@phdthesis{Weiss2017,
  author    = {Weiß, Sandra Elisabeth},
  title     = {Erstmalige Sauerstoff-basierte MR-Lungenfunktionsanalyse im Schulkindesalter - lassen sich Ver{\"a}nderungen der Ventilation bei ehemals fr{\"u}hgeborenen Kindern nachweisen?},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-143730},
  school      = {Universit{\"a}t W{\"u}rzburg},
  year      = {2017},
  abstract  = {Oxygen-enhanced functional low-field MRI of the lung in formerly very low birth weight infants with and without bronchopulmonary dysplasia (BPD) Clemens Wirth1, Sandra Weiß1, Daniel St{\"a}b1, Wolfgang Thomas2, Henning Neubauer1, Helge Hebestreit2, Herbert K{\"o}stler1, Dietbert Hahn1, Meinrad Beer1 1 Institute of Radiology, 2 Department of Pediatrics, University of Wuerzburg, Germany Purpose: To assess functional lung abnormalities in formerly very low birth weight infants (VLBW) with and without BPD compared with children born at term without lung pathology in an oxygen-enhanced open low-field MRI. Materials and methods: 40 children aged 7-12 years were included in this study. 10 children had BPD, 15 were VLBW without BPD (non-BPD) and 15 formerly term infants served as controls (CON). Sagittal T1-weighted single inversion multi-gradientecho sequences were acquired for both lungs at an open low-field MRI (Magnetom Open 0.2 Tesla, Siemens Medical Solutions, Erlangen, Germany). Acquisition was performed in 2 cycles: whilst breathing ambient air, then 100\% oxygen via breathing mask. The mean relative change of the T1 relaxation time (ΔT1) between the two cycles was calculated after pixelwise subtraction of the parameter maps. ΔT1 of the different groups was compared statistically. Results: ΔT1 of the different groups was calculated as follows: CON 10.7 +/- 2.3\%; Non-BPD 10.8 +/- 3.0\%; BPD 9.2 +/- 3.1\%. ΔT1 was significantly lower in the BPD group compared to both other groups (Mann-Whitney-U; p<0.05). There was no significant change of ΔT1 between the Non-BPD and the control group (p=0.93). Subanalysis of the lobes showed inhomogenieties of ΔT1 in the BPD group. Conclusion: Functional oxygen-enhanced MRI shows significant differences of ΔT1 in patients with BPD compared to children without BPD, reflecting probable long term functional sequelae of disturbed pulmonary vascular and alveolar development of the disease.},
  subject      = {MRT},
  language  = {de}
}
@article{BluemelLinkeHerrmannetal.2016,
  author    = {Bluemel, Christina and Linke, Fraenze and Herrmann, Ken and Simunovic, Iva and Eiber, Matthias and Kestler, Christian and Buck, Andreas K. and Schirbel, Andreas and Bley, Thorsten A. and Wester, Hans-Juergen and Vergho, Daniel and Becker, Axel},
  title     = {Impact of \(^{68}\)Ga-PSMA PET/CT on salvage radiotherapy planning in patients with prostate cancer and persisting PSA values or biochemical relapse after prostatectomy},
  series = {EJNMMI Research},
  volume    = {6},
  journal   = {EJNMMI Research},
  number    = {78},
  doi       = {10.1186/s13550-016-0233-4},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-147798},
  year      = {2016},
  abstract  = {Background Salvage radiotherapy (SRT) is clinically established in prostate cancer (PC) patients with PSA persistence or biochemical relapse (BCR) after prior radical surgery. PET/CT imaging prior to SRT may be performed to localize disease recurrence. The recently introduced \(^{68}\)Ga-PSMA outperforms other PET tracers for detection of recurrence and is therefore expected also to impact radiation planning. Forty-five patients with PSA persistence (16 pts) or BCR (29 pts) after prior prostatectomy, scheduled to undergo SRT of the prostate bed, underwent \(^{68}\)Ga-PSMA PET/CT. The median PSA level was 0.67 ng/ml. The impact of \(^{68}\)Ga-PSMA PET/CT on the treatment decision was assessed. Patients with oligometastatic (≤5 lesions) PC underwent radiotherapy (RT), with the extent of the RT area and dose escalation being based on PET positivity. Results Suspicious lesions were detected in 24/45 (53.3 \%) patients. In 62.5 \% of patients, lesions were only detected by 68Ga-PSMA PET. Treatment was changed in 19/45 (42.2 \%) patients, e.g., extending SRT to metastases (9/19), administering dose escalation in patients with morphological local recurrence (6/19), or replacing SRT by systemic therapy (2/19). 38/45 (84.4 \%) followed the treatment recommendation, with data on clinical follow-up being available in 21 patients treated with SRT. All but one showed biochemical response (mean PSA decline 78 ± 19 \%) within a mean follow-up of 8.12 ± 5.23 months. Conclusions \(^{68}\)Ga-PSMA PET/CT impacts treatment planning in more than 40 \% of patients scheduled to undergo SRT. Future prospective studies are needed to confirm this significant therapeutic impact on patients prior to SRT.},
  language  = {en}
}
@article{GilbertBoehmEdenetal.2016,
  author    = {Gilbert, Fabian and B{\"o}hm, Dirk and Eden, Lars and Schmalzl, Jonas and Meffert, Rainer H. and K{\"o}stler, Herbert and Weng, Andreas M. and Ziegler, Dirk},
  title     = {Comparing the MRI-based Goutallier Classification to an experimental quantitative MR spectroscopic fat measurement of the supraspinatus muscle},
  series = {BMC Musculoskeletal Disorders},
  volume    = {17},
  journal   = {BMC Musculoskeletal Disorders},
  number    = {355},
  doi       = {10.1186/s12891-016-1216-3},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-147788},
  year      = {2016},
