@article{TackeLangeBentlageetal.1983,
  author    = {Tacke, Reinhold and Lange, Hartwig and Bentlage, Anke and Sheldrick, William S. and Ernst, Ludger},
  title     = {2.2.5.5-Tetraorganyl-1.4-dioxa-2.5-disilacyclohexane/2,2,5,5-Tetraorganyl-1,4-dioxa-2,5-disilacyclohexanes},
  series = {Zeitschrift f{\"u}r Naturforschung B},
  volume    = {38},
  journal   = {Zeitschrift f{\"u}r Naturforschung B},
  number    = {2},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-128423},
  pages     = {190-193},
  year      = {1983},
  abstract  = {The 2,2,5,5-tetraorganyl-1,4-dioxa-2,5-disilacyclohexanes 2a-2c were prepared by condensation of the corresponding (hydroxymethyl)diorganylsilanes 1 a-1 c. The constitution of the heterocycles was confirmed by elemental analyses, cryoscopic measurements, mass spectrometry, and NMR-spectroscopic \((^1H, ^{13}C)\) investigations. The molecular structure of 2 b was determined by X-ray diffraction analysis.},
  language  = {de}
}
@article{TackeLangeSheldricketal.1983,
  author    = {Tacke, Reinhold and Lange, Hartwig and Sheldrick, William S. and Lambrecht, G{\"u}nter and Moser, Ulrich and Mutschler, Ernst},
  title     = {Sila-Pharmaka, 31. Mitt. [1] Synthese, Struktur und pharmakologische Eigenschaften von Diphenyl(2-piperidinoethoxymethyl)silanol und seinem Kohlenstoff-Analogon},
  series = {Zeitschrift f{\"u}r Naturforschung B},
  volume    = {38},
  journal   = {Zeitschrift f{\"u}r Naturforschung B},
  number    = {6},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-128410},
  pages     = {738-746},
  year      = {1983},
  abstract  = {In the course of systematic investigations on sila-substituted parasympatholytics the diphenyl(2-aminoethoxymethyl)silanols 3b and 4b (and its carbon analogue 4a) were synthesized and characterized by their physical and chemical properties. In the solid state 4a and 4b form strong O-H---N hydrogen bonds, which are intramolecular (4a) and intermolecular (4b), respectively. 4a and 4b were found to be weak antimuscarinic agents (4b >4a) and strong papaverine-like spasmolytics (4a ≈4b).},
  language  = {de}
}
@article{TackeLinohAttarBashietal.1982,
  author    = {Tacke, Reinhold and Linoh, Haryanto and Attar-Bashi, Moayad T. and Sheldrick, William S. and Ernst, Ludger and Niedner, Roland and Frohnecke, Joachim},
  title     = {Sila-Pharmaka, 26. Mitt. [1] Darstellung und Eigenschaften potentiell curarewirksamer Silicium-Verbindungen, III},
  series = {Zeitschrift f{\"u}r Naturforschung B},
  volume    = {37},
  journal   = {Zeitschrift f{\"u}r Naturforschung B},
  number    = {11},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-128402},
  pages     = {1461-1471},
  year      = {1982},
  abstract  = {The potentially curare-like silicon compounds 8a- 8f were synthesized and investigated with respect to their structure-activity relationships. The conformations of the compounds in the solid state and in solution were studied by X-ray diffraction analysis (8a- 8e) and IR NMR spectroscopy (8a- 8f), respectively. The muscle relaxing properties of 8a- 8f were investigated on the mouse. The observed structure-activity relationships are not in accordance with the classical "14 {\AA} model" for neuromuscular blocking agents.},
  language  = {de}
}
@article{JaiswalLambrechtMutschleretal.1991,
  author    = {Jaiswal, Neelam and Lambrecht, G{\"u}nter and Mutschler, Ernst and Tacke, Reinhold and Malik, Kafait U.},
