@article{HeiserMuellerRuchholtzUlrichs1994, author = {Heiser, A. and M{\"u}ller-Ruchholtz, W. and Ulrichs, Karin}, title = {Isolation of Islets of Langerhans: Improvement of the Isolation Technique Using the Pig Model.}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-87765}, year = {1994}, abstract = {During the last view years, interest in pancreatic islet transplantation for the cure of type I diabetes has increased markedly. A serious barrier to clinical islet transplantation is the isolation of a sufficient mass of viable and functional islets. We used a porcine islet isolation model to examine various parameters of the isolation procedure and to improve isolation technique.}, subject = {Langerhans-Inseln}, language = {en} } @article{DickneiteSchorlemmerSedlaceketal.1987, author = {Dickneite, G. and Schorlemmer, H. U. and Sedlacek, H. H. and Falk, W. and Ulrichs, Karin and M{\"u}ller-Ruchholtz, W.}, title = {Suppression of macrophage function and prolongation of graft survival by the new guanidinic-like structure, 15-deoxyspergualin}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-86991}, year = {1987}, abstract = {No abstract available.}, subject = {Makrophage}, language = {en} } @article{WinotoMorbachLeyhausenMuellerRuchholtzetal.1988, author = {Winoto-Morbach, S. and Leyhausen, G. and M{\"u}ller-Ruchholtz, W. and Ulrichs, Karin}, title = {The Electromagnetic Separation Principle: A Basis for Human Pancreatic Islet Transplantation}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-82520}, year = {1988}, abstract = {No abstract available}, subject = {Allergie}, language = {en} } @article{UlrichsMuellerRuchholtz1991, author = {Ulrichs, Karin and M{\"u}ller-Ruchholtz, Wolfgang}, title = {Modulation of pancreatic islet allo immunogenicity and immunobiological in vitro and in vivo consequences}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-78261}, year = {1991}, abstract = {No abstract available.}, subject = {Immunobiologie}, language = {en} } @article{KrzymanskiWaagaUlrichsetal.1991, author = {Krzymanski, M. and Waaga, A. M. and Ulrichs, Karin and M{\"u}ller-Ruchholtz, Wolfgang}, title = {Long-standing rat kidney graft survival by a combination of organ perfusion with MHC class II monoclonal antibody and immunosuppression with reduced doses of 15-deoxyspergualin.}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-64442}, year = {1991}, abstract = {No abstract available}, subject = {Niere}, language = {en} } @article{StraussMoskalenkoTiurbeetal.2012, author = {Strauss, Armin and Moskalenko, Vasily and Tiurbe, Christian and Chodnevskaja, Irina and Timm, Stephan and Wiegering, Verena A. and Germer, Chrioph Thomas and Ulrichs, Karin}, title = {Goettingen Minipigs (GMP): Comparison of Two Different Models for Inducing Diabetes}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-75119}, year = {2012}, abstract = {Purpose: Preclinical experiments on large animals are indispensable for evaluating the effectiveness of diabetes therapies. Miniature swine are well suited for such studies due to their physiological and pathophysiological responses. Methods: We compare two methods for inducing diabetes in Goettingen minipigs (GMP), in five with the beta cell toxin streptozotocin (STZ) and in five other GMP by total pancreatectomy (PE). Glucose homeostasis was assessed with the intravenous glucose-tolerance test (IVGTT) and continual monitoring of interstitial glucose levels. At conclusion of the observation period, the pancreata were examined histologically. Three non-diabetic GMP served as control group. Results: The IVGTT revealed markedly diabetic profiles in both GMP groups. STZ-GMP were found to harbor residual C-peptides and scattered insulin-positive cells in the pancreas. PE-GMP survived the total pancreatectomy only with intensive postoperative care. Conclusions: Although both methods reliably induced diabetes in GMP, the PE-GMP clearly had more health problems and required a greater expenditure of time and resources. The PE-GMP model, however, was better at eliminating endogenous insulin and C-peptide than the STZ-GMP model.}, subject = {G{\"o}ttingen}, language = {en} } @article{KekowUlrichs1986, author = {Kekow, J. and Ulrichs, Karin}, title = {Determination of total immunoreactive rat insulin (IRI) in culture supernatants of rat islets by an enzyme linked immunosorbent assay (ELISA) as a routine method to assess the viability of rat islets prior to their use in islet transplantation}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-72989}, year = {1986}, abstract = {No abstract available}, subject = {Immunobiologie}, language = {en} } @article{UlrichsKellerMuellerRuchholtz1985, author = {Ulrichs, Karin and Keller, R. and M{\"u}ller-Ruchholtz, W.}, title = {Serological demonstration and manipulation of passenger cells (PC) in pancreas islet grafts}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-72944}, year = {1985}, abstract = {No abstract available}, subject = {Immunobiologie}, language = {en} } @article{LausUlrichsMuellerRuchholtz1986, author = {Laus, R. and Ulrichs, Karin and M{\"u}ller-Ruchholtz, W.}, title = {Molecular Specificity of Human Heterophile Antibodies (HHA) in Normal Human Serum (NHS) Reacting with Xenogeneic Cells.