@article{Schneider1989, author = {Schneider, Wolfgang}, title = {M{\"o}glichkeiten der fr{\"u}hen Vorhersage von Leseleistungen im Grundschulalter}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-86509}, year = {1989}, abstract = {Im vorliegenden Beitrag werdenneuere nends in der Forschung zur fr{\"u}hen Prognose von Leseleistungen dargestellt. Der {\"U}berblick ergibt, daß sich insbesondere solche Forschungsarbeiten bew{\"a}hrt haben, die an kognitiven Informationsverarbeitungsmodellen orientiert sind. {\"U}ber die Verkn{\"u}pfung von korrelativen L{\"a}ngsschnitt- und experimentellen Trainingsstudien ließ sich belegen, daß die im Vorschul- bzw. Kindergartenalter beobachtete Informationsverarbeitungskompetenz eine kausale Beziehung zu der schulischen Leseleistung aufwies. Es wurde weiterhin gezeigt, daß phonologische Kompetenzen im Vorschulalter auch effizient trainiert werden k{\"o}nnen. Trotz dieser insgesamt beeindruckenden Befunde scheinen individuelle Prognosen des Schriftspracherwerbs nach wie vor jedoch problematisch.}, subject = {Prognose}, language = {de} } @article{Schneider1993, author = {Schneider, Wolfgang}, title = {Introduction: The early prediction of reading and spelling}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-87418}, year = {1993}, abstract = {No abstract available.}, subject = {Prognose}, language = {en} } @article{ShityakovFoersterRethwilmetal.2014, author = {Shityakov, Sergey and F{\"o}rster, Carola and Rethwilm, Axel and Dandekar, Thomas}, title = {Evaluation and Prediction of the HIV-1 Central Polypurine Tract Influence on Foamy Viral Vectors to Transduce Dividing and Growth-Arrested Cells}, doi = {10.1155/2014/487969}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-112763}, year = {2014}, abstract = {Retroviral vectors are potent tools for gene delivery and various biomedical applications. To accomplish a gene transfer task successfully, retroviral vectors must effectively transduce diverse cell cultures at different phases of a cell cycle. However, very promising retroviral vectors based on the foamy viral (FV) backbone lack the capacity to efficiently transduce quiescent cells. It is hypothesized that this phenomenon might be explained as the inability of foamy viruses to form a pre-integration complex (PIC) with nuclear import activity in growth-arrested cells, which is the characteristic for lentiviruses (HIV-1). In this process, the HIV-1 central polypurine tract (cPPT) serves as a primer for plus-strand synthesis to produce a "flap" element and is believed to be crucial for the subsequent double-stranded cDNA formation of all retroviral RNA genomes. In this study, the effects of the lentiviral cPPT element on the FV transduction potential in dividing and growth-arrested (G1/S phase) adenocarcinomic human alveolar basal epithelial (A549) cells are investigated by experimental and theoretical methods. The results indicated that the HIV-1 cPPT element in a foamy viral vector background will lead to a significant reduction of the FV transduction and viral titre in growth-arrested cells due to the absence of PICs with nuclear import activity.}, subject = {Evaluation}, language = {en} }