@article{FroehlichSassenrathNadjiOhletal.2022,
  author    = {Fr{\"o}hlich, Ellen and Sassenrath, Claudia and Nadji-Ohl, Minou and Unteroberd{\"o}rster, Meike and R{\"u}ckriegel, Stefan and Brelie, Christian von der and Roder, Constantin and Forster, Marie-Therese and Schommer, Stephan and L{\"o}hr, Mario and Pala, Andrej and Goebel, Simone and Mielke, Dorothee and Gerlach, R{\"u}diger and Renovanz, Mirjam and Wirtz, Christian Rainer and Onken, Julia and Czabanka, Marcus and Tatagiba, Marcos Soares and Rohde, Veit and Ernestus, Ralf-Ingo and Vajkoczy, Peter and Gansland, Oliver and Coburger, Jan},
  title     = {Resilience in lower grade glioma patients},
  series = {Cancers},
  volume    = {14},
  journal   = {Cancers},
  number    = {21},
  issn      = {2072-6694},
  doi       = {10.3390/cancers14215410},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-297518},
  year      = {2022},
  abstract  = {Current data show that resilience is an important factor in cancer patients' well-being. We aim to explore the resilience of patients with lower grade glioma (LGG) and the potentially influencing factors. We performed a cross-sectional assessment of adult patients with LGG who were enrolled in the LoG-Glio registry. By phone interview, we administered the following measures: Resilience Scale (RS-13), distress thermometer, Montreal Cognitive Assessment Test for visually impaired patients (MoCA-Blind), internalized stigmatization by brain tumor (ISBI), Eastern Cooperative Oncological Group performance status (ECOG), patients' perspective questionnaire (PPQ) and typical clinical parameters. We calculated correlations and multivariate regression models. Of 74 patients who were assessed, 38\% of those showed a low level of resilience. Our results revealed significant correlations of resilience with distress (p < 0.001, -0.49), MOCA (p = 0.003, 0.342), ECOG (p < 0.001, -0.602), stigmatization (p < 0.001, -0.558), pain (p < 0.001, -0.524), and occupation (p = 0.007, 0.329). In multivariate analyses, resilience was negatively associated with elevated ECOG (p = 0.020, β = -0.383) and stigmatization levels (p = 0.008, β = -0.350). Occupation showed a tendency towards a significant association with resilience (p = 0.088, β = -0.254). Overall, low resilience affected more than one third of our cohort. Low functional status is a specific risk factor for low resilience. The relevant influence of stigmatization on resilience is a novel finding for patients suffering from a glioma and should be routinely identified and targeted in clinical routine.},
  language  = {en}
}
@article{UeceylerSchliesserEvdokimovetal.2022,
  author    = {{\"U}{\c{c}}eyler, Nurcan and Schließer, Mira and Evdokimov, Dimitar and Radziwon, Jakub and Feulner, Betty and Unterecker, Stefan and Rimmele, Florian and Walter, Uwe},
  title     = {Reduced midbrain raphe echogenicity in patients with fibromyalgia syndrome},
  series = {PloS One},
  volume    = {17},
  journal   = {PloS One},
  number    = {11},
  doi       = {10.1371/journal.pone.0277316},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-300639},
  year      = {2022},
  abstract  = {Objectives The pathogenesis of fibromyalgia syndrome (FMS) is unclear. Transcranial ultrasonography revealed anechoic alteration of midbrain raphe in depression and anxiety disorders, suggesting affection of the central serotonergic system. Here, we assessed midbrain raphe echogenicity in FMS. Methods Sixty-six patients underwent transcranial sonography, of whom 53 were patients with FMS (27 women, 26 men), 13 patients with major depression and physical pain (all women), and 14 healthy controls (11 women, 3 men). Raphe echogenicity was graded visually as normal or hypoechogenic, and quantified by digitized image analysis, each by investigators blinded to the clinical diagnosis. Results Quantitative midbrain raphe echogenicity was lower in patients with FMS compared to healthy controls (p<0.05), but not different from that of patients with depression and accompanying physical pain. Pain and FMS symptom burden did not correlate with midbrain raphe echogenicity as well as the presence and severity of depressive symptoms. Conclusion We found reduced echogenicity of the midbrain raphe area in patients with FMS and in patients with depression and physical pain, independent of the presence or severity of pain, FMS, and depressive symptoms. Further exploration of this sonographic finding is necessary before this objective technique may enter diagnostic algorithms in FMS and depression.},
  language  = {en}
}
@article{EderMaasSchubmannetal.2022,
  author    = {Eder, Andreas B. and Maas, Franzisca and Schubmann, Alexander and Krishna, Anand and Erle, Thorsten M.},
  title     = {Motivations underlying self-infliction of pain during thinking for pleasure},
  series = {Scientific Reports},
  volume    = {12},
