@article{ChristlFreund1985, author = {Christl, Manfred and Freund, S.}, title = {Substituierte Benzobenzvalene und Diazabenzobenzvalene - Synthesen aus Diels-Alder-Addukten des Benzvalens und NMR-Spektroskopie}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-58183}, year = {1985}, abstract = {No abstract available}, subject = {Organische Chemie}, language = {de} } @article{ChristlMattauch1985, author = {Christl, Manfred and Mattauch, B.}, title = {Versuche zur Synthese eines formalen Nitriloxid-Addukts des Benzols. 1,3-Dipolare Cycloadditionen an Bicyclo[2.2.0]hex-5-en-2,3-dicarbons{\"a}ureanhydrid, Dewarbenzol und 1,4-Cyclohexadien}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-58216}, year = {1985}, abstract = {No abstract available}, subject = {Organische Chemie}, language = {de} } @article{ChristlLanzendoerferGroetschetal.1985, author = {Christl, Manfred and Lanzend{\"o}rfer, U. and Gr{\"o}tsch, M. M. and Hegmann, J.}, title = {Prim{\"a}raddukt, γ-Ketoketen und einige Folgeprodukte der Reaktion von 6-Oxo-5-phenyl-1,3,4-oxadiazin-2-carbons{\"a}ure-methylester mit Norbornen}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-58220}, year = {1985}, abstract = {No abstract available}, subject = {Organische Chemie}, language = {de} } @article{SchenkRuebBurschka1985, author = {Schenk, Wolfdieter A. and Rueb, Doris and Burschka, Christian}, title = {Ein Dithioester als allylartiger 4e-Ligand}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-57831}, year = {1985}, abstract = {No abstract available}, subject = {Anorganische Chemie}, language = {de} } @article{UlrichsKellerMuellerRuchholtz1985, author = {Ulrichs, Karin and Keller, R. and M{\"u}ller-Ruchholtz, W.}, title = {Serological demonstration and manipulation of passenger cells (PC) in pancreas islet grafts}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-72944}, year = {1985}, abstract = {No abstract available}, subject = {Immunobiologie}, language = {en} } @article{HarnischWeissSebald1985, author = {Harnisch, U. and Weiss, H. and Sebald, Walter}, title = {The primary structure of the iron-sulfur subunit of ubiquinol-cytochrome c reductase from Neurospora, determined by cDNA and gene sequencing}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-62631}, year = {1985}, abstract = {No abstract available}, subject = {Biochemie}, language = {en} } @article{GabelliniHarnischMcCarthyetal.1985, author = {Gabellini, N. and Harnisch, U. and McCarthy, J. E. and Hauska, G. and Sebald, Walter}, title = {Cloning and expression of the fbc operon encoding the FeS protein, cytochrome b and cytochrome c\(_1\) from the Rhodopseudomonas sphaeroides b/c\(_1\) complex}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-62642}, year = {1985}, abstract = {The gene for the FeS protein of the Rhodopseudomonas sphaeroides b/c1 complex was identified by means of crosshybridization with a segment of the gene encoding the corresponding FeS protein of Neurospora crassa. Plasmids (pRSF1-14) containing the cross-hybridizing region, covering in total 13.5 kb of chromosomal DNA, were expressed in vitro in a homologous system. One RSF plasmid directed the synthesis of all three main polypeptides of the R. sphaeroides blc1 complex: the FeS protein, cytochrome b and cytochrome c1• The FeS protein and cytochrome c1 were apparently synthesized as precursor fonns. None of the pRSF plasmids directed the synthesis of the 10-kd polypeptide found in b/c1 complex preparations. Partial sequencing of the cloned region was performed. Several sites of strong homology between R. sphaeroides and eukaryotic polypeptides of the b/c1 complex were identified. The genes encode the three b/c1 polypeptides in the order: (5') FeS protein, cytochrome b, cytochrome c1• The three genes are transcribed to give a polycistronic mRNA of 2.9 kb. This transcriptional unit has been designated the jbc operon; its coding capacity corresponds to the size of the polycistronic mRNA assuming that only the genes for the FeS protein (jbcF), cytochrome b (jbcß) and cytochrome c1 (jbcC) are present. This could indicate that these three subunits constitute the minimal catalytic unit of the b/c1 complex from photosynthetic membranes.