  abstract  = {Background The Goutallier Classification is a semi quantitative classification system to determine the amount of fatty degeneration in rotator cuff muscles. Although initially proposed for axial computer tomography scans it is currently applied to magnet-resonance-imaging-scans. The role for its clinical use is controversial, as the reliability of the classification has been shown to be inconsistent. The purpose of this study was to compare the semi quantitative MRI-based Goutallier Classification applied by 5 different raters to experimental MR spectroscopic quantitative fat measurement in order to determine the correlation between this classification system and the true extent of fatty degeneration shown by spectroscopy. Methods MRI-scans of 42 patients with rotator cuff tears were examined by 5 shoulder surgeons and were graduated according to the MRI-based Goutallier Classification proposed by Fuchs et al. Additionally the fat/water ratio was measured with MR spectroscopy using the experimental SPLASH technique. The semi quantitative grading according to the Goutallier Classification was statistically correlated with the quantitative measured fat/water ratio using Spearman's rank correlation. Results Statistical analysis of the data revealed only fair correlation of the Goutallier Classification system and the quantitative fat/water ratio with R = 0.35 (p < 0.05). By dichotomizing the scale the correlation was 0.72. The interobserver and intraobserver reliabilities were substantial with R = 0.62 and R = 0.74 (p < 0.01). Conclusion The correlation between the semi quantitative MRI based Goutallier Classification system and MR spectroscopic fat measurement is weak. As an adequate estimation of fatty degeneration based on standard MRI may not be possible, quantitative methods need to be considered in order to increase diagnostic safety and thus provide patients with ideal care in regard to the amount of fatty degeneration. Spectroscopic MR measurement may increase the accuracy of the Goutallier classification and thus improve the prediction of clinical results after rotator cuff repair. However, these techniques are currently only available in an experimental setting.},
  language  = {en}
}
@article{BaurRitterGermeretal.2016,
  author    = {Baur, Johannes and Ritter, Christian O. and Germer, Christoph-Thomas and Klein, Ingo and Kickuth, Ralph and Steger, Ulrich},
  title     = {Transarterial chemoembolization with drug-eluting beads versus conventional transarterial chemoembolization in locally advanced hepatocellular carcinoma},
  series = {Hepatic Medicine},
  volume    = {2016},
  journal   = {Hepatic Medicine},
  number    = {8},
  doi       = {10.2147/HMER.S105395},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-146553},
  pages     = {69-74},
  year      = {2016},
  abstract  = {Purpose: In hepatocellular carcinoma patients with large or multinodal tumors, where curative treatment options are not feasible, transarterial therapies play a major role. Transarterial chemoembolization (TACE) with drug-eluting beads (DEB-TACE) is a promising new approach due to higher intratumoral and lower systemic concentration of the chemotherapeutic agent compared to conventional TACE (cTACE). Patients and methods: In a retrospective analysis, 32 patients with hepatocellular carcinoma who received either DEB or a cTACE were compared regarding survival time, disease recurrence, and side effects such as pain and fever. Results: No significant differences could be detected between the cTACE and DEB-TACE groups with regard to mean hospital stay, appearance of postinterventional fever, or 30-day mortality. However, the application of intravenous analgesics as postinterventional pain medication was needed more often in patients treated with DEB-TACE (57.1\% vs 12.5\%, P=0.0281). The overall median survival after the initial procedure was 10.8 months in the cTACE group and 9.2 months in the DEB-TACE group, showing no significant difference. Conclusion: No survival benefit for patients treated with either DEB-TACE or cTACE was observed. Surprisingly, a higher rate of postinterventional pain could be detected after DEB-TACE.},
  language  = {en}
}
@phdthesis{Evangelista2016,
  author    = {Evangelista, Laura},
  title     = {Innovative Anwendungen der diffusionsgewichteten MRT in der p{\"a}diatrischen muskuloskelettalen Bildgebung},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-145065},
  school      = {Universit{\"a}t W{\"u}rzburg},
  year      = {2016},
  abstract  = {Die vorliegende Arbeit untesucht die Darstellung tumor{\"o}ser und entz{\"u}ndlicher muskuloskelettaler L{\"a}sionen mit der diffusionsgewichteten MRT-Bildgebung bei Kindern und Jugendlichen. Es sollten die Machbarkeit und die Zuverl{\"a}ssigkeit der Methode in der klinischen Routinebildgebung {\"u}berpr{\"u}ft werden. Zus{\"a}tzlich untersuchten wir den Einsatz von ADC-Werten zur Differenzierung von malignen und benignen Tumoren sowie bei inflammatorischen Knochen- und Weichteilbefunden. Wie die klassische MRT, ist die diffusionsgewichtete Bildgebung nicht-invasiv: da der Bildkontrast allein mittels magnetischer Feldgradienten erzielt wird, erfordert sie weder eine Injektion von Kontrastmitteln, noch den Einsatz von ionisierender Strahlung. Sie garantiert eine schnelle Aquisitionstechink um Artefakte zu begrenzen und die Untersuchungen kindergerechter zu gestalten. Die von uns erfassten Daten wurden in zwei unterschiedlichen Studien aufgeteilt. Die Erste Studie erfasst Ergebnisse bzgl. der Detektion und Dignit{\"a}tsabsch{\"a}tzung kinderlicher muskuloskelettaler Tumoren mittels diffusionsgewichteten MRT Bilder. Das zweite Forschungsprojekt, befasst sich mit dem erstmaligen Einsatz der diffusionsgewichteten MRT zur Identifikation und Differenzierung von Knochenmark{\"o}dem, Weichteil{\"o}dem und Synovitis bei p{\"a}diatrischen Patienten.},
  subject      = {Diffusionsgewichtete Magnetresonanztomographie},
  language  = {de}
}
@phdthesis{Richter2015,
  author    = {Richter, Julia Babette Marianne},
  title     = {Vergleich der Wertigkeit von Magnetresonanz-Enterographie und farbkodierter Duplex-Sonographie bei chronisch entz{\"u}ndlichen Darmerkrankungen im Kindes- und Jugendlichenalter},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-140336},
  school      = {Universit{\"a}t W{\"u}rzburg},
