@article{SchickSchlegel2022,
  author    = {Schick, Martin Alexander and Schlegel, Nicolas},
  title     = {Clinical implication of phosphodiesterase-4-inhibition},
  series = {International Journal of Molecular Sciences},
  volume    = {23},
  journal   = {International Journal of Molecular Sciences},
  number    = {3},
  issn      = {1422-0067},
  doi       = {10.3390/ijms23031209},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-284511},
  year      = {2022},
  abstract  = {The pleiotropic function of 3′,5′-cyclic adenosine monophosphate (cAMP)-dependent pathways in health and disease led to the development of pharmacological phosphodiesterase inhibitors (PDE-I) to attenuate cAMP degradation. While there are many isotypes of PDE, a predominant role of PDE4 is to regulate fundamental functions, including endothelial and epithelial barrier stability, modulation of inflammatory responses and cognitive and/or mood functions. This makes the use of PDE4-I an interesting tool for various therapeutic approaches. However, due to the presence of PDE4 in many tissues, there is a significant danger for serious side effects. Based on this, the aim of this review is to provide a comprehensive overview of the approaches and effects of PDE4-I for different therapeutic applications. In summary, despite many obstacles to use of PDE4-I for different therapeutic approaches, the current data warrant future research to utilize the therapeutic potential of phosphodiesterase 4 inhibition.},
  language  = {en}
}
@article{MaiellaroLohseKitteetal.2016,
  author    = {Maiellaro, Isabella and Lohse, Martin J. and Kitte, Robert J. and Calebiro, Davide},
  title     = {cAMP Signals in Drosophila Motor Neurons Are Confined to Single Synaptic Boutons},
  series = {Cell Reports},
  volume    = {17},
  journal   = {Cell Reports},
  number    = {5},
  doi       = {10.1016/j.celrep.2016.09.090},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-162324},
  pages     = {1238-1246},
  year      = {2016},
  abstract  = {The second messenger cyclic AMP (cAMP) plays an important role in synaptic plasticity. Although there is evidence for local control of synaptic transmission and plasticity, it is less clear whether a similar spatial confinement of cAMP signaling exists. Here, we suggest a possible biophysical basis for the site-specific regulation of synaptic plasticity by cAMP, a highly diffusible small molecule that transforms the physiology of synapses in a local and specific manner. By exploiting the octopaminergic system of Drosophila, which mediates structural synaptic plasticity via a cAMP-dependent pathway, we demonstrate the existence of local cAMP signaling compartments of micrometer dimensions within single motor neurons. In addition, we provide evidence that heterogeneous octopamine receptor localization, coupled with local differences in phosphodiesterase activity, underlies the observed differences in cAMP signaling in the axon, cell body, and boutons.},
  language  = {en}
}