@article{GruendemannGorboulevGambaryanetal.1994,
  author    = {Gr{\"u}ndemann, Dirk and Gorboulev, Valentin and Gambaryan, Stepan and Veyhl, Maike and Koepsell, Hermann},
  title     = {Drug excretion mediated by a new prototype of polyspecific transporter},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-59327},
  year      = {1994},
  abstract  = {CATIO~IC drugs of different types and structures (antihistaminics, antiarrhythmics, sedatives, opiates, cytostatics and antibiotics, for example) are excreted in mammals by epithelial cells of the renal proximal tubules and by hepatocytes in the liver<sup>1-4</sup>. In the proximal tubules, two functionally disparate transport systems are involved which are localized in the basolateral and luminal plasma membrane and are different from the previously identified neuronal monoamine transporters and A TP-dependent multidrug exporting proteins<sup>1-3,5-12</sup>. Here we report the isolation of a complementary DNA from rat kidney that encodes a 556-amino-acid membrane protein, OCT1, which has the functional characteristics of organic cation uptake over the basolateral membrane of renal proximal tubules and of organic cation uptake into hepatocytes. OCTl is not homologous to any other known protein and is found in kidney, liver and intestine. As OCTl translocates hydrophobic and hydrophilic organic cations of different structures, it is considered to be a new prolotype of polyspecific transporters that are important for drug elimination.},
  subject      = {Biologie},
  language  = {en}
}
@article{GorboulevAkhundovaGrzeschiketal.1994,
  author    = {Gorboulev, Valentin G. and Akhundova, Aida and Grzeschik, K.-H. and Fahrenholz, Falk},
  title     = {Organization and chromosomal localization of the gene for the human bombesin receptor subtype expressed in pregnant uterus},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-32572},
  year      = {1994},
  abstract  = {The gene encoding the human homologue of the guinea pig uterine bombesm receptor [( 1992) Eur. J. Biochem. 208,405] was isolated from a genomic lambda library by the PCR/homology screening approach. The gene spans more than 4 kb and consists of 3 exons and 2 introns. The deduced amino acid sequence shows about 86\% identity to that of guinea pig bombesin receptor. This subtype of bombesin receptor is expressed in the pregnant uterus and in two human tumour cell lines, T47D (ductal breast carcinoma) and A431 (epidermal carcinoma). PCR analysis of genomic DNA from human-mouse cell hybrids allows the cloned gene to be localized to the region q26q28 on chromosome X.},
  language  = {en}
}