@article{UlrichsEcksteinMuellerBuchholtz1994, author = {Ulrichs, Karin and Eckstein, V. and M{\"u}ller-Buchholtz, W.}, title = {Xenogeneic T-cell-mediated immune reactivity in the model of pig-to-humans: first findings with native stimulator cells}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-44755}, year = {1994}, abstract = {No abstract available}, subject = {Chirurgie}, language = {en} } @inproceedings{HeiserUlrichsEcksteinetal.1992, author = {Heiser, A. and Ulrichs, Karin and Eckstein, V. and M{\"u}ller-Ruchholtz, W.}, title = {Xenogeneic Cellular Response of Human Lymphocytes Against Porcine Lymphocytes and Isolated Pancreatic Islets}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-45479}, year = {1992}, abstract = {no abstract available}, language = {en} } @article{EngemannUlrichsThiedeetal.1990, author = {Engemann, R. and Ulrichs, Karin and Thiede, A. and M{\"u}ller-Ruchholtz, W. and Hamelmann, H.}, title = {Value of a physiological liver transplant model in rats. Induction of specific graft tolerance in a fully allogeneic strain combination}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-45622}, year = {1990}, abstract = {No abstract available}, language = {en} } @inproceedings{EcksteinUlrichsMeinckeetal.1991, author = {Eckstein, V. and Ulrichs, Karin and Meincke, G. and M{\"u}lller-Ruchholtz, W.}, title = {Transplantation of Diabetic Patients With Xenogeneic Pancreatic Islets Has to Consider Natural Xenophile Antibodies (NXA) In Patients Sera As a Major Obstacle to Success}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-45707}, year = {1991}, abstract = {No abstract available}, subject = {Immunbiologie}, language = {en} } @article{KrzymanskiWaagaUlrichsetal.1991, author = {Krzymanski, Maciej and Waaga, Ana M. and Ulrichs, Karin and Deja, Aadam and Oko, Andrzej and Rommel, Thomas and M{\"u}ller-Ruchholtz, Wolfgang}, title = {The influence of MHC class II antigen blockade by perfusion with a monoclonal antibody on rat renal graft survival}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-64431}, year = {1991}, abstract = {To decrease immunogenicity of the rat kidney, grafts were perfused with an anti-MHC class li monoclonal antibody (mAb ). How effectively this procedure blocked dass li-positive cells, which were mainly dendritic in appearance, was checked by immunostaining renal sections after perfusion and comparing them with in vitro stained sections. Optimum conditions were applied for graft pretreatment before transplantation. This procedure prolonged graft survival, though not satisfactorily from the biological point ofview (9.6 ± 0.8 versus 7.7 ± 0.5 days in the control group; P < 0.02). The dendritic cells were not killed but blocked. Several hours after transplantation, the mAb dissociated from these dass li-positive cells. It was also shown that donor cells migrate into the recipient's spieen early after transplantation. The number of these cells was smaller when the transplanted organ was perfused with the mAb. Further studies are suggested to deplete the graft of donor dendritic cells more adequately. They should also combine graft perfusion with antidass II mAb and recipient immunosuppression at reduced doses.}, subject = {Chirurgie}, language = {en} } @article{WaagaUlrichsKrzymanskietal.1990, author = {Waaga, AM and Ulrichs, Karin and Krzymanski, M. and Treumer, J. and Hansmann, ML and Rommel, T. and M{\"u}ller-Ruchholz, W.}, title = {The immunosuppressive agent 15-deoxyspergualin induces tolerance and modulates MHC-antigen expression and interleukin-1 production in the early phase of rat allograft responses}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-45253}, year = {1990}, abstract = {No abstract available}, subject = {Chirurgie}, language = {en} } @inproceedings{HeiserUlrichsEcksteinetal.1992, author = {Heiser, A. and Ulrichs, Karin and Eckstein, V. and M{\"u}ller-Ruchholtz, W.}, title = {The Human Cell Mediated Response to Xenogeneic (Porcine) Transplantation Antigen Depends on the Stimulator Cell Compartment}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-45670}, year = {1992}, abstract = {No abstract available}, language = {en} } @article{WinotoMorbachLeyhausenMuellerRuchholtzetal.1988, author = {Winoto-Morbach, S. and Leyhausen, G. and M{\"u}ller-Ruchholtz, W. and Ulrichs, Karin}, title = {The Electromagnetic Separation Principle: A Basis for Human Pancreatic Islet Transplantation}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-82520}, year = {1988}, abstract = {No abstract available}, subject = {Allergie}, language = {en} } @article{UlrichsKaitschickBartlettetal.1992, author = {Ulrichs, Karin and Kaitschick, J. and Bartlett, R. and M{\"u}ller-Ruchholtz, W.}, title = {Suppression of natural xenophile antibodies with the novel immunomodulating drug leflunomide}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-45202}, year = {1992}, abstract = {No abstract available}, subject = {Chirurgie}, language = {en} } @article{DickneiteSchorlemmerSedlaceketal.1987, author = {Dickneite, G. and Schorlemmer, H. U. and Sedlacek, H. H. and Falk, W. and Ulrichs, Karin and M{\"u}ller-Ruchholtz, W.}, title = {Suppression of macrophage function and prolongation of graft survival by the new guanidinic-like structure, 15-deoxyspergualin}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-86991}, year = {1987}, abstract = {No abstract available.