}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-72921}, year = {1986}, abstract = {No abstract available}, subject = {Immunobiologie}, language = {en} } @article{KrzymanskiWaagaUlrichsetal.1991, author = {Krzymanski, Maciej and Waaga, Ana M. and Ulrichs, Karin and Deja, Aadam and Oko, Andrzej and Rommel, Thomas and M{\"u}ller-Ruchholtz, Wolfgang}, title = {The influence of MHC class II antigen blockade by perfusion with a monoclonal antibody on rat renal graft survival}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-64431}, year = {1991}, abstract = {To decrease immunogenicity of the rat kidney, grafts were perfused with an anti-MHC class li monoclonal antibody (mAb ). How effectively this procedure blocked dass li-positive cells, which were mainly dendritic in appearance, was checked by immunostaining renal sections after perfusion and comparing them with in vitro stained sections. Optimum conditions were applied for graft pretreatment before transplantation. This procedure prolonged graft survival, though not satisfactorily from the biological point ofview (9.6 ± 0.8 versus 7.7 ± 0.5 days in the control group; P < 0.02). The dendritic cells were not killed but blocked. Several hours after transplantation, the mAb dissociated from these dass li-positive cells. It was also shown that donor cells migrate into the recipient's spieen early after transplantation. The number of these cells was smaller when the transplanted organ was perfused with the mAb. Further studies are suggested to deplete the graft of donor dendritic cells more adequately. They should also combine graft perfusion with antidass II mAb and recipient immunosuppression at reduced doses.}, subject = {Chirurgie}, language = {en} } @article{DeltzUlrichsSchacketal.1986, author = {Deltz, Eberhard and Ulrichs, Karin and Schack, Thorsten and Friedrichs, Birgit and M{\"u}ller-Ruchholtz, Wolfgang and M{\"u}ller-Hermelink, Hans K. and Thiede, Arnulf}, title = {Graft-versus-host reaction in small bowel transplantation and possibilities for its circumvention}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-64425}, year = {1986}, abstract = {No abstract available}, subject = {D{\"u}nndarm}, language = {en} } @article{UlrichsWinotoMorbachHeringetal.1990, author = {Ulrichs, Karin and Winoto-Morbach, S. and Hering, B. and M{\"u}ller-Ruchholtz, W.}, title = {A Useful Biotechnological Approach to Solve the Problem of Graft Purity in Human Pancreatic Islet Transplantation}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-45619}, year = {1990}, abstract = {No abstract available}, subject = {Chirurgie}, language = {en} } @article{UlrichsMuellerRuchholtz1985, author = {Ulrichs, Karin and M{\"u}ller-Ruchholtz, W.}, title = {Further Analyses of Pancreas Islet Immunogenicity, a Major Barrier to Successful Islet Transplantation}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-45563}, year = {1985}, abstract = {No abstract available}, subject = {Chirurgie}, language = {en} } @article{UlrichsMuellerRuchholtz1988, author = {Ulrichs, Karin and M{\"u}ller-Ruchholtz, W.}, title = {Expression of MHC Structures on Immunologically Reactive and Non Reactive Cells in Islets of Langerhans and Other Tissues}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-45557}, year = {1988}, abstract = {No abstract available}, subject = {Chirurgie}, language = {en} } @article{WaagaUlrichsKrzymanskietal.1990, author = {Waaga, AM and Ulrichs, Karin and Krzymanski, M. and Treumer, J. and Hansmann, ML and Rommel, T. and M{\"u}ller-Ruchholz, W.}, title = {The immunosuppressive agent 15-deoxyspergualin induces tolerance and modulates MHC-antigen expression and interleukin-1 production in the early phase of rat allograft responses}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-45253}, year = {1990}, abstract = {No abstract available}, subject = {Chirurgie}, language = {en} } @article{UlrichsEcksteinMuellerBuchholtz1994, author = {Ulrichs, Karin and Eckstein, V. and M{\"u}ller-Buchholtz, W.}, title = {Xenogeneic T-cell-mediated immune reactivity in the model of pig-to-humans: first findings with native stimulator cells}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-44755}, year = {1994}, abstract = {No abstract available}, subject = {Chirurgie}, language = {en} } @article{UlrichsBosseWackeretal.1994, author = {Ulrichs, Karin and Bosse, M. and Wacker, HH and Heiser, A. and M{\"u}ller-Ruchholtz, W.}, title = {Histologic analysis of the porcine pancreas to improve islet yield and integrity after collagenase digestion}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-45166}, year = {1994}, abstract = {No abstract available}, subject = {Chirurgie}, language = {en} } @article{HeiserUlrichsMuellerRuchholtz1994, author = {Heiser, A. and Ulrichs, Karin and M{\"u}ller-Ruchholtz, W.}, title = {Influence of porcine strain, age, and pH of the isolation medium on porcine pancreatic islet isolation success}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-45171}, year = {1994}, abstract = {No abstract available}, subject = {Chirurgie}, language = {en} } @article{WinotoMorbachKroutHeiseretal.1994, author = {Winoto-Morbach, S. and Krout, OS and Heiser, A. and Ulrichs, Karin and M{\"u}ller-Ruchholtz, W.}, title = {Lectin binding to acinar tissue for complete magnetophoretic purification of porcine pancreatic islets depends on the composition and pH of the incubation medium}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-45183}, year = {1994}, abstract = {No abstract available}, subject = {Chirurgie}, language = {en} } @article{UlrichsWangMuellerBuchholtz1994, author = {Ulrichs, Karin and Wang, H. and M{\"u}ller-Buchholtz, W.}, title = {Down-regulation of xenophile antibodies by 15-deoxyspergualin in an experimental animal model}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-44733}, year = {1994}, abstract = {No abstract available}, subject = {Chirurgie}, language = {en} }