  year      = {2015},
  abstract  = {In der S3-Leitlinie „Diagnostik und Therapie des Morbus Crohn" von 2008 war lediglich die Sonographie als prim{\"a}r bildgebendes Verfahren verankert; der Einsatz der D{\"u}nndarm-MRT blieb optional und ohne feste Position im Diagnostik-Algorithmus der CED. Im Unterschied hierzu st{\"a}rkt die 2014 aktualisierte entsprechende S3-Leitlinie den Stellenwert der MRT als bildgebende Modalit{\"a}t. Weiterhin bestehen bleibt die Sonographie als prim{\"a}re Bildgebung; eine MRT soll jedoch ebenfalls erfolgen: zur Prim{\"a}rdiagnostik, zur Erkennung extraintestinaler Komplikationen und zur Beurteilung endoskopisch nicht einsehbarer Darmabschnitte. Dar{\"u}ber hinaus kann sie in Verlaufskontrollen angewendet werden, falls erforderlich. Da sich diese jungen Patienten bei langer Krankheitsdauer in der Regel einer hohen Zahl an Untersuchungen unterziehen, sollte die M{\"o}glichkeit, dies strahlenexpositionsfrei durchf{\"u}hren zu k{\"o}nnen, unbedingt gew{\"a}hrleistet werden. Andernfalls ist mit einer erh{\"o}hten Rate an Malignomen im sp{\"a}teren Lebensalter zu rechnen. Daraus ergibt sich die Bedeutung einer Korrelation von mittels Ultraschall wie MRT erhobenen Befunden bei kindlicher CED. Hierzu liegen bislang nur wenige Untersuchungen vor, die zumeist auf den additiven Wert der Sonographie zur MRT und/oder dem additiven Wert der MR-Perfusionsanalyse fokussieren. Der hier vorgestellte Ansatz einer direkten Korrelation der Parameter Wanddicke und Perfusionsmarker zwischen Sonographie und MRT sowie gegen{\"u}ber klinischen Aktivit{\"a}tsmarkern (shPCDAI) ist innovativ. F{\"u}r das MRT konnten wir eine signifikante Korrelation von Wanddicke und Signalintensit{\"a}tszunahme zwei Minuten nach Kontrastmittelgabe f{\"u}r das terminale Ileum, der Pr{\"a}dilektionsstelle des Morbus Crohn, nachweisen. Ein Zusammenhang zwischen Wanddicke und klinischem Aktivit{\"a}tsindex konnte nicht gezeigt werden, jedoch zwischen Signalintensit{\"a}tszunahme und short PCDAI. Die Perfusionsanalyse sollte daher unserer Ansicht nach bei MRT-Untersuchungen zur Beantwortung der Frage „aktive Entz{\"u}ndung" herangezogen werden. F{\"u}r die Sonographie konnten wir keinen Zusammenhang von Wanddicke und Perfusion, jedoch eine signifikante Korrelation von Wanddicke und short PCDAI nachweisen. Die Perfusion korrelierte wiederum nicht mit dem klinischen Aktivit{\"a}tsindex. Die morphologische Wanddickenanalyse sollte daher f{\"u}r Sonographie-Untersuchungen zur Beantwortung der Frage „aktive Entz{\"u}ndung" herangezogen werden. Bei der Korrelation der MRT- und Sonographie-Ergebnisse zeigte sich ein gutes {\"U}bereinstimmen der Daten der Darmwanddicken-Messungen, die h{\"o}chste Korrelation ergab sich im terminalen Ileum. Auch f{\"u}r Signalintensit{\"a}tszunahmen (MRT) und Perfusion (FKDS) zeigte sich ein gutes {\"U}bereinstimmen - mit Ausnahme des Rektosigmoids (sp{\"a}te KM-Phase). Die gr{\"o}ßte Korrelation war auch hier im terminalen Ileum zu finden. Dies belegt die gute Vergleichbarkeit beider Modalit{\"a}ten. Eine Korrelation von MRAIs - USAI - shPCDAI ließ sich nicht nachweisen. Dies k{\"o}nnte an einer divergenten Einsch{\"a}tzung der Erkrankungsaktivit{\"a}t, jedoch auch an der kleinen Fallzahl liegen. Zur Erstellung des shPCDAI waren die retrospektiv erhobenen Variablen teils nicht ausreichend. Hauptlimitation f{\"u}r den USAI war die - teils durch Darmgas{\"u}berlagerung bedingte - unvollst{\"a}ndige Dokumentation. Die St{\"a}rke des MRAI lag dagegen bei konstant vorliegenden Messungen in f{\"u}nf Darmabschnitten. Trotz dieser Limitationen belegt die vorliegende Arbeit die Gleichwertigkeit beider Methoden in der Beurteilung von Darmwanddicken und eine bessere Korrelation wie Aussagekraft der MRT bei der Perfusionsanalyse. Aktuelle Publikationen belegen die Bedeutung Diffusionsgewichteter-MR-Bildgebung bei der CED-Diagnostik. Die DWI wurde im Rahmen unserer Untersuchung nicht angewendet, wird aber in Zukunft als vielversprechender, additiver Baustein oder sogar Ersatz f{\"u}r die Kontrastmittelgabe (Perfusionsanalyse) f{\"u}r MRT bei CED zu evaluieren sein.},
  subject      = {Magnetresonanztomographie},
  language  = {de}
}
@article{DuhrKennKickuthetal.2011,
  author    = {Duhr, Carolin D. and Kenn, Werner and Kickuth, Ralph and Kerscher, Alexander G. and Germer, Christoph-Thomas and Hahn, Dietbert and Pelz, Joerg O. W.},
  title     = {Optimizing of preoperative computed tomography for diagnosis in patients with peritoneal carcinomatosis},
  series = {World Journal of Surgical Oncology},
  volume    = {9},
  journal   = {World Journal of Surgical Oncology},
  number    = {171},
  doi       = {10.1186/1477-7819-9-171},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-138024},
  year      = {2011},
  abstract  = {Background and Objective This study evaluates whether Computer Tomography is an effective procedure for preoperative staging of patients with Peritoneal Carcinomatosis. Method A sample of 37 patients was analyzed with contrast enhanced abdominal Computer Tomography, followed by surgical staging. All Computer Tomography scans were evaluated 3 times by 2 radiologists with one radiologist reviewing 2 times. The efficacy of Computer Tomography was evaluated using the Spearman correlation coefficient. Correlations were analyzed by abdominopelvic region to assess results of the Peritoneal Carcinomatosis Index (PCI) aggregating the 13 regions. Surgical findings were compared to radiological findings. Results Results indicate high correlations between the surgical and radiological Peritoneal Carcinomatosis Indices. Analyses of the intra-class correlation between the first and second reading of one radiologist suggest high intra-observer reliability. Correlations by abdominopelvic region show higher values in the upper and middle regions and relatively lower values in the lower regions and the small bowel (correlation coefficients range between 0.418 and 0.726, p < 0.010; sensitivities range between 50\% and 96\%; and specificities range between 62\% and 100\%). Conclusion Computer Tomography represents an effective procedure in the preoperative staging of patients with PC. However, results by abdominopelvic region show lower correlation, therefore suggest lower efficacy. These results are supported by analyses of sensitivity and accuracy by lesion size. This suggests that Computer Tomography is an effective procedure for pre-operative staging but less for determining a tumor's accurate extent.},