}, subject = {Biochemie}, language = {en} } @article{McCarthySchairerSebald1985, author = {McCarthy, J. E. and Schairer, H. U. and Sebald, Walter}, title = {Translational initiation frequency of atp genes from Escherichia coli: identification of an intercistronic sequence that enhances translation}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-62657}, year = {1985}, abstract = {The c, b and {\"o} subunit genes of the Escherichia coli atp operon were cloned individually in an expression vector between the tac fusion promoter and the galK gene. The relative rates of subunit synthesis directed by the cloned genes were similar in vitro andin vivo and compared favourably with the subunit stoichiometry of the assembled proton-translocating A TP synthase of E. coli in vivo. The rate of synthesis of subunit c was at least six times that of subunit b and 18 times that of subunit {\"o}. Progressive shortening of the long intercistronic sequence lying upstream of the subunit c gene showed that maximal expression of this gene is dependent upon the presence of a sequence stretching > 20 bp upstream of the Shine-Dalgarno site. This sequence thus acts to enhance the rate of translational initiation. The possibility that similar sequences might perform the same function in other operons of E. coli and bacteriophage A is also discussed. Translation of the subunit b cistron is partially coupled to translation of the preceding subunit c cistron. In conclusion, the expression of all the atp operon genes could be adjusted to accommodate the subunit requirements of A TP synthase assembly primarily by means of mechanisms which control the efficiency of translational initiation and re-initiation at the respective cistron start codons.}, subject = {Biochemie}, language = {en} } @article{LindenmaierDittmarHauseretal.1985, author = {Lindenmaier, W. and Dittmar, K. E. and Hauser, H. and Necker, A. and Sebald, Walter}, title = {Isolation of a functional human interleukin 2 gene from a cosmid library by recombination in vivo}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-62662}, year = {1985}, abstract = {A method has been developed that allows the isolation of genomic clones from a cosmid library by homologaus recombination in vivo. This method was used to isolate a human genomic interleukin 2 (IL2) gene. The genomic cosmid library was packaged in vivo into A. phage particles. A recombination-proficient host strain carrying IL2 cDNA sequences in a non-homologaus plasmid vector was infected by the packaged cosmid library. After in vivo packaging and reinfection, recombinants carrying the antibiotic resistance genes of both vectors were selected. From a recombinant cosmid clone the chromosomal IL2 genewas restored. After DNA mediated gene transfer into mouse Ltk- cells human IL2 was expressed constitutively.}, subject = {Biochemie}, language = {en} } @article{SchartlSchmidtAndersetal.1985, author = {Schartl, Manfred and Schmidt, C. R. and Anders, A. and Barnekow, A.}, title = {Elevated expression of the cellular src gene in tumors of differing etiologies in Xiphophorus}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-61889}, year = {1985}, abstract = {No abstract available}, subject = {Physiologische Chemie}, language = {en} } @incollection{Klawitter1985, author = {Klawitter, J{\"o}rg}, title = {Einige Vorbemerkungen zur Tagung "Macht - Elite - Vorbild", Faktoren gesellschaftlichen Wandels in der Umweltkrise}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-44283}, publisher = {Universit{\"a}t W{\"u}rzburg}, year = {1985}, abstract = {No abstract available}, subject = {Medizinische Ethik}, language = {de} } @book{Wehgartner1985, author = {Wehgartner, Irma}, title = {Ein Grabbild des Achilleusmalers}, isbn = {3-11-010690-6}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-53425}, publisher = {Universit{\"a}t W{\"u}rzburg}, year = {1985}, abstract = {No abstract available}, subject = {Achilleus-Maler}, language = {de} } @article{HoffmannBurschka1985, author = {Hoffmann, Gerhard Georg and Burschka, Christian}, title = {(I\(_2\)GaS-i-C\(_3\)H\(_7\))\(_2\), das erste butterfly-Molek{\"u}l mit vierfach koordiniertem Gallium}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-31432}, year = {1985}, abstract = {No abstract available}, subject = {Chemie}, language = {de} } @article{SimonNerzPresteretal.1985, author = {Simon, M. M. and Nerz, G. and Prester, M. and Moll, Heidrun}, title = {Immunoregulation by mouse T cell clones III. Cloned H-Y-specific cytotoxic T cells secrete a soluble mediator(s) that inhibits cytotoxic responses by acting on both Lyt-2\(^-\) and L3T4\(^-\)- lymphocytes}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-31625}, year = {1985}, abstract = {In this study we report that cloned Thy-l +, L3T4-, Lyt-l-, Lyt-2+, H-Y-specific and H-2Db-restricted cytotoxic T ce11 lines (CTLL) when indueed by lectin or antigen secrete a soluble mediator(s) (SF) that inhibits proliferation and generation of cytotoxic lymphocytes (CTL) in mixed lymphocyte cultures (MLC). The biological activity was separable by gel filtration and appeared as a broad peak in the moleeular mass range between 10000 and 50000 kDa. It was found that the suppressive activity released by CTLL neither strictly correlates with their cytotoxic potential nor with their ability to produce immune interferon or Iymphotoxin. SF was shown to elicitits activity in an antigen-nonspeeific manner in that it suppressed the maturation of T lymphocytes responding to both, the appropriate H-Y antigen as weH as to unrelated H_2d alloantigens or to the hapten 2,4,6-trinitrophenyl (TNP). The effect of SF on CTL responses was most pronounced in early phases of primary or secondary MLC. When analyzed for its inhibitory activity on precursor ceHs in populations selected for either Lyt-2- or L3T4- lymphocytes, it was found that SF interfered with the maturation of both subsets. The inhibition of CTL responses elicited by SF could not be reversed by the addition of exogenous interleukin 2. The findtng that SF also inhi. bited the proliferation of some but not a11 antigen-dependent cloned T ceHs with helper or eytc'toxic potential provides evidence that the faetor also may regulate effector lymphl)cytes. In addition, the results support the assumption that SF exerts its effect direetly on the responder rather than the stimulator population, and demonstrate that the development of CTL from their preeursor eeHs is contro11ed at least in part by the eytotoxic effeetor cells themselves via a soluble factor(s) that interferes with distinct stages of T ce11 maturation. These findings again emphasize the expression of multiple functions by CTL and indieate their possible role du ring the course of an immune response by their capability to eliminate target cells and to secrete a soluble product(s) that mediates feedback contro!.}, subject = {Infektionsbiologie}, language = {en} } @article{SchmaehlFrankLutzetal.1985, author = {Schm{\"a}hl, D. and Frank, HK and Lutz, WK and Stransky, M. and Ritzel, G. and Beaufort, F. and Vutuc, C.}, title = {Ern{\"a}hrung und Krebs}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-55224}, year = {1985}, abstract = {No abstract available}, subject = {Medizin}, language = {de} } @article{ChristlLangHerzogetal.1985, author = {Christl, Manfred and Lang, Reinhard and Herzog, Clemens and Stangl, Roland and Peters, Karl and Peters, Eva-Maria and Schnering, Hans Georg von}, title = {Reaktion von Homobenzvalen mit Tetracyanethylen : Bildung eines Tetracyandihydrobarbaralan- und eines Tetracyancyclopropan-Derivats}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-31839}, year = {1985}, abstract = {In den Reaktionen von Tetracyanethylen (TCNE) und 5,6-Dichlor-2,3-dicyan-p-benzochinon mit Benzvalen haben wir k{\"u}rzlich die ersten Beispiele f{\"u}r die lange gesuchte einstufige 1,4-Cycloaddition eines Alkens an ein Vinylcyclopropan gcfunden(I~J. Sie ist als [(.,2.