  title     = {Pharmacological characterization of the vascular muscarinic receptors mediating relaxation and contraction in rabbit aorta},
  series = {Journal of Pharmacology and Experimental Therapeutics},
  volume    = {258},
  journal   = {Journal of Pharmacology and Experimental Therapeutics},
  number    = {3},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-128358},
  pages     = {842-850},
  year      = {1991},
  abstract  = {Studies were performed in the rabbit aortic rings, precontracted with norepinephrine, to determine the subtype(s) of muscarinic receptors involved in endothelium-dependent relaxation and contraction in the absence of endothelium elicited by cholinergic stimuli. Acetylcholine (ACh) and arecaidine propargyl ester (APE), a M2 and M3 agonist, produced a dose-dependent relaxation and contraction in endothelium-intact and endothelium-denuded rabbit aortic rings, respectively. Both of these responses were blocked by the muscarinic receptor antagonist atropine. M1 selective agonist McN-A-343 [4-[N-(3-chlorophenyl)carbamoyloxy]-2-butinyltrimethylammonium+ ++ chloride] did not produce any effect on the tone of precontracted aortic rings. ACh- and APE-induced relaxation in aortic rings with intact endothelium was selectively blocked by M3 receptor antagonists hexahydrosila-difenidol and p-fluoro-hexahydro-sila-difenidol (pA2 of 7.84 and 7.18) but not by M1 antagonist pirenzepine or M2 receptor antagonists AF-DX 116 [11-(2-[(diethylamino)methyl]- 1-piperidinyl]acetyl)-5, 11-dihydro-6H-pyrido-[2,3-b][1,4]-benzo-diazepin-6-one] and methoctramine. ACh- and APE-induced contraction was inhibited by M2 receptor antagonists AF-DX 116 and methoctramine (pA2 of 7.11 and 6.71) but not by pirenzepine, hexahydro-sila-difenidol or p-fluoro-hexahydro-sila-difenidol. ACh- and APE-induced relaxation or contraction were not altered by nicotinic receptor antagonist hexamethonium or cyclooxygenase inhibitor indomethacin. These data suggest that relaxation elicited by cholinergic stimulin in endothelium-intact aortic rings is mediated via release of endothelium-derived relaxing factor consequent to activation of M3 receptors located on endothelial cells, whereas the contraction in aortic rings denuded of their endothelium is mediated via stimulation of M2 receptors located on smooth muscle cells.},
  language  = {en}
}
@article{TackeLinohStumpfetal.1983,
  author    = {Tacke, Reinhold and Linoh, Haryanto and Stumpf, Burghard and Abraham, Wolf-Rainer and Kieslich, Klaus and Ernst, Ludger},
  title     = {Mikrobiologische Umwandlung von Silicium-Verbindungen: Enantioselektive Reduktion von Acetessigs{\"a}ure-(trimethylsilylalkyl)estern und deren Carba-Analoga},
  series = {Zeitschrift f{\"u}r Naturforschung B},
  volume    = {38},
  journal   = {Zeitschrift f{\"u}r Naturforschung B},
  number    = {5},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-128304},
  pages     = {616-620},
  year      = {1983},
  abstract  = {The trimethylsilylalkyl acetoacetates 1 b and 2 b as well as their carba analogues 1 a and 2 a have been reduced microbiologically by Kloeckera corticis (ATCC 20109), leading to the corresponding ( + )-3(S)-hydroxybutanoates 3b, 4b, 3a, and 4a. The enantiomeric purity was found to be 80\% (3a, 3b, 4b) and 65\% (4a), respectively. The reduction of lb and 2b is - to our knowledge - the first example for a controlled microbiological transformation of organosilicon substrates.},
  language  = {de}
}
@article{TackeLinkBentlageFeltenetal.1985,
