@article{TackeLinohStumpfetal.1983, author = {Tacke, Reinhold and Linoh, Haryanto and Stumpf, Burghard and Abraham, Wolf-Rainer and Kieslich, Klaus and Ernst, Ludger}, title = {Mikrobiologische Umwandlung von Silicium-Verbindungen: Enantioselektive Reduktion von Acetessigs{\"a}ure-(trimethylsilylalkyl)estern und deren Carba-Analoga}, series = {Zeitschrift f{\"u}r Naturforschung B}, volume = {38}, journal = {Zeitschrift f{\"u}r Naturforschung B}, number = {5}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-128304}, pages = {616-620}, year = {1983}, abstract = {The trimethylsilylalkyl acetoacetates 1 b and 2 b as well as their carba analogues 1 a and 2 a have been reduced microbiologically by Kloeckera corticis (ATCC 20109), leading to the corresponding ( + )-3(S)-hydroxybutanoates 3b, 4b, 3a, and 4a. The enantiomeric purity was found to be 80\% (3a, 3b, 4b) and 65\% (4a), respectively. The reduction of lb and 2b is - to our knowledge - the first example for a controlled microbiological transformation of organosilicon substrates.}, language = {de} } @article{TackeLinohAttarBashietal.1982, author = {Tacke, Reinhold and Linoh, Haryanto and Attar-Bashi, Moayad T. and Sheldrick, William S. and Ernst, Ludger and Niedner, Roland and Frohnecke, Joachim}, title = {Sila-Pharmaka, 26. Mitt. [1] Darstellung und Eigenschaften potentiell curarewirksamer Silicium-Verbindungen, III}, series = {Zeitschrift f{\"u}r Naturforschung B}, volume = {37}, journal = {Zeitschrift f{\"u}r Naturforschung B}, number = {11}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-128402}, pages = {1461-1471}, year = {1982}, abstract = {The potentially curare-like silicon compounds 8a- 8f were synthesized and investigated with respect to their structure-activity relationships. The conformations of the compounds in the solid state and in solution were studied by X-ray diffraction analysis (8a- 8e) and IR NMR spectroscopy (8a- 8f), respectively. The muscle relaxing properties of 8a- 8f were investigated on the mouse. The observed structure-activity relationships are not in accordance with the classical "14 {\AA} model" for neuromuscular blocking agents.}, language = {de} }