@article{WieberLangRohseetal.1994,
  author    = {Wieber, Markus and Lang, Stefan and Rohse, Stefan and Habersack, Ralph and Burschka, Christian},
  title     = {Synthese und Kristallstruktur von Triphenyltelluroniumsulfid},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-47151},
  year      = {1994},
  abstract  = {No abstract available},
  subject      = {Chemie},
  language  = {de}
}
@article{Wehgartner1994,
  author    = {Wehgartner, Irma},
  title     = {R{\"o}ntgenstrahlen und Arch{\"a}ologie},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-53827},
  year      = {1994},
  abstract  = {Naturwissenschaftliche Untersuchungsmethoden werden heute ganz selbstverst{\"a}ndlich zur wissenschaftlichen Erforschung arch{\"a}ologischer Objekte herangezogen. Dies gilt f{\"u}r die Materialbestimmung und die Kl{\"a}rung von Herstellungstechniken ebenso wie f{\"u}r die Feststellung von Alter oder Zugeh{\"o}rigkeit zu einer bestimmten Kulturlandschaft. Zugleich spielen diese Methoden bei der Echtheitspr{\"u}fung von St{\"u}cken unklarer Provenienz eine nicht unerhebliche Rolle.},
  subject      = {Arch{\"a}ologie},
  language  = {de}
}
@article{WaelbroeckCamusTastenoyetal.1994,
  author    = {Waelbroeck, M. and Camus, J. and Tastenoy, M. and Feifel, R. and Mutschler, E. and Tacke, R. and Strohmann, C. and Rafeiner, K. and Rodrigues de Miranda, J. F. and Lambrecht, G.},
  title     = {Binding and functional properties of hexocyclium and sila-hexocyclium derivatives to muscarinic receptor suhtypes},
  series = {British Journal of Pharmacology},
  volume    = {112},
  journal   = {British Journal of Pharmacology},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-128265},
  pages     = {505-514},
  year      = {1994},
  abstract  = {1 We have compared the binding properties of several hexocyclium and sila-hexocyclium derivatives to muscarinic Ml receptors (in rat brain, human neuroblastoma (NB-OK I) cells and calf superior cervical ganglia), rat heart M2 receptors, rat pancreas M3 receptors and M4 receptors in rat striatum, with their functional antimuscarinic properties in rabbit vas deferens (Ml/M4-like), guinea-pig atria (M2), and guinea-pig ileum (M3) muscarinic receptors. 2 Si la-substitution (C/Si exchange) of hexocyclium (~ sila-hexocyclium) and demethyl-hexocyclium (~demethyl-sila-hexocyclium) did not significantly affect their affinities for muscarinic receptors. By contrast, sila-substitution of demethoxy-hexocyclium increased its affinity 2 to 3 fold for all the muscarinic receptor subtypes studied. 3 The p-fluoro- and p-chloro-derivatives of sila-hexocyclium had lower affinities than the parent compound at the four receptor subtypes, in binding and pharmacological studies. 4 In binding studies, o-methoxy-sila-hexocyclium (Ml = M4 ~ M3 ~ M2) had a much lower affinity than sila-hexocyclium for the four receptor subtypes, and discriminated the receptor subtypes more poorly than sila-hexocyclium (Ml = M3> M4> M2)' This is in marked contrast with the very clear selectivity of demethoxy-sila-hexocyclium for the prejunctional MtlM4-like heteroreceptors in rabbit vas deferens. 5 The tertiary amines demethyl-hexocyclium, demethyl-sila-hexocyclium and demethyl-o-methoxy-silahexocyclium had 10 to 30 fold lower affinities than the corresponding quaternary ammonium derivatives.},
  language  = {en}
}
@article{VortkampGesslerPaslieretal.1994,
  author    = {Vortkamp, Andrea and Gessler, Manfred and Paslier, D. Le and Elaswarapu, R. and Smith, S. and Grzeschik, Karl-Heinz},
  title     = {Isolation of a yeast artificial chromosome contig spanning the Greig cephalopolysyndactyly syndrome (GCPS) gene region},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-30182},
  year      = {1994},
