@article{HeinrichNandaRehnetal.2013,
  author    = {Heinrich, T. and Nanda, I. and Rehn, M. and Zollner, U. and Frieauff, E. and Wirbelauer, J. and Grimm, T. and Schmid, M.},
  title     = {Live-Born Trisomy 22: Patient Report and Review},
  series = {Molecular Syndromology},
  volume    = {3},
  journal   = {Molecular Syndromology},
  number    = {6},
  issn      = {1661-8769},
  doi       = {10.1159/000346189},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-196535},
  pages     = {262-269},
  year      = {2013},
  abstract  = {Trisomy 22 is a common trisomy in spontaneous abortions. In contrast, live-born trisomy 22 is rarely seen due to severe organ malformations associated with this condition. Here, we report on a male infant with complete, non-mosaic trisomy 22 born at 35 + 5 weeks via caesarean section. Peripheral blood lymphocytes and fibroblasts showed an additional chromosome 22 in all metaphases analyzed (47,XY,+22). In addition, array CGH confirmed complete trisomy 22. The patient's clinical features included dolichocephalus, hypertelorism, flattened nasal bridge, dysplastic ears with preauricular sinuses and tags, medial cleft palate, anal atresia, and coronary hypospadias with scrotum bipartitum. Essential treatment was implemented in close coordination with the parents. The child died 29 days after birth due to respiratory insufficiency and deterioration of renal function. Our patient's history complements other reports illustrating that children with complete trisomy 22 may survive until birth and beyond.},
  language  = {en}
}
@article{KuehnSchoenEdelmannetal.2013,
  author    = {K{\"u}hn, Heike and Sch{\"o}n, Franz and Edelmann, Karola and Brill, Stefan and M{\"u}ller, Joachim},
  title     = {The Development of Lateralization Abilities in Children with Bilateral Cochlear Implants},
  series = {ORL},
  volume    = {75},
  journal   = {ORL},
  number    = {2},
  issn      = {0301-1569},
  doi       = {10.1159/000347193},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-196375},
  pages     = {55-67},
  year      = {2013},
  abstract  = {Objectives: The purpose of this study was to investigate the development of lateralization skills in children who received bilateral cochlear implants (CIs) in sequential operations. Methods: The lateralization skills of 9 children with a mean age of 4.1 years at the first surgery and 5.5 years at the second surgery were assessed at 3 time intervals. Children were assessed with a 3-loudspeaker setup (front, left and right) at 0.9 years (interval I) and 1.6 years (interval II) after the second implantation, and after 5.3 years of bilateral implant use (interval III) with a 9-loudspeaker setup in the frontal horizontal plane between -90° and 90° azimuth. Results: With bilateral implants, a significant decrease in lateralization error was noted between test interval I (45.0°) and II (23.3°), with a subsequent significant decrease at test interval III (4.7°). Unilateral performance with the CI did not improve significantly between the first 2 intervals; however, there was a bias of responses towards the unilateral side by test interval III. Conclusions: The lateralization abilities of children with bilateral CIs develop in a relatively short period of time (1-2 years) after the second implant. Children appear to be able to acquire binaural skills after bilateral cochlear implantation.},
  language  = {en}
}
@article{MatthiesBrillKagaetal.2013,
  author    = {Matthies, Cordula and Brill, Stefan and Kaga, Kimitaka and Morita, Akio and Kumakawa, Kozo and Skarzynski, Henryk and Claassen, Andre and Hui, Yau and Chiong, Charlotte and M{\"u}ller, Joachim and Behr, Robert},
  title     = {Auditory Brainstem Implantation Improves Speech Recognition in Neurofibromatosis Type II Patients},
  series = {ORL},
  volume    = {75},
  journal   = {ORL},
  number    = {5},
  issn      = {0301-1569},
  doi       = {10.1159/000350568},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-196383},
  pages     = {282-295},
  year      = {2013},