  language  = {en}
}
@article{NordbeckBeerKoestleretal.2012,
  author    = {Nordbeck, Peter and Beer, Meinrad and K{\"o}stler, Herbert and Ladd, Mark E. and Quick, Harald H. and Bauer, Wolfgang R. and Ritter, Oliver},
  title     = {Cardiac catheter ablation under real-time magnetic resonance guidance},
  series = {European Heart Journal},
  volume    = {33},
  journal   = {European Heart Journal},
  number    = {15},
  doi       = {10.1093/eurheartj/ehs139},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-125638},
  year      = {2012},
  abstract  = {One of the main shortcomings of interventional electrophysiology (EP) is its inability to generate sufficient soft tissue contrast for intra-procedural visualization of the myocardium and the surrounding tissue, using conventional imaging techniques. Interventional cardiovascular magnetic resonance imaging (MRI) aims at bringing about significant improvements to the complex and decisive EP interventions far beyond the capabilities of currently available supportive imaging techniques used to surmount the drawbacks of fluoroscopy, as MRI not only allows of precise three-dimensional exposure of the cardiovascular morphology, but also proves to be a promising technique exclusively suitable for direct visualization of arrhythmogenic substrate and therapeutic effects. The major challenge posed by clinical …},
  language  = {en}
}
@article{LiuHuNiemannetal.2013,
  author    = {Liu, Dan and Hu, Kai and Niemann, Markus and Herrmann, Sebastian and Cikes, Maja and St{\"o}rk, Stefan and Beer, Meinrad and Gaudron, Philipp Daniel and Morbach, Caroline and Knop, Stefan and Geissinger, Eva and Ertl, Georg and Bijnens, Bart and Weidemann, Frank},
  title     = {Impact of Regional Left Ventricular Function on Outcome for Patients with AL Amyloidosis},
  series = {PLoS ONE},
  volume    = {8},
  journal   = {PLoS ONE},
  number    = {3},
  doi       = {10.1371/journal.pone.0056923},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-130293},
  pages     = {e56923},
  year      = {2013},
  abstract  = {Objectives The aim of this study was to explore the left ventricular (LV) deformation changes and the potential impact of deformation on outcome in patients with proven light-chain (AL) amyloidosis and LV hypertrophy. Background Cardiac involvement in AL amyloidosis patients is associated with poor outcome. Detecting regional cardiac function by advanced non-invasive techniques might be favorable for predicting outcome. Methods LV longitudinal, circumferential and radial peak systolic strains (Ssys) were assessed by speckle tracking imaging (STI) in 44 biopsy-proven systemic AL amyloidosis patients with LV hypertrophy (CA) and in 30 normal controls. Patients were divided into compensated (n = 18) and decompensated (n = 26) group based on clinical assessment and followed-up for a median period of 345 days. Results Ejection fraction (EF) was preserved while longitudinal Ssys (LSsys) was significantly reduced in both compensated and decompensated groups. Survival was significantly reduced in decompensated group (35\% vs. compensated 78\%, P = 0.001). LSsys were similar in apical segments and significantly reduced in basal segments between two patient groups. LSsys at mid-segments were significantly reduced in all LV walls of decompensated group. Patients were further divided into 4 subgroups according to the presence or absence of reduced LSsys in no (normal), only basal (mild), basal and mid (intermediate) and all segments of the septum (severe). This staging revealed continuously worse prognosis in proportion to increasing number of segments with reduced LSsys (mortality: normal 14\%, mild 27\%, intermediate 67\%, and severe 64\%). Mid-septum LSsys<11\% suggested a 4.8-fold mortality risk than mid-septum LSsys≥11\%. Multivariate regression analysis showed NYHA class and mid-septum LSsys were independent predictors for survival. Conclusions Reduced deformation at mid-septum is associated with worse prognosis in systemic amyloidosis patients with LV hypertrophy.},
  language  = {en}
}
@phdthesis{RungeHiemer2015,
  author    = {Runge-Hiemer, Pamela},
  title     = {Elastographie (qualitativ und semiquantitativ) am Hals bei Kindern und Jugendlichen},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-135048},
  school      = {Universit{\"a}t W{\"u}rzburg},
  year      = {2015},
  abstract  = {In unserer Studie kamen die neuen Verfahren qualitative und semiquantitative Elastographie zum Einsatz. Es sollte gezeigt werden, ob sie als Erg{\"a}nzung zu den herk{\"o}mmlichen sonographischen Verfahren die Diagnosestellung von Erkrankungen am Hals bei Kindern und Jugendlichen verbessern k{\"o}nnen. Bei der Untersuchung mittels semiquantitativer Elastographie konnten wir in unserer Studie beim Vergleich Schilddr{\"u}sen-Normalbefund und Hashimoto-Thyreoiditis einen signifikanten Unterschied der Scherwellengeschwindigkeiten nachweisen. Es zeigte sich, dass Patienten mit Hashimoto-Thyreoiditis signifikant h{\"o}here Scherwellengeschwindigkeiten aufweisen als Patienten mit Normalbefund. F{\"u}r die anderen untersuchten Schilddr{\"u}senerkrankungen, Struma diffusa und Struma nodosa und f{\"u}r die Erkrankungen der Lymphknoten, benigne Ver{\"a}nderung/Entz{\"u}ndung, maligne Ver{\"a}nderung und Abszess, ließ sich kein signifikanter