  author    = {Tacke, Reinhold and Link, Matthias and Bentlage-Felten, Anke and Zilch, Harald},
  title     = {Zum thermischen Verhalten einiger Kohlens{\"a}ure[(methylphenylsilyl)methyl]ester-Derivate},
  series = {Zeitschrift f{\"u}r Naturforschung B},
  volume    = {40},
  journal   = {Zeitschrift f{\"u}r Naturforschung B},
  number    = {7},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-128293},
  pages     = {942-947},
  year      = {1985},
  abstract  = {The synthesis and the thermal behaviour of the (methylphenylsilyl)methyl carbonates \(CH_3(C_6H_5)Si(H)CH_2OC(O)X (6: X = OCH_3; 7: X = Cl; 8: X = N(CH_3)_2)\) is described. 8 rearranges in toluene solution at 100 °C quantitatively to give the carbam oyloxysilane \(C_6H_5(CH_3)_2SiOC(O)N(CH_3)_2\) (11), whereas neat 6 and 7 at 135 °C undergo quantitative formation of \(C_6H_5(CH_3)_2SiOCH_3\) (12) and \(C_6H_5(CH_3)_2SiCl\) (13), respectively. The formation of 12 and 13 is explained by a rearrangement reaction (by analogy to the rearrangement of 8), follow ed by a decarboxylation. The thermally induced transformations 6 →12, 7 →13, and 8 →11 were found to be first-order reactions with half-lifes of ~2.6 h (135 °C, neat), ~4.5 h (135 °C, neat), and ~3.7 h (100 °C, in toluene), respectively.},
  language  = {de}
}
@article{TackeNiederer1978,
  author    = {Tacke, Reinhold and Niederer, Reinhold},
  title     = {Sila-Pharmaka, 9. Mitt. [1] Darstellung und Eigenschaften potentiell curarewirksamer Silicium-Verbindungen, I},
  series = {Zeitschrift f{\"u}r Naturforschung B},
  volume    = {33},
  journal   = {Zeitschrift f{\"u}r Naturforschung B},
  number    = {4},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-128277},
  pages     = {412-416},
  year      = {1978},
  abstract  = {Organosilicon compounds 8, 9 and 10 with potential curare-like action and their precursors 0, 6 and 7 were synthesized for the first time. 0-10 were characterized by their physical and chemical properties, and their structures were confirmed by analyses, IH NMR and mass spectroscopy (only for 0-7). The pharmacological and toxicological data of 8, 9 and 10 are reported.},
  language  = {de}
}
@article{SaadTacke1977,
  author    = {Saad, S. M. and Tacke, Reinhold},
  title     = {Zur Darstellung von 1,1,3,3-Tetramethyl-1,3-disila-2,4,7-trioxa-cycloheptan (1) und 1,1,3,3-Tetramethyl-1,3-disila-2,4,8-trioxa-cyclooctan (2)},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-86958},
  year      = {1977},
  abstract  = {No abstract available.},
  subject      = {Anorganische Analyse},
  language  = {de}
}
@article{TackeBentlageFeltenLinohetal.1986,
  author    = {Tacke, Reinhold and Bentlage-Felten, Anke and Linoh, Haryanto and Magda, Stephen},
  title     = {Sila-Analoga des Triparanols und Ethamoxytriphetols: Synthese sowie pharmakologische und toxikologische Eigenschaften},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-86940},
  year      = {1986},
  abstract  = {No abstract available.},
  language  = {de}
}
@article{TackeLinkJoppienetal.1986,
  author    = {Tacke, Reinhold and Link, Matthias and Joppien, Hartmut and Ernst, Ludger},
  title     = {Sila-Substitution des Akarizids Fenbutatinoxid und einiger seiner Derivate: Synthese und Eigenschaften von Hexakis[(dimethylphenylsilyl)methyl]distannoxan und Tris[(dimethylphenylsilyl)methyl](1,2,4-triazol-1-yl)stannan},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-86937},
  year      = {1986},
  abstract  = {No abstract available.},