  abstract  = {This prospective study aimed to determine speech understanding in neurofibromatosis type II (NF2) patients following implantation of a MED-EL COMBI 40+ auditory brainstem implant (ABI). Patients (n = 32) were enrolled postsurgically. Nonauditory side effects were evaluated at fitting and audiological performance was determined using the Sound Effects Recognition Test (SERT), Monosyllable-Trochee-Polysyllable (MTP) test and open-set sentence tests. Subjective benefits were determined by questionnaire. ABI activation was documented in 27 patients, 2 patients were too ill for testing and 3 patients were without any auditory perception. SERT and MTP outcomes under auditory-only conditions improved significantly between first fitting and 12-month follow-up. Open-set sentence recognition improved from 5\% at first fitting to 37\% after 12 months. The number of active electrodes had no significant effect on performance. All questionnaire respondents were 'satisfied' to 'very satisfied' with their ABI. An ABI is an effective treatment option in NF2 patients with the potential to provide open-set speech recognition and subjective benefits. To our knowledge, the data presented herein is exceptional in terms of the open-set speech perception achieved in NF2 patients.},
  language  = {en}
}
@article{deZeeuwAkizawaAgarwaletal.2013,
  author    = {de Zeeuw, Dick and Akizawa, Tadao and Agarwal, Rajiv and Audhya, Paul and Bakris, George L. and Chin, Melanie and Krauth, Melissa and Lambers Heerspink, Hiddo J. and Meyer, Colin J. and McMurray, John J. and Parving, Hans-Henrik and Pergola, Pablo E. and Remuzzi, Giuseppe and Toto, Robert D. and Vaziri, Nosratola D. and Wanner, Christoph and Warnock, David G. and Wittes, Janet and Chertow, Glenn M.},
  title     = {Rationale and Trial Design of Bardoxolone Methyl Evaluation in Patients with Chronic Kidney Disease and Type 2 Diabetes: The Occurrence of Renal Events (BEACON)},
  series = {American Journal of Nephrology},
  volume    = {37},
  journal   = {American Journal of Nephrology},
  number    = {3},
  issn      = {0250-8095},
  doi       = {10.1159/000346948},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-196832},
  pages     = {212-222},
  year      = {2013},
  abstract  = {Background: Chronic kidney disease (CKD) associated with type 2 diabetes mellitus constitutes a global epidemic complicated by considerable renal and cardiovascular morbidity and mortality, despite the provision of inhibitors of the renin-angiotensin-aldosterone system (RAAS). Bardoxolone methyl, a synthetic triterpenoid that reduces oxidative stress and inflammation through Nrf2 activation and inhibition of NF-κB was previously shown to increase estimated glomerular filtration rate (eGFR) in patients with CKD associated with type 2 diabetes mellitus. To date, no antioxidant or anti-inflammatory therapy has proved successful at slowing the progression of CKD. Methods: Herein, we describe the design of Bardoxolone Methyl Evaluation in Patients with Chronic Kidney Disease and Type 2 Diabetes: the Occurrence of Renal Events (BEACON) trial, a multinational, multicenter, double-blind, randomized, placebo-controlled Phase 3 trial designed to determine whether long-term administration of bardoxolone methyl (on a background of standard therapy, including RAAS inhibitors) safely reduces renal and cardiac morbidity and mortality. Results: The primary composite endpoint is time-to-first occurrence of either end-stage renal disease or cardiovascular death. Secondary endpoints include the change in eGFR and time to occurrence of cardiovascular events. Conclusion: BEACON will be the first event-driven trial to evaluate the effect of an oral antioxidant and anti-inflammatory drug in advanced CKD.},
  language  = {en}
}
@article{PfisterSchwarzJanczyketal.2013,
  author    = {Pfister, Roland and Schwarz, Katharina A. and Janczyk, Markus and Dale, Rick and Freeman, Jonathan B.},
  title     = {Good things peak in pairs: a note on the bimodality coefficient},
  series = {Frontiers in Psychology},
  volume    = {4},
  journal   = {Frontiers in Psychology},
  issn      = {1664-1078},
  doi       = {10.3389/fpsyg.2013.00700},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-190413},