Unterschied feststellen. Die Sensitivit{\"a}t und Spezifit{\"a}t konnte durch Einsatz des neuen Verfahrens der qualitativen Elastographie nicht gesteigert werden. W{\"a}hrend sich bei der Schilddr{\"u}sendiagnostik geringere Werte f{\"u}r Sensitivit{\"a}t und Spezifit{\"a}t im Vergleich zu den herk{\"o}mmlichen Verfahren zeigten, unterschieden sich die Werte bei der Lymphknotenuntersuchung Reader-abh{\"a}ngig. Bei der Schilddr{\"u}senuntersuchung lag die Bildqualit{\"a}t der konventionellen Sonographie {\"u}ber der der qualitativen Elastographie. Dagegen wurde bei der Lymphknotenuntersuchung die Bildqualit{\"a}t der Elastographiebilder h{\"o}her bewertet als jene der herk{\"o}mmlichen Verfahren. Insgesamt konnte in unserer Studie gezeigt werden, dass Patienten mit Hashimoto-Thyreoiditits signifikant h{\"o}here Scherwellengeschwindigkeiten im Schilddr{\"u}sengewebe aufweisen, als bei Normalbefund. In der Diagnostik von Schilddr{\"u}sen- und Lymphknotenerkrankungen konnte bez{\"u}glich des neuen Verfahrens der qualitativen Elastographie eine {\"U}berlegenheit gegen{\"u}ber der konventionellen Sonographie nicht nachgewiesen werden. Um die Ergebnisse unserer Studie abschließend bewerten zu k{\"o}nnen, w{\"a}re eine Validierung anhand einer gr{\"o}ßeren Patientengruppe n{\"o}tig.},
  subject      = {Elastographie},
  language  = {de}
}
@article{NessBleySchmidtetal.2013,
  author    = {Ness, Thomas and Bley, Thorsten A. and Schmidt, Wolfgang A. and Lamprecht, Peter},
  title     = {The Diagnosis and Treatment of Giant Cell Arteritis},
  series = {Deutsches {\"A}rzteblatt International},
  volume    = {110},
  journal   = {Deutsches {\"A}rzteblatt International},
  number    = {21},
  doi       = {10.3238/arztebl.2013.0376},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-131676},
  pages     = {376-86},
  year      = {2013},
  abstract  = {Background: Giant cell arteritis (GCA) is the most common systemic vasculitis in persons aged 50 and above (incidence, 3.5 per 100 000 per year). It affects cranial arteries, the aorta, and arteries elsewhere in the body, e.g., in the limbs. Methods: We selectively review the pertinent literature, including guidelines and recommendations from Germany and abroad. Results: The typical symptoms of new-onset GCA are bi-temporal headaches, jaw claudiacation, scalp tenderness, visual disturbances, systemic symptoms such as fever and weight loss, and polymyalgia. The diagnostic assessment comprises laboratory testing (erythrocyte sedimentation rate, C-reactive protein), imaging studies (duplex sonography, high-resolution magnetic resonance imaging, positron-emission tomography), and temporal artery biopsy. The standard treatment is with corticosteroids (adverse effects: diabetes mellitus, osteoporosis, cataract, arterial hypertension). A meta-analysis of three randomized controlled trials led to a recommendation for treatment with methotrexate to lower the recurrence rate and spare steroids. Patients for whom methotrexate is contraindicated or who cannot tolerate the drug can be treated with azathioprine instead. Conclusion: Giant cell arteritis, if untreated, progresses to involve the aorta and its collateral branches, leading to various complications. Late diagnosis and treatment can have serious consequences, including irreversible loss of visual function.},
  language  = {en}
}
@phdthesis{Fritz2014,
  author    = {Fritz, Doroth{\´e}e Ulrike},
  title     = {Retrospektive Analyse der computertomographisch gesteuerten Punktionen an einem Kollektiv von 951 Patienten},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-126347},
  school      = {Universit{\"a}t W{\"u}rzburg},
  year      = {2014},
  abstract  = {Ziel dieser Arbeit war es, den Stellenwert der CT-gesteuerten Punktion hinsichtlich Komplikationsrate, nicht auswertbaren Biopsien, deren statistische Kenngr{\"o}ßen in der Gesamtheit und deren Zusammenhang bez{\"u}glich Nadelgr{\"o}ße, Punktionsweg und L{\"a}sionsgr{\"o}ße zu ermitteln. Insgesamt konnte retrospektiv ein Kollektiv von 1019 Punktionen an 951 Patienten im Institut f{\"u}r R{\"o}ntgendiagnostik der Universit{\"a}t W{\"u}rzburg mit einem Follow-up von 2 Jahren untersucht werden. Es konnten in 96 \% der F{\"a}lle vom Pathologen auswertbare Proben gewonnen werden. Bei 951 Patienten konnten 38 Biopsien nicht histologisch ausgewertet werden. Es bestand ein signifikanter Zusammenhang bez{\"u}glich der Dicke der Biopsienadel und der histologischen Auswertbarkeit. 19/20 G Nadeln f{\"u}hrten in 20 \% der F{\"a}lle zu nicht beurteilbaren Proben, 15/16 G und 17/18 G Nadeln hingegen nur bei 1,8 \% und 3,6 \% der Punktionen. Bei komplikationslosen Punktionen ergaben sich seltener histologisch nicht auswertbare Proben (3,5 \%) als bei Biopsien, die eine Komplikation verursachten bzw. nach sich zogen (6,3 \%). Die Biopsien fanden in 57 \% der F{\"a}lle mit 17/18 G Nadeln statt. Bei 40 \% der Punktionen wurden 15/16 G Nadeln verwendet. In lediglich 4,3 \% und 6,7 \% der F{\"a}lle kamen 19/20 G Nadeln und Knochenstanzen zum Einsatz. In der Gesamtheit des Kollektivs ergab sich eine Sensitivit{\"a}t von 92 \% bei einer Spezifit{\"a}t von 100 \%. Die Kenngr{\"o}ßen variierten in den anatomischen Subgruppen. Von 951 Punktionen erwiesen sich 6,8 \% als falsch negativ, 73,2 \% als richtig positiv und 16,7 \% als richtig negativ. 