@article{KarnatiGuntasRajendranetal.2022,
  author    = {Karnati, Srikanth and Guntas, Gulcan and Rajendran, Ranjithkumar and Shityakov, Sergey and H{\"o}ring, Marcus and Liebisch, Gerhard and Kosanovic, Djuro and Erg{\"u}n, S{\"u}leyman and Nagai, Michiaki and F{\"o}rster, Carola Y.},
  title     = {Quantitative lipidomic analysis of Takotsubo syndrome patients' serum},
  series = {Frontiers in Cardiovascular Medicine},
  volume    = {9},
  journal   = {Frontiers in Cardiovascular Medicine},
  number    = {797154},
  issn      = {2297-055X},
  doi       = {10.3389/fcvm.2022.797154},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-270832},
  year      = {2022},
  abstract  = {Takotsubo syndrome (TTS), also known as the transient left ventricular apical ballooning syndrome, is in contemporary times known as novel acute cardiac syndrome. It is characterized by transient left ventricular apical akinesis and hyperkinesis of the basal left ventricular portions. Although the precise etiology of TTS is unknown, events like the sudden release of stress hormones, such as the catecholamines and the increased inflammatory status might be plausible causes leading to the cardiovascular pathologies. Recent studies have highlighted that an imbalance in lipid accumulation might promote a deviant immune response as observed in TTS. However, there is no information on comprehensive profiling of serum lipids of TTS patients. Therefore, we investigated a detailed quantitative lipid analysis of TTS patients using ES-MSI. Our results showed significant differences in the majority of lipid species composition in the TTS patients compared to the control group. Furthermore, the computational analyses presented was able to link the altered lipids to the pro-inflammatory cytokines and disseminate possible mechanistic pathways involving TNFα and IL-6. Taken together, our study provides an extensive quantitative lipidome of TTS patients, which may provide a valuable Pre-diagnostic tool. This would facilitate the elucidation of the underlying mechanisms of the disease and to prevent the development of TTS in the future.},
  language  = {en}
}
@article{AlWarhiElmaidomyMaheretal.2022,
  author    = {Al-Warhi, Tarfah and Elmaidomy, Abeer H. and Maher, Sherif A. and Abu-Baih, Dalia H. and Selim, Samy and Albqmi, Mha and Al-Sanea, Mohammad M. and Alnusaire, Taghreed S. and Ghoneim, Mohammed M. and Mostafa, Ehab M. and Hussein, Shaimaa and El-Damasy, Ashraf K. and Saber, Entesar Ali and Elrehany, Mahmoud A. and Sayed, Ahmed M. and Othman, Eman M. and El-Sherbiny, Mohamed and Abdelmohsen, Usama Ramadan},
  title     = {The wound-healing potential of Olea europaea L. Cv. Arbequina leaves extract: an integrated in vitro, in silico, and in vivo investigation},
  series = {Metabolites},
  volume    = {12},
  journal   = {Metabolites},
  number    = {9},
  issn      = {2218-1989},
  doi       = {10.3390/metabo12090791},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-286150},
  year      = {2022},
  abstract  = {Olea europaea L. Cv. Arbequina (OEA) (Oleaceae) is an olive variety species that has received little attention. Besides our previous work for the chemical profiling of OEA leaves using LC-HRESIMS, an additional 23 compounds are identified. An excision wound model is used to measure wound healing action. Wounds are provided with OEA (2\% w/v) or MEBO\(^®\) cream (marketed treatment). The wound closure rate related to vehicle-treated wounds is significantly increased by OEA. Comparing to vehicle wound tissues, significant levels of TGF-β in OEA and MEBO\(^®\) (p < 0.05) are displayed by gene expression patterns, with the most significant levels in OEA-treated wounds. Proinflammatory TNF-α and IL-1β levels are substantially reduced in OEA-treated wounds. The capability of several lignan-related compounds to interact with MMP-1 is revealed by extensive in silico investigation of the major OEA compounds (i.e., inverse docking, molecular dynamics simulation, and ΔG calculation), and their role in the wound-healing process is also characterized. The potential of OEA as a potent MMP-1 inhibitor is shown in subsequent in vitro testing (IC\(_{50}\) = 88.0 ± 0.1 nM). In conclusion, OEA is introduced as an interesting therapeutic candidate that can effectively manage wound healing because of its anti-inflammatory and antioxidant properties.},
  language  = {en}
}