  year      = {2013},
  abstract  = {A commentary on Assessing bimodality to detect the presence of a dual cognitive process by Freeman, J. B., and Dale, R. (2013). Behav. Res. Methods 45, 83-97. doi: 10.3758/s13428-012-0225-x},
  language  = {en}
}
@article{FoersterPfisterSchmidtsetal.2013,
  author    = {Foerster, Anna and Pfister, Roland and Schmidts, Constantin and Dignath, David and Kunde, Wilfried},
  title     = {Honesty saves time (and justifications)},
  series = {Frontiers in Psychology},
  volume    = {4},
  journal   = {Frontiers in Psychology},
  issn      = {1664-1078},
  doi       = {10.3389/fpsyg.2013.00473},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-190451},
  year      = {2013},
  abstract  = {A commentary on Honesty requires time (and lack of justifications) by Shalvi, S., Eldar, O., and Bereby-Meyer, Y. (2012). Psychol. Sci. 23, 1264-1270. doi: 10.1177/0956797612443835},
  language  = {en}
}
@article{MeuleVoegele2013,
  author    = {Meule, Adrian and V{\"o}gele, Claus},
  title     = {The psychology of eating},
  series = {Frontiers in Psychology},
  volume    = {4},
  journal   = {Frontiers in Psychology},
  issn      = {1664-1078},
  doi       = {10.3389/fpsyg.2013.00215},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-190460},
  year      = {2013},
  abstract  = {No abstract available.},
  language  = {en}
}
@article{Meule2013,
  author    = {Meule, Adrian},
  title     = {Impulsivity and overeating: a closer look at the subscales of the Barratt Impulsiveness Scale},
  series = {Frontiers in Psychology},
  volume    = {4},
  journal   = {Frontiers in Psychology},
  issn      = {1664-1078},
  doi       = {10.3389/fpsyg.2013.00177},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-190497},
  year      = {2013},
  abstract  = {No abstract available.},
  language  = {en}
}
@article{Hurtienne2013,
  author    = {Hurtienne, J{\"o}rn},
  title     = {Inter-coder reliability of categorising force-dynamic events in human-technology interaction},
  volume    = {1},
  number    = {1},
  issn      = {2197-2796},
  doi       = {10.1515/gcla-2013-0005},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-194127},
  pages     = {59-78},
  year      = {2013},
  abstract  = {Two studies are reported that investigate how readily accessible and applicable ten force-dynamic categories are to novices in describing short episodes of human-technology interaction (Study 1) and that establish a measure of inter-coder reliability when re-classifying these episodes into force-dynamic categories (Study 2). The results of the first study show that people can easily and confidently relate their experiences with technology to the definitions of force-dynamic events (e.g. "The driver released the handbrake" as an example of restraint removal). The results of the second study show moderate agreement between four expert coders across all ten force-dynamic categories (Cohen's kappa = .59) when re-classifying these episodes. Agreement values for single force-dynamic categories ranged between 'fair' and 'almost perfect', i.e. between kappa = .30 and .95. Agreement with the originally intended classifications of study 1 was higher than the pure inter-coder reliabilities. Single coders achieved an average kappa of .71, indicating substantial agreement. Using more than one coder increased kappas to almost perfect: up to .87 for four coders. A qualitative analysis of the predicted versus the observed number of category confusions revealed that about half of the category disagreement could be predicted from strong overlaps in the definitions of force-dynamic categories. From the quantitative and qualitative results, guidelines are derived to aid the better training of coders in order to increase inter-coder reliability.},
  language  = {en}
}
@article{WeberGraef2013,
  author    = {Weber, Christoph and Gr{\"a}f, Stephan},
  title     = {Eine halb so schlimme T{\"a}uschung},
  series = {JURA - Juristische Ausbildung},
  volume    = {36},
  journal   = {JURA - Juristische Ausbildung},
  number    = {1},
  issn      = {1612-7021},