58 Bei Pankreas-Punktionen lag die falsch negativ Rate mit 23,1 \% am h{\"o}chsten. Niedrige falsch negativ Raten zeigten sich bei Pleura- (2,9 \%), Lungen- (5,3 \%) und Muskel-/Weichteilpunktionen (1,5 \%). Als signifikant erwies sich der Zusammenhang zwischen Biopsienadelgr{\"o}ße und histologischem Ergebnis. Falsch negative Ergebnisse waren besonders bei Anwendungen von 19/20 G Nadeln zu verzeichnen (17,5 \%). Bei 17/18 G Nadeln und Knochenstanzen traten insgesamt nur in 7,5 \% und 7,9 \% falsch negative Ergebnisse auf. Der Durchmesser der L{\"a}sion beeinflusste signifikant das histologische Ergebnis. Bei falsch negativen Ergebnissen betrug der Durchmesser im Mittelwert 3,4 cm. Bei richtig positiven Punktionen lag der L{\"a}sionsdurchmesser bei 4,1 cm. In 18,4 \% der F{\"a}lle f{\"u}hrte eine Probeentnahme zu einer Komplikation. Davon erwiesen sich 14,8 \% als Minor- und 3,6 \% als Majorkomplikation, wie zum Beispiel ein Pneumothorax mit Notwendigkeit einer Drainagelegung. Die meisten Komplikationen traten bei Punktionen der Lunge (14 \%) auf. Dabei zeigten die Nadeln 19/20 G mit 40 \% die h{\"o}chste Komplikationsrate. Dies ist nicht der Tatsache geschuldet, dass die d{\"u}nneren Nadeln vorwiegend bei tiefen L{\"a}sionen zum Einsatz kamen. Auch bei tieferen Punktionen ist die Komplikationsrate der dickeren Nadeln geringer, als die der d{\"u}nnen. 15/16 G Nadeln kamen bei einer durchschnittlichen Tiefe von 5,6 cm zum Einsatz, 17/18 G Nadeln bei 6,6 cm und 19/20 G Nadeln bei 7,2 cm. Betrachtet man jedoch die Nadelgruppen 17/18 G und 19/20 G f{\"u}r sich, zeigte sich, dass der Abstand zur Haut bei Komplikationen nicht gr{\"o}ßer war, als ohne Komplikation. Bei 15/16 G Nadeln war der Punktionsweg bei Komplikationen signifikant gr{\"o}ßer als bei Punktionen ohne Komplikation. Bei Lungenpunktionen im Speziellen war der Punktionsweg ebenfalls f{\"u}r 15/16 G l{\"a}nger, wenn ein Pneumothorax aufgetreten ist, als bei komplikationslosen Biopsien. 59 Es zeigte sich, dass bei Wiederholungspunktionen die L{\"a}sionen tiefer lagen, als bei einmaligen Punktionen. Die L{\"a}sionsgr{\"o}ße lag durchschnittlich bei 4 cm. Beim Auftreten einer Komplikation erwies sich der Durchmesser der L{\"a}sion, besonders f{\"u}r Lungenbiopsien, als signifikant kleiner (MV = 3,5), als bei komplikationslosen Biopsien. Ein wichtiger Faktor f{\"u}r die Treffsicherheit, den positiven Vorhersagewert und die Komplikationsrate spielte die Erfahrung des jeweiligen Punkteurs. Diese Arbeit konnte belegen, dass der Radiologe mit 20 Jahren Erfahrung die niedrigste Komplikationsrate (15 \%) und gleichzeitig die geringste falsch negativ Rate (12 \%) hatte.},
  subject      = {Computertomograph},
  language  = {de}
}
@article{GassenmaierPetritschKunzetal.2015,
  author    = {Gassenmaier, Tobias and Petritsch, Bernhard and Kunz, Andreas S. and Gkaniatsas, Spyridon and Gaudron, Philipp D. and Weidemann, Frank and Nordbeck, Peter and Beer, Meinrad},
  title     = {Long term evolution of MRI characteristics in a case of atypical left lateral wall hypertrophic cardiomyopathy},
  series = {World Journal of Cardiology},
  volume    = {7},
  journal   = {World Journal of Cardiology},
  number    = {6},
  doi       = {10.4330/wjc.v7.i6.357},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-124934},
  pages     = {357-360},
  year      = {2015},
  abstract  = {We are reporting a long-time magnetic resonance imaging (MRI) follow-up in a rare case of cardiac left lateral wall hypertrophy. Hypertrophic cardiomyopathy (HCM) is the most common genetic cardiovascular disorder and a significant cause of sudden cardiac death. Cardiac magnetic resonance (CMR) imaging can be a valuable tool for assessment of detailed information on size, localization, and tissue characteristics of hypertrophied myocardium. However, there is still little knowledge of long-term evolution of HCM as visualized by magnetic resonance imaging. Recently, our group reported a case of left lateral wall HCM as a rare variant of the more common forms, such as septal HCM, or apical HCM. As we now retrieved an old cardiac MRI acquired in this patient more than 20 years ago, we are able to provide the thrilling experience of an ultra-long MRI follow-up presentation in this rare case of left lateral wall hypertrophy. Furthermore, this case outlines the tremendous improvements in imaging quality within the last two decades of CMR imaging.},
  language  = {en}
}
@article{BaurSchedelbeckPulzeretal.2015,
  author    = {Baur, Johannes and Schedelbeck, Ulla and Pulzer, Alina and Bluemel, Christina and Wild, Vanessa and Fassnacht, Martin and Steger, U.},
  title     = {A case report of a solitary pancreatic metastasis of an adrenocortical carcinoma},
  series = {BMC Surgery},
  volume    = {15},
  journal   = {BMC Surgery},
  number    = {93},
  doi       = {10.1186/s12893-015-0076-3},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-126130},
  year      = {2015},
  abstract  = {Background Solitary metastases to the pancreas are rare. Therefore the value of resection in curative intention remains unclear. In the literature there are several promising reports about resection of solitary metastasis to the pancreas mainly of renal origin. Case presentation Here we report for the first time on the surgical therapy of a 1.5 cm solitary pancreatic metastasis of an adrenocortical carcinoma. The metastasis occurred almost 6 years after resection of the primary tumor. A partial pancreatoduodenectomy was performed and postoperatively adjuvant mitotane treatment was initiated. During the follow-up of 3 years after surgery no evidence of tumor recurrence occurred. Conclusion Resection of pancreatic tumors should be considered, even if the mass is suspicious for metastatic disease including recurrence of adrenocortical cancer.},
  language  = {en}
}
@article{SauerGoltzGassenmaieretal.2014,
  author    = {Sauer, Stephanie and Goltz, Jan P. and Gassenmaier, Tobias and Kunz, Andreas S. and Bley, Thorsten A. and Klein, Detlef and Petritsch, Bernhard},
  title     = {Partial Segmental Thrombosis of the Corpus Cavernosum (PSTCC) diagnosed by contrast-enhanced ultrasound: a case report},
  series = {BMC Urology},
  volume    = {14},
  journal   = {BMC Urology},
  number    = {100},
  doi       = {10.1186/1471-2490-14-100},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-126495},
  year      = {2014},
