@article{KosmalaGruschwitzVeldhoenetal.2020,
  author    = {Kosmala, Aleksander and Gruschwitz, Philipp and Veldhoen, Simon and Weng, Andreas Max and Krauss, Bernhard and Bley, Thorsten Alexander and Petritsch, Bernhard},
  title     = {Dual-energy CT angiography in suspected pulmonary embolism: influence of injection protocols on image quality and perfused blood volume},
  series = {The International Journal of Cardiovascular Imaging},
  volume    = {36},
  journal   = {The International Journal of Cardiovascular Imaging},
  number    = {10},
  issn      = {1569-5794},
  doi       = {10.1007/s10554-020-01911-8},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-314739},
  pages     = {2051-2059},
  year      = {2020},
  abstract  = {Abstract To compare intravenous contrast material (CM) injection protocols for dual-energy CT pulmonary angiography (CTPA) in patients with suspected acute pulmonary embolism with regard to image quality and pulmonary perfused blood volume (PBV) values. A total of 198 studies performed with four CM injection protocols varying in CM volume and iodine delivery rates (IDR) were retrospectively included: (A) 60 ml at 5 ml/s (IDR = 1.75gI/s), (B) 50 ml at 5 ml/s (IDR = 1.75gI/s), (C) 50 ml at 4 ml/s (IDR = 1.40gI/s), (D) 40 ml at 3 ml/s (IDR = 1.05gI/s). Image quality and PBV values at different resolution settings were compared. Pulmonary arterial tract attenuation was highest for protocol A (397 ± 110 HU; p vs. B = 0.13; vs. C = 0.02; vs. D < 0.001). CTPA image quality of protocol A was rated superior compared to protocols B and D by reader 1 (p = 0.01; < 0.001), and superior to protocols B, C and D by reader 2 (p < 0.001; 0.02; < 0.001). Otherwise, there were no significant differences in CTPA quality ratings. Subjective iodine map ratings did not vary significantly between protocols A, B, and C. Both readers rated protocol D inferior to all other protocols (p < 0.05). PBV values did not vary significantly between protocols A and B at resolution settings of 1, 4 and 10 (p = 0.10; 0.10; 0.09), while otherwise PBV values displayed a decreasing trend from protocol A to D (p < 0.05). Higher CM volume and IDR are associated with superior CTPA and iodine map quality and higher absolute PBV values.},
  language  = {en}
}
@article{GuggenbergerBley2020,
  author    = {Guggenberger, Konstanze Viktoria and Bley, Thorsten Alexander},
  title     = {Imaging in Vasculitis},
  series = {Current Rheumatology Reports},
  volume    = {22},
  journal   = {Current Rheumatology Reports},
  number    = {34},
  issn      = {1523-3774},
  doi       = {10.1007/s11926-020-00915-6},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-232762},
  year      = {2020},
  abstract  = {Purpose of Review: Vasculitides are characterized by mostly autoimmunologically induced inflammatory processes of vascularstructures. They have various clinical and radiologic appearances. Early diagnosis and reliable monitoring are indispensable foradequate therapy to prevent potentially serious complications. Imaging, in addition to laboratory tests and physical examination,constitutes a key component in assessing disease extent and activity. This review presents current standards and some typicalfindings in the context of imaging in vasculitis with particular attention to large vessel vasculitides. Recent Findings: Recently, imaging has gained importance in the management of vasculitis, especially regarding large vesselvasculitides (LVV). Recently, EULAR (European League Against Rheumatism) has launched its recommendations concerningthe diagnosis of LVVs. Imaging is recommended as the preferred complement to clinical examination. Color-coded duplexsonography is considered the first choice imaging test in suspected giant cell arteritis, and magnetic resonance imaging isconsidered the first choice in suspected Takayasu'sarteritis. Summary: Due to diversity of clinical and radiologic presentations, diagnosis and therapy monitoring of vasculitides mayconstitute a challenge. As a result of ongoing technological progress, a variety of non-invasive imaging modalities now playan elemental role in the interdisciplinary management of vasculitic diseases.},
  language  = {en}
}
@article{GrunzWenigKunzetal.2020,
  author    = {Grunz, Jan-Peter and Wenig, Andreas Max and Kunz, Andreas Steven and Veyhl-Wichmann, Maike and Schmitt, Rainer and Gietzen, Carsten Herbert and Pennig, Lenhard and Herz, Stefan and Erg{\"u}n, S{\"u}leyman and Bley, Thorsten Alexander and Gassenmaier, Tobias},
  title     = {3D cone-beam CT with a twin robotic x-ray system in elbow imaging: comparison of image quality to high-resolution multidetector CT},
  series = {European Radiology Experimental},
  volume    = {4},
  journal   = {European Radiology Experimental},
  doi       = {10.1186/s41747-020-00177-y},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-229877},