  journal   = {Scientific Reports},
  number    = {1},
  doi       = {10.1038/s41598-022-14775-w},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-301059},
  year      = {2022},
  abstract  = {Previous research suggested that people prefer to administer unpleasant electric shocks to themselves rather than being left alone with their thoughts because engagement in thinking is an unpleasant activity. The present research examined this negative reinforcement hypothesis by giving participants a choice of distracting themselves with the generation of electric shock causing no to intense pain. Four experiments (N = 254) replicated the result that a large proportion of participants opted to administer painful shocks to themselves during the thinking period. However, they administered strong electric shocks to themselves even when an innocuous response option generating no or a mild shock was available. Furthermore, participants inflicted pain to themselves when they were assisted in the generation of pleasant thoughts during the waiting period, with no difference between pleasant versus unpleasant thought conditions. Overall, these results question that the primary motivation for the self-administration of painful shocks is avoidance of thinking. Instead, it seems that the self-infliction of pain was attractive for many participants, because they were curious about the shocks, their intensities, and the effects they would have on them.},
  language  = {en}
}
@article{KaethnerEidelHaegeetal.2022,
  author    = {K{\"a}thner, Ivo and Eidel, Matthias and H{\"a}ge, Anne-Sophie and Gram, Annika and Pauli, Paul},
  title     = {Observing physicians acting with different levels of empathy modulates later assessed pain tolerance},
  series = {British Journal of Health Psychology},
  volume    = {27},
  journal   = {British Journal of Health Psychology},
  number    = {2},
  doi       = {10.1111/bjhp.12553},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-258368},
  pages     = {434-448},
  year      = {2022},
  abstract  = {Objectives The patient-physician relationship is essential for treatment success. Previous studies demonstrated that physicians who behave empathic in their interaction with patients have a positive effect on health outcomes. In this study, we investigated if the mere perception of physicians as empathic/not empathic modulates pain despite an emotionally neutral interaction with the patients. Methods N = 60 women took part in an experimental study that simulated a clinical interaction. In the paradigm, each participant watched two immersive 360° videos via a head-mounted display from a patient's perspective. The physicians in the videos behaved either empathic or not empathic towards a third person. Importantly, these physicians remained emotionally neutral in the subsequent virtual interaction with the participants. Finally, participants received a controlled, painful pressure stimulus within the narratives of the videos. Results The physicians in the high compared with the low empathy videos were rated as more empathic and more likable, indicating successful experimental manipulation. In spite of later neutral behaviour of physicians, this short observation of physicians' behaviour towards a third person was sufficient to modulate pain tolerance of the participants. Conclusions The finding of this study that the mere observation of physicians' behaviour towards a third person modulates pain, despite a neutral direct interaction with the participants, has important clinical implications. Further, the proposed paradigm enables investigating aspects of patient-physician communication that are difficult to examine in a clinical setting.},
  language  = {en}
}
@article{SchmalzlFenwickReicheletal.2022,
  author    = {Schmalzl, Jonas and Fenwick, Annabel and Reichel, Thomas and Schmitz, Benedikt and Jordan, Martin and Meffert, Rainer and Plumhoff, Piet and Boehm, Dirk and Gilbert, Fabian},
  title     = {Anterior deltoid muscle tension quantified with shear wave ultrasound elastography correlates with pain level after reverse shoulder arthroplasty},
  series = {European Journal of Orthopaedic Surgery \& Traumatology},
  volume    = {32},
  journal   = {European Journal of Orthopaedic Surgery \& Traumatology},
  number    = {2},
  issn      = {1432-1068},
  doi       = {10.1007/s00590-021-02987-1},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-268441},
  pages     = {333-339},
  year      = {2022},