  abstract  = {Background Partial segmental thrombosis of the corpus cavernosum (PSTCC) is a rare disease predominantly occurring in young men. Cardinal symptoms are pain and perineal swelling. Although several risk factors are described in the literature, the exact etiology of penile thrombosis remains unclear in most cases. MRI or ultrasound (US) is usually used for diagnosing this condition. Case presentation We report a case of penile thrombosis after left-sided varicocele ligature in a young patient. The diagnosis was established using contrast-enhanced ultrasound (CEUS) and was confirmed by contrast-enhanced magnetic resonance imaging (ceMRI). Successful conservative treatment consisted of systemic anticoagulation using low molecular weight heparin and acetylsalicylic acid. Conclusion PSTCC is a rare condition in young men and appears with massive pain and perineal swelling. In case of suspected PSTCC utilization of CEUS may be of diagnostic benefit.},
  language  = {en}
}
@article{TranGiaWechBleyetal.2015,
  author    = {Tran-Gia, Johannes and Wech, Tobias and Bley, Thorsten and K{\"o}stler, Herbert},
  title     = {Model-Based Acceleration of Look-Locker T1 Mapping},
  series = {PLoS One},
  volume    = {10},
  journal   = {PLoS One},
  number    = {4},
  doi       = {10.1371/journal.pone.0122611},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-126436},
  pages     = {e0122611},
  year      = {2015},
  abstract  = {Mapping the longitudinal relaxation time \(T_1\) has widespread applications in clinical MRI as it promises a quantitative comparison of tissue properties across subjects and scanners. Due to the long scan times of conventional methods, however, the use of quantitative MRI in clinical routine is still very limited. In this work, an acceleration of Inversion-Recovery Look-Locker (IR-LL) \(T_1\) mapping is presented. A model-based algorithm is used to iteratively enforce an exponential relaxation model to a highly undersampled radially acquired IR-LL dataset obtained after the application of a single global inversion pulse. Using the proposed technique, a \(T_1\) map of a single slice with 1.6mm in-plane resolution and 4mm slice thickness can be reconstructed from data acquired in only 6s. A time-consuming segmented IR experiment was used as gold standard for \(T_1\) mapping in this work. In the subsequent validation study, the model-based reconstruction of a single-inversion IR-LL dataset exhibited a \(T_1\) difference of less than 2.6\% compared to the segmented IR-LL reference in a phantom consisting of vials with \(T_1\) values between 200ms and 3000ms. In vivo, the \(T_1\) difference was smaller than 5.5\% in WM and GM of seven healthy volunteers. Additionally, the \(T_1\) values are comparable to standard literature values. Despite the high acceleration, all model-based reconstructions were of a visual quality comparable to fully sampled references. Finally, the reproducibility of the \(T_1\) mapping method was demonstrated in repeated acquisitions. In conclusion, the presented approach represents a promising way for fast and accurate \(T_1\) mapping using radial IR-LL acquisitions without the need of any segmentation.},
  language  = {en}
}
@phdthesis{TranGia2014,
  author    = {Tran-Gia, Johannes},
  title     = {Model-Based Reconstruction Methods for MR Relaxometry},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-109774},
  school      = {Universit{\"a}t W{\"u}rzburg},
  year      = {2014},
  abstract  = {In this work, a model-based acceleration of parameter mapping (MAP) for the determination of the tissue parameter T1 using magnetic resonance imaging (MRI) is introduced. The iterative reconstruction uses prior knowledge about the relaxation behavior of the longitudinal magnetization after a suitable magnetization preparation to generate a series of fully sampled k-spaces from a strongly undersampled acquisition. A Fourier transform results in a spatially resolved time course of the longitudinal relaxation process, or equivalently, a spatially resolved map of the longitudinal relaxation time T1. In its fastest implementation, the MAP algorithm enables the reconstruction of a T1 map from a radial gradient echo dataset acquired within only a few seconds after magnetization preparation, while the acquisition time of conventional T1 mapping techniques typically lies in the range of a few minutes. After validation of the MAP algorithm for two different types of magnetization preparation (saturation recovery \& inversion recovery), the developed algorithm was applied in different areas of preclinical and clinical MRI and possible advantages and disadvantages were evaluated.},
  subject      = {Kernspintomographie},
  language  = {en}
}
@article{BiedererMirsadraeeBeeretal.2012,
  author    = {Biederer, J{\"u}rgen and Mirsadraee, S. and Beer, M. and Molinari, F. and Hintze, C. and Bauman, G. and Both, M. and Van Beek, E. J. R. and Wild, J. and Puderbach, M.},
  title     = {MRI of the lung (3/3)—current applications and future perspectives},
  series = {Insights into Imaging},
  volume    = {3},
  journal   = {Insights into Imaging},
  number    = {4},
  doi       = {10.1007/s13244-011-0142-z},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-124348},
  pages     = {373-386},
  year      = {2012},