  subject      = {Chemische Synthese},
  language  = {de}
}
@article{TackeWiesenberger1991,
  author    = {Tacke, Reinhold and Wiesenberger, Frank},
  title     = {(Acetoxymethyl)methylphenylgerman: Synthese, thermisches Verhalten und olfaktorische Eigenschaften},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-86927},
  year      = {1991},
  abstract  = {No abstract available.},
  subject      = {Chemische Synthese},
  language  = {de}
}
@article{TackeWiesenbergerLopezMrasetal.1992,
  author    = {Tacke, Reinhold and Wiesenberger, Frank and Lopez-Mras, Angel and Sperlich, J{\"o}rg and Mattern, G{\"u}nter},
  title     = {Neuartige zwitterionische λ5-Spirosilicate: Synthese und Kristallstruktur von Bis[1,2-benzoldiolato(2-)][2-(dimethylammonio)phenyl]silicat sowie Synthese von Bis[2,3-naphthalindiolato(2-)][2-(dimethylammonio)phenyl]silicat-Hemiacetonitril-Solvat},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-86916},
  year      = {1992},
  abstract  = {No abstract available.},
  subject      = {Silicate},
  language  = {de}
}
@article{TackeKropfgansTafeletal.1994,
  author    = {Tacke, Reinhold and Kropfgans, Martin and Tafel, Andrea and Wiesenberger, Frank and Sheldrick, William S. and Mutschler, Ernst and Egerer, Hansj{\"o}rg and Rettenmayr, Nikola and Gross, Jan and Waelbroeck, Magali and Lambrecht, G{\"u}nter},
  title     = {(Hydroxymethyl)diphenyl(piperidinoalkyl)silane des Typs (HOCH2)(C6H5)2Si(CH2)nNC5H10 (n = 2,3) und deren Methoiodide: Synthese, Struktur und antimuscarinische Eigenschaften},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-86904},
  year      = {1994},
  abstract  = {No abstract available.},
  language  = {de}
}
@article{TackeHallerZeiler1979,
  author    = {Tacke, Reinhold and Haller, Ingo and Zeiler, Hans-Joachim},
  title     = {Sila-Analoga der Antiseptica Octafoniumchlorid und p-tert-Butylphenol},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-86893},
  year      = {1979},
  abstract  = {No abstract available.},
  subject      = {Silaanaloga},
  language  = {de}
}
@article{TackeSperlichStrohmannetal.1992,
  author    = {Tacke, Reinhold and Sperlich, J{\"o}rg and Strohmann, Carsten and Frank, Brigitta and Mattern, G{\"u}nter},
  title     = {Bis[3,4,5,6-tetrabrom-1,2-benzoldiolato(2-)]-(pyrrolidiniomethyl)silicat-Acetonitril-Solvat [(C6Br4O2)2SiCH2(H)NC4H8 · CH3CN]: Synthese sowie Kristall- und Molek{\"u}lstruktur eines zwitterionischen [lambda]5-Spirosilicats},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-86884},
  year      = {1992},
  abstract  = {Single crystal X-ray studies on bis[3,4,5,6-tetrabromo-1 ,2-benzenediolato(2- )](pyrrolidiniomethyl)silicate acetonitrile solvate [(C6Br40 2hSiCH2(H)NC4H8 · CH3CN; monoclinic, P2t/c, a = 808.5(4), b = 1533.0(8), c = 2212.6(1) pm, ß = 97.67(2)0 , Z = 4] revealed a zwitterionic structure with a pentacoordinate, formally negatively charged silicon atom and a positively charged ammonium moiety. The silicon atom is surrounded by four oxygen atoms and one carbon atom in a trigonalbipyramidal fashion, with the carbon atom in an equatorial position. The structure is displaced by 7.0\% from the trigonal bipyramid towards the square pyramid. The zwitterion and the CH3CN molecule form intermolecular N-H · · · N hydrogen bonds.},
  subject      = {Kristallstruktur},
  language  = {de}
}
@article{SperlichBechtMuehleisenetal.1993,
  author    = {Sperlich, J{\"o}rg and Becht, Joachim and M{\"u}hleisen, Mathias and Wagner, Stephan A. and Mattern, G{\"u}nter and Tacke, Reinhold},