  abstract  = {Disruption of the zinc finger gene GLI3 has been shown to be the cause of Greig cephalopolysyndactyly syndrome (GCPS), at least in some GCPS translocation patients. To characterize this genomic region on human chromosome 7p13, we have isolated a VAC contig of more than 1000 kb including the GLI3 gene. In this contig the gene itself spans at least 200-250 kb. A CpG island is located in the vicinity of the 5' region of the known GLI3 cDNA, implying a potential promoter region.},
  language  = {en}
}
@article{UlrichsWangMuellerBuchholtz1994,
  author    = {Ulrichs, Karin and Wang, H. and M{\"u}ller-Buchholtz, W.},
  title     = {Down-regulation of xenophile antibodies by 15-deoxyspergualin in an experimental animal model},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-44733},
  year      = {1994},
  abstract  = {No abstract available},
  subject      = {Chirurgie},
  language  = {en}
}
@article{UlrichsEcksteinTibelletal.1994,
  author    = {Ulrichs, Karin and Eckstein, V. and Tibell, A. and Groth, C. G. and Korsgren, O. and M{\"u}ller-Ruchholtz, W. and Thiede, A.},
  title     = {Nat{\"u}rliche und induzierte xenoreaktive Antik{\"o}rper vor und nach klinischer Transplantation f{\"o}taler porziner Pankreasinselzellen},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-72967},
  year      = {1994},
  abstract  = {No abstract available.},
  subject      = {Antik{\"o}rper},
  language  = {de}
}
@article{UlrichsEcksteinMuellerBuchholtz1994,
  author    = {Ulrichs, Karin and Eckstein, V. and M{\"u}ller-Buchholtz, W.},
  title     = {Xenogeneic T-cell-mediated immune reactivity in the model of pig-to-humans: first findings with native stimulator cells},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-44755},
  year      = {1994},
  abstract  = {No abstract available},
  subject      = {Chirurgie},
  language  = {en}
}
@article{UlrichsEcksteinKorsgrenetal.1994,
  author    = {Ulrichs, Karin and Eckstein, V. and Korsgren, O. and Tibell, A. and Groth, C. G. and M{\"u}ller-Ruchholtz, W.},
  title     = {Characterization of natural and induced human xenophile antibodies before and after transplantation of the fetal porcine endocrine pancreas},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-86985},
  year      = {1994},
  abstract  = {No abstract available.},
  subject      = {Bauspeicheldr{\"u}se},
  language  = {de}
}
@article{UlrichsBosseWackeretal.1994,
  author    = {Ulrichs, Karin and Bosse, M. and Wacker, HH and Heiser, A. and M{\"u}ller-Ruchholtz, W.},
  title     = {Histologic analysis of the porcine pancreas to improve islet yield and integrity after collagenase digestion},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-45166},
  year      = {1994},
  abstract  = {No abstract available},
  subject      = {Chirurgie},
  language  = {en}
}
@article{ToenniesBacherForcheletal.1994,
  author    = {T{\"o}nnies, D. and Bacher, G. and Forchel, Alfred and Waag, A. and Litz, Th. and Hommel, D. and Becker, Charles R. and Landwehr, G. and Heuken, M. and Scholl, M.},
  title     = {Optical study of interdiffusion in CdTe and ZnSe based quantum wells},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-37750},
  year      = {1994},
  abstract  = {No abstract available},
  language  = {en}
}
@article{TonyShenReuschetal.1994,
  author    = {Tony, H. P. and Shen, B. J. and Reusch, P. and Sebald, Walter},
  title     = {Design of human interleukin-4 antagonists inhibiting interleukin-4-dependent and interleukin-13-dependent responses in T-cells and B-cells with high efficiency},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-62394},
  year      = {1994},
