort."},
  language  = {en}
}
@unpublished{ArrowsmithBraunschweigStennett2017,
  author    = {Arrowsmith, Merle and Braunschweig, Holger and Stennett, Tom},
  title     = {Formation and Reactivity of Electron-Precise B-B Single and Multiple Bonds},
  series = {Angewandte Chemie, International Edition},
  volume    = {56},
  journal   = {Angewandte Chemie, International Edition},
  number    = {1},
  doi       = {10.1002/anie.201610072},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-145631},
  pages     = {96-115},
  year      = {2017},
  abstract  = {Recent years have seen rapid advances in the chemistry of small molecules containing electron-precise boron-boron bonds. This review provides an overview of the latest methods for the controlled synthesis of B-B single and multiple bonds as well as the ever-expanding range of reactivity displayed by the latter.},
  language  = {en}
}
@unpublished{ArrowsmithBoehnkeBraunschweigetal.2017,
  author    = {Arrowsmith, Merle and B{\"o}hnke, Julian and Braunschweig, Holger and Celik, Mehmet Ali},
  title     = {Reactivity of a Dihydrodiborene with CO: Coordination, Insertion, Cleavage and Spontaneous Cyclic Alkyne Formation},
  series = {Angewandte Chemie, International Edition},
  journal   = {Angewandte Chemie, International Edition},
  doi       = {10.1002/anie.201707907},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-153318},
  year      = {2017},
  abstract  = {Under a CO atmosphere the dihydrodiborene [(cAAC)HB=BH(cAAC)] underwent coordination of CO concomitant with reversible hydrogen migration from boron to the carbene carbon atom, as well as reversible CO insertion into the B=B bond. Heating of the CO-adduct resulted in two unusual cAAC ring-expansion products, one presenting a B=C bond to a six-membered 1,2-azaborinane-3-ylidene, the other an unprecedented nine-membered cyclic alkyne resulting from reductive cleavage of CO and spontaneous C≡C triple bond formation.},
  language  = {en}
}
@unpublished{ArrowsmithBoehnkeBraunschweigetal.2017,
  author    = {Arrowsmith, Merle and B{\"o}hnke, Julian and Braunschweig, Holger and Deißenberger, Andrea and Dewhurst, Rian and Ewing, William and H{\"o}rl, Christian and Mies, Jan and Muessig, Jonas},
  title     = {Simple Solution-Phase Syntheses of Tetrahalodiboranes(4) and their Labile Dimethylsulfide Adducts},
  series = {Chemical Communications},
  volume    = {53},
  journal   = {Chemical Communications},
  doi       = {10.1039/C7CC03148C},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-149438},
  pages     = {8265-8267},
  year      = {2017},
  abstract  = {Convenient, solution-phase syntheses of tetrahalodiboranes(4) B\(_2\)F\(_4\), B\(_2\)Cl\(_4\) and B\(_2\)I\(_4\) are presented herein from common precursor B\(_2\)Br\(_4\). In addition, the dimethylsulfide adducts B\(_2\)Cl\(_4\)(SMe\(_2\))\(_2\) and B\(_2\)Br\(_4\)(SMe\(_2\))\(_2\) are conveniently prepared in one-step syntheses from the commercially-available starting material B\(_2\)(NMe\(_2\))\(_4\). The results provide simple access to the full range of tetrahalodiboranes(4) for the exploration of their untapped synthetic potential.},
  language  = {en}
}