  abstract  = {Introduction Reverse shoulder arthroplasty (RSA) leads to medialization and distalization of the centre of rotation of the shoulder joint resulting in lengthening of the deltoid muscle. Shear wave ultrasound elastography (SWE) is a reliable method for quantifying tissue stiffness. The purpose of this study was to analyse if deltoid muscle tension after RSA correlates with the patients' pain level. We hypothesized that higher deltoid muscle tension would be associated with increased pain. Material and methods Eighteen patients treated with RSA were included. Constant score (CS) and pain level on the visual analogue scale (VAS) were analysed and SWE was performed on both shoulders. All three regions of the deltoid muscle were examined in resting position and under standardized isometric loading. Results Average patient age was 76 (range 64-84) years and average follow-up was 15 months (range 4-48). The average CS was 66 points (range 35-89) and the average pain level on the VAS was 1.8 (range 0.5-4.7). SWE revealed statistically significant higher muscle tension in the anterior and middle deltoid muscle region in patients after RSA compared to the contralateral non-operated side. There was a statistically significant correlation between pain level and anterior deltoid muscle tension. Conclusion SWE revealed increased tension in the anterior and middle portion of the deltoid muscle after RSA in a clinical setting. Increased tension of the anterior deltoid muscle portion significantly correlated with an increased pain level. SWE is a powerful, cost-effective, quick, dynamic, non-invasive, and radiation-free imaging technique to evaluate tissue elasticity in the shoulder with a wide range of applications.},
  language  = {en}
}
@phdthesis{Hausmann2022,
  author    = {Hausmann, Johannes Stephan},
  title     = {Schmerzverlauf, k{\"o}rperliche Aktivit{\"a}t und Funktion pr{\"a}operativ, drei, sechs und zw{\"o}lf Monate nach minimal-invasiver H{\"u}fttotalendoprothetik mittels direktem anterioren Zugang},
  doi       = {10.25972/OPUS-27248},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-272486},
  school      = {Universit{\"a}t W{\"u}rzburg},
  year      = {2022},
  abstract  = {Hintergrund: Die vorgestellten Daten demonstrieren das klinische Ergebnis von Patienten, die sich eine H{\"u}fttotalendoprothese (THA) unterzogen haben. Als Zugangsweg wurde der minimal-invasive, direkt anteriore Zugang in Einzelschnitttechnik gew{\"a}hlt (MIS-DAA). Die Patientin wurden bis zw{\"o}lf Monate nach Operation beobachtet. Methoden: Es wurden die Daten von 73 Probanden mittels der folgenden Fragebogen ausgewertet: Harris Hip Score (HHS), eXtra Short Musculoskeletal Functional Assessment questionnaire (XSFMA), Short Form 36 (SF-36) health survey und Patient Health Questionaire 9 „deutsch" (PHQ-9 D). Zur Schmerzmessung kam eine visuelle Analogskala (VAS von 0-4) zum Einsatz. Daneben wurde die Aktivit{\"a}t mit Hilfe des Schrittz{\"a}hlers Stepwatch™ Activity Monitor (SAM) und eines 25m Gehtests auf Zeit (T25-FW) erfasst. W{\"a}hrend der gesamten Aufzeichnung wurden auch Komplikationen erfasst. Ergebnisse: Zw{\"o}lf Monate nach der Operation verbesserten sich die HHS-Werte signifikant von 55,2 pr{\"a}operativ auf 92,4 (Werte 0 - 100). Der FSFMA Funktionsscore fiel ebenfalls signifikant von 39,4 auf 10,3 und der Beeintrachtigungsscore von 47,0 auf 15,8. Der Score f{\"u}r die Physis (PCS) stieg im SF 36 signifikant von 27,5 pr{\"a}operativ auf 47,5 nach zw{\"o}lf Monaten. Der Score f{\"u}r mentale Gesundheit (MCS) fiel dagegen sogar leicht von 57,6 auf 55,0. Dagegen fiel die Pr{\"a}valenz der mittels PHQ-9 D gemessenen Somatisierungsst{\"o}rungen von elf auf einen Fall. Die Schmerzreduktion durch die Operation zeigte sich durch einen R{\"u}ckgang auf der VAS von 2,41 auf 0,35 zw{\"o}lf Monate postoperativ. Die durchschnittlich t{\"a}glich absolvierten Lastwechsel nahmen laut Schrittz{\"a}hlermessung signifikant von 5113 pr{\"a}operativ auf 6402 zu. Außerdem stieg die Gehgeschwindigkeit im T25-FW signifikant von 22,06 s (= 1,13 m/s) auf 18,14 s (= 1,38 m/s). Es wurden keine schwerwiegenden Komplikationen, wie z.B. Transplantatlockerungen, festgestellt. Zusammenfassung: In der Zusammenschau der Ergebnisse zeigt sich ein Jahr nach MIS-DAA-THA, dass die Patienten eine signifikant bessere Funktion, Aktivit{\"a}t und weniger Schmerzen aufweisen. Der MIS-DA-Zugang ist sicher und weist keine erh{\"o}hte Komplikationsrate auf.},
  subject      = {H{\"u}ftgelenkprothese},
  language  = {de}
}
@phdthesis{Dietz2022,
  author    = {Dietz, Christopher Andreas},
  title     = {Distinguishing phenotypes of Complex Regional Pain Syndrome},
  doi       = {10.25972/OPUS-25632},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-256327},
  school      = {Universit{\"a}t W{\"u}rzburg},
  year      = {2022},
  abstract  = {This work investigated phenotypes of complex regional pain syndrome (CRPS) with special interest in sensory abnormalities. Quantitative sensory testing (QST) was used to assess sensory function. In addition, clinical and sensory differences of fracture and CRPS patients were addressed. Finally, the longitudinal outcome of CRPS patients was part of this thesis.},
  language  = {en}
}