  doi       = {10.1515/jura-2014-0009},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-195484},
  pages     = {81-93},
  year      = {2013},
  abstract  = {Kein Abstract verf{\"u}gbar.},
  language  = {en}
}
@article{GedalinDroege2013,
  author    = {Gedalin, Michael and Dr{\"o}ge, Wolfgang},
  title     = {Ion dynamics in quasi-perpendicular collisionless interplanetary shocks: a case study},
  series = {Frontiers in Physics},
  volume    = {1},
  journal   = {Frontiers in Physics},
  issn      = {2296-424X},
  doi       = {10.3389/fphy.2013.00029},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-189407},
  pages     = {29},
  year      = {2013},
  abstract  = {Interplanetary shocks are believed to play an important role in the acceleration of charged particles in the heliosphere. While the acceleration to high energies proceeds via the diffusive mechanism at the scales exceeding by far the shock width, the initial stage (injection) should occur at the shock itself. Numerical tracing of ions is done in a model quasi-perpendicular shock front with a typical interplanetary shock parameters (Mach number, upstream ion temperature). The analysis of the distribution of the transmitted solar wind is used to adjust the cross-shock potential which is not directly measured. It is found that, for typical upstream ion temperatures, acceleration of the ions from the tail of the solar wind distribution is unlikely. Pickup ions with a shell distribution are found to be effectively energized and may be injected into further diffusive acceleration regime. Pre-accelerated ions are efficiently upscaled in energies. A part of these ions is returned to the upstream region where they can further be diffusively accelerated.},
  language  = {en}
}
@article{NejadLangHahnetal.2013,
  author    = {Nejad, B. Chokoufe and Lang, J.-N. Lang and Hahn, T. and Mirabella, E.},
  title     = {FormCalc 8: Better Algebra and Vectorization},
  series = {Acta Physica Polonica B},
  volume    = {44},
  journal   = {Acta Physica Polonica B},
  number    = {11},
  doi       = {10.5506/APhysPolB.44.2231},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-128618},
  pages     = {2231-2239},
  year      = {2013},
  abstract  = {We present Version 8 of the Feynman-diagram calculator FormCalc. New features include, in particular, significantly improved algebraic simplification as well as vectorization of the generated code. The Cuba Library, used in FormCalc, features checkpointing to disk for all integration algorithms.},
  language  = {en}
}
@article{WobserSiedelKneitzetal.2013,
  author    = {Wobser, Marion and Siedel, Claudia and Kneitz, Hermann and Br{\"o}cker, Eva-Bettina and Goebeler, Mathias and Houben, Roland and Geissinger, Eva},
  title     = {Microvessel Density and Expression of Vascular Endothelial Growth Factor and its Receptors in Different Subtypes of Primary Cutaneous B-cell Lymphoma},
  series = {Acta Dermato-Venereologica},
  volume    = {93},
  journal   = {Acta Dermato-Venereologica},
  number    = {6},
  doi       = {10.2340/00015555-1589},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-128608},
  pages     = {656-662},
  year      = {2013},
  abstract  = {A proangiogenic micromilieu is associated with a worse prognosis in systemic lymphoma. Hence, targeting the tumour microenvironment and its vasculature has evolved as a promising novel treatment strategy. The role of tumour neoangiogenesis in cutaneous B-cell lymphoma, however, has not yet been elucidated. Therefore, we examined the expression of vascular endothelial growth factor (VEGF) and its receptors VEGFR-1 and VEGFR-2, as well as microvessel density by immunohistochemistry in paraffin-embedded specimens of different subtypes of primary cutaneous B-cell lymphomas, systemic diffuse large B-cell lymphoma, and cutaneous B-cell pseudolymphoma. Primary cutaneous large B-cell lymphoma (PCLBCL) were characterized by significantly higher intratumoral expression levels of VEGF and its receptors in comparison with the indolent lymphoma subtypes. Moreover, PCLBCL exhibited significantly higher intratumoral microvessel counts. Our study provides evidence that the most aggressive subtype of cutaneous B-cell lymphoma, PCLBCL, is characterized by a proangiogenic micromilieu.},