  title     = {Zwitterionische Bis[vic-arendiolato(2-)][(morpholinio)alkyl]silicate: Synthese sowie strukturelle Charakterisierung in L{\"o}sung und im Kristall},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-73153},
  year      = {1993},
  abstract  = {No abstract available.},
  subject      = {Silicate},
  language  = {de}
}
@article{TackeBentlagemTowartetal.1980,
  author    = {Tacke, Reinhold and Bentlagem, A. and Towart, R. and Meyer, H. and Bossert, F. and Vater, W. and Stoepe, K.},
  title     = {Sila-Analoga von Nifedipin-{\"a}hnlichen 4-Aryl-2.6-dimethyl-1.4-dihydropyridin-3.5-dicarbons{\"a}ure-dialkylestern, I},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-82430},
  year      = {1980},
  abstract  = {no abstract available},
  subject      = {Chemie},
  language  = {de}
}
@article{TackeSaad1977,
  author    = {Tacke, Reinhold and Saad, S. M.},
  title     = {Silylation of cellulose},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-78368},
  year      = {1977},
  abstract  = {Ethane-l:2-diol and propane-l:3-diol reaet with 1: 1:3:3-tetramethyl-l:3-dichlorodisiloxane forming the corresponding rings. However, no ring compounds could be traced tbrough the reaction between butane-l :4-diol, glycerol and the dichlorodisiloxane respectively, where only polymeric compounds are formed. The silylation products of the di- and trihydroxy alcohols, as model compounds, has confirmed that the ring formation during silylation of cellulose with dichlorodisiloxane is uncertain.},
  subject      = {Anorganische Chemie},
  language  = {en}
}
@article{TackeBentlageTowartetal.1983,
  author    = {Tacke, Reinhold and Bentlage, Anke and Towart, Robertson and M{\"o}ller, Eike},
  title     = {Sila-pharmaca, XXV. Sila-analogues of nifedipine-like dialkyl 2,6-dimethyl-4-aryl-1,4 dihydropyridine-3,5-dicarboxylates, III},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-78357},
  year      = {1983},
  abstract  = {IS neue C/Si-Analogenpaare (C-Verbindungen und sila- bzw. disila-substituierte Derivate), die sich strukturell vom Nifedipin ableiten, wurden synthetisiert. Diese und einige weitere C/Si-Paare wurden hinsichtlich ihrer physikochemischen und pharmakologischen Eigenschaften vergleichend untersucht. Mittels reversed-phase-D{\"u}nnschichtchromatographie wurde gezeigt, daß die Sila- bzw. Disila-Analoga lipophiler sind als die entsprechenden C-Verbindungen. Bez{\"u}glich der spasmolytischen in vitra-Aktivit{\"a}ten zeigen die Si-Verbindungen in erster N{\"a}herung {\"a}hnliche Struktur-Wirkungs-Beziehungen wie ihre Carba-Analoga. Dagegen konnten hinsichtlich der ill vlva-Effekte (cardiovascul{\"a}re und antihypertensive Aktivit{\"a}t) in einigen F{\"a}llen große Unterschiede nachgewiesen werden.},
  subject      = {Anorganische Chemie},
  language  = {en}
}
@article{TackeWuttkeHenke1992,
  author    = {Tacke, Reinhold and Wuttke, F. and Henke, H.},
  title     = {Zur Stereochemie der mikrobiellen Reduktion von rac-Acetyl( t-butyl)methylphenylsilan mit Trigonopsis variabilis (DSM 70714) und Corynebacterium dioxydans (ATCC 21766): Aufkl{\"a}rung der absoluten Konfiguration der Biotransformationsprodukte (SiR,CR)- und ( SiS ,CR)-t-Butyl( 1-hydroxyethyl)methylphenylsilan},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-64176},
  year      = {1992},
  abstract  = {No abstract available},
  subject      = {Anorganische Chemie},
  language  = {en}
}