@article{KayaZeebDelacWolfetal.2022,
  author    = {Kaya-Zeeb, Sinan and Delac, Saskia and Wolf, Lena and Marante, Ana Luiza and Scherf-Clavel, Oliver and Thamm, Markus},
  title     = {Robustness of the honeybee neuro-muscular octopaminergic system in the face of cold stress},
  series = {Frontiers in Physiology},
  volume    = {13},
  journal   = {Frontiers in Physiology},
  issn      = {1664-042X},
  doi       = {10.3389/fphys.2022.1002740},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-288753},
  year      = {2022},
  abstract  = {In recent decades, our planet has undergone dramatic environmental changes resulting in the loss of numerous species. This contrasts with species that can adapt quickly to rapidly changing ambient conditions, which require physiological plasticity and must occur rapidly. The Western honeybee (Apis mellifera) apparently meets this challenge with remarkable success, as this species is adapted to numerous climates, resulting in an almost worldwide distribution. Here, coordinated individual thermoregulatory activities ensure survival at the colony level and thus the transmission of genetic material. Recently, we showed that shivering thermogenesis, which is critical for honeybee thermoregulation, depends on octopamine signaling. In this study, we tested the hypothesis that the thoracic neuro-muscular octopaminergic system strives for a steady-state equilibrium under cold stress to maintain endogenous thermogenesis. We can show that this applies for both, octopamine provision by flight muscle innervating neurons and octopamine receptor expression in the flight muscles. Additionally, we discovered alternative splicing for AmOARβ2. At least the expression of one isoform is needed to survive cold stress conditions. We assume that the thoracic neuro-muscular octopaminergic system is finely tuned in order to contribute decisively to survival in a changing environment.},
  language  = {en}
}
@article{HyunvanderGraaffAlbaceteetal.2014,
  author    = {Hyun, Tae Kyung and van der Graaff, Eric and Albacete, Alfonso and Eom, Seung Hee and Grosskinsky, Dominik K. and B{\"o}hm, Hannah and Janschek, Ursula and Rim, Yeonggil and Ali, Walid Wahid and Kim, Soo Young and Roitsch, Thomas},
  title     = {The Arabidopsis PLAT Domain Protein1 is Critically Involved in Abiotic Stress Tolerance},
  series = {PLOS ONE},
  volume    = {9},
  journal   = {PLOS ONE},
  number    = {11},
  doi       = {10.1371/journal.pone.0112946},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-114648},
  pages     = {e112946},
  year      = {2014},
  abstract  = {Despite the completion of the Arabidopsis genome sequence, for only a relatively low percentage of the encoded proteins experimental evidence concerning their function is available. Plant proteins that harbour a single PLAT (Polycystin, Lipoxygenase, Alpha-toxin and Triacylglycerol lipase) domain and belong to the PLAT-plant-stress protein family are ubiquitously present in monocot and dicots. However, the function of PLAT-plant-stress proteins is still poorly understood. Therefore, we have assessed the function of the uncharacterised Arabidopsis PLAT-plant-stress family members through a combination of functional genetic and physiological approaches. PLAT1 overexpression conferred increased abiotic stress tolerance, including cold, drought and salt stress, while loss-of-function resulted in opposite effects on abiotic stress tolerance. Strikingly, PLAT1 promoted growth under non-stressed conditions. Abiotic stress treatments induced PLAT1 expression and caused expansion of its expression domain. The ABF/ABRE transcription factors, which are positive mediators of abscisic acid signalling, activate PLAT1 promoter activity in transactivation assays and directly bind to the ABRE elements located in this promoter in electrophoretic mobility shift assays. This suggests that PLAT1 represents a novel downstream target of the abscisic acid signalling pathway. Thus, we showed that PLAT1 critically functions as positive regulator of abiotic stress tolerance, but also is involved in regulating plant growth, and thereby assigned a function to this previously uncharacterised PLAT domain protein. The functional data obtained for PLAT1 support that PLAT-plant-stress proteins in general could be promising targets for improving abiotic stress tolerance without yield penalty.},
  language  = {en}
}