}, subject = {Makrophage}, language = {en} } @article{UlrichsMuellerRuchholtz1989, author = {Ulrichs, Karin and M{\"u}ller-Ruchholtz, W.}, title = {Significant manipulative procedures to reduce immunogenicity of human islet allografts}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-45155}, year = {1989}, abstract = {No abstract available}, subject = {Chirurgie}, language = {en} } @article{UlrichsKellerMuellerRuchholtz1985, author = {Ulrichs, Karin and Keller, R. and M{\"u}ller-Ruchholtz, W.}, title = {Serological demonstration and manipulation of passenger cells (PC) in pancreas islet grafts}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-72944}, year = {1985}, abstract = {No abstract available}, subject = {Immunobiologie}, language = {en} } @article{UlrichsSchangKelleretal.1984, author = {Ulrichs, Karin and Schang, T. and Keller, R. and M{\"u}ller-Ruchholtz, W.}, title = {Reactivity of pancreas islet cells with antisera of known specificity}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-45466}, year = {1984}, abstract = {No abstract available}, language = {en} } @article{EcksteinMuellerBuchholtzUlrichs1994, author = {Eckstein, V. and M{\"u}ller-Buchholtz, W. and Ulrichs, Karin}, title = {Reaction patterns of natural xenophile antibodies in human sera with pancreatic islet cells and porcine lymphocytes}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-44742}, year = {1994}, abstract = {No abstract available}, subject = {Chirurgie}, language = {en} } @article{HeiserUlrichsMuellerRuchholtz1994, author = {Heiser, A. and Ulrichs, Karin and M{\"u}ller-Ruchholtz, W.}, title = {Prophylactic trypsin inhibition during the isolation procedure guarantees reproducible, high porcine islet yields}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-45531}, year = {1994}, abstract = {Abstract: For isolating islets from the porcine pancreas, we established a semiautomated digestion method. Although the isolation technique was standardized and collagenase of controlled quality was used, until now the reproducibility of high islet yields was unsatisfactory. Our hypothesis was that pancreatic trypsin was responsible for this failure. The aim of this study was to investigate the effect of endogenous trypsin on islet yield. Our results demonstrate that a high trypsin level correlates with poor islet yield, whereas low trypsin activity always correlates with high islet yield. Specific inhibition of trypsin results in low trypsin activity and reproducible, high islet yields.}, language = {en} } @inproceedings{HedkeEcksteinMayetal.1993, author = {Hedke, K. and Eckstein, V. and May, G. and Kaden, J. and M{\"u}ller-Ruchholtz, W. and Ulrichs, Karin}, title = {Production of Xenophile Antibodies (XA) in Type I Diabetic Patients is Strongly Influenced by Diabetes and/or Dialysis}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-45642}, year = {1993}, abstract = {No abstract available}, language = {en} } @article{UlrichsKuhlencordtMuellerRuchholtz1979, author = {Ulrichs, Karin and Kuhlencordt, KM and M{\"u}ller-Ruchholtz, W.}, title = {Plating inhibition assay (PIA): a new test for cell mediated cytotoxicity}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-45443}, year = {1979}, abstract = {No abstract available}, language = {en} } @article{KekowUlrichsMuellerRuchholtzetal.1987, author = {Kekow, J. and Ulrichs, Karin and M{\"u}ller-Ruchholtz, W. and Gross, WL}, title = {Pancreas transplantation: a study of insulin secretion in isolated islets of Langerhans and in sera using a new enzyme-linked immunosorbent assay}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-45229}, year = {1987}, abstract = {No abstract available}, subject = {Chirurgie}, language = {en} } @article{WinotoMorbachUlrichsLeyhausenetal.1989, author = {Winoto-Morbach, Supandi and Ulrichs, Karin and Leyhausen, Gaby and M{\"u}ller-Ruchholtz, Wolfgang}, title = {New principle for large-scale preparation of purified human pancreas islets}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-45600}, year = {1989}, abstract = {Because successful human islet transplantation requires large quantities of viable islets that must be separated from the highly immunogenic exocrine tissue and because handpicking is too time-consuming and laborious to be clinically relevant, a new approach for solving this problem has been established in rat models. It is based on the principle that magnetic microspheres (MMSs) coupled to lectins with binding specificity for the exocrine tissue portion are trapped in an electromagnetic field, thus providing effluent islets of a high degree of purity. In this study our aim was to adapt this princip'le to human islet preparations. In this context our prime interest was focused on a lectin suitable for human pancreatic tissue. Of 19 different lectins tested, only 1, Wisteria floribunda agglutinin (WFA), is suitable, as shown by immunofluorescence, MMS-Iectin binding, and magnetic separation}, subject = {Immunbiologie}, language = {en} } @inproceedings{WinotoMorbachUlrichsMuellerRuchholtz1991, author = {Winoto-Morbach, S. and Ulrichs, Karin and M{\"u}ller-Ruchholtz, W.}, title = {New Developments in Biodegradable Microspheres For Magnetic Separation Techniques}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-45712}, year = {1991}, abstract = {No abstract available}, subject = {Immunbiologie}, language = {en} }