  year      = {2020},
  abstract  = {Background Elbow imaging is challenging with conventional multidetector computed tomography (MDCT), while cone-beam CT (CBCT) provides superior options. We compared intra-individually CBCT versus MDCT image quality in cadaveric elbows. Methods A twin robotic x-ray system with new CBCT mode and a high-resolution clinical MDCT were compared in 16 cadaveric elbows. Both systems were operated with a dedicated low-dose (LD) protocol (equivalent volume CT dose index [CTDI\(_{vol(16 cm)}\)] = 3.3 mGy) and a regular clinical scan dose (RD) protocol (CTDI\(_{vol(16 cm)}\) = 13.8 mGy). Image quality was evaluated by two radiologists (R1 and R2) on a seven-point Likert scale, and estimation of signal intensity in cancellous bone was conducted. Wilcoxon signed-rank tests and intraclass correlation coefficient (ICC) statistics were used. Results The CBCT prototype provided superior subjective image quality compared to MDCT scans (for RD, p ≤ 0.004; for LD, p ≤ 0.001). Image quality was rated very good or excellent in 100\% of the cases by both readers for RD CBCT, 100\% (R1) and 93.8\% (R2) for LD CBCT, 62.6\% and 43.8\% for RD MDCT, and 0.0\% and 0.0\% for LD MDCT. Single-measure ICC was 0.95 (95\% confidence interval 0.91-0.97; p < 0.001). Software-based assessment supported subjective findings with less "undecided" pixels in CBCT than dose-equivalent MDCT (p < 0.001). No significant difference was found between LD CBCT and RD MDCT. Conclusions In cadaveric elbow studies, the tested cone-beam CT prototype delivered superior image quality compared to high-end multidetector CT and showed a potential for considerable dose reduction.},
  language  = {en}
}
@article{GrunzGietzenLuetkensetal.2020,
  author    = {Grunz, Jan-Peter and Gietzen, Carsten Herbert and Luetkens, Karsten and Wagner, Matthias and Kalb, Karlheinz and Bley, Thorsten Alexander and Lehmkul, Luka and van Schoonhoven, J{\"o}rg and Gassenmaier, Tobias and Schmitt, Rainer},
  title     = {The importance of radial multiplanar reconstructions for assessment of triangular fibrocartilage complex injury in CT arthrography of the wrist},
  series = {BMC Musculoskeletal Disorders},
  volume    = {21},
  journal   = {BMC Musculoskeletal Disorders},
  doi       = {10.1186/s12891-020-03321-2},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-236075},
  year      = {2020},
  abstract  = {Background: Triangular fibrocartilage complex (TFCC) lesions commonly cause ulnar-sided wrist pain and instability of the distal radioulnar joint. Due to its triangular shape, discontinuity of the TFCC is oftentimes difficult to visualize in radiological standard planes. Radial multiplanar reconstructions (MPR) may have the potential to simplify diagnosis in CT wrist arthrography. The objective of this study was to assess diagnostic advantages provided by radial MPR over standard planes for TFCC lesions in CT arthrography. Methods: One hundred six patients (49 women, 57 men; mean age 44.2 ± 15.8 years) underwent CT imaging after wrist arthrography. Two radiologists (R1, R2) retrospectively analyzed three randomized datasets for each CT arthrography. One set contained axial, coronal and sagittal planes (MPR\(_{Standard}\)), while the other two included an additional radial reconstruction with the rotating center either atop the ulnar styloid (MPR\(_{Styloid}\)) or in the ulnar fovea (MPR\(_{Fovea}\)). Readers evaluated TFCC differentiability and condition. Suspected lesions were categorized using Palmer's and Atzei's classification and diagnostic confidence was stated on a fivepoint Likert scale. Results: Compared to standard planes, differentiability of the superficial and deep TFCC layer was superior in radial reconstructions (R1/R2; MPR\(_{Fovea}\): p < 0.001; MPRStyloid: p ≤ 0.007). Palmer and Atzei lesions were present in 86.8\% (92/106) and 52.8\% (56/106) of patients, respectively. Specificity, sensitivity and accuracy for central Palmer lesions did not differ in radial and standard MPR. For peripheral Atzei lesions, sensitivity (MPR\(_{Standard}\) 78.6\%/80.4\%, MPR\(_{Styloid}\) 94.6\%/94.6\%, MPR\(_{Fovea}\) 91.1\%/89.3\%) and accuracy (MPR\(_{Standard}\) 86.8\%/86.8\%, MPR\(_{Styloid}\) 96.2\%/96.2\%, MPR\(_{Fovea}\) 94.3\%/93.4\%) improved with additional styloid-centered (p = 0.004/0.008) and foveacentered (p = 0.039/0.125) reconstructions. No substantial difference was observed between both radial MPR (p = 0.688/0.250). Interrater agreement was almost perfect for each dataset (κ\(_{Standard}\) = 0.876, κ\(_{Styloid}\) = 0.894, κ\(_{Fovea}\) = 0.949). Diagnostic confidence increased with addition of either radial MPR (p < 0.001). Conclusions: Ancillary radial planes improve accuracy and diagnostic confidence for detection of peripheral TFCC lesions in CT arthrography of the wrist.},
  language  = {en}
}