  abstract  = {Human interleukin-4 possesses two distinct sites for receptor activation. A signaHing site, comprising residues near the C-terminus on helix D, determines the efficacy of interleukin-4 signal transduction without affecting the binding to the interleukin-4 receptor a subunit. A complete antagonist and a series of low-efficacy agonist variants of human interleukin-4 could be generated by introducing combinations of two or three negatively charged aspartic acid residues in this site at positions 121, 124, and 125. One of the double variants, designated [R121D,Y124D]interleukin-4, with replacements of b{\"o}th Arg121 and Tyr124 by aspartic acid residues was completely inactive in all analysed cellular responses. The loss of efficacy in [R121D,Y124D]interleukin-4 is estimated to be larger than 2000-fold. Variant [R121D,Y124D]interleukin-4 was also a perfect antagonist for inhibition of interleukin-13-dependent responses in B-cells and the TF-1 cellline with a K\(_i\) value of approximately 100 pM. In addition, inhibition of both interleukin-4-induced and interleuk.in-13- induced responses could be obtained by monoclonal antibody X2/45 raised against interleukin-4Rm the extracellular domain of the interleuk.in-4 receptor a subunit. These results indicate that efficient interleukin-4 antagonists can be designed on the basis of a sequential two-step activation model. In addition, the experiments indicate the functional participation of the interleukin-4 receptor a subunit in the interleukin-13 receptor system.},
  subject      = {Biochemie},
  language  = {en}
}
@article{TackeWagnerSperlich1994,
  author    = {Tacke, Reinhold and Wagner, S. A. and Sperlich, J.},
  title     = {Synthese von (-)-(Acetoxymethyl)(hydroxy-methyl)methyl(phenyl)german [(-)-MePhGe(CH\(_2\)OAc)(CH\(_2\)OH)] durch eine Esterase-katalysierte Umesterung: Die erste enzymatische Synthese eines optisch aktiven Germans},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-64310},
  year      = {1994},
  abstract  = {No abstract available.},
  subject      = {Anorganische Chemie},
  language  = {de}
}
@article{TackeSperlichBecker1994,
  author    = {Tacke, Reinhold and Sperlich, J. and Becker, B.},
  title     = {Bis[2,3-naphthalenediolato(2-)](pyrrolidinio-methyl)germanate-tetartoacetonitrile, the first zwitterionic \(\lambda_5\)-germanate: synthesis and crystal structure analysis},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-64329},
  year      = {1994},
  abstract  = {The zwitterionic spirocyclic \(\lambda_5\)-germanate bis(2,3-naphthalenediolato( 2-)](pyrrolidiniomethyl)germanate (8) was synthesized and the crystal structure of its tetartoacetonitrile solvate 8 · 1/4 CH\(_3\)CN studied by single-crystal X-ray diffraction. Compound 8 was prepared by reaction of (MeO)\(_3\)GeCH\(_2\)NC\(_4\)H\(_8\) (11; NC\(_4\)H\(_8\) = pyrrolidino) with two equivalents of 2,3-naphthalenediol (isolated as 8 · 1/4 CH\(_3\)CN; yield 92\%). The coordination polyhedron around the pentacoordi- naphthalenediolatonate germanium atom of 8 · 1/4 CH\(_3\)CN can be described as a strongly distorted trigonal bipyramid (the structure is displaced by 38.9\% from the ideal trigonal bipyrarnid towards the ideal square pyramid), the carbon atom occupying an equatorial position. In the crystal lattice of 8 · 1/4 CH\(_3\)CN, the zwitterions form intermolecular N-H ... o hydrogen bonds leading to the formation of dimers. 1H- and \(^{13}\C-NMR studies revealed that 8 also exists in solution ([D\(_6\)]DMSO).},
  subject      = {Anorganische Chemie},
  language  = {en}
}
@article{TackePikiesWiesenbergeretal.1994,
  author    = {Tacke, Reinhold and Pikies, J. and Wiesenberger, F. and Ernst, L. and Schomburg, D. and Waelbroeck, M. and Christophe, J. and Lambrecht, G. and Gross, J. and Mutschler, E.},
  title     = {Sila-biperiden und endo-Sila-biperiden: Synthesen, Kristallstrukturen und antimuscarinische Eigenschaften},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-64303},
  year      = {1994},