  abstract  = {Background MRI of the lung is recommended in a number of clinical indications. Having a non-radiation alternative is particularly attractive in children and young subjects, or pregnant women. Methods Provided there is sufficient expertise, magnetic resonance imaging (MRI) may be considered as the preferential modality in specific clinical conditions such as cystic fibrosis and acute pulmonary embolism, since additional functional information on respiratory mechanics and regional lung perfusion is provided. In other cases, such as tumours and pneumonia in children, lung MRI may be considered an alternative or adjunct to other modalities with at least similar diagnostic value. Results In interstitial lung disease, the clinical utility of MRI remains to be proven, but it could provide additional information that will be beneficial in research, or at some stage in clinical practice. Customised protocols for chest imaging combine fast breath-hold acquisitions from a "buffet" of sequences. Having introduced details of imaging protocols in previous articles, the aim of this manuscript is to discuss the advantages and limitations of lung MRI in current clinical practice. Conclusion New developments and future perspectives such as motion-compensated imaging with self-navigated sequences or fast Fourier decomposition MRI for non-contrast enhanced ventilation- and perfusion-weighted imaging of the lung are discussed. Main Messages • MRI evolves as a third lung imaging modality, combining morphological and functional information. • It may be considered first choice in cystic fibrosis and pulmonary embolism of young and pregnant patients. • In other cases (tumours, pneumonia in children), it is an alternative or adjunct to X-ray and CT. • In interstitial lung disease, it serves for research, but the clinical value remains to be proven. • New users are advised to make themselves familiar with the particular advantages and limitations.},
  language  = {en}
}
@article{BiedererBeerHirschetal.2012,
  author    = {Biederer, J. and Beer, M. and Hirsch, W. and Wild, J. and Fabel, M. and Puderbach, M. and Van Beek, E. J. R.},
  title     = {MRI of the lung (2/3). Why … when … how?},
  series = {Insights into Imaging},
  volume    = {3},
  journal   = {Insights into Imaging},
  number    = {4},
  doi       = {10.1007/s13244-011-0146-8},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-124268},
  pages     = {355-371},
  year      = {2012},
  abstract  = {Background Among the modalities for lung imaging, proton magnetic resonance imaging (MRI) has been the latest to be introduced into clinical practice. Its value to replace X-ray and computed tomography (CT) when radiation exposure or iodinated contrast material is contra-indicated is well acknowledged: i.e. for paediatric patients and pregnant women or for scientific use. One of the reasons why MRI of the lung is still rarely used, except in a few centres, is the lack of consistent protocols customised to clinical needs. Methods This article makes non-vendor-specific protocol suggestions for general use with state-of-the-art MRI scanners, based on the available literature and a consensus discussion within a panel of experts experienced in lung MRI. Results Various sequences have been successfully tested within scientific or clinical environments. MRI of the lung with appropriate combinations of these sequences comprises morphological and functional imaging aspects in a single examination. It serves in difficult clinical problems encountered in daily routine, such as assessment of the mediastinum and chest wall, and even might challenge molecular imaging techniques in the near future. Conclusion This article helps new users to implement appropriate protocols on their own MRI platforms. Main Messages • MRI of the lung can be readily performed on state-of-the-art 1.5-T MRI scanners. • Protocol suggestions based on the available literature facilitate its use for routine • MRI offers solutions for complicated thoracic masses with atelectasis and chest wall invasion. • MRI is an option for paediatrics and science when CT is contra-indicated},
  language  = {en}
}
@article{MonteliusLjungbergHornetal.2012,
  author    = {Montelius, Mikael and Ljungberg, Maria and Horn, Michael and Forssell-Aronsson, Eva},
  title     = {Tumour size measurement in a mouse model using high resolution MRI},
  series = {BMC Medical Imaging},
  volume    = {12},
  journal   = {BMC Medical Imaging},
  number    = {12},
  doi       = {10.1186/1471-2342-12-12},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-124049},
  year      = {2012},
  abstract  = {Background Animal models are frequently used to assess new treatment methods in cancer research. MRI offers a non-invasive in vivo monitoring of tumour tissue and thus allows longitudinal measurements of treatment effects, without the need for large cohorts of animals. Tumour size is an important biomarker of the disease development, but to our knowledge, MRI based size measurements have not yet been verified for small tumours (10-2-10-1 g). The aim of this study was to assess the accuracy of MRI based tumour size measurements of small tumours on mice. Methods 2D and 3D T2-weighted RARE images of tumour bearing mice were acquired in vivo using a 7 T dedicated animal MR system. For the 3D images the acquired image resolution was varied. The images were exported to a PC workstation where the tumour mass was determined assuming a density of 1 g/cm3, using an in-house developed tool for segmentation and delineation. The resulting data were compared to the weight of the resected tumours after sacrifice of the animal using regression analysis. Results Strong correlations were demonstrated between MRI- and necropsy determined masses. In general, 3D acquisition was not a prerequisite for high accuracy. However, it was slightly more accurate than 2D when small (<0.2 g) tumours were assessed for inter- and intraobserver variation. In 3D images, the voxel sizes could be increased from 1603 μm3 to 2403 μm3 without affecting the results significantly, thus reducing acquisition time substantially. Conclusions 2D MRI was sufficient for accurate tumour size measurement, except for small tumours (<0.2 g) where 3D acquisition was necessary to reduce interobserver variation. Acquisition times between 15 and 50 minutes, depending on tumour size, were sufficient for accurate tumour volume measurement. Hence, it is possible to include further MR investigations of the tumour, such as tissue perfusion, diffusion or metabolic composition in the same MR session.},
  language  = {en}
}