  language  = {en}
}
@article{PoppeBroeckerTrautmann2013,
  author    = {Poppe, Lidia M. and Br{\"o}cker, Eva-Bettina and Trautmann, Axel},
  title     = {The One-nail Brown Band: Macro- and Micro-morphology},
  series = {Acta Dermato-Venereologica},
  volume    = {93},
  journal   = {Acta Dermato-Venereologica},
  number    = {4},
  doi       = {10.2340/00015555-1505},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-128566},
  pages     = {479-480},
  year      = {2013},
  abstract  = {No abstract available.},
  language  = {en}
}
@article{Schneider2013,
  author    = {Schneider, Peter},
  title     = {Paradigm Shift},
  series = {Deutsches {\"A}rzteblatt International},
  volume    = {110},
  journal   = {Deutsches {\"A}rzteblatt International},
  number    = {22},
  doi       = {10.3238/arztebl.2013.0401a},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-128858},
  pages     = {401},
  year      = {2013},
  abstract  = {No abstract available.},
  language  = {en}
}
@article{MuellenbachRoewerKranke2013,
  author    = {M{\"u}llenbach, Ralf Michael and Roewer, Norbert and Kranke, Peter},
  title     = {Quality Assurance Would Be Welcome},
  series = {Deutsches {\"A}rzteblatt international},
  volume    = {110},
  journal   = {Deutsches {\"A}rzteblatt international},
  number    = {27-28},
  doi       = {10.3238/arztebl.2013.0485a},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-128844},
  pages     = {485},
  year      = {2013},
  abstract  = {No abstract available.},
  language  = {en}
}
@article{vanOorschotRadesLordick2013,
  author    = {van Oorschot, Birgitt and Rades, Dirk and Lordick, Florian},
  title     = {Connections Are Clearly More Complex},
  series = {Deutsches {\"A}rzteblatt international},
  volume    = {110},
  journal   = {Deutsches {\"A}rzteblatt international},
  number    = {44},
  doi       = {10.3238/arztebl.2013.0753a},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-128837},
  pages     = {753},
  year      = {2013},
  abstract  = {No abstract available.},
  language  = {en}
}
@article{KressHuettenhoferLandryetal.2013,
  author    = {Kress, Michaela and H{\"u}ttenhofer, Alexander and Landry, Marc and Kuner, Rohini and Favereaux, Alexandre and Greenberg, David and Bednarik, Josef and Heppenstall, Paul and Kronenberg, Florian and Malcangio, Marzia and Rittner, Heike and {\"U}{\c{c}}eyler, Nurcan and Trajanoski, Zlatko and Mouritzen, Peter and Birklein, Frank and Sommer, Claudia and Soreq, Hermona},
  title     = {microRNAs in nociceptive circuits as predictors of future clinical applications},
  series = {Frontiers in Molecular Neuroscience},
  volume    = {6},
  journal   = {Frontiers in Molecular Neuroscience},
  number    = {33},
  doi       = {10.3389/fnmol.2013.00033},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-154597},
  year      = {2013},
  abstract  = {Neuro-immune alterations in the peripheral and central nervous system play a role in the pathophysiology of chronic pain, and non-coding RNAs - and microRNAs (miRNAs) in particular - regulate both immune and neuronal processes. Specifically, miRNAs control macromolecular complexes in neurons, glia and immune cells and regulate signals used for neuro-immune communication in the pain pathway. Therefore, miRNAs may be hypothesized as critically important master switches modulating chronic pain. In particular, understanding the concerted function of miRNA in the regulation of nociception and endogenous analgesia and defining the importance of miRNAs in the circuitries and cognitive, emotional and behavioral components involved in pain is expected to shed new light on the enigmatic pathophysiology of neuropathic pain, migraine and complex regional pain syndrome. Specific miRNAs may evolve as new druggable molecular targets for pain prevention and relief. Furthermore, predisposing miRNA expression patterns and inter-individual variations and polymorphisms in miRNAs and/or their binding sites may serve as biomarkers for pain and help to predict individual risks for certain types of pain and responsiveness to analgesic drugs. miRNA-based diagnostics are expected to develop into hands-on tools that allow better patient stratification, improved mechanism-based treatment, and targeted prevention strategies for high risk individuals.},