+.2s)+ 112J-Prozeß der Dicls-Alder-Addition nahe verwandtllbl. Allerdings entsteht das betreffende TCNE-Addukt, ein Dihydrosemibullvalen-Derivat, nur in einer Ausbeute von wenigen Prozent. Die Hauptprodukte gehen aus einer Zwitterionischen Zwischenstufe hervor, die durch Anlagerung von TCNE an die Benzvalen-n-Bindung resultiert. Professor Rolf Huisgen zum 65. Geburtstag gewidmet}, subject = {Chemie}, language = {de} } @article{GleiterBischofGubernatoretal.1985, author = {Gleiter, Rolf and Bischof, Peter and Gubernator, Klaus and Christl, Manfred and Schwager, Luis and Vogel, Pierre}, title = {2,3-Bis(methylene)bicyclo[2.1.1]hexane and 3,4-Bis(methylene)tricyclo[3.1.0.0\(^{2,6}\)]hexane : Interaction between a π System and a Cyclobutane or Bicyclobutane Moiety}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-31845}, year = {1985}, abstract = {The He (I) photoelectron spectra of 2-bicyclo[2.1.l]hexene (1), 2,3-bis(methylene)bicyclo[2.1.l]hexane (3), and 3,4-bis(methylene)tricyclo[3.l.O.0\(^{2.6}\)]hexane (4) have been investigated. The assignment given is based on a ZDO model and semiempirical calculations. Tagether with the PE data of benzvalene (2), the reported data allow a comparison between 1-2 and 3-4. This yields a measure of the interactions between 8 cyclobutane or 8 bicyclobutane moiety and a double bond system within a ZDO model. The resonance integral found in the case of 1 and 3 amounts to -1.9 eV, that for 2 and 4, to -2.3 eV. The investigations furthermore reveal that the electronic factors which contribute to the higher reactivity of the bicyclobutane compounds amount to 5 kcal/mol.}, subject = {Chemie}, language = {en} } @article{SirenSvarstroemFraserPaakkari1985, author = {Sir{\´e}n, Anna-Leena and Svarstr{\"o}m-Fraser, M. and Paakkari, I.}, title = {Central cardiovascular effects of the endoperoxide analogue U-46619 i.c.v. in rats}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-49064}, year = {1985}, abstract = {Thromboxanes are abundantly present in the rat brain but their possible physiological functions in the brain are not known. The prostaglandin endoperoxide analogue U-46619 is a selective agonist of TxA2 receptors in many peripheral tissues. In the present study the ·central cardiovascular and ventilatory effects of U-46619 were investigated in rats. In conscious spontaneously hypertensive rats (SHR) U-46619 (1-100 nmol/kg i.c.v.) induced a strong dose-related increase in blood pressure but had no significant effect on heart rate. In conscious normotensive rats (NR) neither blood pressure nor heart rate was significantly affected. Furthermore, U-46619 (0.1-100 nmol/kg i.c.v.) had no significant effect on blood pressure, heart rate or ventilation in urethane-anaesthetised NR . The results demonstrate an increased sensitivity of SHR to TxA2.}, subject = {Medizin}, language = {en} } @article{WieberWirthBurschka1985, author = {Wieber, Markus and Wirth, Dieter and Burschka, Christian}, title = {Darstellung und Struktur einiger \(\eta^5\)-Cyclopentadienyldicarbonyleisenbismut-Verbindungen Cp(CO)\(_2\)FeBiX\(_2\) mit f{\"u}nffach koordiniertem Bismutatom}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-46840}, year = {1985}, abstract = {No abstract available}, subject = {Chemie}, language = {de} } @article{SchenkLeissnerBurschka1985, author = {Schenk, Wolfdieter A. and Leissner, Johanna and Burschka, Christian}, title = {Vier- und f{\"u}nffach koordinierte Schwefelmonoxid-Komplexe des Rhodiums und Iridiums}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-46838}, year = {1985}, abstract = {No abstract available}, subject = {Chemie}, language = {de} }