@article{WillemsDettaBaldinietal.2024,
  author    = {Willems, Suzanne and Detta, Elena and Baldini, Lorenzo and Tietz, Deniz and Trabocchi, Andrea and Brunschweiger, Andreas},
  title     = {Diversifying DNA-tagged amines by isocyanide multicomponent reactions for DNA-encoded library synthesis},
  series = {ACS Omega},
  volume    = {9},
  journal   = {ACS Omega},
  number    = {7},
  issn      = {2470-1343},
  doi       = {10.1021/acsomega.3c07136},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-349809},
  pages     = {7719-7724},
  year      = {2024},
  abstract  = {In DNA-encoded library synthesis, amine-substituted building blocks are prevalent. We explored isocyanide multicomponent reactions to diversify DNA-tagged amines and reported the Ugi-azide reaction with high yields and a good substrate scope. In addition, the Ugi-aza-Wittig reaction and the Ugi-4-center-3-component reaction, which used bifunctional carboxylic acids to provide lactams, were explored. Five-, six-, and seven-membered lactams were synthesized from solid support-coupled DNA-tagged amines and bifunctional building blocks, providing access to structurally diverse scaffolds.},
  language  = {en}
}