  abstract  = {Starting from trichloro(vinyl)silane (Cl\(_3\)SiCH=CH\(_2\)), the musearinic antagonists sila-biperiden [rac-(SiRS,C2SR>-ao-2] and endosila- biperiden [rac-(SiRS,C2SR)-endo-2] were prepared by a seven-step synthesis. Both silanols are configurationally stableininert organic solvents but undergo slow epimerization in aqueous solution (pH 7.4, 32°C) by inversion of the configuration at the silicon atom. The relative configurations of sila-biperiden and endo-sila-biperiden were detennined by single-crystal X-ray diffraction. Both compounds form intennolecular 0-H · · · N hydrogen bonds in the crystal leading to the fonnation of centrosymmetric dimers (sila-biperiden) and infinite chains (endo-sila-biperiden), respectively. Sila-biperiden is a silicon analogue (C/Si exchange) of the antiparkinsonian drug biperiden [rac-(CRS/C2SR}-exo-1]. In functional phannacological experiments, as well as in radioligand competition studies, biperiden, sila-biperiden and endo-sila-biperiden behaved as simple competitive antagonists at muscarinic Ml-, M2-, M3- and M4-receptors. The three compounds displayed the highest affinity for Ml-receptors (pA\(_2\) values: 8.72-8.80; pK\(_i\) values: 8.8-9.1), intermediate affinity for M4- and M3-receptors, and lowest affinity for M2-receptors (pA\(_2\) values: 7.57-7.79; pK\(_i\) values: 7.7-7.8). The affinity profile (Ml >. M4 > M3 > M2) of biperiden, sila-biperiden and endo-sila-biperiden is qualitatively similar to that of the M1-selective muscarinic antagonist pirenzepine. The antimuscarinic properlies of the C/Si analogues biperiden and sila-biperiden are almost identical.},
  subject      = {Anorganische Chemie},
  language  = {en}
}
@article{TackeMuehleisenJones1994,
  author    = {Tacke, Reinhold and M{\"u}hleisen, M. and Jones, P. G.},
  title     = {Das erste zwitterionische, optisch aktive Disilicat mit pentakoordiniertem Silicium},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-64343},
  year      = {1994},
  abstract  = {No abstract available},
  subject      = {Anorganische Chemie},
  language  = {de}
}
@article{TackeMuehleisenJones1994,
  author    = {Tacke, Reinhold and M{\"u}hleisen, M. and Jones, P. G.},
  title     = {The first zwitterionic, optically active disilicate with pentacoordinate silicon},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-64358},
  year      = {1994},
  abstract  = {No abstract available},
  subject      = {Anorganische Chemie},
  language  = {en}
}
@article{TackeMuehleisen1994,
  author    = {Tacke, Reinhold and M{\"u}hleisen, M.},
  title     = {Bis[benzilato(2-)-O\(^1\),O\(^2\)][2-(dimethylammonio)ethoxy]silicate: synthesis and structural characterization of a zwitterionic \(\lambda^5\)Si-silicate with a SiO\(_5\) framework},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-64400},
  year      = {1994},
  abstract  = {No abstract available},
  subject      = {Anorganische Chemie},
  language  = {en}
}
@article{TackeMuehleisen1994,
  author    = {Tacke, Reinhold and M{\"u}hleisen, M.},
  title     = {Hexakoordiniertes Silicium in einer molekularen Verbindung mit einer F\(_5\)SiC-Einheit},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-64365},
  year      = {1994},
  abstract  = {No abstract available},
  subject      = {Anorganische Chemie},
  language  = {de}
}
@article{TackeMuehleisen1994,
  author    = {Tacke, Reinhold and M{\"u}hleisen, M.},
  title     = {Hexacoordinate silicon in a compound with an F\(_5\)SiC unit},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-64378},
  year      = {1994},
  abstract  = {No abstract available},
  subject      = {Anorganische Chemie},
  language  = {en}
}
@article{TackeLopezMrasJones1994,
  author    = {Tacke, Reinhold and Lopez-Mras, A. and Jones, P. G.},
  title     = {Syntheses, crystal structure analyses, and NMR studies of [2-(dimethylammonio)phenyl]bis[glycolato(2-)-O1,O2]silicate and related zwitterionic spirocyclic \(\lambda_5\)Si-silicates},
  url       = {http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-64339},
  year      = {1994},
  abstract  = {No abstract available},
  subject      = {Anorganische Chemie},
  language  = {en}
}