  language  = {en}
}
@unpublished{WeithmannKlug2013,
  author    = {Weithmann, Sabrina and Klug, Stefan},
  title     = {Integrative Sustainable Concepts for Individual Mobility in Asia - A Qualitative Analysis of Carsharing and Taxi Services in Singapore},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-145982},
  year      = {2013},
  abstract  = {Singapore has a unique and proactive approach towards managing the national transport system. This article explores the integrative approach of carsharing into the overall transport system from an individual sustainable mobility perspective. The authors argue that for Singapore, taxi services are the strongest competitor for the establishment of free-floating carsharing systems. Low taxi fares and a high distribution rate provide easy access for consumers and show great advantages in correspondence with the prevalent transport measures. Furthermore, the Singaporean government considers taxi services as part of public transport that helps bridging public transportation gaps in door-to-door travel. The article draws on literature review and expert interviews to evaluate the current market conditions and analyse the pros and cons of carsharing systems and taxi services as integrated part of the public transport system. The authors conclude by stating that from a sustainable perspective, the goal is to replace private car ownership. Provision of multi modal choices and therefore co-existence of different individual transport opportunities is indispensable.},
  language  = {en}
}
@article{BuderGesierichGelbrichetal.2013,
  author    = {Buder, Kristina and Gesierich, Anja and Gelbrich, G{\"o}tz and Goebeler, Matthias},
  title     = {Systemic treatment of metastatic uveal melanoma: review of literature and future perspectives},
  series = {Cancer Medicine},
  volume    = {2},
  journal   = {Cancer Medicine},
  number    = {5},
  doi       = {10.1002/cam4.133},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-97175},
  pages     = {674-686},
  year      = {2013},
  abstract  = {Up to 50\% of patients with uveal melanoma develop metastatic disease with poor prognosis. Regional, mainly liver-directed, therapies may induce limited tumor responses but do not improve overall survival. Response rates of metastatic uveal melanoma (MUM) to systemic chemotherapy are poor. Insights into the molecular biology of MUM recently led to investigation of new drugs. In this study, to compare response rates of systemic treatment for MUM we searched Pubmed/Web of Knowledge databases and ASCO website (1980-2013) for "metastatic/uveal/melanoma" and "melanoma/eye." Forty studies (one case series, three phase I, five pilot, 22 nonrandomized, and two randomized phase II, one randomized phase III study, data of three expanded access programs, three retrospective studies) with 841 evaluable patients were included in the numeric outcome analysis. Complete or partial remissions were observed in 39/841 patients (overall response rate [ORR] 4.6\%; 95\% confidence intervals [CI] 3.3-6.3\%), no responses were observed in 22/40 studies. Progression-free survival ranged from 1.8 to 7.2, median overall survival from 5.2 to 19.0 months as reported in 21/40 and 26/40 studies, respectively. Best responses were seen for chemoimmunotherapy (ORR 10.3\%; 95\% CI 4.8-18.7\%) though mainly in first-line patients. Immunotherapy with ipilimumab, antiangiogenetic approaches, and kinase inhibitors have not yet proven to be superior to chemotherapy. MEK inhibitors are currently investigated in a phase II trial with promising preliminary data. Despite new insights into genetic and molecular background of MUM, satisfying systemic treatment approaches are currently lacking. Study results of innovative treatment strategies are urgently awaited.},
  language  = {en}
}